当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > A phase I/IIa study of adjuvant immunotherapy with tumour antigen-pulsed dendritic cells in patients with hepatocellular carcinoma.

A phase I/IIa study of adjuvant immunotherapy with tumour antigen-pulsed dendritic cells in patients with hepatocellular carcinoma.

Abstract：

BACKGROUND:To date, no adjuvant treatment has been shown to have a clear benefit in patients with hepatocellular carcinoma (HCC). In this prospective phase I/IIa study, we evaluated the safety and efficacy of adjuvant dendritic cell (DC) therapy in HCC patients who received primary treatment for HCC. METHODS:Twelve HCC patients who had no viable tumour after primary treatments were included. Dendritic cell vaccines pulsed with cytoplasmic transduction peptide-attached alpha-fetoprotein, glypican-3 and melanoma-associated antigen 1 recombinant fusion proteins were injected subcutaneously near to inguinal lymph nodes. Adverse effects, time to progression (TTP), and associated immune responses were evaluated after DC vaccination. RESULTS:Nine of 12 patients had no tumour recurrence up to 24 weeks after DC vaccination. Among a total of 144 adverse events, 129 events (89.6%) were regarded as adverse drug reactions, all of which were grade 1 or 2. The majority of patients showed enhanced anti-tumour immune responses after DC vaccination. Recurrence-free patients exhibited relatively stronger anti-tumour immune responses than patients who developed recurrence after DC vaccination, as evidenced by lymphocyte proliferation and IFN-γ ELISPOT assays. The median time of TTP was 36.6 months in the DC-vaccination group and 11.8 months in the control group (hazard ratio, 0.41; 95% confidence interval, 0.18-0.95; P=0.0031 by log-rank test). CONCLUSIONS:Adjuvant DC vaccine for HCC was safe and well tolerated in phase I/IIa study, and preliminary efficacy data are encouraging to warrant further clinical study in patients with HCC after primary treatments.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Lee JH,Lee Y,Lee M,Heo MK,Song JS,Kim KH,Lee H,Yi NJ,Lee KW,Suh KS,Bae YS,Kim YJ

doi

10.1038/bjc.2015.430

subject

Has Abstract

pub_date

2015-12-22 00:00:00

pages

1666-76

issue

12

eissn

0007-0920

issn

1532-1827

pii

bjc2015430

journal_volume

113

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Combination versus sequential single agent chemotherapy in advanced breast cancer: associations with metastatic sites and long-term survival. The Western Cancer Study Group and The Southeastern Cancer Study Group.

    abstract：:Two hundred and twenty-two patients with advanced breast cancer were randomised in two separate trials of similar design to either concomitant combination treatment or sequential use of the same drugs given as single agents changed only at disease progression. Both trials used cyclophosphamide, methotrexate, 5-fluorou...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/bjc.1989.46

    authors： Chlebowski RT,Smalley RV,Weiner JM,Irwin LE,Bartolucci AA,Bateman JR

    更新日期：1989-02-01 00:00:00

  • Combined effects of goserelin and tamoxifen on estradiol level, breast density, and endometrial thickness in premenopausal and perimenopausal women with early-stage hormone receptor-positive breast cancer: a randomised controlled clinical trial.

    abstract：BACKGROUND:This study is to investigate the effects of geserelin+tamoxifen (TAM) on estradiol level, breast density (BD), endometrial thickness (ET), and blood lipids in premenopausal and perimenopausal women with hormone receptor-positive early-stage breast cancer. METHODS:This study recruited 110 premenopausal and p...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2013.324

    authors： Yang H,Zong X,Yu Y,Shao G,Zhang L,Qian C,Bian Y,Xu X,Sun W,Meng X,Ding X,Chen D,Zou D,Xie S,Zheng Y,Zhang J,He X,Sun C,Yu X,Ni J

    更新日期：2013-08-06 00:00:00

  • Successful receptor-mediated radiation therapy of xenografted human midgut carcinoid tumour.

