Abstract：
:Burnet proposed in the 1950's that the immune system is engaged in identifying and destroying abnormal cancerous cells. This process, termed immune surveillance, has been at the centre of intense debate for decades. Results using immunodeficient mice lend support to the immune surveillance hypothesis. We surmised that immune surveillance would be hampered by the inhibitory effect of naturally occurring FoxP3(+) regulatory T cells, a population of T cells shown to be present at an increased frequency in a variety of human tumours. The carcinogen, methylcholanthrene was injected subcutaneously into mice and the steady development of fibrosarcomas was observed over approximately 200 days. These fibrosarcomas were strikingly infiltrated with FoxP3(+) regulatory T cells implying that these cells impinge upon immune-mediated rejection of the tumour. This was confirmed by partial ablation of FoxP3(+) regulatory T-cell activity, which resulted in a marked reduction in tumour incidence. The reduction of tumour incidence was ablated in mice that lacked interferon gamma. These data offer strong support for the concept of immune surveillance and indicate that this process is limited by the inhibitory effect of FoxP3(+) regulatory T cells.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Betts G,Twohig J,Van den Broek M,Sierro S,Godkin A,Gallimore Adoi
10.1038/sj.bjc.6603824subject
Has Abstractpub_date
2007-06-18 00:00:00pages
1849-54issue
12eissn
0007-0920issn
1532-1827pii
6603824journal_volume
96pub_type
杂志文章abstract：:Erbicin is a human anti-ErbB2 single-chain antibody fragment with high affinity and selectivity for ErbB2-positive cancer cells. Two anti-ErbB2 immunoconjugates, called Erb-hRNase and Erb-hcAb, have been prepared and found to be selectively cytotoxic on ErbB2-positive cancer cells in vitro and vivo. In Erb-hRNase, Erb...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604022
更新日期：2007-11-19 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：1977-05-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.265
更新日期：1986-12-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.244
更新日期：1975-10-01 00:00:00
abstract：:Human primary thyroid follicular epithelial cells were transfected with a plasmid containing an origin-defective SV40 genome (SVori-) to produce several immortal cell lines. Two of the 10 cell lines analysed expressed specific features of thyroid epithelial function (iodide-trapping and thyroglobulin production). Thes...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.387
更新日期：1989-12-01 00:00:00
abstract：:The incidence of nodal metastasis in early gastric carcinoma (EGC) is 10-20%. However, the optimal nodal dissection for early gastric carcinoma has not been established. A retrospective study was conducted in 392 consecutive patients who underwent potentially curative distal gastrectomy for EGC between 1962 and 1990. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.540
更新日期：1995-12-01 00:00:00
abstract：:To assess the precise role of IGF1 in benign and malignant breast diseases, we analysed the tissular localisation, characterised, and quantified specific insulin-like growth factor 1 (IGF1) binding sites in these heterogenous tissues, using histo-autoradiographic analysis (HAA). The 125I-IGF1 binding was performed on ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.252
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND:The clinical utility of machine-learning (ML) algorithms for breast cancer risk prediction and screening practices is unknown. We compared classification of lifetime breast cancer risk based on ML and the BOADICEA model. We explored the differences in risk classification and their clinical impact on screenin...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0937-0
更新日期：2020-09-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.388
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated. METHODS:Eligible patients (9 wit...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.468
更新日期：2013-09-03 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.132
更新日期：1986-06-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690385
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:The arachidonic acid metabolite 12(S)-HETE is suspected to enhance metastatic spread by inducing cancer cell- and lymph endothelial cell (LEC) motility. However, the molecular mechanisms leading to 12(S)-HETE-triggered cell migration are still elusive. METHODS:To delineate the signalling pathways involved i...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.201
更新日期：2016-07-26 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1054/bjoc.2000.1549
更新日期：2000-12-01 00:00:00
abstract：:Soluble and nuclear oestrogen receptor status was determined in both the central and peripheral portions of tumour for 37 cases of adenocarcinoma of the endometrium. Of these, 29 had functional receptor in the peripheral biopsy, but only 19 retained functional receptor in the centre. Six of the 10 patients whose tumou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1983.34
更新日期：1983-02-01 00:00:00
abstract：:The presence or absence of lymphocytic mucopolysaccharides (MPS) is studied in 223 subjects: 100 normals (controls); 8 cancer patients cured for more than 6 years; 30 cancer patients at the start of their treatment; and 85 relatives of first degree consanguinity of these last patients. The data are studied by statisti...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.147
更新日期：1973-09-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.376
更新日期：1993-09-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,多中心研究
doi：10.1038/sj.bjc.6604838
更新日期：2009-01-27 00:00:00
abstract：:The prostate cancer cell lines PC3 and LNCaP have been shown to lack expression of the tumour suppressor gene MMAC1/PTEN, in contrast to the immortalized non-tumorigenic epithelial lines PNT1a and PNT2. We have measured the effects of reintroduction of wild type (wt) and mutant MMAC1 genes on to these genetic backgrou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1400
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Combined oral contraceptive (COC) use reduces epithelial ovarian cancer (EOC) risk. However, little is known about risk with COC use before the first full-term pregnancy (FFTP). METHODS:This Canadian population-based case-control study (2001-2012) included 854 invasive cases/2139 controls aged ⩾40 years who...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.400
更新日期：2017-01-17 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.273
更新日期：1980-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6603626
更新日期：2007-03-26 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.575
更新日期：2013-10-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0968
更新日期：2000-02-01 00:00:00
abstract：:Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function. The doxorubicin-resistant MRP1-overexpressing human SCLC cell line GLC(4)-Adr was highly sen...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604010
更新日期：2007-10-22 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.377
更新日期：1996-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.284
更新日期：1996-06-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.56
更新日期：1991-02-01 00:00:00
abstract：:Alternative splicing of survivin mRNA gives rise to multiple isoforms, that is, survivin and 3 splice variants, survivin-2B, survivin-3B and survivin-DeltaEx3. The aim of this study was to compare the expression of survivin, survivin-2B and survivin-DeltaEx3 in normal breast tissue, fibroadenomas, primary breast cance...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602314
更新日期：2005-01-17 00:00:00
abstract：BACKGROUND:Locally advanced oesophageal cancer (LAEC) is associated with poor survival and more effective treatments are needed. The aim of this phase I trial was to assess the maximum tolerated dose (MTD) of a novel weekly docetaxel and cisplatin regimen concurrent with radical radiotherapy. METHODS:Patients with unr...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6606051
更新日期：2011-01-18 00:00:00
