Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) trials.

abstract：BACKGROUND:To evaluate the prognostic value of lymph node density (LND) in patients with lymph node-positive cervical cancer. METHODS:A total of 88 consecutive patients were included in our study. Patients were treated with cisplatin-based concomitant chemoradiotherapy after surgical staging was performed at the Medic...

journal_title：British journal of cancer

authors： Polterauer S,Hefler L,Seebacher V,Rahhal J,Tempfer C,Horvat R,Reinthaller A,Grimm C

更新日期：2010-08-24 00:00:00

abstract：:In the BUPA Study, a prospective study of 22,000 men attending a screening centre in London, serum samples were collected and stored. The concentration of beta-carotene was measured in the stored serum samples from 271 men who were subsequently notified as having cancer and from 533 unaffected controls, matched for ag...

journal_title：British journal of cancer

authors： Wald NJ,Thompson SG,Densem JW,Boreham J,Bailey A

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Isolated groups, such as first generation non-Western immigrants, are at risk for suboptimal utilisation of the health care system resulting in a worse outcome. METHODS:From 1989 to 2007, all patients with stomach cancer were selected from the Comprehensive Cancer Centre North-East cancer registry. Associat...

journal_title：British journal of cancer

authors： Siemerink EJ,van der Aa MA,Siesling S,Hospers GA,Mulder NH

更新日期：2011-03-29 00:00:00

abstract：:With the recent approval of the combinations of axitinib with the immune checkpoint inhibitor (ICI) pembrolizumab or avelumab for first-line treatment of advanced renal cell carcinoma, guidance on how to distinguish between immune-related adverse events (AEs) caused by ICI versus axitinib-related AEs is necessary to o...

journal_title：British journal of cancer

authors： Grünwald V,Voss MH,Rini BI,Powles T,Albiges L,Giles RH,Jonasch E

更新日期：2020-09-01 00:00:00

abstract：:Thirty-four patients with progressive low grade non-Hodgkin's lymphoma were treated with 1 microgram oral alfacalcidol daily. Complete response was seen in four patients and a partial response in four patients with an overall response rate of 24%. Median duration of response was 14 months. Disease stabilised in ten ot...

journal_title：British journal of cancer

authors： Raina V,Cunningham D,Gilchrist N,Soukop M

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Systemic inflammatory response (SIR) is important in the relationship between the tumour, the host, and outcome in cancer patients. However, limited data exist regarding the prognostic significance of SIR in bladder cancer. We investigate the utility of pretreatment SIR in patients with urothelial carcinoma ...

journal_title：British journal of cancer

authors： Ku JH,Kang M,Kim HS,Jeong CW,Kwak C,Kim HH

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional c...

journal_title：British journal of cancer

authors： Hirata K,Suzuki H,Imaeda H,Matsuzaki J,Tsugawa H,Nagano O,Asakura K,Saya H,Hibi T

更新日期：2013-07-23 00:00:00

abstract：:Resistance to cytotoxic agents may be encountered during the treatment of acute myeloblastic leukaemia (AML). P-glycoprotein encoded by the MDR-1 gene has been implicated as a potential drug resistance mechanism in leukaemic cells. In recent years, many data have been accrued concerning the expression of P-glycoprotei...

journal_title：British journal of cancer

authors： Holmes JA,West RR

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Robot-assisted radical prostatectomy (RARP) has been rapidly adopted without robust evidence comparing its functional outcomes against laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (ORP) approaches. This study compared patient-reported functional outcomes following RARP, L...

journal_title：British journal of cancer

authors： Nossiter J,Sujenthiran A,Charman SC,Cathcart PJ,Aggarwal A,Payne H,Clarke NW,van der Meulen J

更新日期：2018-02-20 00:00:00

abstract：:Patients who have no residual invasive cancer following neoadjuvant chemotherapy for breast carcinoma have a better overall survival than those with residual disease. Many classification systems assessing pathological response to neoadjuvant chemotherapy include residual ductal carcinoma in situ (DCIS) only in the def...

journal_title：British journal of cancer

authors： Jones RL,Lakhani SR,Ring AE,Ashley S,Walsh G,Smith IE

更新日期：2006-02-13 00:00:00

abstract：:Previous studies have reported inconsistent results regarding the modifying effect of hormone replacement therapy (HRT) on the association of body mass index (BMI) and the risk of colorectal cancer (CRC) among postmenopausal women. We assessed the use of HRT and BMI in 208 postmenopausal women with histologically conf...