    abstract：:Somatostatin receptor (sstr)-mediated radiation therapy is a new therapeutic modality for neuroendocrine (NE) tumours. High expression of sstr in NE tumours leads to tumour-specific uptake of radiolabelled somatostatin analogues and high absorbed doses. In this study, we present the first optimised radiation therapy v...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602845

    authors： Kölby L,Bernhardt P,Johanson V,Schmitt A,Ahlman H,Forssell-Aronsson E,Mäcke H,Nilsson O

    更新日期：2005-11-14 00:00:00

  • Phase II study of the oxygen saturation curve left shifting agent BW12C in combination with the hypoxia activated drug mitomycin C in advanced colorectal cancer.

    abstract：:BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) stabilizes oxyhaemoglobin, causing a reversible left-shift of the oxygen saturation curve (OSC) and tissue hypoxia. The activity of mitomycin C (MMC) is enhanced by hypoxia. In this phase II study, 17 patients with metastatic colorectal cancer resistant to 5-fluorou...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1054/bjoc.2000.1138

    authors： Propper DJ,Levitt NC,O'Byrne K,Braybrooke JP,Talbot DC,Ganesan TS,Thompson CH,Rajagopalan B,Littlewood TJ,Dixon RM,Harris AL

    更新日期：2000-06-01 00:00:00

  • Selective cytotoxic activity of immunotoxins composed of a monoclonal anti-Thy 1.1 antibody and the ribosome-inactivating proteins bryodin and momordin.

    abstract：:The ribosome-inactivating proteins, bryodin, from Bryonia dioica, and momordin, from Momordica charantia, were coupled by a disulphide bond to a monoclonal anti-Thy 1.1 antibody (OX7). Both immunotoxins were specifically cytotoxic to the Thy 1.1-expressing mouse lymphoma cell line AKR-A in vitro. The OX7-bryodin immun...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1988.258

    authors： Stirpe F,Wawrzynczak EJ,Brown AN,Knyba RE,Watson GJ,Barbieri L,Thorpe PE

    更新日期：1988-11-01 00:00:00

  • P53 germline mutations in childhood cancers and cancer risk for carrier individuals.

    abstract：:The family history of cancer in children treated for a solid malignant tumour in the Paediatric Oncology Department at Institute Gustave-Roussy, has been investigated. In order to determine the role of germline p53 mutations in genetic predisposition to childhood cancer, germline p53 mutations were sought in individua...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1167

    authors： Chompret A,Brugières L,Ronsin M,Gardes M,Dessarps-Freichey F,Abel A,Hua D,Ligot L,Dondon MG,Bressac-de Paillerets B,Frébourg T,Lemerle J,Bonaïti-Pellié C,Feunteun J

    更新日期：2000-06-01 00:00:00

  • On the age-dependent association between cancer of the breast and of the endometrium. A nationwide cohort study.

    abstract：:The association between breast and endometrial cancer was investigated in a cohort consisting of 60,065 subjects (99% of all women in whom a first breast cancer was diagnosed in Sweden in 1960-63 and 1968-81). Complete follow-up until 1981 revealed a total of 260 endometrial cancers, as against an expected number of 1...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1987.16

    authors： Adami HO,Krusemo UB,Bergkvist L,Persson I,Pettersson B

    更新日期：1987-01-01 00:00:00

  • Intake of wholegrain products and risk of colorectal cancers in the Diet, Cancer and Health cohort study.

    abstract：BACKGROUND:Consumption of wholegrain (WG) products may protect against colon and rectal cancer. METHODS:The associations between total and individual WG product consumption and colon and rectal cancer risk were prospectively examined using data on 461 incident cases of colon cancer and 283 incident cases of rectal can...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605806

    authors： Egeberg R,Olsen A,Loft S,Christensen J,Johnsen NF,Overvad K,Tjønneland A

    更新日期：2010-08-24 00:00:00

  • Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel.

