Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria.

abstract：BACKGROUND:A decade ago it was reported that childhood cancer incidence was higher in boys than girls in many countries, particularly those with low gross domestic product (GDP) and high infant mortality rate. Research suggests that socio-economic and cultural factors are likely to be responsible. This study aimed to i...

journal_title：British journal of cancer

authors： Bhopal SS,Mann KD,Pearce MS

更新日期：2012-06-26 00:00:00

abstract：:Both host carbogen (95% oxygen/5% carbon dioxide) breathing and nicotinamide administration enhance tumour radiotherapeutic response and are being re-evaluated in the clinic. Non-invasive magnetic resonance imaging (MRI) and 31P magnetic resonance spectroscopy (MRS) methods have been used to give information on the ef...

journal_title：British journal of cancer

authors： Robinson SP,Howe FA,Stubbs M,Griffiths JR

更新日期：2000-06-01 00:00:00

abstract：:Recepteur d'Origine Nantais (RON) is a distinct receptor tyrosine kinase in the c-met proto-oncogene family. We examined the mutational and expression patterns of RON in eight human uroepithelial cell lines. Biological effects of RON overexpression on cancer cells were investigated in vitro, and the prognostic signifi...

journal_title：British journal of cancer

authors： Cheng HL,Liu HS,Lin YJ,Chen HH,Hsu PY,Chang TY,Ho CL,Tzai TS,Chow NH

更新日期：2005-05-23 00:00:00

abstract：:To examine whether weight loss at presentation influences outcome in patients who received chemotherapy for lung cancer or mesothelioma. Multivariate analysis of prospectively collected data 1994-2001. Data were available for age, gender, performance status, histology, stage, response, toxicity, progression-free and o...

journal_title：British journal of cancer

authors： Ross PJ,Ashley S,Norton A,Priest K,Waters JS,Eisen T,Smith IE,O'Brien ME

更新日期：2004-05-17 00:00:00

abstract：:Teratomas have been induced in Japanese quail (Coturnix coturnix Japonica) by intra-testicular injections of 3% zinc chloride solution during a period of testicular growth artificially stimulated by increased photoperiod. These tumours resemble those previously induced by similar methods in domestic fow1 and have hist...

journal_title：British journal of cancer

authors： Guthrie J

更新日期：1971-06-01 00:00:00

abstract：:The cytocidal properties of metronidazole against hypoxic mammalian cells are described. This chemotherapeutic action has been shown to be dependent on drug concentration and duration of exposure. The x-ray TCD50 for a murine anaplastic carcinoma was reduced from 6081 rad to 4643 rad when animals were given metronidaz...

journal_title：British journal of cancer

authors： Foster JL,Conroy PJ,Searle AJ,Willson RL

更新日期：1976-05-01 00:00:00

abstract：:The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curativ...

journal_title：British journal of cancer

authors： Cooper R,Sarioğlu S,Sökmen S,Füzün M,Küpelioğlu A,Valentine H,Görken IB,Airley R,West C

更新日期：2003-09-01 00:00:00

abstract：:This paper investigates the potential for long-term survivorship for young patients diagnosed with Ewing's sarcoma. Data are examined from two successive UKCCSG Ewing's Tumour studies (ET-1 and ET-2). Patients have been followed for up to 20 years. These studies had suggested that better 5-year survival with ET-2 over...

journal_title：British journal of cancer

authors： Weston CL,Douglas C,Craft AW,Lewis IJ,Machin D

更新日期：2004-07-19 00:00:00

abstract：:In the years before human immunodeficiency virus (HIV) infection, the incidence of Kaposi's sarcoma varied markedly across the African continent, and it was a disease primarily affecting men. In contrast, the evidence reviewed here shows that the causal virus-Kaposi's sarcoma associated herpesvirus (KSHV)-is prevalent...

journal_title：British journal of cancer

authors： Dedicoat M,Newton R

更新日期：2003-01-13 00:00:00

abstract：:We retrospectively analysed neuromuscular toxicity associated with paclitaxel 210 mg m(-2) given by 3-h infusion in 247 patients. The severity correlated significantly with total cumulative dose, but could not be predicted by the pretreatment clinical variables or by pharmacokinetic parameters. The toxicity tended to ...

journal_title：British journal of cancer

authors： Kunitoh H,Saijo N,Furuse K,Noda K,Ogawa M

更新日期：1998-05-01 00:00:00

abstract：:Serum levels of the soluble epidermal growth factor receptor (sEGFR) and its ligands epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha) and amphiregulin (AR) were measured in healthy donors and patients with non-small cell lung cancer (NSCLC) and head and neck carcinoma (HNC). In NSCLC, we fou...

