BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses.

Abstract:

BACKGROUND:The co-chaperone protein Bcl-2-associated athanogene-1 (BAG-1) is overexpressed in breast cancer and has been incorporated in the oncotype DX and PAM50 breast cancer prognostic assays. Bcl-2-associated athanogene-1 exists as multiple protein isoforms that interact with diverse partners, including chaperones Hsc70/Hsp70, Ser/Thr kinase Raf-1 and Bcl-2, to promote cancer cell survival. The BAG-1L isoform specifically binds to and increases the transcriptional activity of oestrogen receptor in cells, and in some, but not all studies, BAG-1 expression is predictive of clinical outcome in breast cancer. METHODS:A systematic review of published studies reporting BAG-1 (mRNA and/or protein) expression and clinical outcome in early breast cancer. The REporting Recommendations for Tumour MARKer and Prognostic Studies (REMARK) criteria were used as a template against which data were assessed. Meta-analyses were performed for studies that provided a hazard ratio and 95% confidence intervals for clinical outcomes including disease-free survival or breast cancer-specific survival from univariate analysis. RESULTS:Eighteen studies used differing methodologies and reported on differing outcomes. Meta-analyses were only possible on results from a subset of reported studies. Meta-analyses suggested improved outcome with high BAG-1 mRNA and high BAG-1 nuclear expression by immunohistochemisty. CONCLUSIONS:Increased levels of BAG-1 are associated with better breast cancer outcomes.

journal_name

Br J Cancer

authors

Papadakis ES,Reeves T,Robson NH,Maishman T,Packham G,Cutress RI

doi

10.1038/bjc.2017.130

subject

Has Abstract

pub_date

2017-06-06 00:00:00

pages

1585-1594

issue

12

eissn

0007-0920

issn

1532-1827

pii

bjc2017130

journal_volume

116

pub_type

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