A new indicator of human malignant tumour.

abstract：:The evolution and structure of adenomatous polyps and adenocarcinomata of the colon in NMRI mice induced by dimethylhydrazine are described. Severe toxic reactions in the liver and other organs are produced by dimethylhydrazine (DMH), but tumours are induced only in the colon and around the anus. The 100% incidence an...

journal_title：British journal of cancer

authors： Haase P,Cowen DM,Knowles JC,Cooper EH

更新日期：1973-12-01 00:00:00

abstract：:We have analysed DNA extracted from the serum and peritoneal fluid of 20 ovarian cancer patients for the presence of tumour-specific genetic alterations. The 20 patients included six with stage Ia disease. Using six polymorphic microsatellite loci we were able to detect novel alleles or loss of heterozygosity in 17/20...

journal_title：British journal of cancer

authors： Hickey KP,Boyle KP,Jepps HM,Andrew AC,Buxton EJ,Burns PA

更新日期：1999-08-01 00:00:00

abstract：:A method for testing organic chemicals for their carcinogenic potential is described. Baby hamster kidney cells (BHK-21/C1 13) were exposed to different doses of test compound in liquid tissue culture medium containing rat liver post-mitochondrial supernatant and cofactors (S-9 mix) to aid metabolism, but without seru...

journal_title：British journal of cancer

authors： Styles JA

更新日期：1977-11-01 00:00:00

abstract：:DNA flow cytometry was performed on formalin fixed, paraffin embedded melanocytic naevi. DNA aneuploidy was detected in all three types of naevus but was significantly more frequent in those naevi accepted as precursors of malignancy: that is, dysplastic and congenital pigmented hairy naevi. It may be that the presenc...

journal_title：British journal of cancer

authors： Newton JA,Camplejohn RS,McGibbon DH

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:HOX transcript antisense RNA (HOTAIR), which is expressed from the homebox C gene (HOXC) locus, is capable of reprogramming chromatin organisation and promoting cancer cell metastasis and can simultaneously bind the polycomb repressive complex 2, which enhances H3K27 trimethylation, and the LSD1-CoREST-REST ...

journal_title：British journal of cancer

authors： Li X,Wu Z,Mei Q,Li X,Guo M,Fu X,Han W

更新日期：2013-10-15 00:00:00

abstract：:Vascular endothelial growth factor-C (VEGF-C) functions specifically to induce lymphangiogenesis. We examined the relationship between expression of VEGF-C and clinicopathological features in patients with colorectal cancer. The expression of VEGF-C in the 99 primary tumours and 18 metastatic lymph nodes from colorect...

journal_title：British journal of cancer

authors： Akagi K,Ikeda Y,Miyazaki M,Abe T,Kinoshita J,Maehara Y,Sugimachi K

更新日期：2000-10-01 00:00:00

abstract：:A study involving the measurement of glutathione S-transferase activities and isoenzyme distributions in human ovarian tumours has been carried out. These tumours have been obtained either at initial debulking surgery, prior to cytotoxic chemotherapy, or at second look laparotomy following chemotherapy. The response r...

journal_title：British journal of cancer

authors： Murphy D,McGown AT,Hall A,Cattan A,Crowther D,Fox BW

更新日期：1992-11-01 00:00:00

abstract：:Sixteen chronic myeloid leukaemia (CML) patients in remission were tested with solubilized membrane antigens from CML leukaemic cells, CML blasts, AML blasts and ALL blasts for cellular immunity in vitro by lymphocyte transformation (LT) and leucocyte migration inhibition (LMI) assays. Twelve CML patients in remission...

journal_title：British journal of cancer

authors： Gangal SG,Damle NK,Khare AG,Advani SH

更新日期：1979-09-01 00:00:00

abstract：:Three hundred and ninety women participated in the quality of life (QL) study of ACCOG1, a high-dose vs conventional adjuvant chemotherapy breast cancer trial, for patients with a high risk of relapse. Patients completed the European Organisation for Research and Treatment of Cancer QLQ-C30, questions on menopausal sy...

journal_title：British journal of cancer

authors： Malinovszky KM,Gould A,Foster E,Cameron D,Humphreys A,Crown J,Leonard RC,Anglo Celtic Co-operative Oncology Group.

