Two cases of fatal intoxication due to tranylcypromine overdose.

abstract：:A fast and efficient multiresidue extraction-purification procedure was developed for low levels (ppb range) of phenanthrene and hydroxyphenanthrene in biological matrices, in order to quantify phenanthrene and metabolites in blood, milk, urine, and biological tissues of lactating goats. Detection and identification o...

journal_title：Journal of analytical toxicology

authors： Grova N,Monteau F,Le Bizec B,Feidt C,Andre F,Rychen G

更新日期：2005-04-01 00:00:00

abstract：:A method is presented for the extraction and screening of basic and neutral drugs, including amphetamines. Two milliliters of blood are buffered to pH 9.0 and extracted with n-chlorobutane. Underivatized extracts are analyzed simultaneously on two complementary capillary columns placed together in one injection port u...

journal_title：Journal of analytical toxicology

authors： Watts VW,Simonick TF

更新日期：1986-09-01 00:00:00

abstract：:A feasibility study was performed to examine the effectiveness of hair testing in determining the prevalence of drug use in a young adult population. The study included 200 randomly selected young adults in Norway. It was designed to make the collection, preparation and analysis of the samples as little resource deman...

journal_title：Journal of analytical toxicology

authors： Lund HM,Gjerde H,de Courtade SM,Oiestad EL,Christophersen AS

更新日期：2013-07-01 00:00:00

abstract：:In this study, we investigated the effectiveness of the Roche Kinetic Interaction of Microparticles in Solution (KIMS) screening assay for cannabinoid metabolites. Urine specimens (N = 1689) were collected during elimination of cannabinoids from 25 subjects with a history of marijuana use. Specimens were analyzed conc...

journal_title：Journal of analytical toxicology

authors： Lyons TP,Okano CK,Kuhnle JA,Bruins MR,Darwin WD,Moolchan ET,Huestis MA

更新日期：2001-10-01 00:00:00

abstract：:A gas chromatographic (GC) method was developed for the detection of propylene glycol dinitrate (PGDN) in rodent skin following extraction with ethyl acetate. Known quantities of PGDN contained in the torpedo fuel Otto Fuel II were added to homogenates of rat skin, which were subsequently extracted with two 10-mL port...

journal_title：Journal of analytical toxicology

authors： Godin CS,Pollard DL

更新日期：1992-11-01 00:00:00

abstract：:Solid-phase extraction (SPE) and a one-step derivatization are combined with gas chromatography-negative ion chemical ionization-mass spectrometry to simplify a previously reported method for the determination of naltrexone and its metabolite, 6-beta-naltrexol, in human plasma. Deuterated isotopomers of naltrexone and...

journal_title：Journal of analytical toxicology

authors： Huang W,Moody DE,Foltz RL,Walsh SL

更新日期：1997-07-01 00:00:00

abstract：:A rapid and sensitive solid-phase extraction method for the lysergic acid diethylamide (LSD) metabolite 2-oxo-3-hydroxy-LSD (O-H-LSD) was developed for use in a forensic laboratory. The method uses a positive-pressure manifold anion-exchange polymer-based solid-phase extraction with subsequent analysis by liquid chrom...

journal_title：Journal of analytical toxicology

authors： Horn CK,Klette KL,Stout PR

更新日期：2003-10-01 00:00:00

abstract：:A method that measures 12 analytes in urine and reflects possible exposure to pesticides was developed. The sample preparation involves enzyme hydrolysis and solvent extraction through the use of laboratory robotics, followed by phase-transfer catalysis derivatization and silica cleanup. Samples are analyzed by capill...

journal_title：Journal of analytical toxicology

authors： Hill RH Jr,Shealy DB,Head SL,Williams CC,Bailey SL,Gregg M,Baker SE,Needham LL

更新日期：1995-09-01 00:00:00

abstract：:A case of lethal overdose by heroin ingestion is presented. The concentrations of drugs were measured several hours after death. Heroin, 06-monoacetylmorphine, and morphine were identified and quantitated in blood, urine, and gastrointestinal contents by gas chromatography-mass spectrometry and high-performance liquid...

journal_title：Journal of analytical toxicology

authors： Rop PP,Fornaris M,Salmon T,Burle J,Bresson M

更新日期：1997-05-01 00:00:00

abstract：:Six cases involving the antidepressant mirtazapine were analyzed in detail at the San Diego County Medical Examiner's Office from 2004 to 2005. Mirtazapine was initially detected and confirmed in each of these cases by a liquid-liquid gas chromatography (GC)-MS basic drug screen. Following another liquid-liquid basic ...

