Squamous carcinoma of the oesophagus: histological criteria and their prognostic significance.

abstract：BACKGROUND:There is a need for sensitive and specific blood-borne markers for the detection of gastric cancer. Raised serum macrophage inhibitory factor (MIF) levels have been proposed as a marker for gastric cancer diagnosis but, to date, studies have only encompassed patients from high-incidence areas. METHODS:We ha...

journal_title：British journal of cancer

authors： Shimwell NJ,Ward DG,Mohri Y,Mohri T,Pallan L,Teng M,Miki YC,Kusunoki M,Tucker O,Wei W,Morse J,Johnson PJ

更新日期：2012-10-23 00:00:00

abstract：BACKGROUND:Melanoma is highly resistant to current modalities of therapy, with the extent of pigmentation playing an important role in therapeutic resistance. Nuclear factor-κB (NF-κB) is constitutively activated in melanoma and can serve as a molecular target for cancer therapy and steroid/secosteroid action. METHODS...

journal_title：British journal of cancer

authors： Janjetovic Z,Brozyna AA,Tuckey RC,Kim TK,Nguyen MN,Jozwicki W,Pfeffer SR,Pfeffer LM,Slominski AT

更新日期：2011-12-06 00:00:00

abstract：:Caveolin-1 and -2 (CAV1, CAV2) are closely linked genes localised to the fragile region of 7q31 (FRA7G), and loss of heterozygosity involving this region has been reported in breast cancer. Several studies have suggested that CAV1 is a negative regulator of HER2/neu signal transduction in vitro. However, the clinical ...

journal_title：British journal of cancer

authors： Sagara Y,Mimori K,Yoshinaga K,Tanaka F,Nishida K,Ohno S,Inoue H,Mori M

更新日期：2004-08-31 00:00:00

abstract：:In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenol...

journal_title：British journal of cancer

authors： Hardell L,Sandström A

更新日期：1979-06-01 00:00:00

abstract：:Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) and conventional malignant melanoma may demonstrate significant morphologic overlap at the light microscopic and ultrastructural level. Consequently, the clinically relevant distinction between primary clear cell sarcoma and metastatic me...

journal_title：British journal of cancer

authors： Langezaal SM,Graadt van Roggen JF,Cleton-Jansen AM,Baelde JJ,Hogendoorn PC

更新日期：2001-02-01 00:00:00

abstract：:Primary liver cancer, predominantly consisting of hepatocellular carcinoma (HCC), is one of the most common and aggressive human malignancies worldwide. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression post-transcriptionally. Emerging evidence indicates that miRNAs are often deregu...

journal_title：British journal of cancer

authors： Huang S,He X

更新日期：2011-01-18 00:00:00

abstract：:Serum concentrations of oestradiol-17β were measured by radio-immunoassay during 40 menstrual cycles from 38 normal premenopausal women. Repeated samples were studied from 25 normal postmenopausal women. The method was highly specific and extremely sensitive. In premenopausal women the pattern of serum oestradiol-17β ...

journal_title：British journal of cancer

authors： England PC,Skinner LG,Cottrell KM,Sellwood RA

更新日期：1974-06-01 00:00:00

abstract：BACKGROUND:Gold(III) porphyrin 1a is a new class of anticancer drug, which inhibits cell proliferation of wide range of human cancer cell lines and induces apoptosis in human nasopharyngeal carcinoma cells. However, the underlying signalling mechanism by which gold(III) porphyrin 1a modifies the intracellular apoptosis...

journal_title：British journal of cancer

authors： Li W,Xie Y,Sun RW,Liu Q,Young J,Yu WY,Che CM,Tam PK,Ren Y

更新日期：2009-07-21 00:00:00

abstract：:The reactivation of U.V.-irradiated adenovirus 2 in HeLa cells is enhanced 8-9 fold if the cells are given a brief hyperthermic shock before infection. Maximum reactivation is achieved by heating for 10 min at 45.5 degrees C and with a delay of 36 h between heating and infection. The induction process requires protein...

journal_title：British journal of cancer

authors： Piperakis SM,McLennan AG

更新日期：1984-02-01 00:00:00

abstract：:We cytogenetically investigated six osteoid osteomas, one osteoblastoma and one aggressive osteoblastoma, and observed clonal structural changes in one osteoid osteoma and in the aggressive osteoblastoma. Clonal chromosome changes had not been reported previously in osteoid osteoma, whereas the only reported chromosom...

journal_title：British journal of cancer

authors： Dal Cin P,Sciot R,Samson I,De Wever I,Van den Berghe H

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:To date, no adjuvant treatment has been shown to have a clear benefit in patients with hepatocellular carcinoma (HCC). In this prospective phase I/IIa study, we evaluated the safety and efficacy of adjuvant dendritic cell (DC) therapy in HCC patients who received primary treatment for HCC. METHODS:Twelve HC...

