A thin layer chromatographic method for high volume screening of urine for methylphenidate abuse.

abstract：:The analysis of biological specimens collected at autopsy for the presence of exogenous insulin(s) is of special interest in select death investigations as they may be suspected in the cause of a death. Technical challenges include the limited stability of insulin, and the forensic requirement of differentiating endog...

journal_title：Journal of analytical toxicology

authors： Legg KM,Labay LM,Aiken SS,Logan BK

更新日期：2019-08-23 00:00:00

abstract：:The aim of this study is to investigate the distribution of methamphetamine (MA) and its metabolite amphetamine (AP) in rat models of acute and subacute MA-ethanol combination abuse. Rats were fed with 20% ethanol for 4 weeks (chronic active-drinking group), and MA was injected intraperitoneally into chronically drink...

journal_title：Journal of analytical toxicology

authors： Liang M,Liu Y,Zheng N,Ananda S,Liu L

更新日期：2012-01-01 00:00:00

abstract：:An original high-performance liquid chromatographic-mass spectrometric (HPLC-MS) procedure was developed for the determination of cyanide (CN) in whole blood. After the addition of K13C15N as internal standard, blood was placed in a microdiffusion device, the inner well of which was filled with a mixture of taurine (5...

journal_title：Journal of analytical toxicology

authors： Tracqui A,Raul JS,Géraut A,Berthelon L,Ludes B

更新日期：2002-04-01 00:00:00

abstract：:Cyclopropylfentanyl is a fentanyl analog implicated in 78 deaths in Europe and over 100 deaths in the United States, but toxicological information including metabolism data about this drug is scarce. The aim of this study was to provide the exact structure of abundant and unique metabolites of cyclopropylfentanyl alon...

journal_title：Journal of analytical toxicology

authors： Vikingsson S,Rautio T,Wallgren J,Åstrand A,Watanabe S,Dahlén J,Wohlfarth A,Konradsson P,Wu X,Kronstrand R,Gréen H

更新日期：2019-09-10 00:00:00

abstract：:Given that external contamination must be considered in hair analysis, there is still a demand for reliable tools to differentiate between incorporation of drugs into the hair as a result of drug consumption and of the hair shaft by external contamination. With the aim of establishing alternative discrimination parame...

journal_title：Journal of analytical toxicology

authors： Scholz C,Quednow BB,Herdener M,Kraemer T,Baumgartner MR

更新日期：2019-08-23 00:00:00

abstract：:The classical definitions of method detection limit (MDL) and limit of quantitation (LOQ) are redefined using calibration curve regression analysis. Traditional ways of determining these parameters provide scant information on the daily precision of the analysis at all concentration levels. These parameters are time c...

journal_title：Journal of analytical toxicology

authors： Schep RA

更新日期：1990-09-01 00:00:00

abstract：:This paper describes two relatively simple methods for the microdetermination of urinary cadmium (U-Cd) and urinary nickel (U-Ni) using electrothermal atomic absorption spectrometry. Reduction of nonspecific absorption interferences was achieved by temperature programming and background correction using a deuterium ar...

journal_title：Journal of analytical toxicology

authors： Ong CN,Chua LH,Lee BL,Ong HY,Chia KS

更新日期：1990-01-01 00:00:00

abstract：:An analytical method for determining exposure to 2,2'-dichlorodiethyl sulfide (sulfur mustard, HD) has been enhanced. The method is based on the cleavage of adducted HD (protein-hydroxyethylthioethyl esters) to produce thiodiglycol. Following cleavage, a deuterated internal standard is added, and the analytes are extr...

journal_title：Journal of analytical toxicology

authors： Lawrence RJ,Smith JR,Boyd BL,Capacio BR

更新日期：2008-01-01 00:00:00

abstract：:The identification of benzodiazepines (BZD) in biological fluids can be a challenging process. The large number of various BZD in pharmaceutical distribution, with similar core structures, and individual metabolic profiles all contribute to a complicated and time-consuming analysis. The purpose of the current study wa...

journal_title：Journal of analytical toxicology

authors： DeRienz RT,Holler JM,Manos ME,Jemionek J,Past MR

更新日期：2008-07-01 00:00:00

abstract：:Two cases of death following the ingestion of tranylcypromine are presented. High concentrations of tranylcypromine were determined in blood, urine, and liver by gas-liquid chromatography. Tranylcypromine was extracted from buffered blood with n-butyl chloride. The evaporated extract was derivatized with trifluoroacet...