journal_title：British journal of cancer

authors： Hoffmeister M,Raum E,Winter J,Chang-Claude J,Brenner H

更新日期：2007-12-03 00:00:00

abstract：:Cell fusion has been used to analyse the genetic determinants of metastasis at the cellular level. Highly metastatic mouse melanoma cells were fused with diploid mouse lymphocytes and a range of hybrid clones isolated and tested for tumorigenicity and metastatic potential by s.c. injection into newborn, histocompatibl...

journal_title：British journal of cancer

authors： Sidebottom E,Clark SR

更新日期：1983-03-01 00:00:00

abstract：:The phenotypic expression of cells derived from human anaplastic astrocytomas, rat glioma, normal human adult and foetal brain tissue have been examined for differentiated and malignancy-associated properties. Glial fibrillary acidic protein (GFAP), high affinity glutamate and gamma-amino butyric acid (GABA) uptake an...

journal_title：British journal of cancer

authors： Frame MC,Freshney RI,Vaughan PF,Graham DI,Shaw R

更新日期：1984-03-01 00:00:00

abstract：:Squamous cell carcinomas of the anus are rare neoplasias that account for about 3% of large bowel tumours. Infections with human papillomaviruses are frequently detected in these cancers, suggesting that pathogenic pathways in anal carcinomas and in carcinomas of the uterine cervix are similar. Little is known regardi...

journal_title：British journal of cancer

authors： Heselmeyer K,du Manoir S,Blegen H,Friberg B,Svensson C,Schröck E,Veldman T,Shah K,Auer G,Ried T

更新日期：1997-01-01 00:00:00

abstract：:The influence of anaesthetics on the in vivo response of B16 melanoma to melphalan was studied using an in vitro cell-survival assay. Three anaesthetics were used, Saffan (Althesin) Sagatal (Nembutal) and Hypnorm. When Saffan was administered to tumour-bearing animals before melphalan there was a significant increase ...

journal_title：British journal of cancer

authors： Peacock JH,Stephens TC

更新日期：1978-12-01 00:00:00

abstract：:This study explored the relationships of serum insulin-like growth factors, IGF-I and IGF-II, and their binding proteins (IGFBP)-2 and IGFBP-3, with key clinicopathological parameters in 92 patients with colorectal cancer (cases). Comparisons were made with 57 individuals who had a normal colonoscopy (controls). Seria...

journal_title：British journal of cancer

authors： Renehan AG,Jones J,Potten CS,Shalet SM,O'Dwyer ST

更新日期：2000-11-01 00:00:00

abstract：:Emerging evidences suggest the existence of a new mode of epidermal growth factor receptor (EGFR) signalling pathway in which activated EGFR undergoes nuclear translocalization and subsequently regulates gene expression and potentially mediates other cellular processes. This signalling route is distinct from the bette...

journal_title：British journal of cancer

authors： Lo HW,Hung MC

更新日期：2007-01-01 00:00:00

abstract：:Based on single agent activities and the additive or synergistic effects of three individual drugs in gastric cancer, we performed a phase II study of a new regimen combining epirubicin, docetaxel and cisplatin (EDP) for unresectable gastric cancer. The patients with histologically confirmed metastatic or recurrent, u...

journal_title：British journal of cancer

authors： Lee SH,Kang WK,Park J,Kim HY,Kim JH,Lee SI,Park JO,Kim K,Jung CW,Park YS,Im YH,Lee MH,Park K

更新日期：2004-07-05 00:00:00

abstract：:Comfrey is a rat liver toxin and carcinogen that has been used as a vegetable and herbal remedy by humans. In order to evaluate the mechanisms underlying its carcinogenicity, we examined the mutagenicity of comfrey in the transgenic Big Blue rat model. Our results indicate that comfrey is mutagenic in rat liver and th...

journal_title：British journal of cancer

authors： Mei N,Guo L,Fu PP,Heflich RH,Chen T

更新日期：2005-03-14 00:00:00

abstract：:Twenty patients with non-Hodgkin's lymphoma were treated with a combination of cyclophosphamide (750 mg m(-2), day 1), epidoxorubicin (60 mg m(-2), day 1), vincristine (1.4 mg m(-2), day 1) and prednisone (100 mg m(-2), days 1-5) every 14 days. Shortening of intervals was associated with the prophylactic employment of...

journal_title：British journal of cancer

authors： Pronzato P,Lionetto R,Botto F,Pensa F,Tognoni A

更新日期：1998-09-01 00:00:00

abstract：:The aim of the study was to evaluate efficacy and tolerance of epirubicin and gemcitabine as first-line chemotherapy in patients with advanced non-small-cell lung cancer. A phase I study was performed with the combination of escalating doses of epirubicin intravenously on day 1 and a fixed dose of gemcitabine on days ...

