Expression of E-cadherin, alpha-catenin, and beta-catenin in the process of lymph node metastasis in oral squamous cell carcinoma.

abstract：:We have analysed 174 gastric carcinomas from the United Kingdom and from Japan for the presence of Epstein-Barr virus (EBV) using in situ hybridisation for the small EBV-encoded nuclear RNAs (EBERs). EBV was detected in the tumour cells in all of six undifferentiated gastric carcinomas with prominent lymphoid stroma (...

journal_title：British journal of cancer

authors： Rowlands DC,Ito M,Mangham DC,Reynolds G,Herbst H,Hallissey MT,Fielding JW,Newbold KM,Jones EL,Young LS

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. METHODS:From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced HCC (Eastern Coopera...

journal_title：British journal of cancer

authors： Chow PK,Machin D,Chen Y,Zhang X,Win KM,Hoang HH,Nguyen BD,Jin MY,Lobo R,Findlay M,Lim CH,Tan SB,Gandhi M,Soo KC,Asia-Pacific Hepatocellular Carcinoma Trials Group.

更新日期：2011-09-27 00:00:00

abstract：:The syndecans are a family of cell-surface heparan sulphate proteoglycans that regulate cell behaviour by binding extracellular matrix molecules such as growth factors. The syndecan family has four members, of which syndecan-1 is the most studied and best characterized. We have studied the prognostic significance of s...

journal_title：British journal of cancer

authors： Anttonen A,Kajanti M,Heikkilä P,Jalkanen M,Joensuu H

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:The interaction between human prostate cancer (PCa) cells and bone marrow (BM) endothelium follows a rolling-and-adhesion cascade mediated by E-selectin ligand (ESL): E-selectin. This adhesion is enabled by elevated expression of α-1,3-fucosyltransferases (FTs), enzymes responsible for ESL-mediated bone meta...

journal_title：British journal of cancer

authors： Li J,Guillebon AD,Hsu JW,Barthel SR,Dimitroff CJ,Lee YF,King MR

更新日期：2013-12-10 00:00:00

abstract：:One hundred and one histologically confirmed gastric cancer patients in Gwynedd, North Wales, were matched by sex, age and social class to two hospital inpatients without cancer. Seventy-seven of the gastric cancer cases were also matched, using the same criteria, to a patient with a confirmed cancer of a different si...

journal_title：British journal of cancer

authors： Galpin OP,Whitaker CJ,Whitaker R,Kassab JY

更新日期：1990-05-01 00:00:00

abstract：:The utility of external beam radiotherapy for the treatment of malignant brain tumours is compromised by the need to avoid excessive radiation damage to normal CNS tissues. This review describes the current status of targeted radiotherapy, an alternative strategy for brain tumour treatment that offers the exciting pro...

journal_title：British journal of cancer

authors： Zalutsky MR

更新日期：2004-04-19 00:00:00

abstract：:Although cancer of the cervix is traditionally considered not to be responsive to steroid hormones, an in vitro study has reported that the addition of oestrogen increased cellular proliferation in a cervix cancer cell line that was inhibited by progesterone. We investigated whether the reported in vitro effects of oe...

journal_title：British journal of cancer

authors： Bhattacharya D,Redkar A,Mittra I,Sutaria U,MacRae KD

更新日期：1997-01-01 00:00:00

abstract：:A retrospective seroepidemiologic study was performed to examine the association between human papillomaviruses (HPV) 16 infection and carcinomas of the oropharynx, the oesophagus, penis and vagina. Sera were selected from the serum bank from the Antoni van Leeuwenhoek Hospital (Netherlands Cancer Institute) and the S...

journal_title：British journal of cancer

authors： Van Doornum GJ,Korse CM,Buning-Kager JC,Bonfrer JM,Horenblas S,Taal BG,Dillner J

更新日期：2003-04-07 00:00:00

abstract：BACKGROUND:Gestational trophoblastic diseases (GTDs) are related to trophoblasts, and human chorionic gonadotropin (hCG) is secreted by GTDs as well as normal placentas. However, the asparagine-linked sugar chains on hCG contain abnormal biantennary structures in invasive mole and choriocarcinoma, but not normal pregna...

journal_title：British journal of cancer

authors： Niimi K,Yamamoto E,Fujiwara S,Shinjo K,Kotani T,Umezu T,Kajiyama H,Shibata K,Ino K,Kikkawa F

更新日期：2012-12-04 00:00:00

abstract：BACKGROUND:HOX transcript antisense RNA (HOTAIR), which is expressed from the homebox C gene (HOXC) locus, is capable of reprogramming chromatin organisation and promoting cancer cell metastasis and can simultaneously bind the polycomb repressive complex 2, which enhances H3K27 trimethylation, and the LSD1-CoREST-REST ...

