Abstract:
:The frequency, in women with breast cancer, of mutations and other variants in the susceptibility gene, BRCA1, was investigated using a population-based case-control-family study. Cases were women living in Melbourne or Sydney, Australia, with histologically confirmed, first primary, invasive breast cancer, diagnosed before the age of 40 years, recorded on the state Cancer Registries. Controls were women without breast cancer, frequency-matched for age, randomly selected from electoral rolls. Full manual sequencing of the coding region of BRCA1 was conducted in a randomly stratified sample of 91 cases; 47 with, and 44 without, a family history of breast cancer in a first- or second-degree relative. All detected variants were tested in a random sample of 67 controls. Three cases with a (protein-truncating) mutation were detected. Only one case had a family history; her mother had breast cancer, but did not carry the mutation. The proportion of Australian women with breast cancer before age 40 who carry a germline mutation in BRCA1 was estimated to be 3.8% (95% CI 0.3-12.6%). Seven rare variants were also detected, but for none was there evidence of a strong effect on breast cancer susceptibility. Therefore, on a population basis, rare variants are likely to contribute little to breast cancer incidence.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Southey MC,Tesoriero AA,Andersen CR,Jennings KM,Brown SM,Dite GS,Jenkins MA,Osborne RH,Maskiell JA,Porter L,Giles GG,McCredie MR,Hopper JL,Venter DJdoi
10.1038/sj.bjc.6690008subject
Has Abstractpub_date
1999-01-01 00:00:00pages
34-9issue
1eissn
0007-0920issn
1532-1827journal_volume
79pub_type
杂志文章abstract::The hybrid cell line BH2 was derived by fusion between an AKR thymoma BW5147 (HGPRT-) and C57BL thymoma EL-4R (TK-). The hybrid cells showed a near-tetraploid modal number of chromosomes, in contrast to the near-diploid stem-lines of both parental cell populations; most of the BH2 hybrid cells acquired marker chromoso...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.255
更新日期:1981-11-01 00:00:00
abstract::Phyto-oestrogens are plant compounds structurally similar to oestradiol, which have been proposed to have protective effects against breast cancer. The main class of phyto-oestrogens in the Western diet is lignans. Literature reports on the effect of lignans in breast cancer risk have been conflicting. We performed th...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/sj.bjc.6605003
更新日期:2009-05-05 00:00:00
abstract::The vaso-active drug hydralazine causes a considerable increase in the cytotoxic effect of melphalan towards the KHT tumour in mice. The enhancement in response, measured as the concentration of melphalan required to achieve a given tumour response, is 3.0 and 2.35 when determined using the regrowth delay assay and th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.177
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Chemerin, a known chemoattractant, participates in multiple biological events. However, its role in cancer remains largely unknown. METHODS:Chemerin expression was evaluated by real-time PCR, western blot and immunohistochemistry. Forced expression, RNAi, immunoprecipitation, etc. were used in function and ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0077-y
更新日期:2018-05-01 00:00:00
abstract::The aim of this study was to determine the dose-limiting toxicity (DLT) and establish the recommended dose for mitomycin C added every 3 weeks to the standard combination dose of capecitabine. Cohorts of at least three patients with pretreated gastrointestinal carcinoma received capecitabine 1000 mg m(-2) orally twice...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/sj.bjc.6602025
更新日期:2004-08-31 00:00:00
abstract:BACKGROUND:Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear. METHODS:From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic regression. RESULTS:Den...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6606085
更新日期:2011-03-01 00:00:00
abstract::Aminoglutethimide has been used in combination with hydrocortisone in patients with advanced prostatic cancer with the rationale that it causes a 'medical adrenalectomy'. Both objective and subjective responses have been recorded. We have examined the effect of AG and HC alone and in combination on plasma androgen lev...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.40
更新日期:1988-02-01 00:00:00
abstract::The overall tumour incidence and breast cancer incidence related to hormone replacement therapy (HRT) were followed in a population-based cohort of 29 508 women, aged 25-65 when interviewed in 1990-92. By the end of the follow up in December 1999, there were 226 611 person-years of observation. A total of 1145 maligna...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.1899
更新日期:2001-09-01 00:00:00
abstract::Two transplantable, highly immunogenic syngeneic C57BL fibrosarcomas, FS1 and FS6, were shown to have tumour-specific rejection antigens, as shown by excision of the primary tumours and i.p. or i.m. injection of graded doses of the specific and unrelated tumour cells. I.p. challenge with tumour cells induced a large a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.253
更新日期:1978-11-01 00:00:00
abstract::Chemotherapy during a viable pregnancy may be associated with adverse perinatal outcomes. We conducted a prospective cohort study to examine the perinatal outcomes of babies born following in utero exposure to chemotherapy in Australia and New Zealand. Over 18 months we identified 24 births, of >400 g and/or >20-weeks...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0563-x
更新日期:2019-10-01 00:00:00
abstract::The objective of this study was to examine the relationship between educational level and mortality from cancer in the city of Barcelona. The data were derived from a record linkage between the Barcelona Mortality Registry and the Municipal Census. The relative risks (RR) of death and 95% confidence intervals (CIs) ac...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690108
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Current evidence indicates that a stem cell-like sub-population within malignant glioblastomas, that overexpress members of the adenosine triphosphate-binding cassette (ABC) family transporters, is responsible for multidrug resistance and tumour relapse. Eradication of the brain tumour stem cell (BTSC) compa...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.188
更新日期:2013-05-28 00:00:00
