Abstract:
:The prognostic value of several clinical and histopathological characteristics has been evaluated in patients with Dukes' B and C carcinoma of the rectum and the rectosigmoid. Data on 260 Dukes' B and 208 Dukes' C tumours entered into a prospective, randomized clinical trial of post-operative radiotherapy (50 Gy given with 2 Gy/fraction in an overall time of 7 weeks) were analyzed by means of the Cox proportional hazards model. The Dukes' stages B and C were analyzed in two separate multivariate analyses. In patients with Dukes' B tumours, a poor prognosis was associated with age above 60, perineural and venous invasion, tumour located less than 10 cm from the anal verge and elevated pre-operative carcinoembryonic antigen (CEA) (greater than 3.2 ng ml-1). In patients with Dukes' C tumours, perineural and venous invasion, tumour located less than 10 cm from the anal verge, and elevated pre-operative CEA were associated with a poor prognosis. In addition, a large tumour diameter had a strong, negative influence on the prognosis. Males seemed to have a poorer prognosis than females among the Dukes' C patients. Resection of neighbouring organs was also associated with a poor prognosis in this stage. Post-operative radiotherapy as administered in the present series had no significant influence on prognosis. Based on the derived prognostic models patients with a hazard of death above the median in each stage were selected. A separate analysis of the survival in these high risk patients showed no survival benefit from radiotherapy. The proportional hazards model may be a useful tool in selecting patients for more aggressive adjuvant treatment.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Bentzen SM,Balslev I,Pedersen M,Teglbjaerg PS,Hanberg-Soerensen F,Bone J,Jacobsen NO,Overgaard J,Sell A,Bertelsen Kdoi
10.1038/bjc.1988.192subject
Has Abstract,Author List Incompletepub_date
1988-08-01 00:00:00pages
195-201issue
2eissn
0007-0920issn
1532-1827journal_volume
58pub_type
杂志文章abstract:BACKGROUND:A Population-Based Cancer Registry (PBCR) was set up in Sikkim (a state in the North Eastern India) in 2003. We examined incidence rates by ethnic groups from 2003-2008. METHODS:Age-adjusted incidence rates (AARs) per 100,000 person-years were calculated by direct method using the world standard population,...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.598
更新日期:2012-02-28 00:00:00
abstract::Squamous cell carcinomas of the anus are rare neoplasias that account for about 3% of large bowel tumours. Infections with human papillomaviruses are frequently detected in these cancers, suggesting that pathogenic pathways in anal carcinomas and in carcinomas of the uterine cervix are similar. Little is known regardi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.547
更新日期:1997-01-01 00:00:00
abstract::Ultrafiltrates from spleen inhibited both DNA synthesis and the proliferation of normal lymphocytes stimulated inculture from both mouse and man without apparent cytotoxicity. However, the same doses of this spleen ultrafiltrate will kill up to two-thirds of the leukaemic lymphoblasts from both mouse and man after 24 ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1975.280
更新日期:1975-12-01 00:00:00
abstract::To find out whether ultrasound-guided fine-needle aspiration (FNA) and ultrasound and stereotactic-guided large core needle biopsy (LCNB) are reliable alternatives to needle-localised open breast biopsy (NLBB) in daily practice, we performed a retrospective study and evaluated the validity of these methods. In all, 71...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6601559
更新日期:2004-02-09 00:00:00
abstract::Fc-receptor-bearing cells forming EA rosettes with antibody-coated human erythrocytes (Ripley) were studied in cell suspensions and in purified preparations of mononuclear cells (MC) from 20 human malignant tumours. The EA rosettes were studied in preparations made by cytocentrifugation and the rosette-forming cells i...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.34
更新日期:1982-02-01 00:00:00
abstract::Expression of CDX2, a caudal-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to Cdx2 develop multiple intestinal adenomatous polyps. To clarify the role of CDX2 in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of C...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690068
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:The vascular disrupting agent ombrabulin shows synergy with docetaxel in vivo. Recommended phase II doses were determined in a dose escalation study in advanced solid tumours. METHODS:Ombrabulin (30-min infusion, day 1) followed by docetaxel (1-h infusion, day 2) every 3 weeks was explored. Ombrabulin was e...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.137
更新日期:2014-04-29 00:00:00
abstract::No published data are available concerning the activity and tolerability of intramuscularly administered granulocyte colony-stimulating factor (G-CSF) in humans. To fill this gap, 19 patients with advanced ovarian cancer previously treated with at least one first-line chemotherapy cycle received the following myelosup...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1994.186
更新日期:1994-05-01 00:00:00
abstract::Cytochrome P450 3A is a drug-metabolising enzyme activity due to CYP3A4 and CYP3A5 gene products, that is involved in the inactivation of anticancer drugs. This study analyses the potential of cytochrome P450 3A enzyme in human colorectal cancer to impact anticancer therapy with drugs that are cytochrome P450 3A subst...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600494
更新日期:2002-09-09 00:00:00
abstract::Using flow cytometry and immunocytochemistry, we investigated the reactivities of two different murine monoclonal antibodies (MAbs), MRK 16 and MRK 20, specific to adriamycin-resistant K562 cells (K562/ADM) with peripheral human mononuclear cells (MNC) (mainly blastic cells and lymphocytes) from 31 patients with leuka...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.309
更新日期:1989-10-01 00:00:00
abstract::The purpose of this study was to compare the growth-inhibitory effect of cisplatin-paclitaxel with that obtained with a cisplatin-docetaxel combination and to assess the type of interaction. Concomitant use of taxanes and cisplatin was studied in seven human ovarian carcinoma cell lines, using the 96-well plate clonog...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690046
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Previous epidemiologic studies have shown inconsistent results for the association between alcohol intake and endometrial cancer risk. Most of the studies, however, assessed alcohol intake after cancer diagnosis, or measured alcohol intake at baseline only. METHODS:We prospectively examined the association ...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.2014.257
