Validation of blood and liver oxymorphone analysis using LC-MS-MS: concentrations in 30 fatal overdoses.

abstract：:Pharmacogenomics is the study of the linkage between an individual's genotype and the disposition of drugs in the body. The first association between adverse drug reactions and inherited variations was recognized in the 1950s, and since then, pharmacogenomics has come a long way. The importance of pharmacogenomics is ...

journal_title：Journal of analytical toxicology

authors： Kupiec TC,Raj V,Vu N

更新日期：2006-03-01 00:00:00

abstract：:A method for analyzing urine for the presence of basic drugs and their metabolites using two fused silica capillary columns is described along with operating conditions and column characteristics. Urine extracts were injected into a gas chromatograph equipped with nitrogen phosphorous detectors (GC/NPD) and two capill...

journal_title：Journal of analytical toxicology

authors： Hime GW,Bednarczyk LR

更新日期：1982-09-01 00:00:00

abstract：:Methods for extraction of cocaine, some of its metabolites, morphine, and codeine from hair and methods for analyzing the extracts have been investigated. Results of these studies have shown that extractions with 0.1N HCl are efficient at removing the target compounds from hair and appear to be as effective as enzymat...

journal_title：Journal of analytical toxicology

authors： Welch MJ,Sniegoski LT,Allgood CC,Habram M

更新日期：1993-11-01 00:00:00

abstract：:A sensitive and specific gas chromatography/mass spectrometry (GC/MS) method has been developed for the simultaneous analysis of methampthetamine and its metabolites (amphetamine, p-hydroxymethamphetamine, and p-hydroxyamphetamine) in monkey urine. The method has been applied to the analysis of urine samples from monk...

journal_title：Journal of analytical toxicology

authors： Yamamoto T,Takano R,Egashira T,Yamanaka Y,Terada M

更新日期：1989-03-01 00:00:00

abstract：:For many reasons, forensic toxicologists are being asked to determine and report their measurement uncertainty in blood alcohol analysis. While understood conceptually, the elements and computations involved in determining measurement uncertainty are generally foreign to most forensic toxicologists. Several establishe...

journal_title：Journal of analytical toxicology

authors： Gullberg RG

更新日期：2012-04-01 00:00:00

abstract：:A case of lethal overdose by prilocaine, a local anaesthetic, is presented. The patient died in the dental office during treatment, and the time course of events was documented. The drug concentration in blood, urine, and liver was measured. ...

journal_title：Journal of analytical toxicology

authors： Kaliciak HA,Chan SC

更新日期：1986-03-01 00:00:00

abstract：:A fast and efficient multiresidue extraction-purification procedure was developed for low levels (ppb range) of phenanthrene and hydroxyphenanthrene in biological matrices, in order to quantify phenanthrene and metabolites in blood, milk, urine, and biological tissues of lactating goats. Detection and identification o...

journal_title：Journal of analytical toxicology

authors： Grova N,Monteau F,Le Bizec B,Feidt C,Andre F,Rychen G

更新日期：2005-04-01 00:00:00

abstract：:This report describes a possible suicide by overdosage with diltiazem. The decreased, a 39-year-old male who had been under treatment for an unidentified heart condition, was discovered on the bathroom floor in his residence. Comprehensive drug screens performed on available postmortem specimens revealed the presence ...

journal_title：Journal of analytical toxicology

authors： Kalin JR,Wood KM,Lee AJ

更新日期：1994-05-01 00:00:00

abstract：:Synthetic cannabinoids are a group of compounds that are structurally diverse and are commonly found in various herbal incense and potpourri blends, which are sold in convenience stores, smoke shops and over the Internet. During the past few years, multiple state and federal legislations have been enacted controlling ...

journal_title：Journal of analytical toxicology

authors： Shanks KG,Behonick GS,Dahn T,Terrell A

更新日期：2013-10-01 00:00:00

abstract：:cis(Z)-Clopenthixol and trans(E)-clopenthixol were determined by gas chromatography-mass spectrometry and high-performance liquid chromatography-diode-array detection in necropic samples from a postmortem case. The peripheral blood concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol were 278 and 177 ng/mL,...

journal_title：Journal of analytical toxicology

authors： Rop PP

更新日期：2001-07-01 00:00:00

abstract：:Understanding cocaine and metabolites urinary excretion following smoking is important for interpretation of urine test results in judicial, workplace and treatment settings. In National Institute on Drug Abuse approved studies on a secure research unit, six subjects smoked placebo, 10, 20, and 40 mg cocaine with a pr...

