Abstract：
BACKGROUND:The integrin-binding protein osteopontin is strongly associated with tumour development, yet is an abundant dietary component as a constituent of human and bovine milk. Therefore, we tested the effect of orally administered osteopontin (o-OPN) on the development of subcutaneous tumours in mice. METHODS:Bovine milk osteopontin was administered in drinking water to tumour-bearing immune-competent mice. Tumour growth, proliferation, necrosis, apoptosis and blood vessel size and number were measured. Expression of the α₉ integrin was determined. RESULTS:o-OPN suppressed tumour growth, increased the extent of necrosis, and induced formation of abnormally large blood vessels. Anti-OPN reactivity detected in the plasma of OPN-null mice fed OPN suggested that tumour-blocking peptides were absorbed during digestion, but the o-OPN effect was likely distinct from that of an RGD peptide. Expression of the α₉ integrin was detected on both tumour cells and blood vessels. Potential active peptides from the α₉ binding site of OPN were identified by mass spectrometry following in vitro digestion, and injection of these peptides suppressed tumour growth. CONCLUSIONS:These results suggest that peptides derived from o-OPN are absorbed and interfere with tumour growth and normal vessel development. o-OPN-derived peptides that target the α₉ integrin are likely involved.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Rittling SR,Wejse PL,Yagiz K,Warot GA,Hui Tdoi
10.1038/bjc.2014.10subject
Has Abstractpub_date
2014-03-04 00:00:00pages
1269-77issue
5eissn
0007-0920issn
1532-1827pii
bjc201410journal_volume
110pub_type
杂志文章abstract：BACKGROUND:The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management of cancer pain, and preclinical studies indicate that opioids have the p...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
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更新日期：2014-08-26 00:00:00
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journal_title：British journal of cancer
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pub_type： 杂志文章,评审
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.45
更新日期：1982-02-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6601575
更新日期：2004-02-23 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2012-10-09 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6690098
更新日期：1999-02-01 00:00:00
