Cells bearing Fc receptors in human malignant solid tumours.

Abstract:

:Fc-receptor-bearing cells forming EA rosettes with antibody-coated human erythrocytes (Ripley) were studied in cell suspensions and in purified preparations of mononuclear cells (MC) from 20 human malignant tumours. The EA rosettes were studied in preparations made by cytocentrifugation and the rosette-forming cells identified by their nonspecific-esterase activity and phagocytic capacity. Fc receptors were found on 16 +/- 20% of all cells in the primary cell suspensions. Significantly more tumour-infiltrating lymphocytes had detectable Fc receptors normal control subjects (14 +/- 6%). There was a significant correlation between the proportion of lymphocytes lacking T and B markers (null cells) and the proportion of lymphocytes with Fc receptors. Fc receptors were also found on most tumour-infiltrating macrophages, on some T lymphocytes and polymorphonuclear cells and on a smaller percentage of the tumour cells. The significance of the Fc receptor and its usefulness as a marker of "host infiltration" into the tumours is discussed.

journal_name

Br J Cancer

authors

Svennevig JL,Andersson TR

doi

10.1038/bjc.1982.34

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

201-8

issue

2

eissn

0007-0920

issn

1532-1827

journal_volume

45

pub_type

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