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Effect of prostaglandins and hormones on cyclic AMP formation in rat hepatomas and liver tissue.

Abstract：

:The formation of cyclic AMP was studied in normal liver, subcutaneous hepatomas derived from MH1C1 cells, and premalignant liver and primary hepatomas induced by the carcinogens 2-acetylaminofluorene (AAF) and 4-dimethylamino-azobenzene (DAB). While only very slight effects of prostaglandins (PG) were seen in slices of normal liver, all the hepatomas responded strongly to PGE1 and PGE2. The hepatomas also had increase PGE1-sensitive adenylate-cyclase activity. PGF1alpha and PGF2alpha did not increase the cAMP level significantly either in the liver or in the hepatomas. During AAF carcinogenesis the response to PGE1 increased slightly during the carcinogen feeding, and was greatly elevated only in the fully developed hepatomas. This is in contrast to the increase in adrenalin response seen during carcinogenesis, which starts much earlier, and reaches a peak value within 8--10 weeks. It is concluded that various hepatomas have elevated responsiveness to PGE1 and PGE2 as well as to adrenalin, but the course of change in the tissues' ability to respond to these agents during carcinogenesis is very different.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Brønstad GO,Christoffersen T,Johansen EJ,Oye I

doi

10.1038/bjc.1978.281

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

737-44

issue

6

eissn

0007-0920

issn

1532-1827

journal_volume

38

pub_type

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