Abstract:
:This report describes a possible suicide by overdosage with diltiazem. The decreased, a 39-year-old male who had been under treatment for an unidentified heart condition, was discovered on the bathroom floor in his residence. Comprehensive drug screens performed on available postmortem specimens revealed the presence of 6.9 mg/L diltiazem, 0.182 g/100 mL ethanol, and a trace of propranolol in blood, and 4.7 mg/L diltiazem and 0.251 g/100 mL ethanol in urine.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Kalin JR,Wood KM,Lee AJdoi
10.1093/jat/18.3.180subject
Has Abstractpub_date
1994-05-01 00:00:00pages
180-2issue
3eissn
0146-4760issn
1945-2403journal_volume
18pub_type
杂志文章abstract::An improved method for the simultaneous determination of cocaine and its metabolites, benzoylecgonine (BE), norcocaine, and ecgoninemethylester (EME), in rat plasma and urine is described. Following derivatization of EME to p-fluorococaine, chromatography was performed on two high-performance liquid chromatography (HP...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/24.6.438
更新日期:2000-09-01 00:00:00
abstract::Solid-phase extraction (SPE) and a one-step derivatization are combined with gas chromatography-negative ion chemical ionization-mass spectrometry to simplify a previously reported method for the determination of naltrexone and its metabolite, 6-beta-naltrexol, in human plasma. Deuterated isotopomers of naltrexone and...
journal_title:Journal of analytical toxicology
pub_type: 临床试验,杂志文章
doi:10.1093/jat/21.4.252
更新日期:1997-07-01 00:00:00
abstract::A sensitive and specific gas chromatography/mass spectrometry (GC/MS) method has been developed for the simultaneous analysis of methampthetamine and its metabolites (amphetamine, p-hydroxymethamphetamine, and p-hydroxyamphetamine) in monkey urine. The method has been applied to the analysis of urine samples from monk...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/13.2.117
更新日期:1989-03-01 00:00:00
abstract::A woman was alleged to have committed suicide by consuming a gasoline additive shortly before jumping from a second floor balcony within her home. She was found dead by police with a multitude of injuries, lying nude in a partially evaporated unknown residue that was later determined to be methanol. Samples collected ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.7.734
更新日期:2005-10-01 00:00:00
abstract::Previous measurements of elemental concentrations in liver mitochondria have generally required homogenization and fractionation of liver tissue, a procedure in which it is difficult to rule out ion movement between subcellular units. New techniques involving cryoultramicrotomy of rapidly frozen tissue, high resolutio...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/9.4.145
更新日期:1985-07-01 00:00:00
abstract::As an approved medicinal product and reportedly an abused substance that have been associated with death and "considered to be a factor...of impaired driving, sexual assault, and other violent crimes", triazolam is controlled at the same level (Level III) as flunitrazepam in Taiwan. Alleged misuses of this substance h...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.2.118
更新日期:2005-03-01 00:00:00
abstract::A sensitive and specific method for the quantitative determination of D,L-methadone (MD) and its metabolites, D,L-2-ethyl-1,5-dimethyl-3, 3-diphenylpyrrolinium (EDDP) and D,L-2-ethyl-5-methyl-3, 3-diphenyl-1-pyrroline (EMDP), in hair has been developed. Deuterated internal standards of MD, EMDP, and EDDP were added to...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/20.6.355
更新日期:1996-10-01 00:00:00
abstract::In preparation for a treatment program concerning the medical coprescription of heroin and methadone to treatment-resistant addicts in the Netherlands, we studied a novel strategy for monitoring co-use of illicit (nonprescribed) heroin. A deuterated analogue of heroin was added (1:20) to pharmaceutical, smokable heroi...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.6.564
更新日期:2005-09-01 00:00:00
abstract::Bupropion is a "second generation" antidepressant agent structurally related to the phenethylamines. Postmortem toxicology data are presented from three suicidal drug overdoses in which bupropion was detected. In two cases in which bupropion was the major toxicology finding, peripheral blood levels of the parent drug ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/17.7.436
更新日期:1993-11-01 00:00:00
abstract::We present an analytical method for the determination of heroin, free 6-acetylmorphine (6-AM), and free morphine in blood, urine, and vitreous humor. This method is used in postmortem cases where heroin is the suspected cause of death. The analytical protocol includes the following steps: liquid-liquid extraction at p...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/21.2.127
更新日期:1997-03-01 00:00:00
abstract::A method is presented for the extraction and screening of basic and neutral drugs, including amphetamines. Two milliliters of blood are buffered to pH 9.0 and extracted with n-chlorobutane. Underivatized extracts are analyzed simultaneously on two complementary capillary columns placed together in one injection port u...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/10.5.198
更新日期:1986-09-01 00:00:00
abstract::Synthetic cannabinoids emerged on the designer drug market in recent years due to their ability to produce cannabis-like effects without the risk of detection by traditional drug testing techniques such as immunoassay and gas chromatography-mass spectrometry. As government agencies work to schedule existing synthetic ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkv137
更新日期:2016-04-01 00:00:00
abstract::For many reasons, forensic toxicologists are being asked to determine and report their measurement uncertainty in blood alcohol analysis. While understood conceptually, the elements and computations involved in determining measurement uncertainty are generally foreign to most forensic toxicologists. Several establishe...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bks012
更新日期:2012-04-01 00:00:00
abstract::Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that are infiltrating the heroin market. Methoxyacetylfentanyl and cyclopropylfentanyl were reported by the Drug Enforcement Administration (DEA) in their third quarter report of 2017 to have been chemically identified seven and five t...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bky035
更新日期:2018-11-01 00:00:00