journal_title：Journal of analytical toxicology

authors： Kirkton C,McIntyre IM

更新日期：2006-11-01 00:00:00

abstract：:This study of 20,089 urine specimens from chronic pain patients provided a unique opportunity to evaluate the prevalence of prescription opiates and metabolites, assess the usefulness of inclusion of normetabolites in the test panel, and compare opiate and oxycodone screening results to liquid chromatography with tand...

journal_title：Journal of analytical toxicology

authors： Heltsley R,Zichterman A,Black DL,Cawthon B,Robert T,Moser F,Caplan YH,Cone EJ

更新日期：2010-01-01 00:00:00

abstract：:A simple, rapid, and reliable gas-liquid chromatographic (GLC) confirmation procedure was developed for urine samples found positive by the EMIT-dau benzodiazepine metabolite assay. The procedure involves acid hydrolysis, organic extraction, and identification using GLC-nitrogen-phosphorus detection (NPD). The method ...

journal_title：Journal of analytical toxicology

authors： Verebey K,Jukofsky D,Mulé SJ

更新日期：1982-11-01 00:00:00

abstract：:Because mycotoxins occur worldwide in grain and grain products, evaluating their effects on the health of the population has become important. The development of a high performance liquid chromatographic (HPLC) procedure was investigated for the analysis of aflatoxin B1, citrinin, and ochratoxin A, from hydrolyzed hum...

journal_title：Journal of analytical toxicology

authors： Orti DL,Hill RH Jr,Liddle JA,Needham LL,Vickers L

更新日期：1986-03-01 00:00:00

abstract：:There has been a recent and significant increase in the use and availability of hemp seed oil products. These products are being marketed as a healthy source of essential omega fatty acids when taken orally. Although the health aspects of these oils is open to debate, the probability that oils derived from the hemp se...

journal_title：Journal of analytical toxicology

authors： Bosy TZ,Cole KA

更新日期：2000-10-01 00:00:00

abstract：:A simple, rapid method for the gas-liquid chromatographic (GLC) determination of valproic acid in serum without prior derivatization on a Nukol wide-bore capillary column is presented. The method was determined to have a lower limit of detection (LOD) of 5 mg/L and a lower limit of quantitation (LOQ) of 10 mg/L; the m...

journal_title：Journal of analytical toxicology

authors： Wohler AS,Poklis A

更新日期：1997-07-01 00:00:00

abstract：:Benzoylecgonine (BZE) extraction from urine was explored using Cerex Polycrom Clin II solid-phase extraction (SPE) columns and the Speedisk 48 Pressure Processor as an alternative to the Prep1 automated sample processor and XTRX Type RP/W columns. Linearity for urine standards extracted using the Cerex-Speedisk method...

journal_title：Journal of analytical toxicology

authors： Kuhnle JA,Churley M,Kawasaki SY,Lyons TP,Bruins MR

更新日期：2001-10-01 00:00:00

abstract：:The abuse of the designer amphetamines such as 3,4-methylenedioxymethamphetamine (MDMA) is increasing throughout the world. They have become popular drugs at all night techno dance parties, and their detection is an important issue. The objective of the presented study was to identify an unknown compound detected by t...

journal_title：Journal of analytical toxicology

authors： Maresova V,Hampl J,Chundela Z,Zrcek F,Polasek M,Chadt J

更新日期：2005-07-01 00:00:00

abstract：:At the end of 2010, the U.S. Drug Enforcement Administration (DEA) used its emergency scheduling authority to temporarily control five chemicals, JWH-018, JWH-073, JWH-200, CP-47497, and cannabicyclohexanol (CP-47497 C8), often referred to as "Spice", K2, or "synthetic cannabinoids" because of their reported cannabis-...

journal_title：Journal of analytical toxicology

authors： Coulter C,Garnier M,Moore C

更新日期：2011-09-01 00:00:00

abstract：:We describe a method using a gas chromatograph with electron ionization detection (GCD) for the simultaneous determination of morphine, codeine, 6-monoacetylmorphine, ethylmorphine, and dihydrocodeine in blood. The method employs propionic anhydride in the presence of triethylamine to propionylate free hydroxyl groups...

journal_title：Journal of analytical toxicology

authors： Mykkänen S,Seppälä J,Ariniemi K,Lillsunde P

更新日期：2000-03-01 00:00:00

abstract：:The purpose of this study was to determine the performance characteristics of the Cozart Methadone Microplate ELISA assay for the detection of methadone and methadone metabolites in hair specimens. One hundred and ten hair specimens were collected from volunteers (n=46) with a history of drug use and from drug-related...

