Cancer incidence in the Falkland Islands.

abstract：BACKGROUND:Inconsistencies between mitotic index (MI) and Ki67 measures have been identified in many breast tumour samples. The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2- tumours having discrepant MI and Ki67. METHODS:We included a cohort of breast cancer patients initiall...

journal_title：British journal of cancer

authors： Rossi L,Laas E,Mallon P,Vincent-Salomon A,Guinebretiere JM,Lerebours F,Rouzier R,Pierga JY,Reyal F

更新日期：2015-09-29 00:00:00

abstract：:Tissue from 54 histologically-identified basal cell carcinomas of the skin was obtained at surgery and assayed using a combination of functional and immunochemical procedures for matrix metalloproteinases (MMPs) with collagenolytic activity and for MMPs with gelatinolytic activity. Collagenolytic enzymes included MMP-...

journal_title：British journal of cancer

authors： Varani J,Hattori Y,Chi Y,Schmidt T,Perone P,Zeigler ME,Fader DJ,Johnson TM

更新日期：2000-02-01 00:00:00

abstract：:Caveolin-1 (CAV1) and caveolin 2 (CAV2) are the principal structural proteins of caveolae, sphingolipid and cholesterol-rich invaginations of the plasma membrane involved in vesicular trafficking and signal transduction. Over the recent years there has been controversy about their role in breast cancer and their suita...

journal_title：British journal of cancer

authors： Elsheikh SE,Green AR,Rakha EA,Samaka RM,Ammar AA,Powe D,Reis-Filho JS,Ellis IO

更新日期：2008-07-22 00:00:00

abstract：:Hypomethylation has been reported to be responsible for the activation of several oncogenes. The possibility that hypomethylation is involved in the regulation of MET transcription was investigated through the analysis of the methylation status of one CpG island containing 43 CpGs in six cases of papillary carcinoma, ...

journal_title：British journal of cancer

authors： Scarpino S,Di Napoli A,Rapazzotti-Onelli M,Pilozzi E,Ruco L

更新日期：2004-08-16 00:00:00

abstract：:A sedentary lifestyle, obesity, and a Westernized diet have been implicated in the aetiology of both colorectal cancer and non-insulin dependent diabetes mellitus, leading to the hypothesis that hyperinsulinaemia may promote colorectal cancer. We prospectively examined the association between colorectal cancer risk an...

journal_title：British journal of cancer

authors： Nilsen TI,Vatten LJ

更新日期：2001-02-02 00:00:00

abstract：:Patients with recurrent or refractory head and neck squamous cell carcinoma received cisplatin/epinephrine injectable gel or placebo gel injected directly into the clinically dominant tumour. The double-blind phase III trial comprised of up to 6 weekly treatments over 8 weeks, 4 weekly evaluation visits, and then mont...

journal_title：British journal of cancer

authors： Werner JA,Kehrl W,Pluzanska A,Arndt O,Lavery KM,Glaholm J,Dietz A,Dyckhoff G,Maune S,Stewart ME,Orenberg EK,Leavitt RD

更新日期：2002-10-21 00:00:00

abstract：:Members of the public are increasingly consulted over health care and research priorities. Patient involvement in determining cancer research priorities, however, has remained underdeveloped. This paper presents the findings of the first consultation to be conducted with UK cancer patients concerning research prioriti...

journal_title：British journal of cancer

authors： Corner J,Wright D,Hopkinson J,Gunaratnam Y,McDonald JW,Foster C

更新日期：2007-03-26 00:00:00

abstract：:Laminin-332 is major component of epithelial basement membrane, and has an important role in cell migration and tumour invasion. Recently, the phosphatidylinositol 3-kinase (PI3K) activation induced by laminin-332 during carcinogenesis or tumour invasion has been highlighted in skin squamous cell carcinoma. The expres...

journal_title：British journal of cancer

authors： Baba Y,Iyama KI,Hirashima K,Nagai Y,Yoshida N,Hayashi N,Miyanari N,Baba H

更新日期：2008-03-11 00:00:00

abstract：BACKGROUND:To evaluate the possible association between paediatric head computed tomography (CT) examination and increased subsequent risk of malignancy and benign brain tumour. METHODS:In the exposed cohort, 24 418 participants under 18 years of age, who underwent head CT examination between 1998 and 2006, were ident...

journal_title：British journal of cancer

authors： Huang WY,Muo CH,Lin CY,Jen YM,Yang MH,Lin JC,Sung FC,Kao CH

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:This multicentre, open-label study evaluated the efficacy and safety of SPI-1620, an analogue of endothelin-1, administered in combination with docetaxel as second-line treatment for patients with advanced biliary tract cancer (ABTC). METHODS:Eligible patients received continuous cycles of combination thera...

journal_title：British journal of cancer

authors： Kim R,Chiorean EG,Amin M,Rocha-Lima CMS,Gandhi J,Harris WP,Song T,Portnoy D