更新日期:2014-07-08 00:00:00
abstract::The murine dose of i.v. C. parvum (466 microgram) was compared with a single, low, human-equivalent dose of 70 microgram and with repeated weekly low doses. All treatments increased the antibody titre against C. parvum (CP). However, repeated doses stimulated a much higher titre than single doses. In all treated anima...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1980.64
更新日期:1980-03-01 00:00:00
abstract:BACKGROUND:The need to unfold the underlying mechanisms of lung cancer aggressiveness, the deadliest cancer in the world, is of prime importance. Because Fas-associated death domain protein (FADD) is the key adaptor molecule transmitting the apoptotic signal delivered by death receptors, we studied the presence and cor...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.196
更新日期:2012-06-05 00:00:00
abstract::A recent study showed an association between a single base substitution, T-->C, in the promotor region of the CYP17 gene, the risk of breast cancer and age at menarche in Asian, African-American and Latino women from California and Hawaii. The C allele was associated with increased risk of breast cancer, significantly...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.340
更新日期:1998-06-01 00:00:00
abstract::We investigated trends in first-time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population-based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991-2006. We identified new cases of HCC through record...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604563
更新日期:2008-09-02 00:00:00
abstract::The blood-brain barrier is a major obstacle for the chemotherapeutic drugs to effectively reach primary or secondary brain tumours. Stealth liposomal drugs are highly accumulated in tumoural tissues. In the present study we investigated the relative accumulation of(99m)Tc-DTPA radiolabelled stealth liposomal doxorubic...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1459
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:To evaluate the anticancer activity of erlotinib in patients with previously treated, advanced non-small cell lung cancer (NSCLC) whose dose is increased to that associated with a maximal level of tolerable skin toxicity (i.e., target rash (TR)); to characterise the pharmacokinetics (PK) and pharmacodynamics...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.332
更新日期:2011-09-27 00:00:00
abstract:BACKGROUND:Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repair gene mutation (Lynch syndrome), who are at high risk of colorectal c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0580-9
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:We evaluated the efficacy and safety of the modified FOLFOX6 (mFOLFOX6) regimen as a neoadjuvant chemotherapy in gastric cancer patients. METHODS:Seventy-three patients with T2-T4 or N+ were enroled. Preoperative chemotherapy consisted of three cycles of mFOLFOX6. The primary end points were the response ra...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.126
更新日期:2016-06-14 00:00:00
abstract::The multivariate lognormal survival model can be used to determine the relationship of prognostic covariates to two important parameters of malignancy. Cured fraction and median survival time among uncured patients. Analysis with this model revealed that cured fraction is primarily a function of histologic type and no...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.196
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Progression-free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate must be done for each indication and each intervention. We aimed to identify all studies evaluating the validity of PFS as a surrogate for OS in oncology, and to describ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0805-y
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0623-2
更新日期:2019-12-01 00:00:00
abstract::Functionally active telomerase is affected at various steps including transcriptional and post-transcriptional levels of major telomerase components (hTR and human telomerase reverse transcriptase (hTERT)). We therefore developed a rapid and sensitive method to quantify hTERT and its splicing variants as well as the h...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602546
更新日期:2005-05-23 00:00:00
abstract::Fibroblast growth factors (FGFs) and fibroblast growth factor receptors (FGFRs) have been increasingly recognized to play an important role in the pathobiology of pancreatic malignancy. We have investigated the effects of FGF-1 and FGF-2 on the behaviour and adhesion properties of human pancreatic adenocarcinoma cell ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.1813
更新日期:2001-06-15 00:00:00
abstract::In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been established using a panel of six parent human ovarian carcinoma lines, two (HX/110 and PXN/87) being derived from previously untreated patients. Resistance has been gene...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.5
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Elderly cancer patients form a heterogeneous population in which therapeutic decision-making is often difficult. The aim of this randomised phase II trial was to evaluate the feasibility and activity of weekly docetaxel/gemcitabine (DG) followed by erlotinib after progression (arm A) vs erlotinib followed by...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-10-11 00:00:00
abstract::The Type 1 family of growth factor receptors includes epidermal growth factor receptor (EGFR), c-erbB-2, c-erbB-3 and c-erbB-4. Overexpression of the first two members is associated with poorer prognosis in patients with breast carcinoma. In this study we examined the expression of c-erbB-4 protein using the monoclona...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.1057
更新日期:2000-03-01 00:00:00
abstract::We analysed antibodies specific for human p53 in sera from primary breast cancer patients using three different immunoassays and we related these results to the p53 level in tumour tissue detected by immunohistochemistry. Only 44% (11/25) of apparently enzyme-linked immunosorbent assay (ELISA)-positive sera were from ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.242
更新日期:1995-06-01 00:00:00
abstract::The effects of polymorphisms in genes coding for key folate metabolism enzymes such as thymidylate synthetase (TS) on colorectal neoplasia risk are likely to be influenced by gene-gene and gene-nutrient interactions. We investigated the combined effects of three polymorphisms in the TS gene region, TSER, TS 3R G>C, an...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604056
更新日期:2007-11-19 00:00:00