journal_title：Journal of analytical toxicology

authors： Cooper G,Wilson L,Reid C,Baldwin D,Hand C,Spiehler V

更新日期：2005-10-01 00:00:00

abstract：:A method is presented for the positive identification of quinine and quinidine. The method requires extraction of the compounds from an alkaline solution into an organic solvent and concentration of the sample by evaporation of the solvent. The sample is chromatographed without derivatization and may be detected by th...

journal_title：Journal of analytical toxicology

authors： Furner RL,Brown GB,Scott JW

更新日期：1981-11-01 00:00:00

abstract：:Oxymorphone (OM), a prescription opioid and metabolite of oxycodone, was included in the recently published proposed revisions to the Mandatory Guidelines for Federal Workplace Drug Testing Programs. To facilitate toxicological interpretation, this study characterized the time course of OM and its metabolite, noroxymo...

journal_title：Journal of analytical toxicology

authors： DePriest AZ,Heltsley R,Black DL,Mitchell JM,LoDico C,Flegel R,Cone EJ

更新日期：2016-10-01 00:00:00

abstract：:Exposure to drugs and toxins is a major cause for the rising number of emergency department visits each year. Immunoassays are commonly used in the emergency department to provide rapid turnaround time for acute care. The purpose of this study was to compare two automated immunoassay chemistry analyzers to determine w...

journal_title：Journal of analytical toxicology

authors： Johnson-Davis KL,Thompson CD,Clark CJ,McMillin GA,Lehman CM

更新日期：2012-06-01 00:00:00

abstract：:Carfentanil is a mu (μ) opioid receptor agonist and is estimated to be ~10,000 times more potent than morphine in animal (non-human) models. It is not approved for human use and is only used to immobilize large exotic animals in veterinary medicine. In mid-2016, carfentanil emerged as a contaminant in street heroin in...

journal_title：Journal of analytical toxicology

authors： Shanks KG,Behonick GS

更新日期：2017-07-01 00:00:00

abstract：:Dried blood spots (DBS) on filter paper have been used in human medicine since the 1960s, predominantly for screening in-borne metabolic disorders and more recently, for toxicology. Despite its 50-year existence, this technology has not been adopted by veterinarians for routine diagnoses and research. We have validate...

journal_title：Journal of analytical toxicology

authors： Lehner AF,Rumbeiha W,Shlosberg A,Stuart K,Johnson M,Domenech R,Langner H

更新日期：2013-09-01 00:00:00

abstract：:A high performance liquid chromatographic method is reported, which incorporates three internal standards (I-cinchonidine, N-propylprocainamide, and para-chlorodisopyramide) for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: quinidine, procainamide, N-acetylprocainamide, and disopyrami...

journal_title：Journal of analytical toxicology

authors： Bridges RR,Jennison TA

更新日期：1983-03-01 00:00:00

abstract：:Synthetic cannabinoids are a group of compounds that are structurally diverse and are commonly found in various herbal incense and potpourri blends, which are sold in convenience stores, smoke shops and over the Internet. During the past few years, multiple state and federal legislations have been enacted controlling ...

journal_title：Journal of analytical toxicology

authors： Shanks KG,Behonick GS,Dahn T,Terrell A

更新日期：2013-10-01 00:00:00

abstract：:In an attempt to improve the sensitivity and selectivity of thin-layer chromatographic analysis for the detection of strychnine and crimidine in biological samples, a rapid high-performance thin-layer chromatographic (HPTLC) method with densitometry is described. Fortified dog serum and stomach content samples were an...

journal_title：Journal of analytical toxicology

authors： De Saqui-Sannes P,Nups P,Le Bars P,Burgat V

更新日期：1996-05-01 00:00:00

abstract：:Since the introduction in 1990, the solid-phase microextraction (SPME) technology has brought significant progress in many fields of forensic sciences due to the versatility of this fast and solventless alternative to conventional extraction techniques. A systematic review about SPME applications in forensic context f...

journal_title：Journal of analytical toxicology

authors： De Giovanni N,Marchetti D

更新日期：2020-04-30 00:00:00

abstract：:Bleach, nitrite, chromate, and hydrogen peroxide-peroxidase are effective urine adulterants used by the illicit drug users to conceal marijuana-positive results. Methods for detecting nitrite and chromate are available. Effects of other oxidizing agents that could possibly be used as adulterants and are difficult to d...

journal_title：Journal of analytical toxicology

authors： Paul BD,Jacobs A

更新日期：2002-10-01 00:00:00