Abstract：
:The level of Gross cell-surface antigen (GCSAa) expression at the surface of murine retrovirus-infected fibroblasts was determined by quantitative absorption of the anti-GCSAa activity of a serum produced in syngeneic W/Fu rats immunized against (C58NT)D lymphoma, and tested in a cytotoxicity assay against E male G2 lymphoma cells. While GCSAa was specifically expressed on Gross-type virus (G-MuLV)-induced lymphoma cells, and while G-MuLV and G-related MuLV induced a high level of GCSAa expression on murine fibroblasts, the Friend-Moloney-Rauscher (FMR) group viruses (FMR MuLV) and xenotropic isolates were also able to induce a high or intermediate level of GCSAa. Since GCSAa has been shown to be borne by glycosylated precursors of the viral nucleocapside (gp95gag and gp85gag), the amount of GCSAa expressed on these cells was compared to the level of cytoplasmic p30. In G- and G-related MuLV-infected cell lines, a significant relationship was found between the amount of GCSAa and the level of p30, whereas in FMR-MuLV or xenotropic virus-infected cells the amount of GCSAa varied independently of the p30 level. These results could explain the discrepancy in the specificity of expression of GCSAa in vivo and in vitro.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Gerlier D,Gisselbrecht S,Guillemain B,Doré JFdoi
10.1038/bjc.1981.97subject
Has Abstractpub_date
1981-05-01 00:00:00pages
659-68issue
5eissn
0007-0920issn
1532-1827journal_volume
43pub_type
杂志文章abstract：:Chordomas are radio- and chemo-resistant tumours and metastasise in as many as 40% of patients. The aim of this study was to identify potential molecular targets for the treatment of chordoma. In view of the reported association of chordoma and tuberous sclerosis complex syndrome, and the available therapeutic agents ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605019
更新日期：2009-05-05 00:00:00
abstract：:Measurements of methotrexate have been made in the liver and plasma of 4 patients and in the bile and plasma of 1 patient receiving [(3)H]methotrexate. Projections from a theoretical model of concentration of methotrexate in liver are confirmed but projections of biliary excretion are not. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.190
更新日期：1973-12-01 00:00:00
abstract：:Overexpression of the c-erbB-2 proto-oncogene in mammary carcinoma is frequently associated with amplification of the c-erbB-2 gene, but it also occurs from single-copy gene. Studies in mammary-derived cell lines have shown that, whether or not the gene is amplified, there is a 6- to 8-fold increase in the accumulatio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.146
更新日期：1995-04-01 00:00:00
abstract：:Supplementary Table 1 and the Supplementary Figure legends were not included when this manuscript was first published. The files are now available here. ...
journal_title：British journal of cancer
pub_type： 已发布勘误
doi：10.1038/s41416-018-0130-x
更新日期：2018-08-01 00:00:00
abstract：:Growth of the transplantable EMR-86 rat mammary carcinoma depends on elevated prolactin levels which are induced by oestrogenic stimulation of the pituitary. We investigated histological and cell kinetic changes during tumour regression after removal of implanted oestrogen pellets (EP), and we especially focused on th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.232
更新日期：1996-05-01 00:00:00
abstract：:The prevalence (lifetime occurrence) rate of cancers of the reproductive system (uterus, ovary, cervix and vagina) and breast cancer was determined for 5,398 living alumnae, 2,622 of whom were former college athletes and 2,776 non-athletes, from data on medical and reproductive history, athletic training and diet. The...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.273
更新日期：1985-12-01 00:00:00
abstract：:The secosteroid hormones, all-trans- and 9-cis-retinoic acid and vitamin D3, have demonstrated significant capacity to control proliferation in vitro of many solid tumour cell lines. Cooperative synergistic effects by these two ligands have been reported, and it is, therefore, possible that greater therapeutic effects...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690018
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:The role of further hormone therapy in castration-resistant prostate cancer (CRPC) remains unclear. We performed a multi-centre randomised phase III study comparing the use of Dexamethasone, Aspirin, and immediate addition of Diethylstilbestrol (DAiS) vs Dexamethasone, Aspirin, and deferred (until disease pr...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2011.7
更新日期：2011-02-15 00:00:00
abstract：:Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease, and its incidence is increasing as the populations in Western countries age. Despite major advances in understanding the genetic landscape of AML and its impact on the biology of the disease, standard therapy has not changed significa...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2017.281
更新日期：2017-10-10 00:00:00
abstract：:We analysed 29 consecutive cases of primary gastric lymphoma (20 men and 9 women) treated in our unit between January 1977 and May 1983. Median age was 55 years. Abdominal pain and weight loss were the main presenting symptoms while there was no palpable disease in the majority of cases. Upper gastrointestinal radiolo...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.206
更新日期：1985-09-01 00:00:00
abstract：BACKGROUND:Eukaryotic translation elongation factor 1A2 (eEF1A2) is a known proto-oncogene. We proposed that stimulation of the eEF1A2 expression in cancer tissues is caused by the loss of miRNA-mediated control. METHODS:Impact of miRNAs on eEF1A2 at the mRNA and protein levels was examined by qPCR and western blot, r...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.243
更新日期：2013-06-11 00:00:00
abstract：:Trastuzumab is the only HER2/neu-directed therapy to have received Food and Drug Administration approval for the treatment of patients with metastatic breast cancer. The efficacy of trastuzumab depends on the HER2/neu status of the tumour and the patient's prior treatment, but even when patients are selected on the ba...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602926
更新日期：2006-01-30 00:00:00