journal_title：Journal of analytical toxicology

authors： Huestis MA,Darwin WD,Shimomura E,Lalani SA,Trinidad DV,Jenkins AJ,Cone EJ,Jacobs AJ,Smith ML,Paul BD

更新日期：2007-10-01 00:00:00

abstract：:During periodate degradation of interfering ephedrine, pseudoephedrine, and phenylpropanolamine in the extraction of methamphetamine from urine, it was observed that a small amount of methamphetamine was demethylated to amphetamine. although all three interfering phenylpropanolamines could be degraded by periodate at ...

journal_title：Journal of analytical toxicology

authors： Paul BD,Past MR,McKinley RM,Foreman JD,McWhorter LK,Snyder JJ

更新日期：1994-10-01 00:00:00

abstract：:A simple, rapid method for the gas-liquid chromatographic (GLC) determination of valproic acid in serum without prior derivatization on a Nukol wide-bore capillary column is presented. The method was determined to have a lower limit of detection (LOD) of 5 mg/L and a lower limit of quantitation (LOQ) of 10 mg/L; the m...

journal_title：Journal of analytical toxicology

authors： Wohler AS,Poklis A

更新日期：1997-07-01 00:00:00

abstract：:A 38-year-old man was admitted in the intensive care unit (ICU) after supposed ingestion of 504 sustained-release tablets of Theralithe™ corresponding ~200 g of lithium carbonate. At the admission, ~19.5 h after ingestion, the patient was conscious with trembling limbs, intense thirst, profuse sweats and vomiting and ...

journal_title：Journal of analytical toxicology

authors： Jamal T,Hennequin C,Gahoual R,Leyris A,Beaudeux JL,Baud FJ,Houzé P

更新日期：2019-08-23 00:00:00

abstract：:Urinary metabolites of famprofazone following oral administration in humans were identified by gas chromatography-mass spectrometry with electron impact-ionization and comparison with the spectra and retention times of authentic standards. The metabolites were determined following selective derivatization with N-methy...

journal_title：Journal of analytical toxicology

authors： Shin HS,Park BB,Choi SN,Oh JJ,Hong CP,Ryu H

更新日期：1998-01-01 00:00:00

abstract：:The List of Prohibited Substances and Methods (the List), an International Standard published yearly by the World Anti-Doping Agency (WADA), determines which substances and methods are prohibited in sport in- and out-of-competition. Stimulants are included within drug class S.6 under the in-competition testing sectio...

journal_title：Journal of analytical toxicology

authors： Boghosian T,Mazzoni I,Barroso O,Rabin O

更新日期：2011-11-01 00:00:00

abstract：:A 5-mg dose of cocaine free base applied to the volar forearm skin surface of a volunteer resulted in a maximal urinary benzoylecgonine concentration of 55 ng/mL at 48 h, using discrete urine specimens. A total of 58 micrograms of benzoylecgonine, representing 1.2% of the dose, was excreted in the 96-h urine. An ident...

journal_title：Journal of analytical toxicology

authors： Baselt RC,Chang JY,Yoshikawa DM

更新日期：1990-11-01 00:00:00

abstract：:Exemplars of current commercial breath-alcohol simulators were studied to ascertain their suitability for control tests and as calibrators in breath-alcohol analysis. Temperature, effluent volumes and pressures, effluent-alcohol concentration, and alcohol depletion were measured for simulators coupled with various cur...

journal_title：Journal of analytical toxicology

authors： Dubowski KM,Essary NA

更新日期：1991-09-01 00:00:00

abstract：:Anticoagulant rodenticides are the largest group of poisons used to kill harmful rodents. Their fundamental mode of action consists in the inhibition of the vitamin K epoxide reductase, which causes blood-clotting alteration, ultimately leading to hemorrhagic events as the cause of death. In this study, we developed a...

journal_title：Journal of analytical toxicology

authors： Leporati M,Salomone A,Golè G,Vincenti M

更新日期：2016-05-01 00:00:00

abstract：:Sterile whole human blood control materials were commercially prepared in batches containing anticoagulants and preservatives and approximately 90, 150, and 230 mg/dL ethanol with and without 0.3% (w/v) sodium azide. Aliquots in sealed vials were stored by the manufacturer at 2-8 degrees C until shipped monthly to thr...