journal_title：Journal of analytical toxicology

authors： Boniface PJ

更新日期：1991-01-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) is an endogenous androgenic steroid produced by the ovaries and adrenal glands. Research suggests that DHEA can be converted to testosterone in peripheral tissues. Classified as a nutritional supplement, this compound may be purchased without a prescription. The military and international...

journal_title：Journal of analytical toxicology

authors： Bosy TZ,Moore KA,Poklis A

更新日期：1998-10-01 00:00:00

abstract：:The fraction of any surface-adsorbed contaminant available for absorption is considered the bioaccessible fraction. Applied previously to contaminants such as pesticides and heavy metals on surfaces such as soil, food and cosmetics, the term may also be used to describe the fraction of drug residue bound to work surfa...

journal_title：Journal of analytical toxicology

authors： Doran GS,Howitt JA

更新日期：2019-03-01 00:00:00

abstract：:The popularity of designer drugs has increased over the past few years as users seek new, cheap and sometimes "legal" ways to get high. This case report focuses on a case that happened in the City of Henderson, Nevada, which involved the designer drug methoxetamine. Methoxetamine is a psychoactive compound that is str...

journal_title：Journal of analytical toxicology

authors： Fassette T,Martinez A

更新日期：2016-10-01 00:00:00

abstract：:In previous experimental studies on heroin metabolites excretion in urine, the first sample was often collected a few hours after intake. In forensic cases, it is sometimes questioned if a positive urine result is expected e.g., 30 min after intake. The aim of this study was to investigate urinary excretion of heroin ...

journal_title：Journal of analytical toxicology

authors： Høiseth G,Gottås A,Berg T,Arnestad M,Halvorsen PS,Bachs LC

更新日期：2017-06-01 00:00:00

abstract：:About 22,000 samples of oral fluid have been collected in five population studies in Norway using either the Intercept or Statsure oral fluid sampling devices. The prevalence of alcohol and drugs was found to be higher in oral fluid samples with small volumes than in those with large volumes for both sampling devices;...

journal_title：Journal of analytical toxicology

authors： Gjerde H,Normann PT,Christophersen AS

更新日期：2010-09-01 00:00:00

abstract：:The gelsemium plants are highly poisonous but toxicological evaluation of suspected poisoning cases has been hampered by the chemical complexity of the gelsemium toxins involved. A novel liquid chromatography-tandem mass spectrometry protocol was optimized for the collective detection of gelsemine and related alkaloid...

journal_title：Journal of analytical toxicology

authors： Lai CK,Chan YW

更新日期：2009-01-01 00:00:00

abstract：:A 59-year-old white male accidentally ingested a mouthful of a plant growth chemical, Cycocel, containing 11.8% of the active ingredient (2-chloroethyl)trimethylammonium chloride (chlormequat). He was seen by a family physician and then transferred to a hospital where he died as a result of ventricular fibrillation, w...

journal_title：Journal of analytical toxicology

authors： Winek CL,Wahba WW,Edelstein JM

更新日期：1990-07-01 00:00:00

abstract：:A rapid and sensitive solid-phase extraction method for the lysergic acid diethylamide (LSD) metabolite 2-oxo-3-hydroxy-LSD (O-H-LSD) was developed for use in a forensic laboratory. The method uses a positive-pressure manifold anion-exchange polymer-based solid-phase extraction with subsequent analysis by liquid chrom...

journal_title：Journal of analytical toxicology

authors： Horn CK,Klette KL,Stout PR

更新日期：2003-10-01 00:00:00

abstract：:Preliminary data regarding the use of vernix caseosa (VC) as an alternative to other biological specimens for the determination of fetal cocaine exposure are presented. Advantages of VC analysis include its presence on all newborn babies, historical record of drug exposure, and ease of collection and storage. Fifteen ...

journal_title：Journal of analytical toxicology

authors： Moore C,Dempsey D,Deitermann D,Lewis D,Leikin J

更新日期：1996-10-01 00:00:00

abstract：:In mothers who had no prenatal care and in their newborns, the presence of cocaine and benzoylecgonine (BE) was determined in urine, hair, and meconium. Samples of urine and hair were obtained from pregnant women who entered the hospital for delivery. Cocaine usage was assessed by a urinary enzyme-multiplied immunoass...

journal_title：Journal of analytical toxicology

authors： DiGregorio GJ,Ferko AP,Barbieri EJ,Ruch EK,Chawla H,Keohane D,Rosenstock R,Aldano A