abstract：BACKGROUND:Radio- and chemotherapy (RT/CT) resistance hampers success in combating small and non-small cell lung cancers (SCLC/NSCLC). The underlying molecular mechanisms of RT/CT resistance of LCs are multifactorial and have been understood in part hitherto. miRNAs, key regulators of mRNAs, are well-recognised oncomir...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.382
更新日期：2012-10-09 00:00:00
abstract：BACKGROUND:The amplification of epidermal growth factor receptor (EGFR) in triple negative breast carcinomas (TNBC) suggests its potential therapeutic application, as for HER-2, using standardised methods of measurement. In this regard, we aimed to compare several methods for evaluating EGFR amplification along with po...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.794
更新日期：2014-02-18 00:00:00
abstract：:To find out whether ultrasound-guided fine-needle aspiration (FNA) and ultrasound and stereotactic-guided large core needle biopsy (LCNB) are reliable alternatives to needle-localised open breast biopsy (NLBB) in daily practice, we performed a retrospective study and evaluated the validity of these methods. In all, 71...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601559
更新日期：2004-02-09 00:00:00
abstract：:The pharmacological interest in lonidamine is related to its ability to enhance the cytotoxic effects of several DNA-damaging anti-tumour agents. This study was undertaken to better understand the in vivo interaction between lonidamine and cisplatin in the treatment of human tumour xenografts, including three carcinom...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.69
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant condition caused by germline FLCN mutations, and characterised by fibrofolliculomas, pneumothorax and renal cancer. The renal cancer risk, cancer phenotype and pneumothorax risk of BHD have not yet been fully clarified. The main focus of this study was t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.463
更新日期：2011-12-06 00:00:00
abstract：:This corrects the article DOI: 10.1038/bjc.2017.85. ...
journal_title：British journal of cancer
pub_type： 杂志文章,已发布勘误
doi：10.1038/bjc.2017.437
更新日期：2018-03-20 00:00:00
abstract：BACKGROUND:Cancer cachexia is a complex wasting syndrome affecting patients with advanced cancer, with systemic inflammation as a key component in pathogenesis. Protein degradation and release of amino acids (AAs) in skeletal muscle are stimulated in cachexia. Here, we define factors contributing to serum AA levels in ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0357-6
更新日期：2019-01-01 00:00:00
abstract：:Birth size of a woman has been positively associated with her breast cancer risk, particularly before menopause, but no study has investigated neonatal growth in relation to this risk. We conducted a case-control study nested within a population-based cohort of women, born in Sweden between 1901 and 1961, covering all...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604702
更新日期：2008-11-04 00:00:00
abstract：BACKGROUND:There is clinical evidence to suggest that tumour necrosis factor-α (TNF-α) may be a therapeutic target in renal cell carcinoma (RCC). Multi-targeted kinase inhibitors, such as sorafenib and sunitinib, have become standard of care in advanced RCC. The anti-TNF-α monoclonal antibody infliximab and sorafenib h...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605889
更新日期：2010-10-12 00:00:00
abstract：:Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proline showed that prol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.123
更新日期：1974-08-01 00:00:00
abstract：BACKGROUND:Overexpression of plasma membrane multi-drug resistance protein 1 (MRP-1) can lead to multidrug resistance. In this study, we describe for the first time the expression of mitochondrial MRP-1 in untreated human normal and cancer cells and tissues. METHODS:MRP-1 expression and subcellular localisation in nor...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.40
更新日期：2012-03-13 00:00:00
abstract：:The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.12
更新日期：1978-01-01 00:00:00
abstract：:Clinical-pathologic-genetic studies were performed on 3 kindreds showing the familial atypical multiple mole-melanoma syndrome (FAMMM). Findings showed vertical transmission, including father-to-son, of cutaneous malignant melanoma and/or FAMMM moles with no sex predilection. A broad spectrum of clinical signs charact...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.203
更新日期：1980-07-01 00:00:00
abstract：:The natural history of 45 cases of smouldering leukaemia has been studied. Males and females were equally represented, with a median age of 60.5. The median survival of the whole group was only 20 months, but rare cases lived 10 years or longer. 38% developed acute leukaemia; the remainder usually died of the results ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.179
更新日期：1982-08-01 00:00:00
abstract：:The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-)biological networks including malignancies. However, except for CXCR4/CXCL12, little is known about the relation between tumour-related chemokine expression and the development and progression of solid tumours like breast...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604621
更新日期：2008-09-16 00:00:00
abstract：BACKGROUND:Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer. METHODS:miR-18a is located in the miR-17-92 cluster and reported to be highly expressed in pancr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.453
更新日期：2011-11-22 00:00:00
abstract：:High-throughput microarrays are being used in expression profiling analyses with the objectives of gene and pathway discovery, functional characterization of genes, and tumor subclassification. This review summarizes bladder cancer studies dealing with both in vitro models and clinical specimens, using distinct microa...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6601406
更新日期：2003-12-15 00:00:00
abstract：:In small-cell lung cancer cell lines resistance to growth inhibition by transforming growth factor (TGF)-beta 1, was previously shown to correlate with lack of TGF-beta receptor I (RI) and II (RII) proteins. To further investigate the role of these receptors, the expression of mRNA for RI, RII and beta-glycan (RIII) w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.201
更新日期：1996-05-01 00:00:00