journal_title：British journal of cancer

authors： Lee JH,Lee Y,Lee M,Heo MK,Song JS,Kim KH,Lee H,Yi NJ,Lee KW,Suh KS,Bae YS,Kim YJ

更新日期：2015-12-22 00:00:00

abstract：:This paper describes the results of a study set up to investigate factors associated with the high proportions of 'death certificate only' registrations (DCOs) for all cancers registered in south-east England between 1987 and 1989 and to identify those which might be subject to registry intervention. DCOs as a proport...

journal_title：British journal of cancer

authors： Pollock AM,Vickers N

更新日期：1995-03-01 00:00:00

abstract：:Two meta-analyses were conducted to quantify the benefit of combining alpha-IFN to 5FU in advanced colorectal cancer in terms of tumour response and survival. Analyses were based on a total of 3254 individual patient data provided by principal investigators of each trial. The meta-analysis of 5FU +/- LV vs. 5FU +/- LV...

journal_title：British journal of cancer

authors： Thirion P,Piedbois P,Buyse M,O'Dwyer PJ,Cunningham D,Man A,Greco FA,Colucci G,Köhne CH,Di Constanzo F,Piga A,Palmeri S,Dufour P,Cassano A,Pajkos G,Pensel RA,Aykan NF,Marsh J,Seymour MT,Meta-Analysis Group in Cancer.

更新日期：2001-03-02 00:00:00

abstract：:The effect of acute carbon monoxide (CO) breathing on blood oxygenation and tumour hypoxia was related to the radiation response of the C3H/Tif mammary carcinoma. Blood gas analysis showed that CO breathing caused a time- and dose-dependent formation of carboxyhaemoglobin (HbCO), a significant left shift of the oxygen...

journal_title：British journal of cancer

authors： Grau C,Khalil AA,Nordsmark M,Horsman MR,Overgaard J

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Operable non-small cell lung cancer (NSCLC) patients whose tumours have spread to regional or central lymph nodes at the time of diagnosis have dismal prognoses compared with those who have limited disease. The current TNM staging system for NSCLC poorly distinguishes patients with lymph-node metastases who ...

journal_title：British journal of cancer

authors： Kilvaer TK,Paulsen EE,Khanehkenari MR,Al-Saad S,Johansen RM,Al-Shibli K,Bremnes RM,Busund LT,Donnem T

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. METHODS:A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and ...

journal_title：British journal of cancer

authors： Feng X,Song M,Preston MA,Ma W,Hu Y,Pernar CH,Stopsack KH,Ebot EM,Fu BC,Zhang Y,Li N,Dai M,Liu L,Giovannucci EL,Mucci LA

更新日期：2020-08-01 00:00:00

abstract：:The last 15 years has seen an explosion of interest in the cancer stem cell (CSC). Although it was initially believed that only a rare population of stem cells are able to undergo self-renewing divisions and differentiate to form all populations within a malignancy, a recent work has shown that these cells may not be ...

journal_title：British journal of cancer

authors： Bomken S,Fiser K,Heidenreich O,Vormoor J

更新日期：2010-08-10 00:00:00

abstract：BACKGROUND:Overexpression of ErbB2 receptor in breast cancer is associated with disease progression and poor prognosis. Trastuzumab, the only humanised anti-ErbB2 antibody currently used in breast cancer, has proven to be effective; however, a relevant problem for clinical practice is that a high fraction of breast can...

journal_title：British journal of cancer

authors： Gelardi T,Damiano V,Rosa R,Bianco R,Cozzolino R,Tortora G,Laccetti P,D'Alessio G,De Lorenzo C

更新日期：2010-02-02 00:00:00

abstract：:Burnet proposed in the 1950's that the immune system is engaged in identifying and destroying abnormal cancerous cells. This process, termed immune surveillance, has been at the centre of intense debate for decades. Results using immunodeficient mice lend support to the immune surveillance hypothesis. We surmised that...

journal_title：British journal of cancer

authors： Betts G,Twohig J,Van den Broek M,Sierro S,Godkin A,Gallimore A

更新日期：2007-06-18 00:00:00

abstract：:The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as pro-photosensitising agents. The compounds were assayed in a cell line derived from a murine mammary tumou...