journal_title：British journal of cancer

authors： Li X,Wu Z,Mei Q,Li X,Guo M,Fu X,Han W

更新日期：2013-10-15 00:00:00

abstract：:Limb-sparing surgeries have been performed more frequently than amputation based on the belief that limb-sparing surgeries provide improved function and quality-of-life (QOL). However, this has not been extensively studied in the paediatric population, which has unique characteristics that have implications for functi...

journal_title：British journal of cancer

authors： Nagarajan R,Clohisy DR,Neglia JP,Yasui Y,Mitby PA,Sklar C,Finklestein JZ,Greenberg M,Reaman GH,Zeltzer L,Robison LL

更新日期：2004-11-29 00:00:00

abstract：:An enzyme activity with the characteristics of reverse transcriptase was detected in marrow from patients with leukaemia in relapse and in firm haematological remission. The endogenous enzyme activities increased following culture, and in remission patients the enzyme activities reached levels equal to or exceeding th...

journal_title：British journal of cancer

authors： Mak TW,Aye MT,Messner H,Sheinin R,Till JE,McCulloch EA

更新日期：1974-06-01 00:00:00

abstract：:Cancer survival rates decrease in the presence of disseminated disease. However, there are few therapies that are effective at eliminating the primary tumour while providing control of distant stage disease. Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumours, resulting in cure...

journal_title：British journal of cancer

authors： Kabingu E,Vaughan L,Owczarczak B,Ramsey KD,Gollnick SO

更新日期：2007-06-18 00:00:00

abstract：:In a study of 157 patients with lymphoid malignancy, the phenotype of the tumour cells was correlated with the histological classification of the tumour using the Rappaport and the Kiel classifications. The markers used included E, Fc gamma, Fc micron (IgM) and C3d rosetting, estimation of SIg and CyIg, and tests for ...

journal_title：British journal of cancer

authors： Habeshaw JA,Catley PF,Stansfeld AG,Brearley RL

更新日期：1979-07-01 00:00:00

abstract：:Patients with refractory metastatic renal cell carcinoma (RCC) were enrolled in a phase II study with teniposide (VM26) and cyclosporin A (CSA) to investigate (1) the effect of CSA on the response rate to VM26; and (2) the effect of CSA on the pharmacokinetics and pharmacodynamics of VM26. Sixteen patients initially r...

journal_title：British journal of cancer

authors： Toffoli G,Sorio R,Gigante M,Corona G,Galligioni E,Boiocchi M

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:New therapeutic options for metastatic pancreatic cancer are urgently needed. In pancreatic cancer, overexpression of the epidermal growth factor receptor 2 (HER2) has been reported in up to 45%. This multicentre phase II study investigated the efficacy and toxicity of the HER2 antibody trastuzumab combined ...

journal_title：British journal of cancer

authors： Harder J,Ihorst G,Heinemann V,Hofheinz R,Moehler M,Buechler P,Kloeppel G,Röcken C,Bitzer M,Boeck S,Endlicher E,Reinacher-Schick A,Schmoor C,Geissler M

更新日期：2012-03-13 00:00:00

abstract：:Natural human interferon beta (beta-IFN) was tested during the early phase of in vitro infection with HTLV-I virus of human cord blood mononuclear cells (CBL), to evaluate whether its antiviral and immunomodulating effects might prevent spreading of infection in the host. beta-IFN was found to reduce HTLV-I transmissi...

journal_title：British journal of cancer

authors： D'Onofrio C,Perno CF,Mazzetti P,Graziani G,Calio' R,Bonmassar E

更新日期：1988-05-01 00:00:00

abstract：:In 101 breast cancer patients, measurement of oestrogen receptor status in multiple biopsies across a tumour reveals a highly significant difference in the proportion of patients remaining either disease-free (P less than 0.04) or alive (P less than 0.005), when those with uniformly receptor positive (++) primary tumo...

journal_title：British journal of cancer

authors： Castagnetta L,Traina A,Di Carlo A,Carruba G,Lo Casto M,Mesiti M,Leake R

更新日期：1989-04-01 00:00:00

abstract：:Serum samples taken between 6 and 20 weeks of gestation were obtained from 28 mothers who gave birth to cryptorchid sons (cases) and from 108 control mothers. In comparison with controls the cases had 10% higher geometric mean oestradiol (95% CI -13% to +39%: P=0.42) and 10% lower geometric mean testosterone (95% CI -...

journal_title：British journal of cancer

authors： Key TJ,Bull D,Ansell P,Brett AR,Clark GM,Moore JW,Chilvers CE,Pike MC

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Human polypyrimidine tract binding protein 3 (PTBP3) was first discovered in 1999 and has been well characterised as a differentiation regulator. However, its role in human cancer has rarely been reported. Our previous study revealed increased PTBP3 protein level in gastric cancer tissues. Downregulation of ...

journal_title：British journal of cancer

authors： Liang X,Shi H,Yang L,Qiu C,Lin S,Qi Y,Li J,Zhao A,Liu J

更新日期：2017-03-28 00:00:00

abstract：:Febrile neutropenia (FN) causes significant morbidity and mortality in patients receiving cytotoxic chemotherapy and can lead to reduced chemotherapy dose intensity and increased overall treatment costs. Antibiotic prophylaxis reduces the incidence of FN. Recent research and meta-analyses confirm that prophylactic flu...