    abstract：:Currently, there are no effective biomarkers for ovarian cancer prognosis or prediction of therapeutic response. The objective of this study was to examine a panel of 10 serum biochemical parameters for their ability to predict response to chemotherapy, progression and survival of ovarian cancer patients. Sera from ov...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604630

    authors： Oikonomopoulou K,Li L,Zheng Y,Simon I,Wolfert RL,Valik D,Nekulova M,Simickova M,Frgala T,Diamandis EP

    更新日期：2008-10-07 00:00:00

  • Patterns of childhood cancer among siblings.

    abstract：:The National Registry of Childhood Tumours contains over 51000 records of children born in Great Britain who developed cancer under the age of 15 years. Patterns of childhood cancer among families containing more than one child with cancer have been studied. A total of 225 "sib pair' families have been ascertained fro...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.331

    authors： Draper GJ,Sanders BM,Lennox EL,Brownbill PA

    更新日期：1996-07-01 00:00:00

  • Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model.

    abstract：BACKGROUND:Epigenetic silencing by promoter methylation and chromatin remodelling affects hundreds of genes and is a causal event for lung cancer. Treatment of patients with low doses of the demethylating agent 5-azacytidine in combination with the histone deacetylase inhibitor entinostat has yielded clinical responses...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.575

    authors： Reed MD,Tellez CS,Grimes MJ,Picchi MA,Tessema M,Cheng YS,March TH,Kuehl PJ,Belinsky SA

    更新日期：2013-10-01 00:00:00

  • Vegetable, fruit and antioxidant nutrient consumption and subsequent risk of hepatocellular carcinoma: a prospective cohort study in Japan.

    abstract：:In a population-based prospective study of 19,998 Japanese individuals, consumption of vegetables, green-yellow and green leafy vegetables was inversely associated with the risk of hepatocellular carcinoma (101 cases), with multivariable hazard ratios for the highest vs lowest tertile of 0.61 (95% confidence interval ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604843

    authors： Kurahashi N,Inoue M,Iwasaki M,Tanaka Y,Mizokami M,Tsugane S,JPHC Study Group.

    更新日期：2009-01-13 00:00:00

  • Epiregulin gene expression as a biomarker of benefit from cetuximab in the treatment of advanced colorectal cancer.

    abstract：BACKGROUND:Anti-EGFR antibody, cetuximab, improves overall survival (OS) in K-ras wild-type chemotherapy-refractory colorectal cancer. Epidermal growth factor receptor ligand epiregulin (EREG) gene expression may further predict cetuximab benefit. METHODS:Tumour samples from a phase III clinical trial of cetuximab plu...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.753

    authors： Jonker DJ,Karapetis CS,Harbison C,O'Callaghan CJ,Tu D,Simes RJ,Malone DP,Langer C,Tebbutt N,Price TJ,Shapiro J,Siu LL,Wong RP,Bjarnason G,Moore MJ,Zalcberg JR,Khambata-Ford S

    更新日期：2014-02-04 00:00:00

  • Oral tegafur in the treatment of gastrointestinal tract cancers: a phase II study.

    abstract：:Fifty patients affected by histologically confirmed gastrointestinal tract cancer (GTC) were treated with oral tegafur (TG) 1,000 mg m-2 p.o. on days 1-14 repeated after a 14 day interval. Out of 42 evaluable patients seven patients had a partial response (PR. 17%) with a median duration of 20.5 weeks, three had a min...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.105

    authors： Palmeri S,Gebbia V,Russo A,Armata MG,Gebbia N,Rausa L

    更新日期：1990-03-01 00:00:00

  • Management preferences in stage I non-seminomatous germ cell tumours of the testis: an investigation among patients, controls and oncologists.

    abstract：:Increasingly, treatment choices leading to the same survival outcome can be offered to cancer patients (e.g. mastectomy or conservative surgery in early breast cancer). Two approaches available for post-orchidectomy, stage I patients with non-seminomatous germ cell tumours of the testis (NSGCTT), particularly those at...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.570

    authors： Cullen MH,Billingham LJ,Cook J,Woodroffe CM

    更新日期：1996-11-01 00:00:00

  • N-methylformamide: antitumour activity and metabolism in mice.

