Abstract:
:Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This study evaluates the feasibility of the surgical identification of sentinel groin nodes using lymphoscintigraphy and a gamma-detecting probe in patients with early vulvar cancer. Technetium-99m-labelled colloid human albumin was administered perilesionally in 37 patients with invasive epidermoid vulvar cancer (T1-T2) and lymphoscintigraphy performed the day before surgery. An intraoperative gamma-detecting probe was used to identify sentinel nodes during surgery. A complete inguinofemoral node dissection was then performed. Sentinel nodes were submitted separately to pathologic evaluation. A total of 55 groins were dissected in 37 patients. Localization of the SN was successful in all cases. Eight cases had positive nodes: in all the sentinel node was positive; the sentinel node was the only positive node in five cases. Twenty-nine patients showed negative sentinel nodes: all of them were negative for lymph node metastases. Lymphoscintigraphy and sentinel-node biopsy under gamma-detecting probe guidance proved to be an easy and reliable method for the detection of sentinel node in early vulvar cancer. This technique may represent a true advance in the direction of less aggressive treatments in patients with vulvar cancer.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
De Cicco C,Sideri M,Bartolomei M,Grana C,Cremonesi M,Fiorenza M,Maggioni A,Bocciolone L,Mangioni C,Colombo N,Paganelli Gdoi
10.1054/bjoc.1999.0918subject
Has Abstractpub_date
2000-01-01 00:00:00pages
295-9issue
2eissn
0007-0920issn
1532-1827pii
S0007092099909187journal_volume
82pub_type
杂志文章abstract::A death certificate-based case-control study was conducted on 207 women aged 25-44 who died of bladder cancer in England and Wales in the period 1971-89 and 411 controls matched on sex, year of death and age at death. An odds ratio of 12.0 (95% CI 1.5-99.7) was found for women with a history of paraplegia. Four of the...
journal_title:British journal of cancer
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 临床试验,杂志文章,随机对照试验
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