journal_title：British journal of cancer

authors： Perotti C,Fukuda H,DiVenosa G,MacRobert AJ,Batlle A,Casas A

更新日期：2004-04-19 00:00:00

abstract：:The frequency, in women with breast cancer, of mutations and other variants in the susceptibility gene, BRCA1, was investigated using a population-based case-control-family study. Cases were women living in Melbourne or Sydney, Australia, with histologically confirmed, first primary, invasive breast cancer, diagnosed ...

journal_title：British journal of cancer

authors： Southey MC,Tesoriero AA,Andersen CR,Jennings KM,Brown SM,Dite GS,Jenkins MA,Osborne RH,Maskiell JA,Porter L,Giles GG,McCredie MR,Hopper JL,Venter DJ

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The addition of breast magnetic resonance imaging (MRI) to screening mammography for women with BRCA mutations significantly increases sensitivity, but there is little data on clinical outcomes. We report screening performance, cancer stage, distant recurrence rate, and breast cancer-specific mortality in ou...

journal_title：British journal of cancer

authors： Passaperuma K,Warner E,Causer PA,Hill KA,Messner S,Wong JW,Jong RA,Wright FC,Yaffe MJ,Ramsay EA,Balasingham S,Verity L,Eisen A,Curpen B,Shumak R,Plewes DB,Narod SA

更新日期：2012-06-26 00:00:00

abstract：:In the search for effective chemotherapy regimens which can be used in multimodality treatment programmes for patients with cancer of the oesophagus, we conducted a phase II trial to determine the activity and toxicity of the combination of cisplatin and etoposide in patients with advanced squamous cell carcinoma of t...

journal_title：British journal of cancer

authors： Kok TC,Van der Gaast A,Dees J,Eykenboom WM,Van Overhagen H,Stoter G,Tilanus HW,Splinter TA

更新日期：1996-09-01 00:00:00

abstract：:When assessing the value of a particular treatment, it is important to consider the impact it may have on the quality of life of those being treated. This is particularly so for cancer patients, whose life expectancy may be short. Patients with advanced colorectal cancer who participated in two international comparati...

journal_title：British journal of cancer

authors： Anderson H,Palmer MK

更新日期：1998-01-01 00:00:00

abstract：:The acute toxicity, pharmacokinetics and hypoxic cytotoxicity of RSU-1069 were investigated using the subcutaneous (sc) rat 9L tumour model. The pharmacokinetics were studied after i.p. injection of RSU-1069 (20 mg kg-1 or 100 mg kg-1). For both doses, the elimination of RSU-1069 followed first-order kinetics in both ...

journal_title：British journal of cancer

authors： Wong KH,Koch CJ,Wallen CA,Wheeler KT

更新日期：1991-04-01 00:00:00

abstract：:Previous studies have shown that multidrug resistance (MDR) in the doxorubicin-selected lung tumour cell lines COR-L23/R, GLC4/ADR and MOR/R is associated with overexpression of the MRP gene. In this study we report that resistance to daunorubicin, vincristine and rhodamine 123 can be partially reversed in these cell ...

journal_title：British journal of cancer

authors： Versantvoort CH,Broxterman HJ,Bagrij T,Scheper RJ,Twentyman PR

更新日期：1995-07-01 00:00:00

abstract：:Imatinib mesilate (Glivec), Novartis Pharmaceuticals) is a novel therapy for the treatment of chronic myeloid leukaemia (CML). We evaluated the cost-effectiveness of imatinib (600 mg daily) when used for the treatment of patients in advanced stages of CML (accelerated phase and blast crisis) against conventional thera...

journal_title：British journal of cancer

authors： Gordois A,Scuffham P,Warren E,Ward S

更新日期：2003-08-18 00:00:00

abstract：:Oesophageal adenocarcinoma has become much more common over the past 50 years, particularly in Britain, with an unexplained male to female ratio of > 4:1. Given the use of asbestos filtration in commercial brewing and reports of its unregulated use in British public houses in the 1970's to clear draught beer "slops", ...

journal_title：British journal of cancer

authors： Fitzgerald RC,Rhodes JM

更新日期：2019-06-01 00:00:00

abstract：:The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including bcl-2, bcl-x(L)and bcl-w...

journal_title：British journal of cancer

authors： Kitamura S,Kondo S,Shinomura Y,Kanayama S,Miyazaki Y,Kiyohara T,Hiraoka S,Matsuzawa Y

更新日期：2000-09-01 00:00:00

abstract：:A total of 165 adult patients with Hodgkin's disease (HD) were questioned following treatment to examine their perceptions of actual and desired involvement and provision of information in the treatment decision-making process. Irrespective of the degree to which patients felt they had been involved in the decision-ma...

journal_title：British journal of cancer

authors： Turner S,Maher EJ,Young T,Young J,Vaughan Hudson G

更新日期：1996-01-01 00:00:00