A new specific method to detect cyanide in body fluids, especially whole blood, by fluorimetry.

abstract：:An analytical method for determining exposure to 2,2'-dichlorodiethyl sulfide (sulfur mustard, HD) has been enhanced. The method is based on the cleavage of adducted HD (protein-hydroxyethylthioethyl esters) to produce thiodiglycol. Following cleavage, a deuterated internal standard is added, and the analytes are extr...

journal_title：Journal of analytical toxicology

authors： Lawrence RJ,Smith JR,Boyd BL,Capacio BR

更新日期：2008-01-01 00:00:00

abstract：:A rapid and simple liquid chromatography tandem mass spectrometry method was developed and validated for the simultaneous determination of L-ephedrine, pseudoephedrine, and caffeine in male Fisher-344 rat plasma at nanogram-per-milliliter concentrations for use in support of toxicology studies. Only 25 μL of plasma is...

journal_title：Journal of analytical toxicology

authors： Cooper SD,Fletcher BL,Silinski MA,Brown SS,Lodge JW,Fernando RA,Collins BJ

更新日期：2011-07-01 00:00:00

abstract：:An analytical procedure for simultaneous determination of codeine and morphine in urine is described. The detection of codeine and morphine is based on liquid-liquid extraction and derivatization to the acetylated compounds. The acetylated codeine and morphine are separated by capillary gas chromatography and identifi...

journal_title：Journal of analytical toxicology

authors： Paul BD,Mell LD Jr,Mitchell JM,Irving J,Novak AJ

更新日期：1985-09-01 00:00:00

abstract：:In methanol intoxication, increased levels of the metabolite formate are associated with metabolic acidosis and an increased risk for ocular and neurological dysfunction. A simple method for plasma formate measurement by adaptation of a manual enzymatic assay to a Cobas Mira S analyzer is presented. Six microliters of...

journal_title：Journal of analytical toxicology

authors： Blomme B,Lheureux P,Gerlo E,Maes V

更新日期：2001-03-01 00:00:00

abstract：:3,4-Methylenedioxypyrovalerone (MDPV) is a psychoactive, synthetic analog of the central nervous system stimulant cathinone. Its recent popularity as a recreational drug in the United States has led to numerous reports to poison control centers across the country. As with other synthetic cathinones, the recreational u...

journal_title：Journal of analytical toxicology

authors： Wyman JF,Lavins ES,Engelhart D,Armstrong EJ,Snell KD,Boggs PD,Taylor SM,Norris RN,Miller FP

更新日期：2013-04-01 00:00:00

abstract：:Analytical chemical procedures are described to determine residues of the drugs clofibrate and tibric acid in animal feed, wastewater, and human urine. Clofibrate was extracted from animal feed and human urine with hexane, whereas residues from wastewater were collected on a Sep-PakTM then eluted with methanol for ana...

journal_title：Journal of analytical toxicology

authors： Oller WL,Kendall DC,Bowman MC

更新日期：1982-07-01 00:00:00

abstract：:While circumventing legislative controls, synthetic piperazines are encountered as "legal" alternatives to ecstasy. Unforeseeable challenges may delay quantitative analysis of these compounds in biological fluids. Enzymatic reactions, matrix interferences and limited knowledge of analyte stability further complicate i...

journal_title：Journal of analytical toxicology

authors： Lau T,LeBlanc R,Botch-Jones S

更新日期：2018-03-01 00:00:00

abstract：:A high-performance liquid chromatographic system based on gradient elution of an alumina packing material coated with polybutadiene is presented. The chromatographic eluent is a mixture of methanol and water, both containing 0.0125M NaOH. The effluent is monitored by photodiode array detection. The system allows detec...

journal_title：Journal of analytical toxicology

authors： Lambert WE,Meyer E,De Leenheer AP

更新日期：1995-03-01 00:00:00

abstract：:In June 1986, an epidemic of poisoning occurred in Sierra Leone, West Africa; it involved 49 persons--with 14 deaths. Our laboratory's approach and investigation of this incident is described. Using positive chemical ionization mass spectrometry and nuclear magnetic resonance spectroscopy, the toxicant was identified ...

journal_title：Journal of analytical toxicology

authors： Hill RH Jr,Alley CC,Ashley DL,Cline RE,Head SL,Needham LL,Etzel RA

更新日期：1990-07-01 00:00:00

abstract：:This study compares fluoride concentrations ([F]) in surface and whole bone for up to 27 days following an acute oral dose of F. Four groups of rats received single oral F dose (50 mg/kg body weight), and the control group received deionized water (n = 10/group). Groups were euthanized at 1, 3, 9, or 27 days after F a...

