Abstract：
BACKGROUND:The lifestyle risk factors for nasopharyngeal carcinoma (NPC) in North Africa are not known. METHODS:From 2002 to 2005, we interviewed 636 patients and 615 controls from Algeria, Morocco and Tunisia, frequency-matched by centre, age, sex, and childhood household type (urban/rural). Conditional logistic regression was used to evaluate the association of lifestyles with NPC risk, controlling for socioeconomic status and dietary risk factors. RESULTS:Cigarette smoking and snuff (tobacco powder with additives) intake were significantly associated with differentiated NPC but not with undifferentiated carcinoma (UCNT), which is the major histological type of NPC in these populations. As demonstrated by a stratified permutation test and by conditional logistic regression, marijuana smoking significantly elevated NPC risk independently of cigarette smoking, suggesting dissimilar carcinogenic mechanisms between cannabis and tobacco. Domestic cooking fumes intake by using kanoun (compact charcoal oven) during childhood increased NPC risk, whereas exposure during adulthood had less effect. Neither alcohol nor shisha (water pipe) was associated with risk. CONCLUSION:Tobacco, cannabis and domestic cooking fumes intake are risk factors for NPC in western North Africa.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Feng BJ,Khyatti M,Ben-Ayoub W,Dahmoul S,Ayad M,Maachi F,Bedadra W,Abdoun M,Mesli S,Bakkali H,Jalbout M,Hamdi-Cherif M,Boualga K,Bouaouina N,Chouchane L,Benider A,Ben-Ayed F,Goldgar DE,Corbex Mdoi
10.1038/sj.bjc.6605281subject
Has Abstractpub_date
2009-10-06 00:00:00pages
1207-12issue
7eissn
0007-0920issn
1532-1827pii
6605281journal_volume
101pub_type
杂志文章abstract：BACKGROUND:The Obermair nomogram was recently developed to predict the risk of relapse in patients with borderline ovarian tumours (BOTs) based on five readily available clinical, biological, and pathological characteristics. We set out to externally validate and assess its robustness using a multi-institutional BOT da...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
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journal_title：British journal of cancer
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