Evaluation of an HPTLC method for the determination of strychnine and crimidine in biological samples.

abstract：:This paper describes two relatively simple methods for the microdetermination of urinary cadmium (U-Cd) and urinary nickel (U-Ni) using electrothermal atomic absorption spectrometry. Reduction of nonspecific absorption interferences was achieved by temperature programming and background correction using a deuterium ar...

journal_title：Journal of analytical toxicology

authors： Ong CN,Chua LH,Lee BL,Ong HY,Chia KS

更新日期：1990-01-01 00:00:00

abstract：:Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique called solid-phase...

journal_title：Journal of analytical toxicology

authors： Guan F,Seno H,Ishii A,Watanabe K,Kumazawa T,Hattori H,Suzuki O

更新日期：1999-01-01 00:00:00

abstract：:This report describes a gas chromatographic procedure using a packed column and a flame ionization detector, which is suitable for the therapeutic monitoring of N-methylformamide (N-MF). N-MF is a polar compound that induces cancer cell maturation in vitro and exhibits antitumor activity with human tumors xenografted ...

journal_title：Journal of analytical toxicology

authors： Griffiths WC,Matook GM,Dexter DL,Crabtree GW,Spremulli EN,Calabresi P,Diamond I

更新日期：1983-03-01 00:00:00

abstract：:A 59-year-old white male accidentally ingested a mouthful of a plant growth chemical, Cycocel, containing 11.8% of the active ingredient (2-chloroethyl)trimethylammonium chloride (chlormequat). He was seen by a family physician and then transferred to a hospital where he died as a result of ventricular fibrillation, w...

journal_title：Journal of analytical toxicology

authors： Winek CL,Wahba WW,Edelstein JM

更新日期：1990-07-01 00:00:00

abstract：:In recent years, several synthetic cannabinoid compounds have become popular recreational drugs of abuse because of their psychoactive properties. This paper presents toxicological findings of synthetic cannabinoids in whole blood from some cases of severe intoxication including quantitative data from recreational use...

journal_title：Journal of analytical toxicology

authors： Kronstrand R,Roman M,Andersson M,Eklund A

更新日期：2013-10-01 00:00:00

abstract：:An arsenic death was investigated six and one half years after the demise. Analysis of tissue embedded in paraffin blocks demonstrated toxic concentrations. Spectrophotometry was employed with the use of a hydride generator to provide specificity and sensitivity to less than 0.05 microgram. ...

journal_title：Journal of analytical toxicology

authors： Bednarczyk LR,Matusiak W

更新日期：1982-09-01 00:00:00

abstract：INTRODUCTION:We encountered unexpected false positive urine results in three patients for amphetamine-type substances by immunoassay, measured as part of community drug prevention programmes. Kavain was identified in all three urine samples by gas chromatography mass spectrometry (GC-MS). No other potential cross-react...

journal_title：Journal of analytical toxicology

authors： Madhavaram H,Patel T,Kyle C

更新日期：2020-12-16 00:00:00

abstract：:Human urine was tested for tricyclic antidepressants with fluorescence polarization immunoassay (FPIA) reagents on Abbott's ADx system and with EIA reagents on Syva's ETS system. A 75-ng/mL imipramine calibrator cutoff was used with the ADx system and a 300-ng/mL nortriptyline calibrator cutoff with the ETS system. Th...

journal_title：Journal of analytical toxicology

authors： Meenan GM,Barlotta S,Lehrer M

更新日期：1990-09-01 00:00:00

abstract：:The popularity of designer drugs has increased over the past few years as users seek new, cheap and sometimes "legal" ways to get high. This case report focuses on a case that happened in the City of Henderson, Nevada, which involved the designer drug methoxetamine. Methoxetamine is a psychoactive compound that is str...

journal_title：Journal of analytical toxicology

authors： Fassette T,Martinez A

更新日期：2016-10-01 00:00:00

abstract：:A hair screening method has been developed for the detection of methamphetamine using an immunoassay analyzer (AxSYM) with a fluorescence polarization immunoassay (FPIA) technique. The method consisted of washing, cutting and digesting a hair sample (5 mg) with an enzymatic digestion solution. The digested hair sample...

