Abstract：
:Eleven groups of workers submitted a total of 21 bronchial tumour-associated antigen preparations and 19 antisera for comparative studies. Many of the antisera proved to be polyspecific despite absorption procedures. Most of the antigen preparations contained some material reactive towards a reference antiserum to normal human serum proteins. While it appeared that no participants were studying identical antigen-antibody reactions, several cross-reactivities were identified in the antisera. When immune reactions to CEA, AFP, NCA, ferritin, lactoferrin, human pepsin and gastricsin, and the pregnancy proteins, SP1 and SP3 were excluded by use of reference antisera and electroimmunoprecipitation methods, there remained 5 antigen-antibody reactions defining unique antigens. The clinical usefulness of any of these 5 antigens has yet to be determined.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Gennings JN,Bagshawe KD,Axelsen NH,Sizaret Pdoi
10.1038/bjc.1981.216subject
Has Abstractpub_date
1981-10-01 00:00:00pages
487-95issue
4eissn
0007-0920issn
1532-1827journal_volume
44pub_type
杂志文章abstract：:TNF-related apoptosis-inducing ligand (TRAIL, also known as Apo-2L) is a promising novel anticancer agent that selectively induces apoptosis in tumour cells and the activity of which can be enhanced by combined treatment with chemo- or radiotherapy. For therapeutic purposes, the use of full-length TRAIL may be favoura...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601910
更新日期：2004-07-05 00:00:00
abstract：:Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA acts in vivo by binding to a membrane receptor known as uPAR. In this study, uPA and uPAR levels were semiquantitated by immunocytochemistry in 36 primary breast carcinomas. Using monoclonal antibody HD-UK 1, uPA...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.268
更新日期：1998-05-01 00:00:00
abstract：:In a meta-analysis of testicular cancer in twins, twins had a 30% increased risk (estimate 1.31, 95% CI 1.1-1.6), providing indirect support for the hypothesis that in utero hormone variations influence risk of testicular cancer. The summary-estimate for dizygotic twins was 1.3 (1.0-1.7) and for monozygotic or same se...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/sj.bjc.6604136
更新日期：2008-01-15 00:00:00
abstract：:Induction of lipolysis in murine white adipocytes, and stimulation of adenylate cyclase in adipocyte plasma membranes, by a tumour-produced lipid mobilizing factor, was attenuated by low concentrations (10(-7)--10(-5)M) of the specific beta3-adrenoceptor antagonist SR59230A. Lipid mobilizing factor (250 nM) produced c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600086
更新日期：2002-02-01 00:00:00
abstract：:During the COVID-19 era, Chinese hospitals have developed a system that enables vulnerable cancer patients to continue to receive high-quality medical care, optimising their survival whilst protecting them. This includes use of digital quick codes, fever clinics and optimal scheduling. We wish to share our experiences...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0856-0
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:A phase Ib study of binimetinib and capecitabine for gemcitabine-pretreated biliary tract cancer (BTC) patients was conducted. METHODS:Binimetinib and capecitabine were dosed twice daily on days 1-14, in 3-week cycles. In the dose-escalation (DE) part, three dose levels (DL) were tested (DL1: binimetinib/ca...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0523-5
更新日期：2019-08-01 00:00:00
abstract：:Large-scale genomic analyses of cutaneous melanoma have revealed insights into the aetiology and heterogeneity of this disease, as well as opportunities to further personalise treatment for patients with targeted and immune therapies. Herein, we review the proposed genomic classification of cutaneous melanoma from lar...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2016.195
更新日期：2016-07-12 00:00:00
abstract：:The association between chromosomal radiosensitivity and genetic predisposition to head and neck cancer was investigated in this study. In all, 101 head and neck cancer patients and 75 healthy control individuals were included in the study. The G(2) assay was used to measure chromosomal radiosensitivity. The results d...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604345
更新日期：2008-05-20 00:00:00
abstract：:Despite encouraging results from recent studies, there is still no consensus to undertake mass screening using the Haemoccult test in the general population. The success of mass screening for colorectal cancer depends among other things on Haemoccult test properties. In on-going screening programmes, the Haemoccult te...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.459
更新日期：1995-10-01 00:00:00
abstract：:The interaction between laminin and the oncoprotein encoded by the c-erbB-2 oncogene was studied in vitro and in vivo in human breast carcinomas. In vitro analysis of breast carcinoma cell lines overexpressing p185HER2 revealed that laminin, but not fibronectin, induced tyrosine phosphorylation and down-modulation of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.560
更新日期：1996-11-01 00:00:00
abstract：BACKGROUND:There is emerging evidence to suggest that the association between socioeconomic circumstances and colorectal cancer incidence has changed over recent decades. METHODS:We conducted a descriptive population-based study to describe the relationship between socioeconomic circumstances and the incidence of colo...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.149
更新日期：2011-05-24 00:00:00
abstract：:Interactions between immune and malignant cells have been known to have clinical relevance for decades. The potential for immune control is now being therapeutically enhanced with checkpoint inhibitors and other novel agents to improve outcomes in cancer. The importance of the immune infiltrate as a prognostic marker ...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2017.220
更新日期：2017-08-08 00:00:00
abstract：BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.223
更新日期：2014-05-27 00:00:00
