Abstract：
:Bupropion is a "second generation" antidepressant agent structurally related to the phenethylamines. Postmortem toxicology data are presented from three suicidal drug overdoses in which bupropion was detected. In two cases in which bupropion was the major toxicology finding, peripheral blood levels of the parent drug were 4.0 and 4.2 mg/L and total metabolite levels were 15 and 16.6 mg/L. Lethal doses in both cases were estimated by history to be less than 10 g.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Friel PN,Logan BK,Fligner CLdoi
10.1093/jat/17.7.436subject
Has Abstractpub_date
1993-11-01 00:00:00pages
436-8issue
7eissn
0146-4760issn
1945-2403journal_volume
17pub_type
杂志文章abstract：:A simple isocratic HPLC procedure for the analysis of cocaine in plasma, with or without an internal standard, is described for the first time. Basified plasma was extracted in ether, re-extracted in acetic acid, which was subsequently basified prior to the final extraction in n-hexane. The hexane extract was evaporat...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/4.6.305
更新日期：1980-11-01 00:00:00
abstract：:N,N-Diethyl-m-toluamide (DEET) is an effective component of several insect repellent products. A 19-year-old woman was admitted to the emergency department following ingestion of 15-25 mL 95% diethyltoluamide (Muscol). Serum and urine toxicology screening tests were negative except for detection of DEET. DEET was qual...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/19.3.197
更新日期：1995-05-01 00:00:00
abstract：:A quantitative gas chromatographic assay for the determination of phenelzine in plasma or other fluids is presented. A stable derivative is formed by cyclization with acetylacetone, and the derivative is separated, purified, and concentrated by liquid-liquid solvent extraction. Analysis of the extracts is by capillary...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/12.2.98
更新日期：1988-03-01 00:00:00
abstract：:The effects of decomposition microclimate on the distribution of dextromethorphan (DXM) and dextrorphan (DXT) in skeletonized remains of rats acutely exposed to DXM were examined. Animals (n = 10) received DXM (75 mg/kg, i.p.), were euthanized 30 min post-dose and immediately allowed to decompose at either Site A (sha...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkw083
更新日期：2016-10-01 00:00:00
abstract：:A rapid and sensitive assay for pyridinium oximes in plasma and tissue was developed. The method was suitable for the analysis of mono- and di-pyridinium oximes and utilizes ultrafiltration followed by cation-exchange high-performance liquid chromatography with UV detection. The assay was originally developed for the ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/31.2.69
更新日期：2007-03-01 00:00:00
abstract：:Cyclopropylfentanyl is a fentanyl analog implicated in 78 deaths in Europe and over 100 deaths in the United States, but toxicological information including metabolism data about this drug is scarce. The aim of this study was to provide the exact structure of abundant and unique metabolites of cyclopropylfentanyl alon...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkz057
更新日期：2019-09-10 00:00:00
abstract：:A method for the simultaneous measurement of buprenorphine and its N-dealkylated metabolite, norbuprenorphine, in human plasma was developed with negative chemical ionization tandem mass spectrometry. Buprenorphine and norbuprenorphine were extracted from biological fluids by solid-phase extraction. The samples were d...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/20.4.229
更新日期：1996-07-01 00:00:00
abstract：:A study of the urinary concentration of fentanyl (F) and its major metabolite norfentanyl (NF) in chronic pain patients treated with the Duragesic continuous release transdermal patches is presented. These patches are available in 10, 20, 30, and 40 cm(2) sizes releasing 25, 50, 75, and 100 microg/h F, respectively. F...