journal_title：Journal of analytical toxicology

authors： Cheong JC,Suh S,Ko BJ,Lee JI,Kim JY,Suh YJ,In MK

更新日期：2013-05-01 00:00:00

abstract：:Pharmacogenomics is the study of the linkage between an individual's genotype and the disposition of drugs in the body. The first association between adverse drug reactions and inherited variations was recognized in the 1950s, and since then, pharmacogenomics has come a long way. The importance of pharmacogenomics is ...

journal_title：Journal of analytical toxicology

authors： Kupiec TC,Raj V,Vu N

更新日期：2006-03-01 00:00:00

abstract：:For many reasons, forensic toxicologists are being asked to determine and report their measurement uncertainty in blood alcohol analysis. While understood conceptually, the elements and computations involved in determining measurement uncertainty are generally foreign to most forensic toxicologists. Several establishe...

journal_title：Journal of analytical toxicology

authors： Gullberg RG

更新日期：2012-04-01 00:00:00

abstract：:The content, chemical form, and distribution of mercury and selenium in edible tissue were determined for several samples of fish and other marine animal organisms (mollusks, crustaceans and pods). For most fish samples, except Pacific blue marlin, 53 to 94% of the total mercury content was present as methylmercury, b...

journal_title：Journal of analytical toxicology

authors： Cappon CJ,Smith JC

更新日期：1982-01-01 00:00:00

abstract：:This manuscript reviews data available in the scientific literature relative to drug testing for the five mandated drug classes and circumstances other than abuse of the drug itself that could result in a positive test. For marijuana, passive inhalation, unknowing oral ingestion, and the use of Marinol are discussed. ...

journal_title：Journal of analytical toxicology

authors： elSohly MA,Jones AB

更新日期：1995-10-01 00:00:00

abstract：:The classical definitions of method detection limit (MDL) and limit of quantitation (LOQ) are redefined using calibration curve regression analysis. Traditional ways of determining these parameters provide scant information on the daily precision of the analysis at all concentration levels. These parameters are time c...

journal_title：Journal of analytical toxicology

authors： Schep RA

更新日期：1990-09-01 00:00:00

abstract：:We describe a method using a gas chromatograph with electron ionization detection (GCD) for the simultaneous determination of morphine, codeine, 6-monoacetylmorphine, ethylmorphine, and dihydrocodeine in blood. The method employs propionic anhydride in the presence of triethylamine to propionylate free hydroxyl groups...

journal_title：Journal of analytical toxicology

authors： Mykkänen S,Seppälä J,Ariniemi K,Lillsunde P

更新日期：2000-03-01 00:00:00

abstract：:The abuse of the designer amphetamines such as 3,4-methylenedioxymethamphetamine (MDMA) is increasing throughout the world. They have become popular drugs at all night techno dance parties, and their detection is an important issue. The objective of the presented study was to identify an unknown compound detected by t...

journal_title：Journal of analytical toxicology

authors： Maresova V,Hampl J,Chundela Z,Zrcek F,Polasek M,Chadt J

更新日期：2005-07-01 00:00:00

abstract：:The Abbott TDx Urine Amphetamine/Methamphetamine II fluorescence polarization immunoassay technique was applied to the determination of D-methamphetamine in hemolyzed whole blood. The assay was found to have 100% cross-reactivity with D-methamphetamine and only an 8% cross-reactivity with L-methamphetamine. Whole bloo...

journal_title：Journal of analytical toxicology

authors： Simonick TF,Watts VW

更新日期：1992-03-01 00:00:00

abstract：:A sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the quantitation of oxymorphone (OM) in human whole blood and liver. Sample preparation was done by solid-phase extraction, using deuterated OM as the internal standard. Separation was achieved using a Waters Aquity UPLC ...

journal_title：Journal of analytical toxicology

authors： Crum ED,Bailey KM,Richards-Waugh LL,Clay DJ,Gebhardt MA,Kraner JC

更新日期：2013-10-01 00:00:00

abstract：:The nitrogen mustards bis(2-chloroethyl)ethylamine (HN1), bis(2-chloroethyl)methylamine (HN2), and tris(2-chloroethyl)amine (HN3) have the potential to be used as chemical terrorism agents because of their extreme vesicant properties. We modified a previously reported method to incorporate automated solid-phase extrac...

journal_title：Journal of analytical toxicology

authors： Lemire SW,Barr JR,Ashley DL,Olson CT,Hayes TL

更新日期：2004-07-01 00:00:00

abstract：:Ethylene glycol (EG), a relatively infrequent cause of fatal intoxication, presents an analytical challenge for forensic confirmation in postmortem toxicology. We report EG and glycolic acid (GA) quantification in postmortem blood by gas chromatography coupled with ion trap mass spectrometry (GC-MS) analysis using a m...