    abstract：:The antitumour activities of N-methylformamide, N-ethylformamide and formamide against a number of murine tumours in vivo (Sarcoma 180, M5076 ovarian sarcoma and TLX5 lymphoma) have been estimated. In all cases N-methyl-formamide had significant activity, formamide had marginal or no activity and N-ethylformamide had ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1982.136

    authors： Gescher A,Gibson NW,Hickman JA,Langdon SP,Ross D,Atassi G

    更新日期：1982-06-01 00:00:00

  • GOLPH3 is a novel marker of poor prognosis and a potential therapeutic target in human renal cell carcinoma.

    abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.124

    authors： Xue Y,Wu G,Liao Y,Xiao G,Ma X,Zou X,Zhang G,Xiao R,Wang X,Liu Q,Long D,Yang J,Xu H,Liu F,Liu M,Xie K,Huang R

    更新日期：2014-04-29 00:00:00

  • Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers.

    abstract：:We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all four samples, wheth...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603298

    authors： Clarke CL,Sandle J,Jones AA,Sofronis A,Patani NR,Lakhani SR

    更新日期：2006-08-21 00:00:00

  • The incidence of B cell leukaemia and lymphopenia in B cell neoplasia in adults: a study using the Kiel classification of non-Hodgkin's lymphoma.

    abstract：:The incidence of B cell leukaemia in 186 consecutive untreated patients with histologically defined B cell neoplasms is described. The lymphomas were classified by the Kiel convention. B cell leukaemia in the context of this paper refers to the situation where a neoplastic clone of B cells in the blood greatly outnumb...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1983.174

    authors： Cader A,Richardson P,Walsh L,Ling NR,MacLennan IC,Jones EL,Leyland M

    更新日期：1983-08-01 00:00:00

  • Phase II study of cetuximab in combination with cisplatin and docetaxel in patients with untreated advanced gastric or gastro-oesophageal junction adenocarcinoma (DOCETUX study).

    abstract：BACKGROUND:The conventional treatment options for advanced gastric patients remain unsatisfactory in terms of response rate, response duration, toxicity, and overall survival benefit. The purpose of this phase II study was to evaluate the activity and safety of cetuximab combined with cisplatin and docetaxel as a first...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/sj.bjc.6605319

    authors： Pinto C,Di Fabio F,Barone C,Siena S,Falcone A,Cascinu S,Rojas Llimpe FL,Stella G,Schinzari G,Artale S,Mutri V,Giaquinta S,Giannetta L,Bardelli A,Martoni AA

    更新日期：2009-10-20 00:00:00

  • Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor.

    abstract：:NRH:Quinone Oxidoreductase 2 (NQO2) has been described as having no enzymatic activity with nicotinamide adenine dinucleotide (NADH) or NADPH as electron donating cosubstrates. Mitomycin C (MMC) is both a substrate for and a mechanistic inhibitor of the NQO2 homologue NQO1. NRH:quinone oxidoreductase 2 catalysed the r...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603414

    authors： Jamieson D,Tung AT,Knox RJ,Boddy AV

    更新日期：2006-11-06 00:00:00

  • Stressful life events and cancer risk.

    abstract：:In a prospective cohort study in Denmark of 8736 randomly selected people, no evidence was found among 1011 subjects who developed cancer that self-reported stressful major life events had increased their risk for cancer. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603471

    authors： Bergelt C,Prescott E,Grønbaek M,Koch U,Johansen C

    更新日期：2006-12-04 00:00:00

  • Risk of cancer in patients with dermatomyositis or polymyositis, and follow-up implications: a Scottish population-based cohort study.

    abstract：:We conducted a national, retrospective population-based cohort study of 705 patients hospitalized with a first diagnosis of dermatomyositis (DM) or polymyositis (PM) during 1982-1996 based on linkage of hospital discharge, cancer registration, and death records in Scotland. Risks of cancer were assessed by calculating...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2001.1699

    authors： Stockton D,Doherty VR,Brewster DH

    更新日期：2001-07-06 00:00:00

  • Intra-tumoural variation of oestrogen receptor status in endometrial cancer.