journal_title：British journal of cancer

authors： van Putten JW,Eppinga P,Erjavec Z,de Leede G,Nabers J,Smeets JB,Th Sleijfer D,Groen HJ

更新日期：2000-02-01 00:00:00

abstract：:Monoclonal antibodies 19-9 and C-50 were used to assay the cancer associated tumour antigens CA 19-9 and CA-50 in plasma from patients with confirmed pancreatic cancer, and related to the blood group and Lewis blood cell status. The plasma expressions of CA 19-9 or CA-50 were similar, including cases where the patient...

journal_title：British journal of cancer

authors： Masson P,Pålsson B,Andrén-Sandberg A

更新日期：1990-07-01 00:00:00

abstract：:Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) and conventional malignant melanoma may demonstrate significant morphologic overlap at the light microscopic and ultrastructural level. Consequently, the clinically relevant distinction between primary clear cell sarcoma and metastatic me...

journal_title：British journal of cancer

authors： Langezaal SM,Graadt van Roggen JF,Cleton-Jansen AM,Baelde JJ,Hogendoorn PC

更新日期：2001-02-01 00:00:00

abstract：:This study has been designed to verify the specific toxicity of saporin, a type 1 ribosome-inactivating protein (RIP), with the same activity as ricin A chain, targeted by a bispecific monoclonal antibody (bimAb) recognising both the CD25 antigen and the RIP. The CD25 antigen is expressed by lymphoid populations upon ...

journal_title：British journal of cancer

authors： Tazzari PL,Zhang S,Chen Q,Sforzini S,Bolognesi A,Stirpe F,Xie H,Moretta A,Ferrini S

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Tumour heterogeneity is documented for many characters, including the production of growth factors, one of the hallmarks of cancer. What maintains heterogeneity remains an open question that has implications for diagnosis and treatment, as drugs that target growth factors are susceptible to the evolution of ...

journal_title：British journal of cancer

authors： Archetti M

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:There have been controversies in prognostic impact of mucinous histology on colorectal cancer, and its implication in patients treated with adjuvant 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is unclear. METHODS:Stage II and III colorectal cancer patients who underwent curative resection followed ...

journal_title：British journal of cancer

authors： Lee DW,Han SW,Lee HJ,Rhee YY,Bae JM,Cho NY,Lee KH,Kim TY,Oh DY,Im SA,Bang YJ,Jeong SY,Park KJ,Park JG,Kang GH,Kim TY

更新日期：2013-05-28 00:00:00

abstract：:Four-coordinate (Pt(II)) platinum-based anticancer drugs are widely used in primary or palliative chemotherapy and produce considerable efficacy in certain clinical applications, for example testicular cancer. However, in many cancers the Pt(II) drugs are beset by poor efficacy mainly due to suboptimal pharmacokinetic...

journal_title：British journal of cancer

authors： Modok S,Scott R,Alderden RA,Hall MD,Mellor HR,Bohic S,Roose T,Hambley TW,Callaghan R

更新日期：2007-07-16 00:00:00

abstract：:During the development of indazolylpyrimidines as novel and potent inhibitors of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR2) tyrosine kinase, we observed that some human tumour xenografts are more sensitive to VEGFR2 kinase inhibitors than others. A better understanding of the basis for this differen...

journal_title：British journal of cancer

authors： Dev IK,Dornsife RE,Hopper TM,Onori JA,Miller CG,Harrington LE,Dold KM,Mullin RJ,Johnson JH,Crosby RM,Truesdale AT,Epperly AH,Hinkle KW,Cheung M,Stafford JA,Luttrell DK,Kumar R

更新日期：2004-10-04 00:00:00

abstract：:Previous studies have suggested that infant vaccinations may reduce the risk of subsequent childhood leukaemia. Vaccination histories were compared in 439 children (ages 0-14) diagnosed with acute lymphoblastic leukaemia (ALL) in nine Midwestern and Mid-Atlantic states (USA) between 1 January 1989 and 30 June 1993 and...

journal_title：British journal of cancer

authors： Groves FD,Gridley G,Wacholder S,Shu XO,Robison LL,Neglia JP,Linet MS

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Currently, none of the available colorectal adenocarcinoma (CAC) testing has been established as a well-accepted diagnosis tool, particularly for the early stage of CAC. The recent discovery of serum microRNA (miRNA) profile has provided a new auxiliary approach for tumour diagnosis. Our study is involved in...

journal_title：British journal of cancer

authors： Zheng G,Du L,Yang X,Zhang X,Wang L,Yang Y,Li J,Wang C

更新日期：2014-11-11 00:00:00