journal_title：Journal of analytical toxicology

authors： Rosano TG,Swift TA,Kranick CJ,Sikirica M

更新日期：2009-10-01 00:00:00

abstract：:A colchicine blood concentration 250 microgram/L was determined in a 39-year-old white female 2 hours following the ingestion of an oral overdose of the drug. At death, 40 hours following ingestion, no drug was detected. Colchicine was extracted from buffered blood using dichloromethane. The evaporated extract was red...

journal_title：Journal of analytical toxicology

authors： Caplan YH,Orloff KG,Thompson BC

更新日期：1980-05-01 00:00:00

abstract：:The synthetic chemical 4-aminobiphenyl (4-ABP) has been shown to be a bladder carcinogen in both man and animals. A valid radioimmunoassay for a metabolite of 4-ABP has been developed as a means to monitor potential human exposure to 4-ABP. The antibody was produced by the immunization of two female New Zealand White ...

journal_title：Journal of analytical toxicology

authors： Johnson HJ Jr,Cernosek SF Jr,Gutierrez-Cernosek RM,Brown LL

更新日期：1980-03-01 00:00:00

abstract：:Intoxications with the antifreeze constituent ethylene glycol (EG) occur infrequently, but may be fatal if not recognized and treated promptly. The aim of the present work was to develop an analytical method for rapid diagnosis of EG poisoning and for monitoring EG removal by hemodialysis. EG was measured by gas chrom...

journal_title：Journal of analytical toxicology

authors： Aarstad K,Dale O,Aakervik O,Ovrebø S,Zahlsen K

更新日期：1993-07-01 00:00:00

abstract：:A high-performance liquid chromatographic system based on gradient elution of an alumina packing material coated with polybutadiene is presented. The chromatographic eluent is a mixture of methanol and water, both containing 0.0125M NaOH. The effluent is monitored by photodiode array detection. The system allows detec...

journal_title：Journal of analytical toxicology

authors： Lambert WE,Meyer E,De Leenheer AP

更新日期：1995-03-01 00:00:00

abstract：:An analytical procedure for the determination of the new pain medication tapentadol and its main metabolite N-desmethyltapentadol (DMT), in urine and oral fluid has been developed and validated using liquid chromatography with tandem mass spectral detection (LC-MS-MS). Oral fluid was collected using Quantisal™ devices...

journal_title：Journal of analytical toxicology

authors： Coulter C,Taruc M,Tuyay J,Moore C

更新日期：2010-10-01 00:00:00

abstract：:A high-performance liquid chromatographic method was used for the detection of etodolac in equine serum and urine. The method consisted of a one-step liquid-liquid extraction, separation on a reversed-phase (RP-18) column and detection using an ultraviolet detector. Additional confirmation methods included a HPLC coup...

journal_title：Journal of analytical toxicology

authors： Koupai-Abyazani MR,Esaw B,Laviolette B

更新日期：1999-05-01 00:00:00

abstract：:An automated column-switching liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometric (LC-APCI-MS) method for the simultaneous determination of frequently encountered benzodiazepine hypnotics and their relevant metabolites in urine has been established. A column-switching online solid-phase ...

journal_title：Journal of analytical toxicology

authors： Miki A,Tatsuno M,Katagi M,Nishikawa M,Tsuchihashi H

更新日期：2002-03-01 00:00:00

abstract：:A method that measures 12 analytes in urine and reflects possible exposure to pesticides was developed. The sample preparation involves enzyme hydrolysis and solvent extraction through the use of laboratory robotics, followed by phase-transfer catalysis derivatization and silica cleanup. Samples are analyzed by capill...

journal_title：Journal of analytical toxicology

authors： Hill RH Jr,Shealy DB,Head SL,Williams CC,Bailey SL,Gregg M,Baker SE,Needham LL

更新日期：1995-09-01 00:00:00

abstract：:The analysis of biological specimens collected at autopsy for the presence of exogenous insulin(s) is of special interest in select death investigations as they may be suspected in the cause of a death. Technical challenges include the limited stability of insulin, and the forensic requirement of differentiating endog...

journal_title：Journal of analytical toxicology

authors： Legg KM,Labay LM,Aiken SS,Logan BK

更新日期：2019-08-23 00:00:00