    abstract：:Soluble and nuclear oestrogen receptor status was determined in both the central and peripheral portions of tumour for 37 cases of adenocarcinoma of the endometrium. Of these, 29 had functional receptor in the peripheral biopsy, but only 19 retained functional receptor in the centre. Six of the 10 patients whose tumou...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1983.34

    authors： Castagnetta L,Lo Casto M,Mercadante T,Polito L,Cowan S,Leake RE

    更新日期：1983-02-01 00:00:00

  • The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer.

    abstract：BACKGROUND:On the base of the microRNA (miRNA) expression signature of bladder cancer (BC), we found that miR-1 and miR-133a were significantly downregulated in BC. In this study, we focussed on the functional significance of miR-1 and miR-133a in BC cell lines and identified a molecular network of these miRNAs. METHO...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.23

    authors： Yoshino H,Chiyomaru T,Enokida H,Kawakami K,Tatarano S,Nishiyama K,Nohata N,Seki N,Nakagawa M

    更新日期：2011-03-01 00:00:00

  • Comparison of prognostic factors in patients in phase I trials of cytotoxic drugs vs new noncytotoxic agents.

    abstract：:The aims of this study were to identify prognostic variables for toxicity and survival in patients with cancer participating in phase I clinical trials and compare characteristics of those treated with cytotoxic chemotherapy (CT) and non-cytotoxic drugs (non-CT). Data were collected from 420 (114 CT, 306 non-CT) patie...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601218

    authors： Han C,Braybrooke JP,Deplanque G,Taylor M,Mackintosh D,Kaur K,Samouri K,Ganesan TS,Harris AL,Talbot DC

    更新日期：2003-10-06 00:00:00

  • Childhood cancer after prenatal exposure to diagnostic X-ray examinations in Britain.

    abstract：:Detailed data were provided by the Oxford Survey of Childhood Cancer OSCC on deaths from childhood cancer in Britain after irradiation of the fetus during diagnostic radiology of the mother. In each age group at death, 0-5, 6-9 and 10-15 years, excess cancer deaths decreased suddenly for births in and after 1958. A ma...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.1990.249

    authors： Mole RH

    更新日期：1990-07-01 00:00:00

  • Enzymic retrodifferentiation during hepatocarcinogenesis and liver regeneration in rats in vivo.

    abstract：:The work presented here has concerned the study of early, as well as late, enzymic changes occurring during diethylnitrosamine-induced hepatocarcinogenesis and liver regeneration after partial hepatectomy in comparison with normal liver differentiation. Rank correlation analysis of the enzyme data suggested a step-wis...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1983.222

    authors： Curtin NJ,Snell K

    更新日期：1983-10-01 00:00:00

  • Chemotherapy of non-small cell lung carcinoma guided by an in vitro drug resistance assay measuring total tumour cell kill.

    abstract：:Specimens from 45 patients with previously-untreated non-small cell lung cancer (NSCLC) were tested for in vitro chemosensitivity to ten drugs utilising the DiSC assay, which measures cell kill in the total (largely non-dividing) tumour cell population. Thirty-five assays were successful and 25 patients with advanced ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.5

    authors： Wilbur DW,Camacho ES,Hilliard DA,Dill PL,Weisenthal LM

    更新日期：1992-01-01 00:00:00

  • Does deprivation affect breast cancer management?

    abstract：:We evaluated whether social deprivation affected decision-making for breast cancer surgery. Of 3419 patients, 53.6% had mastectomy and this was predicted by deprivation, age, tumour size and hospital, all of which retained significance on multivariate analysis, except deprivation. Pathological characteristics and surg...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602390

    authors： Henley NC,Hole DJ,Kesson E,Burns HJ,George WD,Cooke TG

    更新日期：2005-02-28 00:00:00