更新日期：2017-07-11 00:00:00

abstract：:The aims of this study were to identify prognostic variables for toxicity and survival in patients with cancer participating in phase I clinical trials and compare characteristics of those treated with cytotoxic chemotherapy (CT) and non-cytotoxic drugs (non-CT). Data were collected from 420 (114 CT, 306 non-CT) patie...

journal_title：British journal of cancer

authors： Han C,Braybrooke JP,Deplanque G,Taylor M,Mackintosh D,Kaur K,Samouri K,Ganesan TS,Harris AL,Talbot DC

更新日期：2003-10-06 00:00:00

abstract：BACKGROUND:Pre-existing non-cancer conditions may complicate and delay colorectal cancer diagnosis. METHOD:Incident cases (aged ⩾40 years, 2007-2009) with colorectal cancer were identified in the Clinical Practice Research Datalink, UK. Diagnostic interval was defined as time from first symptomatic presentation of col...

journal_title：British journal of cancer

authors： Mounce LTA,Price S,Valderas JM,Hamilton W

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Evasion of apoptosis contributes to the pathogenesis of solid tumours including non-small cell lung cancer (NSCLC). Malignant cells resist apoptosis through over-expression of inhibitor of apoptosis proteins (IAPs), such as X-linked IAP (XIAP). METHODS:A phenylurea-based small molecule inhibitor of XIAP, XI...

journal_title：British journal of cancer

authors： Dean EJ,Ward T,Pinilla C,Houghten R,Welsh K,Makin G,Ranson M,Dive C

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:This study explored the association between smoking and colorectal malignant carcinoma (CRC) in the Chinese population at the national level for the first time. METHODS:In the China Nationwide Retrospective Mortality Survey conducted during 1989-1991, 12,942 CRC cases among 1,136,336 all-cause deaths aged ≥...

journal_title：British journal of cancer

authors： Hou L,Jiang J,Liu B,Nasca PC,Wu Y,Zou X,Han W,Chen Y,Zhang B,Xue F,Pang H,Li J

更新日期：2014-03-04 00:00:00

abstract：BACKGROUND:To evaluate safety, pharmacokinetics, and maximum tolerated dose of roniciclib in patients with advanced malignancies, with dose expansion to evaluate clinical benefit at the recommended phase II dose (RP2D). METHODS:Two phase I dose-escalation studies evaluated two roniciclib dosing schedules: 3 days on/4 ...

journal_title：British journal of cancer

authors： Bahleda R,Grilley-Olson JE,Govindan R,Barlesi F,Greillier L,Perol M,Ray-Coquard I,Strumberg D,Schultheis B,Dy GK,Zalcman G,Weiss GJ,Walter AO,Kornacker M,Rajagopalan P,Henderson D,Nogai H,Ocker M,Soria JC

更新日期：2017-06-06 00:00:00

abstract：:We conducted a case-control study to investigate the role of early infections in the aetiology of childhood acute leukaemias. The study included 280 incident cases (240 acute lymphoblastic leukaemia and 40 acute non-lymphoblastic leukaemia) and 288 hospital controls, frequency matched by age, gender, hospital, catchme...

journal_title：British journal of cancer

authors： Perrillat F,Clavel J,Auclerc MF,Baruchel A,Leverger G,Nelken B,Philippe N,Schaison G,Sommelet D,Vilmer E,Hémon D

更新日期：2002-04-08 00:00:00

abstract：:In order to examine in detail the sensitivity to chemotherapy of tumour cells at various organ sites and at various stages of metastasis, we have used a series of cell lines, all selected from sister subpopulations derived from a single mouse mammary tumour, which can be distinguished and quantitated from normal cells...

journal_title：British journal of cancer

authors： Miller BE,Miller FR,Machemer T,Heppner GH

更新日期：1993-07-01 00:00:00

abstract：:Growth of the transplantable EMR-86 rat mammary carcinoma depends on elevated prolactin levels which are induced by oestrogenic stimulation of the pituitary. We investigated histological and cell kinetic changes during tumour regression after removal of implanted oestrogen pellets (EP), and we especially focused on th...

journal_title：British journal of cancer

authors： Wijsman JH,Cornelisse CJ,Keijzer R,van de Velde CJ,Elvers B,van Dierendonck JH

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:The intestinal uptake of the taxanes paclitaxel and docetaxel is seriously hampered by drug efflux through P-glycoprotein (P-gp) and drug metabolism via cytochrome P450 (CYP) 3A. The resulting low oral bioavailability can be boosted by co-administration of P-gp or CYP3A4 inhibitors. METHODS:Paclitaxel or do...

journal_title：British journal of cancer

authors： Hendrikx JJ,Lagas JS,Wagenaar E,Rosing H,Schellens JH,Beijnen JH,Schinkel AH