更新日期：2006-12-18 00:00:00

abstract：:The lymphocyte marker pattern of non-Hodgkin's lymphoma cells was related to current concepts of lymphoma classification. In a series of 28 lymphomas lymphocyte markers indicated that 2 were of histiocytic origin, 2 were unclassifiable, none were derived from T cells and the remainder were B-cell neoplasms. The immuno...

journal_title：British journal of cancer

authors： Payne SV,Smith JL,Jones DB,Wright DH

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:Necdin (NDN) expression is downregulated in telomerase-immortalised normal human urothelial cells. Telomerase-immortalised normal human urothelial cells have no detected genetic alterations. Accordingly, many of the genes whose expression is altered following immortalisation are those for which epigenetic si...

journal_title：British journal of cancer

authors： De Faveri LE,Hurst CD,Platt FM,Taylor CF,Roulson JA,Sanchez-Carbayo M,Knowles MA,Chapman EJ

更新日期：2013-04-02 00:00:00

abstract：:The pp125 focal adhesion kinase (FAK) is involved in integrin-mediated cell signalling and overexpressed in a variety of solid tumours. Focal adhesion kinase expression has been correlated to invasion and metastasis, but the data on breast cancer are inconclusive. We analysed FAK mRNA, protein levels and expression pa...

journal_title：British journal of cancer

authors： Watermann DO,Gabriel B,Jäger M,Orlowska-Volk M,Hasenburg A,zur Hausen A,Gitsch G,Stickeler E

更新日期：2005-09-19 00:00:00

abstract：BACKGROUND:The aim of this work was to improve the knowledge of the role of histamine in breast cancer by assessing the therapeutic efficacy of histamine and histamine H4 receptor (H4R) ligands in a triple-negative breast cancer (TNBC) model developed in immunocompetent hosts. By using publicly available genomic data, ...

journal_title：British journal of cancer

authors： Nicoud MB,Sterle HA,Massari NA,Táquez Delgado MA,Formoso K,Herrero Ducloux MV,Martinel Lamas D,Cremaschi GA,Medina VA

更新日期：2020-02-01 00:00:00

abstract：:The relationship between colony numbers and concentration of cells plated is an important parameter of clonogenic assay systems. The cloning efficiency for an ideal sample should be independent of cell concentration, thus giving a straight line through the origin when colony numbers are plotted against cell concentrat...

journal_title：British journal of cancer

authors： Eliason JF,Aapro MS,Decrey D,Brink-Petersen M

更新日期：1985-09-01 00:00:00

abstract：:The level of expression of keratinocyte growth factor (KGF) mRNA has been measured in human breast cell lines, purified populations of epithelial cells, myoepithelial cells and fibroblasts from reduction mammoplasty tissue and a panel of 42 breast cancers and 30 non-malignant human breast tissues using a semiquantitat...

journal_title：British journal of cancer

authors： Bansal GS,Cox HC,Marsh S,Gomm JJ,Yiangou C,Luqmani Y,Coombes RC,Johnston CL

更新日期：1997-01-01 00:00:00

abstract：:beta2-Microglobulin (beta2M), a component of MHC class I molecules, is believed to be associated with tumour status in various cancers. In this study, we examined the expression of beta2M at different malignant stages of oral cavity squamous cell carcinoma (OCSCC). To determine the possible correlation between beta2M ...

journal_title：British journal of cancer

authors： Chen CH,Su CY,Chien CY,Huang CC,Chuang HC,Fang FM,Huang HY,Chen CM,Chiou SJ

更新日期：2008-11-04 00:00:00

abstract：:Connective tissue growth factor (CTGF) is a major chemotactic and mitogenic factor for connective tissue cells. The amino acid sequence shares an overall 28-38% identity to IGFBPs and contains critical conserved sequences in the amino terminus. It has been demonstrated that human CTGF specifically binds IGFs with low ...

journal_title：British journal of cancer

authors： Vorwerk P,Wex H,Hohmann B,Oh Y,Rosenfeld RG,Mittler U

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:The National Comprehensive Cancer Network (NCCN) guidelines provide recommendations for staging of prostate cancer patients in the objective regarding presence of locoregional lymph node metastases (LNM) and bone metastases. We tested the performance characteristics of these recommendations in a community se...

journal_title：British journal of cancer

authors： Preisser F,Mazzone E,Nazzani S,Marchioni M,Bandini M,Tian Z,Saad F,Soulières D,Shariat SF,Montorsi F,Huland H,Graefen M,Tilki D,Karakiewicz PI

更新日期：2018-12-01 00:00:00

abstract：:Two aspects of the aerobic metabolism of nitroimidazole markers for hypoxia were investigated. Several normal murine tissues which are likely to be well oxygenated bind misonidazole at rates comparable to those of hypoxic regions in tumours. The possibility that this aerobic activation occurs via an oxygen independent...

journal_title：British journal of cancer

authors： Parliament MB,Wiebe LI,Franko AJ

更新日期：1992-12-01 00:00:00

abstract：:In locally advanced undifferentiated nasopharyngeal carcinoma (UNPC), concomitant chemo-radiotherapy is the only strategy that gave better results over radiation alone in a phase III trial. Adding effective chemotherapy to a concomitant chemo-radiotherapy programme may be a way to improve the results further. 30 patie...

journal_title：British journal of cancer

authors： Benasso M,Sanguineti G,D'Amico M,Corvò R,Ricci I,Numico G,Guarneri D,Vitale V,Pallestrini E,Santelli A,Rosso R