journal_title：British journal of cancer

authors： Lemos-González Y,Rodríguez-Berrocal FJ,Cordero OJ,Gómez C,Páez de la Cadena M

更新日期：2007-05-21 00:00:00

abstract：BACKGROUND:The aim of this work was to improve the knowledge of the role of histamine in breast cancer by assessing the therapeutic efficacy of histamine and histamine H4 receptor (H4R) ligands in a triple-negative breast cancer (TNBC) model developed in immunocompetent hosts. By using publicly available genomic data, ...

journal_title：British journal of cancer

authors： Nicoud MB,Sterle HA,Massari NA,Táquez Delgado MA,Formoso K,Herrero Ducloux MV,Martinel Lamas D,Cremaschi GA,Medina VA

更新日期：2020-02-01 00:00:00

abstract：:The efficacy of photodynamic therapy (PDT) using delta-aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) sensitisation and laser light at 635 nm was investigated in the treatment of experimental hepatic tumours. The model of liver tumours was induced either by local inoculation or by administration of tumour...

journal_title：British journal of cancer

authors： Svanberg K,Liu DL,Wang I,Andersson-Engels S,Stenram U,Svanberg S

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Several tyrosine kinase inhibitors (TKIs) can decrease docetaxel clearance in patients by an unknown mechanism. We hypothesised that these interactions are mediated by the hepatic uptake transporter OATP1B1. METHODS:The influence of 16 approved TKIs on transport was studied in vitro using HEK293 cells expre...

journal_title：British journal of cancer

authors： Hu S,Mathijssen RH,de Bruijn P,Baker SD,Sparreboom A

更新日期：2014-02-18 00:00:00

abstract：:Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group (INRG) Task Force has defined standardised methods for the determination of minimal...

journal_title：British journal of cancer

authors： Beiske K,Burchill SA,Cheung IY,Hiyama E,Seeger RC,Cohn SL,Pearson AD,Matthay KK,International neuroblastoma Risk Group Task Force.

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:We aimed to analyse clinical and gene expression profiles to predict pathologic complete response and disease-free survival using two consecutive, prospective, preoperative chemotherapy trial cohorts. METHODS:Clinicopathological and gene expression data were evaluated in a cohort from two consecutive phase ...

journal_title：British journal of cancer

authors： Okuma HS,Koizumi F,Hirakawa A,Nakatochi M,Komori O,Hashimoto J,Kodaira M,Yunokawa M,Yamamoto H,Yonemori K,Shimizu C,Fujiwara Y,Tamura K

更新日期：2016-08-09 00:00:00

abstract：:The ten most frequently reported pretreatment symptoms on the Rotterdam Symptom Checklist, which was completed by more than 650 patients entering two MRC Lung Cancer Working Party multicentre randomised trials, included general symptoms (tiredness, lack of appetite) and psychological distress (worry, anxiety) in addit...

journal_title：British journal of cancer

authors： Hopwood P,Stephens RJ

更新日期：1995-03-01 00:00:00

abstract：:To identify tumour and tumour-associated antigens in patients with hepatocellular carcinoma (HCC) one may find potential diagnostic markers and immunotherapeutic targets. In the current study, 30 distinct antigens reactive with serum IgG from HCC patients were identified by serological analysis of cDNA expression libr...

journal_title：British journal of cancer

authors： Shi YY,Wang HC,Yin YH,Sun WS,Li Y,Zhang CQ,Wang Y,Wang S,Chen WF

更新日期：2005-03-14 00:00:00

abstract：:More women are living with and surviving breast cancer, because of improvements in breast cancer care. Trastuzumab (Herceptin) has significantly improved outcomes for women with HER2-positive tumours. Concerns about the cardiac effects of trastuzumab (which fundamentally differ from the permanent myocyte loss associat...

journal_title：British journal of cancer

authors： Jones AL,Barlow M,Barrett-Lee PJ,Canney PA,Gilmour IM,Robb SD,Plummer CJ,Wardley AM,Verrill MW

更新日期：2009-03-10 00:00:00

abstract：:With few exceptions, the major limit to high-dose chemotherapeutic treatments is the severity and duration of drug-induced myelosuppression. We have recently developed a monoclonal antibody, MAD11, which reacts with the potent anti-tumour antibiotic doxorubicin and other anthracyclines. To protect directly pluripotent...