abstract::Continuing our previous studies analyzing drugs of abuse in municipal wastewater, a method was developed for the analysis of opiates in wastewater samples using liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS). Eight opiate drugs and metabolites were analyzed including codeine, hydrocodone, hydro...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkw022
更新日期:2016-06-01 00:00:00
abstract::We present a method that permits the simultaneous analysis of carbamazepine (CBZ) and its major biotransformation products, carbamazepine-10,11-epoxide (CBZ-E) and carbamazepine-10,11-dihydroxide (CBZ-diOH), in plasma samples. The method consists of plasma extraction in alkaline medium with NaCl added using chloroform...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/16.2.88
更新日期:1992-03-01 00:00:00
abstract::This article reports the impact of diuresis on urinary excretion of ethanol in seven healthy volunteers who drank 1000 mL of export beer (44 g ethanol) in 30 min and, 120 min later, ingested 500 or 1000 mL of water within 5 min. Urine was voided before drinking started and every 30-60 min for 360 min after the start o...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/23.7.565
更新日期:1999-11-01 00:00:00
abstract::A group of 16 volatile substances (ethyl acetate, 2-propanol, 1-propanol, methanol, acetone, ethanol, acetaldehyde, diethyl ether, methyl ethyl ketone, 1-butanol, 2-butanol, t-butanol, isobutanol, 2-methyl-1-butanol, 3-methyl-1-butanol, 1-pentanol) were qualitatively and quantitatively analyzed through a method develo...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkaa154
更新日期:2020-10-08 00:00:00
abstract::Caffeine is the world's most widely consumed drug with its main source found in coffee. We evaluated the caffeine content of caffeinated and decaffeinated specialty coffee samples obtained from coffee shops. Caffeine was isolated from the coffee by liquid-liquid extraction and analyzed by gas chromatography with nitro...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.7.520
更新日期:2003-10-01 00:00:00
abstract::Comprehensive investigation is necessary for determining the cause of death in cases with positive drug screens. We investigated the case of a male who reportedly expired from an acute asthma attack. He had limited access to both therapeutic drugs and drugs of abuse because he was a state prisoner. His autopsy was rem...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/19.6.522
更新日期:1995-10-01 00:00:00
abstract::A gas chromatographic-chemical ionization mass spectrometric (GC-CIMS) method is described for the determination of cocaine, benzoylecgonine, and norcocaine. The procedure uses stable isotopes as internal standards and a mixture of methane-ammonia as chemical ionization reagent gas. Run-to-run and within-run coefficie...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/4.1.37
更新日期:1980-01-01 00:00:00
abstract::The List of Prohibited Substances and Methods (the List), an International Standard published yearly by the World Anti-Doping Agency (WADA), determines which substances and methods are prohibited in sport in- and out-of-competition. Stimulants are included within drug class S.6 under the in-competition testing sectio...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/anatox/35.9.613
更新日期:2011-11-01 00:00:00
abstract::As a part of ongoing testing of personnel preparing training aids for drug detection dogs at the Naval Criminal Investigative Service Regional Forensic Laboratory, personnel handling methamphetamine (MTH) were subject to voluntary urine drug testing. This provided a model of potential unwitting or environmental exposu...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/30.8.551
更新日期:2006-10-01 00:00:00
abstract::A high-performance liquid chromatographic method was used for the detection of etodolac in equine serum and urine. The method consisted of a one-step liquid-liquid extraction, separation on a reversed-phase (RP-18) column and detection using an ultraviolet detector. Additional confirmation methods included a HPLC coup...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/23.3.200
更新日期:1999-05-01 00:00:00
abstract::Phenazepam and etizolam were the first uncontrolled benzodiazepines available for sale in the UK. Pyrazolam, flubromazepam and diclazepam are not used medicinally anywhere in the world; they are produced exclusively for the uncontrolled, recreational market. It is important to know whether potentially abused drugs lik...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkv122
更新日期:2016-03-01 00:00:00
abstract::A rapid and efficient high-performance liquid chromatographic method using a reversed-phase eluent of methanol-water with butylamine on a silica column was developed for the separation and quantitation of clomipramine (CMI), its demethylated metabolites (desmethyl-clomipramine and didesmethyl-clomipramine [DDCMI]), an...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/20.2.101
更新日期:1996-03-01 00:00:00
abstract::A liquid chromatography-tandem mass spectrometry method was developed for the simultaneous quantification of 26 benzodiazepines and metabolites, zolpidem and zopiclone, in blood, urine, and hair. Drugs were extracted from all matrices by liquid-liquid extraction with 1-chlorobutane. Chromatography was achieved using a...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.7.616
更新日期:2005-10-01 00:00:00
abstract::Methoxphenidine (MXP, 2-MeO-diphenidine) is a dissociative anaesthetic drug of the diarylethylamine type, recently introduced for recreational purposes through the online-based sale of new psychoactive substances (NPS). The concentration of MXP in hair has never been reported, either in cases of chemsex use or in fata...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkab016
更新日期:2021-02-01 00:00:00
abstract::In previous experimental studies on heroin metabolites excretion in urine, the first sample was often collected a few hours after intake. In forensic cases, it is sometimes questioned if a positive urine result is expected e.g., 30 min after intake. The aim of this study was to investigate urinary excretion of heroin ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkx017
更新日期:2017-06-01 00:00:00
abstract::Urine drug testing (UDT) is an emerging standard of care in the evaluation and treatment of chronic non-cancer pain patients with opioid analgesics. UDT may be used both to verify adherence with the opioid analgesic regimen and to monitor abstinence from non-prescribed or illicit controlled substances. In the former s...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bku109
更新日期:2015-01-01 00:00:00