更新日期：1994-09-01 00:00:00

abstract：:Proton nuclear magnetic resonance spectroscopy (1H MRS) has been used to identify ethanol in vivo and to detect other exogenous low molecular weight volatiles in human serum. 1H MRS was used to detect and quantitate 15 human sera containing various concentrations and combinations of ethanol, isopropanol, acetone, and ...

journal_title：Journal of analytical toxicology

authors： Pappas AA,Thompson JR,Fuller GL,Porter WH,Gadsden RH

更新日期：1993-09-01 00:00:00

abstract：:As a part of ongoing testing of personnel preparing training aids for drug detection dogs at the Naval Criminal Investigative Service Regional Forensic Laboratory, personnel handling methamphetamine (MTH) were subject to voluntary urine drug testing. This provided a model of potential unwitting or environmental exposu...

journal_title：Journal of analytical toxicology

authors： Stout PR,Horn CK,Klette KL,Given J

更新日期：2006-10-01 00:00:00

abstract：:1-(4-Methylphenyl)-2-pyrrolidin-1-ylhexan-1-one (4'-methyl-alpha-pyrrolidinohexanophenone, MPHP) is a new designer drug that appeared on the illicit drug market. It is mainly metabolized to 4'-hydroxymethyl-alpha-pyrrolidinohexanophenone (HO-MPHP) followed by oxidation to the respective carboxylic acid. For studies on...

journal_title：Journal of analytical toxicology

authors： Peters FT,Dragan CA,Kauffels A,Schwaninger AE,Zapp J,Bureik M,Maurer HH

更新日期：2009-05-01 00:00:00

abstract：:The aim of the present study was to develop and validate a method for the detection and quantitation of drugs of abuse in oral fluids. Fortified oral fluid samples (made in-house) and samples from donors collected with Quantasil oral fluid collection kits from Immunalysis were screened on an Olympus 5400 using reagent...

journal_title：Journal of analytical toxicology

authors： Kala SV,Harris SE,Freijo TD,Gerlich S

更新日期：2008-10-01 00:00:00

abstract：:There has been a recent and significant increase in the use and availability of hemp seed oil products. These products are being marketed as a healthy source of essential omega fatty acids when taken orally. Although the health aspects of these oils is open to debate, the probability that oils derived from the hemp se...

journal_title：Journal of analytical toxicology

authors： Bosy TZ,Cole KA

更新日期：2000-10-01 00:00:00

abstract：:The Connecticut Department of Public Safety laboratory recently addressed a legal challenge to a hospital alcohol dehydrogenase (ADH)-based serum ethanol determination based on the suggestion of interference by lactate dehydrogenase (LDH)-catalyzed oxidation of lactate. Both ADH- and LDH-oxidations require NAD(+) (pre...

journal_title：Journal of analytical toxicology

authors： Powers RH,Dean DE

更新日期：2009-10-01 00:00:00

abstract：:A novel mass spectrometry detection technique based on a multi-period and multi- experiment (MRM-EPI-MRM3) with library matching in a single run for fast and rapid screening and identification of amphetamine type stimulants (ATS) related drugs in whole blood, urine and dried blood stain was developed and validated. Th...

journal_title：Journal of analytical toxicology

authors： Zubaidi FA,Choo YM,Tan GH,Hamid HA,Choy YK

更新日期：2019-08-23 00:00:00

abstract：:A method for the detection and quantitation of methamphetamine and its major metabolite in hair, nails, sweat, and saliva from habitual users of methamphetamine by mass fragmentography has been developed. Hair and nail samples were washed with water and methanol to remove the external contamination, processed with 0.6...

journal_title：Journal of analytical toxicology

authors： Suzuki S,Inoue T,Hori H,Inayama S

更新日期：1989-05-01 00:00:00

abstract：:Amoxapine, a tricyclic antidepressant, is metabolized to 8-hydroxyamoxapine and 7-hydroxyamoxapine. There are few reports on the metabolism of this drug and correlation of clinical symptoms in overdose patients. Five such patients admitted to the Emergency Unit of the University of Cincinnati Hospital were studied. Cl...

journal_title：Journal of analytical toxicology

authors： Tasset JJ,Pesce AJ

更新日期：1984-05-01 00:00:00

abstract：:Exposure to drugs and toxins is a major cause for the rising number of emergency department visits each year. Immunoassays are commonly used in the emergency department to provide rapid turnaround time for acute care. The purpose of this study was to compare two automated immunoassay chemistry analyzers to determine w...

journal_title：Journal of analytical toxicology

authors： Johnson-Davis KL,Thompson CD,Clark CJ,McMillin GA,Lehman CM

更新日期：2012-06-01 00:00:00