abstract:BACKGROUND:Emergence of drug-resistant cancer phenotypes is a challenge for anti-cancer therapy. Cancer stem cells are identified as one of the ways by which chemoresistance develops. METHOD:We investigated the anti-inflammatory combinatorial treatment (DA) of doxorubicin and aspirin using a preclinical microfluidic m...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0301-9
更新日期:2019-02-01 00:00:00
abstract::Choriocarcinoma can be imaged by external scintigraphy after intravenous administration of radiolabelled antibody directed against human chorionic gonadotrophin (HCG). The purpose of this study was to investigate whether antibody imaging was sufficiently sensitive and specific to improve the selection of patients for ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.134
更新日期:1987-06-01 00:00:00
abstract::There is disagreement concerning the expression of thyroid peroxidase (TPO) in thyroid cancer, some studies finding qualitative as well as quantitative differences compared to normal tissue. To investigate TPO protein expression and its antigenic properties, TPO was captured from a solubilizate of thyroid microsomes b...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.2015
更新日期:2001-09-14 00:00:00
abstract:BACKGROUND:The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation of its prognostic value in a randomised controlled study (SACURA trial). METHODS:The study included 991 stage II colon cancer patients. DR was cl...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01222-8
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:This randomised controlled trial examined the impact of screening for distress followed by two different triage methods on clinically relevant outcomes over a 12-month period. METHODS:Newly diagnosed patients attending a large tertiary cancer centre were randomised to one of the two conditions: (1) screenin...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2012.309
更新日期:2012-08-07 00:00:00
abstract:BACKGROUND:Cisplatin-radiotherapy is a preferred standard for locally advanced, head and neck squamous cell carcinoma (HNSCC). However, the cisplatin-attributable survival benefit is small and toxicity substantial. A biomarker of cisplatin resistance could guide treatment selection and spare morbidity. The ERCC1-XPF nu...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2013.576
更新日期:2013-10-15 00:00:00
abstract::High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing's sarcoma and medulloblastoma. However, the anti-tumour activity of busulfan as a single agent remains to be defined, and this was evaluated in athymic mice bearing advanced ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690126
更新日期:1999-02-01 00:00:00
abstract::Isomerisation to all-trans-retinoic acid (ATRA) is widely accepted as the key mechanism underlying the favourable clinical properties of 13-cis-retinoic acid (13cisRA). As intracellular metabolism of ATRA by CYP26 may result in clinical resistance to 13cisRA, an increase in efficacy may be achieved through modulation ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603779
更新日期:2007-06-04 00:00:00
abstract::To distinguish risk factors for acquisition of cervical human papillomavirus (HPV) infection from the determinants of neoplasia among infected individuals we have conducted a three-arm case-control study nested within a large population-based cohort of women (the Manchester cohort) screened for HPV at entry using L1 c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1523
更新日期:2000-12-01 00:00:00
abstract::Trastuzumab is the only HER2/neu-directed therapy to have received Food and Drug Administration approval for the treatment of patients with metastatic breast cancer. The efficacy of trastuzumab depends on the HER2/neu status of the tumour and the patient's prior treatment, but even when patients are selected on the ba...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602926
更新日期:2006-01-30 00:00:00
abstract::Despite expressing both Fas and Fas ligand, DU145 and LNCaP prostate cancer cells were resistant to anti-Fas-induced cell death. Resistance to Fas-mediated cytotoxicity could be overcome in DU145, but not in LNCaP, cells by pretreating cells with sublethal doses of cytotoxic drugs, such as camptothecin. Activated casp...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690365
更新日期:1999-05-01 00:00:00
abstract::Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.71
更新日期:1987-04-01 00:00:00
abstract::We investigated breast cancer incidence in migrants in the Netherlands in 1988-1998. The standardised incidence ratio for breast cancer in Northwest-Netherlands was statistically significantly reduced for women born in Surinam (0.56), Turkey (0.29) and Morocco (0.22). The proportion of women with advanced stages (III ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601821
更新日期:2004-06-01 00:00:00
abstract::The function of the reticulo-endothelial system in mice bearing Lewis lung carcinomas has been measured by(1) the rate of clearance of carbon particles from the circulation in vivo and calculation of the phagocytic index K; (2) chemotactic locomotion of macrophages in vitro in the presence or absence of serum or tumou...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.197
更新日期:1977-09-01 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is associated with poor survival. To identify prognostic and diagnostic markers and therapeutic targets, we studied ANO1, a recently identified calcium-activated chloride channel (CaCC). METHODS:High-resolution genomic and transcriptomic microarray analysis and ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605823
更新日期:2010-08-24 00:00:00
abstract::Metabolic reprogramming towards aerobic glycolysis is a common feature of transformed cells and can be driven by a network of transcription factors. It is well established that c-Myc and hypoxia-inducible factor-1α (HIF-1α) contribute to metabolic reprogramming by driving the expression of glycolytic target genes. Mor...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2015.360
更新日期:2015-12-01 00:00:00
abstract::The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as pro-photosensitising agents. The compounds were assayed in a cell line derived from a murine mammary tumou...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601722
更新日期:2004-04-19 00:00:00
abstract:BACKGROUND:Impaired drug transport is an important factor that reduces the efficacy of anticancer agents against pancreatic cancer. Here, we report a novel combination chemotherapy using gemcitabine (GEM) and internalised-RGD (iRGD) peptide, which enhances tumour-specific drug penetration by binding neuropilin-1 (NRP1)...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.49
更新日期:2014-03-18 00:00:00