journal_title：Journal of analytical toxicology

authors： Buzalaf MA,Caroselli EE,de Carvalho JG,de Oliveira RC,da Silva Cardoso VE,Whitford GM

更新日期：2005-11-01 00:00:00

abstract：:External contamination of hair or nails by inorganic arsenic compounds cannot effectively be removed with H2O or dilute HCl. The use of a modified Gutzeit apparatus allowed to establish or rule out external contamination. It was found that contaminated samples will generate large amounts of arsine gas when treated wit...

journal_title：Journal of analytical toxicology

authors： Pirl JN,Townsend GF,Valaitis AK,Grohlich D,Spikes JJ

更新日期：1983-09-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA), or ecstasy, is excreted as unchanged drug, 3,4-methylenedioxyamphetamine (MDA), and free and glucuronidated/sulfated 4-hydroxy-3-methoxymethamphetamine (HMMA), and 4-hydroxy-3-methoxyamphetamine (HMA) metabolites. The aim of this paper is to describe the pattern and timeframe ...

journal_title：Journal of analytical toxicology

authors： Abraham TT,Barnes AJ,Lowe RH,Kolbrich Spargo EA,Milman G,Pirnay SO,Gorelick DA,Goodwin RS,Huestis MA

更新日期：2009-10-01 00:00:00

abstract：:A novel mass spectrometry detection technique based on a multi-period and multi- experiment (MRM-EPI-MRM3) with library matching in a single run for fast and rapid screening and identification of amphetamine type stimulants (ATS) related drugs in whole blood, urine and dried blood stain was developed and validated. Th...

journal_title：Journal of analytical toxicology

authors： Zubaidi FA,Choo YM,Tan GH,Hamid HA,Choy YK

更新日期：2019-08-23 00:00:00

abstract：:Understanding cocaine and metabolites urinary excretion following smoking is important for interpretation of urine test results in judicial, workplace and treatment settings. In National Institute on Drug Abuse approved studies on a secure research unit, six subjects smoked placebo, 10, 20, and 40 mg cocaine with a pr...

journal_title：Journal of analytical toxicology

authors： Huestis MA,Darwin WD,Shimomura E,Lalani SA,Trinidad DV,Jenkins AJ,Cone EJ,Jacobs AJ,Smith ML,Paul BD

更新日期：2007-10-01 00:00:00

abstract：:A gas-chromatographic analysis of vinylidene chloride (1,1-dichloroethylene) is presented. Vinylidene chloride was sampled by adsorbing on activated carbon. It was desorbed with carbon disulfide. The desorption efficiency was 97.2 +/- 1.05 (mean +/- standard error). The analytical column was packed with 10% Apiezon L ...

journal_title：Journal of analytical toxicology

authors： Sidhu KS

更新日期：1980-09-01 00:00:00

abstract：:Use of methiopropamine (MPA), a synthetic metamfetamine analog, has been detected since 2011 in Europe, but there is limited information on its acute toxicity. A 30-year-old man was admitted to the emergency department in a confused state, with paranoid delusion, auditory and visual hallucinatory experiences, and inco...

journal_title：Journal of analytical toxicology

authors： Daveluy A,Castaing N,Cherifi H,Richeval C,Humbert L,Faure I,Labadie M,Allorge D,Haramburu F,Molimard M,Titier K

更新日期：2016-11-01 00:00:00

abstract：:Decomposed bone and plasma samples of rats exposed to amitriptyline (AMI) and citalopram (CIT) under different dosing patterns were analyzed. Wistar rats received one acute dose (120 mg AMI/kg and 40 mg CIT/kg; n = 5) or two doses (40 mg AMI/kg and 13 mg CIT/kg, n = 5) 40 min apart. After collection of perimortem bloo...

journal_title：Journal of analytical toxicology

authors： Watterson JH,Cornthwaite HM

更新日期：2013-10-01 00:00:00

abstract：:A high performance liquid chromatographic method is described for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: lidocaine, mexiletine, disopyramide, and quinidine. An isocratic system using a reverse phase column was used to separate these compounds. Coefficients of variation were les...

journal_title：Journal of analytical toxicology

authors： Dusci LJ,Hackett LP

更新日期：1985-03-01 00:00:00

abstract：:Feces are a possible medium to be used for horse doping control. Efficient methods for detecting drugs in feces collected from various animals are routinely applied in institutes of food safety in Belgium. We have already tested whether they are applicable to horse feces. In this report, accelerated solvent extraction...

journal_title：Journal of analytical toxicology

authors： Popot MA,Donval A,Bonnaire Y,Huau J

更新日期：2006-06-01 00:00:00

abstract：:Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique called solid-phase...