journal_title：British journal of cancer

authors： Cullen M,Baijal S

更新日期：2009-09-01 00:00:00

abstract：:In the present study organotypic multicellular spheroids (OMS) were used to study the effects of chemotherapeutic agents on malignant gliomas. Compared with the frequently used cell line models, OMS have several advantages with respect to the preservation of the cellular heterogeneity and the structure of the original...

journal_title：British journal of cancer

authors： Kaaijk P,Troost D,de Boer OJ,Van Amstel P,Bakker PJ,Leenstra S,Bosch DA

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The natural history of prostate cancer is highly variable and difficult to predict accurately. Better markers are needed to guide management and avoid unnecessary treatment. In this study, we validate the prognostic value of a cell cycle progression score (CCP score) independently and in a prespecified linea...

journal_title：British journal of cancer

authors： Cuzick J,Stone S,Fisher G,Yang ZH,North BV,Berney DM,Beltran L,Greenberg D,Møller H,Reid JE,Gutin A,Lanchbury JS,Brawer M,Scardino P

更新日期：2015-07-28 00:00:00

abstract：:The effect on cell-cycle progression in various phases of the cell cycle caused by an acute exposure to hypoxia in absence and presence of misonidazole (MISO) was investigated. Exponentially growing and synchronized cells of the human line NHIK 3025 were exposed to different degrees of hypoxia for a short period (1.5 ...

journal_title：British journal of cancer

authors： Pettersen EO,Lindmo T

更新日期：1983-12-01 00:00:00

abstract：:To evaluate current guidelines criteria for inclusion of women in special 'breast cancer family history' surveillance programmes, records were reviewed of women referred to Scottish breast cancer family clinics between January 1994 and December 2003 but discharged as at 'less than 'moderate' familial risk'. The Scotti...

journal_title：British journal of cancer

authors： Anderson E,Berg J,Black R,Bradshaw N,Campbell J,Carnaghan H,Cetnarkyj R,Drummond S,Davidson R,Dunlop J,Fordyce A,Gibbons B,Goudie D,Gregory H,Holloway S,Longmuir M,McLeish L,Murday V,Miedzybrodska Z,Nicholson D,Pe

更新日期：2008-02-26 00:00:00

abstract：:Serine proteases, such as alpha-chymotrypsin or elastase, caused an aggregation of rat ascites tumour cell lines, AH-130, AH-109A and YS, in a protein free medium which preserved the cell viability. This aggregation, which was monitored spectrophotometrically, was dependent upon the protease activities and was resista...

journal_title：British journal of cancer

authors： Sugihara S,Yamamoto T,Tsuruta J,Tanaka J,Kambara T,Hiraoka T,Miyauchi Y

更新日期：1990-10-01 00:00:00

abstract：:Electrochemotherapy is an anti-tumour treatment that utilizes locally delivered electric pulses to increase cytotoxicity of chemotherapeutic drugs. The aim of our study was to determine whether anti-tumour effectiveness of electrochemotherapy with cisplatin is a consequence of increased plasma membrane permeability ca...

journal_title：British journal of cancer

authors： Cemazar M,Miklavcic D,Scancar J,Dolzan V,Golouh R,Sersa G

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Melatonin reduces the development of breast cancer interfering with oestrogen-signalling pathways, and also inhibits aromatase activity and expression. Our objective was to study the promoters through which melatonin modifies aromatase expression, evaluate the ability of melatonin to regulate cyclooxygenases...

journal_title：British journal of cancer

authors： Martínez-Campa C,González A,Mediavilla MD,Alonso-González C,Alvarez-García V,Sánchez-Barceló EJ,Cos S

更新日期：2009-11-03 00:00:00

abstract：BACKGROUND:Despite the widespread use of neoadjuvant chemotherapy in breast cancer patients, prediction of individual response to treatment remains an unsolved clinical problem. Particularly, administration of an inefficient chemotherapeutic regimen should be avoided. Therefore, a better understanding of the molecular ...

journal_title：British journal of cancer

authors： Michlmayr A,Bachleitner-Hofmann T,Baumann S,Marchetti-Deschmann M,Rech-Weichselbraun I,Burghuber C,Pluschnig U,Bartsch R,Graf A,Greil R,Allmaier G,Steger G,Gnant M,Bergmann M,Oehler R

更新日期：2010-10-12 00:00:00

abstract：:In a case-control study, we investigated 169 women aged 15-49 years with malignant melanoma notified to the Oxford and South Western cancer registries during the years 1971-1976, together with 507 matched controls. Data about medical, reproductive, drug and smoking histories were obtained both by reviewing general pra...

journal_title：British journal of cancer

authors： Adam SA,Sheaves JK,Wright NH,Mosser G,Harris RW,Vessey MP

更新日期：1981-07-01 00:00:00