abstract：:The role of the anti-apoptotic protein Bcl-2 in lung cancer remains controversial. In order to clarify its impact on survival in small and non-small cell lung cancer (NSCLC), we performed a systematic review of the literature. Trials were selected for further analysis if they provided an independent assessment of Bcl-...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1038/sj.bjc.6601095
更新日期：2003-07-07 00:00:00
abstract：BACKGROUND:To evaluate safety, pharmacokinetics, and maximum tolerated dose of roniciclib in patients with advanced malignancies, with dose expansion to evaluate clinical benefit at the recommended phase II dose (RP2D). METHODS:Two phase I dose-escalation studies evaluated two roniciclib dosing schedules: 3 days on/4 ...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2017.92
更新日期：2017-06-06 00:00:00
abstract：:Three hundred and ninety women participated in the quality of life (QL) study of ACCOG1, a high-dose vs conventional adjuvant chemotherapy breast cancer trial, for patients with a high risk of relapse. Patients completed the European Organisation for Research and Treatment of Cancer QLQ-C30, questions on menopausal sy...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603454
更新日期：2006-12-18 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) gene mutations and increased copy numbers are considered as predictors of response to EGFR tyrosine kinase inhibitors (EGFR-TKI) in non-small-cell lung cancer (NSCLC). Lung cancer diagnosis is often based on cytology alone. However, almost all published data on EGFR gene analyse...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604142
更新日期：2008-01-15 00:00:00
abstract：:The aim of this study was to examine the effects of oral and transdermal oestrogen replacement therapy on the risk of colorectal cancer. Data from a nested case-control study, designed to investigate the effect of hormone replacement therapy (HRT) on colorectal cancer were analysed. New cases of colorectal cancer, dia...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601438
更新日期：2004-01-12 00:00:00
abstract：:Bilateral kidney ligation of mice immediately before injection of misonidazole (MIS) prolongs the plasma half-life of this radiosensitizer from about 2 h (in normal mice) to 10-11 h, similar to that in man. Kidney ligation does not, however, change the relative proportions of MIS and its O-demethylated metabolite, Ro-...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.55
更新日期：1979-03-01 00:00:00
abstract：:'de novo' carcinogenesis has been advocated besides 'adenoma carcinoma sequence' as another dominant pathway leading to colorectal carcinoma. Our recent study has demonstrated that the distribution of brain (fetal)-type glycogen phosphorylase (BGP) positive foci (BGP foci) has a close relationship with the location of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1824
更新日期：2001-06-01 00:00:00
abstract：:We have determined the methylation status of the CpG island of the oestrogen receptor alpha gene in seven human ovarian cell lines. Cell lines expressing oestrogen receptor alpha showed no evidence of hypermethylation. In three of four cell lines that produced no detectable oestrogen receptor alpha protein, hypermethy...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600028
更新日期：2002-01-21 00:00:00
abstract：BACKGROUND:Identification of promising biomarkers that predict the prognosis of patients with breast cancer is needed. In this study, we hypothesised that the expression of the epithelial-mesenchymal transition-related biomarker plastin3 (PLS3) in peripheral blood could be a prognostic factor in breast cancer. METHODS...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.132
更新日期：2015-04-28 00:00:00
abstract：:The co-injection of extracellular matrix components, such as Matrigel, with human tumour cells into nude mice has been reported to facilitate tumour formation and growth, but it is unknown whether such components exert similar effects on tumour progression and metastasis. Metastatic behaviour is known to be enhanced w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.284
更新日期：1994-08-01 00:00:00
abstract：BACKGROUND:The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management of cancer pain, and preclinical studies indicate that opioids have the p...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2014.384
更新日期：2014-08-26 00:00:00
abstract：:Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.346
更新日期：1996-07-01 00:00:00
abstract：:A number of polyunsaturated fatty acids have been shown to inhibit the growth of malignant cells in vitro. To investigate whether fatty acids modify the growth of human pancreatic cancer, lauric, stearic, palmitic, oleic, linoleic, alpha-linolenic, gamma-linolenic, arachidonic, docosahexaenoic and eicosapentaenoic (EP...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.161
更新日期：1994-05-01 00:00:00
abstract：:The mechanism of down-regulation of c-myc RNA associated with androgen-induced suppression of the transformed phenotype in the human prostate carcinoma cell line LNCaP was investigated. The synthetic androgen mibolerone (7 alpha-17 alpha-Dimethyl-19-nortestosterone) reversibly inhibits the proliferation of LNCaP cells...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.76
更新日期：1992-03-01 00:00:00
abstract：:Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603028
更新日期：2006-03-27 00:00:00
abstract：BACKGROUND:Low cancer awareness may contribute to delayed diagnosis and poor cancer survival. We aimed to quantify socio-demographic differences in cancer symptom awareness and barriers to symptomatic presentation in the English population. METHODS:Using a uniquely large data set (n=49 270), we examined the associatio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.164
更新日期：2015-07-28 00:00:00
abstract：:There are two main histological groups of testicular germ cell tumours, which may have different risk factors. Some authors have analysed potential risk factors by histological group but few consistent differences have been identified. In this paper we examine risk factors for pure seminoma and other tumours using dat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690611
更新日期：1999-08-01 00:00:00