journal_title：Journal of analytical toxicology

authors： Guan F,Seno H,Ishii A,Watanabe K,Kumazawa T,Hattori H,Suzuki O

更新日期：1999-01-01 00:00:00

abstract：:Exposure to drugs and toxins is a major cause for the rising number of emergency department visits each year. Immunoassays are commonly used in the emergency department to provide rapid turnaround time for acute care. The purpose of this study was to compare two automated immunoassay chemistry analyzers to determine w...

journal_title：Journal of analytical toxicology

authors： Johnson-Davis KL,Thompson CD,Clark CJ,McMillin GA,Lehman CM

更新日期：2012-06-01 00:00:00

abstract：:This study identified ethyl sulfate (EtS) in human urine and compared the excretion characteristics of EtS with that of ethanol and ethyl glucuronide (EtG). Urine samples were collected from healthy subjects after a single ethanol dose, and also selected from routine clinical samples. Simultaneous analysis of EtS and ...

journal_title：Journal of analytical toxicology

authors： Helander A,Beck O

更新日期：2005-07-01 00:00:00

abstract：:The method presented describes a sensitive and specific quantitative assay for the determination of flumazenil in human plasma. Flumazenil and an internal standard, midazolam, are isolated by a basic extraction. The final extract is separated on a 25-m BP-1 capillary column and drugs are detected by selected ion monit...

journal_title：Journal of analytical toxicology

authors： Kintz P,Mangin P

更新日期：1991-07-01 00:00:00

abstract：:A thin layer chromatographic (TLC) method for the high volume screening of urine for methylphenidate (Ritalin) abuse is presented. The method utilizes charcoal extraction of ritalinic acid from urine and a simple test-tube methylation step for the conversion of the ritalinic acid to methylphenidate. The methylphenidat...

journal_title：Journal of analytical toxicology

authors： Manno BR,Manno JE,Dempsey CA

更新日期：1986-05-01 00:00:00

abstract：:The percent recovery of mercury from human hair digest samples, using the peak height cold-vapor atomic adsorption method is 73.0% +/- 10.3%. This value and its reproducibility are raised to 102.2% +/- 6.3% by use of peak area measurements in place of peak height. The so-called matrix effect is thus eliminated, and it...

journal_title：Journal of analytical toxicology

authors： Wigfield DC,Croteau SM,Perkins SL

更新日期：1981-01-01 00:00:00

abstract：:A simple gas chromatography-mass spectrometry (GC-MS) procedure has been developed for the main metabolites of organophosphorus nerve agents, alkylmethylphosphonic acids (AMPAs; alkyl = Et, i-Pr, and pinacolyl) in biofluids via extractive pentafluorobenzylation. The derivatization was carried out under liquid-liquid-s...

journal_title：Journal of analytical toxicology

authors： Miki A,Katagi M,Tsuchihashi H,Yamashita M

更新日期：1999-03-01 00:00:00

abstract：:A blood concentration of tetrahydrocannabinol (THC) in the low nanograms-per-milliliter range is often claimed to result from drug use more than 24-48 h previously. The present investigation determined concentrations of cannabinoids in blood collected at least 24 h from smoking in an in-patient setting. During samplin...

journal_title：Journal of analytical toxicology

authors： Skopp G,Pötsch L

更新日期：2008-03-01 00:00:00

abstract：:Cotinine biomarker measurements involving both smokers and nonsmokers must accommodate a broad range of concentrations. Thus, we have routinely preclassified unknown samples as being either "high" or "low" by using an enzyme-linked immunoassay for cotinine prior to analysis by tandem mass spectrometry (MS). Although t...

journal_title：Journal of analytical toxicology

authors： Bernert JT,Harmon TL,Sosnoff CS,McGuffey JE

更新日期：2005-11-01 00:00:00

abstract：:Oral fluid (OF) is increasingly used for clinical, forensic and workplace drug testing as an alternative to urine. Uncertainties surrounding OF collection device performance, drug stability and testing reproducibility may be partially responsible for delays in the implementation of OF testing in regulated drug testing...

journal_title：Journal of analytical toxicology

authors： Samano KL,Anne L,Johnson T,Tang K,Sample RH

更新日期：2015-10-01 00:00:00

abstract：:Caffeine is the most widely consumed drug in the world with coffee representing a major source of intake. Despite widespread availability, various medical conditions necessitate caffeine-restricted diets. Patients on certain prescription medications are advised to discontinue caffeine intake. Such admonition has impli...

journal_title：Journal of analytical toxicology

authors： McCusker RR,Fuehrlein B,Goldberger BA,Gold MS,Cone EJ

更新日期：2006-10-01 00:00:00