更新日期：2014-05-27 00:00:00

abstract：:This study was undertaken to investigate the intracellular induction of reactive oxygen species (ROS) by cis-dichlorodiammineplatinum (CDDP) and the augmentation of their cytotoxicity in bladder cancer cells (KU7) by enhancement of ROS generation by the glutathione (GSH) depletors buthionine sulphoximine (BSO) and die...

journal_title：British journal of cancer

authors： Miyajima A,Nakashima J,Yoshioka K,Tachibana M,Tazaki H,Murai M

更新日期：1997-01-01 00:00:00

abstract：:Tumour necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL/APO2L) is a recently identified member of the TNF family, which induces programmed cell death in a variety of neoplastic cell types, but not in most nonneoplastic cells. In this study, we report on the identification of two novel alternative splice ...

journal_title：British journal of cancer

authors： Krieg A,Krieg T,Wenzel M,Schmitt M,Ramp U,Fang B,Gabbert HE,Gerharz CD,Mahotka C

更新日期：2003-03-24 00:00:00

abstract：:Previous studies have characterized the enzymatic properties and inhibition of a trypsin-like neutral protease on the surface of Ehrlich ascites cells by means of kinetic analysis. The present study links these kinetic studies with the recently reported role of a tumour-cell membrane-bound serine protease in tumour-in...

journal_title：British journal of cancer

authors： Steven FS,Hulley TP,Griffin MM,Itzhaki S

更新日期：1982-12-01 00:00:00

abstract：:Two cell lines (2-10-1 and 8-10-2) derived by exposure to primary tracheal explants to MNNG in vitro were not tumorigenic in syngeneic F-344 rats or athymic BALB/c (nu/nu) mice at early passage, but became tumorigenic at late passage. These cell lines are therefore suited to study the expression of neoantigens during ...

journal_title：British journal of cancer

authors： Braslawsky GR,Steele V,Kennel SJ,Nettesheim P

更新日期：1981-08-01 00:00:00

abstract：:We used the nation-wide Swedish Family-Cancer Database to examine the risk for testicular cancer in offspring through parental and sibling probands. Among 0-68-year-old offspring, 4082 patients had testicular cancer in years 1961-2000, among whom 68 (1.67%) had an affected father/brother. Standardized incidence ratios...

journal_title：British journal of cancer

authors： Hemminki K,Li X

更新日期：2004-05-04 00:00:00

abstract：:Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from canc...

journal_title：British journal of cancer

authors： Djuzenova CS,Mühl B,Fehn M,Oppitz U,Müller B,Flentje M

更新日期：2006-04-24 00:00:00

abstract：:We examined the levels of expression of the multidrug resistance-associated protein (MRP) gene quantified by Northern blot analysis in comparison with those of the MDR1 gene determined by reverse transcription-polymerase chain reaction (RT-PCR) in 104 non-small-cell lung cancer (NSCLC) specimens [59 adenocarcinoma (Ad...

journal_title：British journal of cancer

authors： Ota E,Abe Y,Oshika Y,Ozeki Y,Iwasaki M,Inoue H,Yamazaki H,Ueyama Y,Takagi K,Ogata T

更新日期：1995-09-01 00:00:00

abstract：:In a longitudinal study of the evolution of serum beta 2-microglobulin (beta 2-m) levels in 37 patients with myelomatosis, those patients with a level of < 4 mg/l at first presentation had a median survival of 46 months, whereas those with an initial level of > mg/l had a median survival of 15 months. THe beta 2-m app...

journal_title：British journal of cancer

authors： Norfolk D,Child JA,Cooper EH,Kerruish S,Ward AM

更新日期：1980-10-01 00:00:00

abstract：:The formation of cyclic AMP was studied in normal liver, subcutaneous hepatomas derived from MH1C1 cells, and premalignant liver and primary hepatomas induced by the carcinogens 2-acetylaminofluorene (AAF) and 4-dimethylamino-azobenzene (DAB). While only very slight effects of prostaglandins (PG) were seen in slices o...

journal_title：British journal of cancer

authors： Brønstad GO,Christoffersen T,Johansen EJ,Oye I

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Gender-associated epigenetic alterations are poorly investigated in male and female familial breast cancer (fBC). MicroRNAs may contribute to the different biology in men and women particularly related to RASSF1A pathways. METHODS:Microarray technology was used to evaluate miRNA profile in 24 male and 43 fe...

journal_title：British journal of cancer

authors： Pinto R,De Summa S,Danza K,Popescu O,Paradiso A,Micale L,Merla G,Palumbo O,Carella M,Tommasi S

更新日期：2014-12-09 00:00:00

abstract：:The natural history of 45 cases of smouldering leukaemia has been studied. Males and females were equally represented, with a median age of 60.5. The median survival of the whole group was only 20 months, but rare cases lived 10 years or longer. 38% developed acute leukaemia; the remainder usually died of the results ...

journal_title：British journal of cancer

authors： Joseph AS,Cinkotai KI,Hunt L,Geary CG

更新日期：1982-08-01 00:00:00