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) testing in oropharyngeal squamous cell carcinoma (OPSCC) is now advocated. Demonstration of transcriptionally active high-risk HPV (HR-HPV) in fresh tumour tissue is considered to be the analytical 'gold standard'. Clinical testing has focused on formalin-fixed paraffin-embedded (F...

journal_title：British journal of cancer

authors： Schache AG,Liloglou T,Risk JM,Jones TM,Ma XJ,Wang H,Bui S,Luo Y,Sloan P,Shaw RJ,Robinson M

更新日期：2013-04-02 00:00:00

abstract：BACKGROUND:Successful introduction of new anticancer agents into the clinic is often hampered by a lack of qualified biomarkers. Studies have been conducted of 17 ELISAs representing a potential panel of pharmacodynamic/predictive biomarkers for drugs targeted to tumour vasculature. METHODS:The fit-for-purpose approac...

journal_title：British journal of cancer

authors： Brookes K,Cummings J,Backen A,Greystoke A,Ward T,Jayson GC,Dive C

更新日期：2010-05-11 00:00:00

abstract：:Fifty-one patients with advanced non-small cell lung carcinoma were treated with a combination of mitomycin C, vinblastine and cis-platin (MVP). Most cycles were given on an out-patient basis. Major side effects were leukopenia and peripheral neurotoxicity; one patient died of sepsis while leukopenic. In 44 evaluable ...

journal_title：British journal of cancer

authors： Giaccone G,Bagatella M,Donadio M,Bonardi GM,Testore F,Ferrati P,Ciuffreda L,Calciati A

更新日期：1987-10-01 00:00:00

abstract：:Tumour markers are important in the diagnosis and monitoring of many tumours. This study tested the hypothesis that an oncofoetal protein, foetal haemoglobin (HbF) is a potential tumour marker in embryonic tumours, useful for management. An immunohistochemical investigation of HbF blood cell (Fc) distribution was carr...

journal_title：British journal of cancer

authors： Wolk M,Martin JE,Nowicki M

更新日期：2007-08-06 00:00:00

abstract：:Malignant melanoma (MM) is thought to arise by sequential accumulation of genetic alterations in normal melanocytes. Previous cytogenetic and molecular studies indicated the 9p21 as the chromosomal region involved in MM pathogenesis. In addition to the CDKN genes (p16/CDKN2A, p15/CDKN2B and p19(ARF), frequently inacti...

journal_title：British journal of cancer

authors： Palmieri G,Cossu A,Ascierto PA,Botti G,Strazzullo M,Lissia A,Colombino M,Casula M,Floris C,Tanda F,Pirastu M,Castello G,Melanoma Cooperative Group.

更新日期：2000-12-01 00:00:00

abstract：:Early detection of relapse has been advocated to improve survival in children with recurrent medulloblastoma. However, the prognostic factors and the longer term outcome of these patients remains unclear. Pattern of recurrences were analysed in three consecutive protocols of the Société Française d'Oncologie Pédiatriq...

journal_title：British journal of cancer

authors： Bouffet E,Doz F,Demaille MC,Tron P,Roche H,Plantaz D,Thyss A,Stephan JL,Lejars O,Sariban E,Buclon M,Zücker JM,Brunat-Mentigny M,Bernard JL,Gentet JC

更新日期：1998-04-01 00:00:00

abstract：:The aim of this study was to assess the relationship between haemoglobin level and quality-of-life in anaemic cancer patients. Patients, diagnosed with one of four cancers, were recruited if their haemoglobin level was <12 g dl(-1) (female) or <13 g dl(-1) (male). The condition-specific Functional Assessment of Cancer...

journal_title：British journal of cancer

authors： Lind M,Vernon C,Cruickshank D,Wilkinson P,Littlewood T,Stuart N,Jenkinson C,Grey-Amante P,Doll H,Wild D

更新日期：2002-04-22 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Gao M,Lin M,Moffitt RA,Salazar MA,Park J,Vacirca J,Huang C,Shroyer KR,Choi M,Georgakis GV,Sasson AR,Talamini MA,Kim J

更新日期：2020-08-01 00:00:00

abstract：:The testis is the third common site of relapse after primary treatment of childhood acute lymphoblastic leukaemia, but in adults relatively few testicular relapses of acute lymphoblastic leukaemia have been reported. In the present investigation the differences in the behaviour of leukaemia in immature and mature rat ...

journal_title：British journal of cancer

authors： Jahnukainen K,Morris I,Roe S,Salmi TT,Mäkipernaa A,Pöllänen P

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:WFDC1/Prostate stromal 20 (ps20) is a small secreted protein highly expressed within the prostate stroma. WFDC1/ps20 expression is frequently downregulated or lost in prostate cancer (PCa) and ps20 has demonstrated growth-suppressive functions in numerous tumour model systems, although the mechanisms of this...

journal_title：British journal of cancer

authors： Hickman OJ,Smith RA,Dasgupta P,Rao SN,Nayak S,Sreenivasan S,Vyakarnam A,Galustian C

更新日期：2016-05-24 00:00:00