journal_title：British journal of cancer

authors： Morelli D,Ménard S,Cazzaniga S,Colnaghi MI,Balsari A

更新日期：1997-01-01 00:00:00

abstract：:A number of rare human inherited syndromes are associated with apparent defects in DNA repair and a greatly increased frequency of cancer. Cell lines derived from such individuals phenotypically resemble certain bacterial mutant strains that have increased sensitivity to radiation or chemical agents and well character...

journal_title：British journal of cancer

authors： Lindahl T

更新日期：1987-08-01 00:00:00

abstract：:Oral capecitabine is a highly active, well-tolerated and convenient treatment for breast and colorectal cancer. This trial assessed the efficacy and safety of single-agent capecitabine in patients with previously treated ovarian cancer. A total of 29 patients with platinum-pretreated relapsed ovarian cancer were enrol...

journal_title：British journal of cancer

authors： Vasey PA,McMahon L,Paul J,Reed N,Kaye SB

更新日期：2003-11-17 00:00:00

abstract：:We evaluated the interaction between hepatitis C virus (HCV) and cigarette smoking on death from hepatocellular cancer in The Japan Collaborative Cohort Study. The odds ratio of death from HCC for smoking was 9.60 (1.50-61.35) and 1.71(0.58-5.08) among anti-HCV positive and negative individuals, respectively. ...

journal_title：British journal of cancer

authors： Fujita Y,Shibata A,Ogimoto I,Kurozawa Y,Nose T,Yoshimura T,Suzuki H,Iwai N,Sakata R,Ichikawa S,Tamakoshi A

更新日期：2006-03-13 00:00:00

abstract：BACKGROUND:The potential for cancer-testis (CT) antigens as targets for immunotherapy in cancer patients has been heavily investigated, and currently cancer vaccine trials based on the CT antigens, MAGE-A3 and NY-ESO-1, are being carried out. METHODS:We used specific q-RT-PCR assays to analyse the expression of the CT...

journal_title：British journal of cancer

authors： Dyrskjøt L,Zieger K,Kissow Lildal T,Reinert T,Gruselle O,Coche T,Borre M,Ørntoft TF

更新日期：2012-06-26 00:00:00

abstract：BACKGROUND:This study was done to investigate the long-term event free and overall survival of high-dose chemotherapy followed by autologous stem cell transplantation (ASCT), compared to maintenance chemotherapy (MT). Patterns of recurrences and late sequelae of both arms were analysed. METHODS:A randomised open label...

journal_title：British journal of cancer

authors： Berthold F,Ernst A,Hero B,Klingebiel T,Kremens B,Schilling FH,Simon T

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Currently, none of the available colorectal adenocarcinoma (CAC) testing has been established as a well-accepted diagnosis tool, particularly for the early stage of CAC. The recent discovery of serum microRNA (miRNA) profile has provided a new auxiliary approach for tumour diagnosis. Our study is involved in...

journal_title：British journal of cancer

authors： Zheng G,Du L,Yang X,Zhang X,Wang L,Yang Y,Li J,Wang C

更新日期：2014-11-11 00:00:00

abstract：BACKGROUND:Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional c...

journal_title：British journal of cancer

authors： Hirata K,Suzuki H,Imaeda H,Matsuzaki J,Tsugawa H,Nagano O,Asakura K,Saya H,Hibi T

更新日期：2013-07-23 00:00:00

abstract：:Between 1971 and 1988, 20 patients with previously undiagnosed non-Hodgkin's lymphoma (NHL), of intermediate or high grade histology presented with extradural spinal cord compression. All had decompressive surgery. The first treatment after surgery was chemotherapy in nine and radiotherapy in 11 patients. At presentat...

journal_title：British journal of cancer

authors： Eeles RA,O'Brien P,Horwich A,Brada M

更新日期：1991-01-01 00:00:00

abstract：:In this study we have screened a series of 29 primary leiomyosarcomas for abnormalities of both the p53 gene and the MDM2 gene, which encodes a p53-associated protein. SSCP (single-strand conformation polymorphism) analysis and direct sequencing of polymerase chain reaction (PCR)-amplified DNA were used to establish t...

journal_title：British journal of cancer

authors： Patterson H,Gill S,Fisher C,Law MG,Jayatilake H,Fletcher CD,Thomas M,Grimer R,Gusterson BA,Cooper CS

更新日期：1994-06-01 00:00:00

abstract：:We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for b...

journal_title：British journal of cancer

authors： Hemminki K,Li X,Vaittinen P,Dong C

更新日期：2000-08-01 00:00:00