journal_title：Journal of analytical toxicology

authors： Dubowski KM,Gadsden RH Sr,Poklis A

更新日期：1997-10-01 00:00:00

abstract：:A suicide caused by oral ingestion of colchicine is reported. Postmortem examination revealed circulating Pelger-Huet polymorphonuclear leukocytes and numerous mitotic and chromatin bodies in tissues with rapid cell turnover. Colchicine was identified by gas chromatography/mass spectrometry (GC/MS) of an organic extra...

journal_title：Journal of analytical toxicology

authors： Clevenger CV,August TF,Shaw LM

更新日期：1991-05-01 00:00:00

abstract：:Cannabinoids were extracted from serum with C18 SPE cartridges and analyzed as their trimethylsilyl (TMS) derivatives. A benchtop gas chromatography-tandem mass spectrometry (GC-MS-MS) system based on an ion trap with external ionization was used. Quantitation was done in relation to trideuterated internal standards i...

journal_title：Journal of analytical toxicology

authors： Weller JP,Wolf M,Szidat S

更新日期：2000-07-01 00:00:00

abstract：:A high-performance liquid chromatographic method was used for the detection of etodolac in equine serum and urine. The method consisted of a one-step liquid-liquid extraction, separation on a reversed-phase (RP-18) column and detection using an ultraviolet detector. Additional confirmation methods included a HPLC coup...

journal_title：Journal of analytical toxicology

authors： Koupai-Abyazani MR,Esaw B,Laviolette B

更新日期：1999-05-01 00:00:00

abstract：:Comprehensive investigation is necessary for determining the cause of death in cases with positive drug screens. We investigated the case of a male who reportedly expired from an acute asthma attack. He had limited access to both therapeutic drugs and drugs of abuse because he was a state prisoner. His autopsy was rem...

journal_title：Journal of analytical toxicology

authors： Merigian K,Blaho K

更新日期：1995-10-01 00:00:00

abstract：:The misuse of the commonly used chemical diethylene glycol (DEG) has lead to many poisonings worldwide. Methods were developed for analysis of DEG and its potential metabolites; ethylene glycol, glycolic acid, oxalic acid, diglycolic acid and hydroxyethoxy acetic acid in human urine, serum and cerebrospinal fluid samp...

journal_title：Journal of analytical toxicology

authors： Perala AW,Filary MJ,Bartels MJ,McMartin KE

更新日期：2014-05-01 00:00:00

abstract：:Although the legitimate clinical use of amphetamine and amphetamine congeners is declining, the illicit use of these drugs remains high. There is a need for a rapid and conclusive method for detecting these compounds in routine urine drug testing, drug screening in drug rehabilitation centers, and as an aid in the dia...

journal_title：Journal of analytical toxicology

authors： Przekop MA,Manno JE,Kunsman GW,Cockerham KR,Manno BR

更新日期：1991-11-01 00:00:00

abstract：:Exposure to drugs and toxins is a major cause for the rising number of emergency department visits each year. Immunoassays are commonly used in the emergency department to provide rapid turnaround time for acute care. The purpose of this study was to compare two automated immunoassay chemistry analyzers to determine w...

journal_title：Journal of analytical toxicology

authors： Johnson-Davis KL,Thompson CD,Clark CJ,McMillin GA,Lehman CM

更新日期：2012-06-01 00:00:00

abstract：:An existing GC-MS method for detecting benzoylecgonine (BZE) in urine was modified by changing derivatizing reagents. This method modification presents a cost-effective alternative derivatization procedure for the detection of BZE in urine by GC-MS. The combination of pentafluoropropanol and acetic anhydride was found...

journal_title：Journal of analytical toxicology

authors： Serafin MC,Paulemon KM,Fuller ZJ,Bronner WE

更新日期：2017-05-01 00:00:00

abstract：:The classical definitions of method detection limit (MDL) and limit of quantitation (LOQ) are redefined using calibration curve regression analysis. Traditional ways of determining these parameters provide scant information on the daily precision of the analysis at all concentration levels. These parameters are time c...

journal_title：Journal of analytical toxicology

authors： Schep RA

更新日期：1990-09-01 00:00:00

abstract：:A method for the determination of the antidepressant drug trazodone is presented. 8-Hydroxyloxapine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection usin...

journal_title：Journal of analytical toxicology

authors： Rifai N,Levtzow CB,Howlett CM,Phillips JC,Parker NC,Cross RE

更新日期：1988-05-01 00:00:00