journal_title：Journal of analytical toxicology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/jat/28.6.422
更新日期：2004-09-01 00:00:00
abstract：:A liquid chromatographic-mass spectrometric assay with atmospheric pressure chemical ionization is presented for quantification (selected-ion mode) of tramadol (T) and O-desmethyltramadol (ODT) in blood plasma after liquid-liquid extraction. The enantiomeric separation was achieved on a Chiralpak AD column containing ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/30.7.463
更新日期：2006-09-01 00:00:00
abstract：:A quantitative analysis was developed for the determination of cocaine, benzoylecgonine, and cocaethylene in oral fluid using liquid chromatography-tandem mass spectrometry. After internal standardization and solid-phase extraction, chromatographic separation was achieved on a reversed-phase column by gradient elution...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/28.8.655
更新日期：2004-11-01 00:00:00
abstract：:Caffeine is the most widely consumed drug in the world with coffee representing a major source of intake. Despite widespread availability, various medical conditions necessitate caffeine-restricted diets. Patients on certain prescription medications are advised to discontinue caffeine intake. Such admonition has impli...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/30.8.611
更新日期：2006-10-01 00:00:00
abstract：:Since the introduction in 1990, the solid-phase microextraction (SPME) technology has brought significant progress in many fields of forensic sciences due to the versatility of this fast and solventless alternative to conventional extraction techniques. A systematic review about SPME applications in forensic context f...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkz077
更新日期：2020-04-30 00:00:00
abstract：:High levels of verapamil (1) were found in the blood, stomach contents, and liver and kidney specimens in a fatal overdose case. The drug was extracted from both acid and enzyme digested tissue with ether, chloroform, and 1-chlorobutane and the digests analysed by both high-performance liquid chromatography and gas ch...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/5.3.105
更新日期：1981-05-01 00:00:00
abstract：:Cannabinoids were extracted from serum with C18 SPE cartridges and analyzed as their trimethylsilyl (TMS) derivatives. A benchtop gas chromatography-tandem mass spectrometry (GC-MS-MS) system based on an ion trap with external ionization was used. Quantitation was done in relation to trideuterated internal standards i...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/24.5.359
更新日期：2000-07-01 00:00:00
abstract：:Exemplars of current commercial breath-alcohol simulators were studied to ascertain their suitability for control tests and as calibrators in breath-alcohol analysis. Temperature, effluent volumes and pressures, effluent-alcohol concentration, and alcohol depletion were measured for simulators coupled with various cur...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/15.5.272
更新日期：1991-09-01 00:00:00
abstract：:Although the legitimate clinical use of amphetamine and amphetamine congeners is declining, the illicit use of these drugs remains high. There is a need for a rapid and conclusive method for detecting these compounds in routine urine drug testing, drug screening in drug rehabilitation centers, and as an aid in the dia...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/15.6.323
更新日期：1991-11-01 00:00:00
abstract：:The Substance Abuse and Mental Health Services Administration (SAMHSA) is currently evaluating hydrocodone (HC) for inclusion in the Mandatory Guidelines for Federal Workplace Drug Testing Programs. This study evaluated the time course of HC, norhydrocodone (NHC), dihydrocodeine (DHC) and hydromorphone (HM) in paired ...
journal_title：Journal of analytical toxicology
pub_type： 临床试验,杂志文章
doi：10.1093/jat/bkv050
更新日期：2015-09-01 00:00:00
abstract：:Sterile whole human blood control materials were commercially prepared in batches containing anticoagulants and preservatives and approximately 90, 150, and 230 mg/dL ethanol with and without 0.3% (w/v) sodium azide. Aliquots in sealed vials were stored by the manufacturer at 2-8 degrees C until shipped monthly to thr...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/21.6.486
更新日期：1997-10-01 00:00:00
abstract：:At the end of 2010, the U.S. Drug Enforcement Administration (DEA) used its emergency scheduling authority to temporarily control five chemicals, JWH-018, JWH-073, JWH-200, CP-47497, and cannabicyclohexanol (CP-47497 C8), often referred to as "Spice", K2, or "synthetic cannabinoids" because of their reported cannabis-...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/anatox/35.7.424
更新日期：2011-09-01 00:00:00
abstract：:A high-performance liquid chromatographic system based on gradient elution of an alumina packing material coated with polybutadiene is presented. The chromatographic eluent is a mixture of methanol and water, both containing 0.0125M NaOH. The effluent is monitored by photodiode array detection. The system allows detec...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/19.2.73
更新日期：1995-03-01 00:00:00
abstract：:Amoxicillin has been causally linked in the lay and medical literature to false-positive urine drug screens for cocaine metabolites. An exhaustive search of the peer-reviewed medical literature revealed no data to support this link. We hypothesized that amoxicillin does not cause false-positive urine drug screens for ...
journal_title：Journal of analytical toxicology
pub_type： 临床试验,杂志文章
doi：10.1093/jat/32.4.315
更新日期：2008-05-01 00:00:00
abstract：:For many reasons, forensic toxicologists are being asked to determine and report their measurement uncertainty in blood alcohol analysis. While understood conceptually, the elements and computations involved in determining measurement uncertainty are generally foreign to most forensic toxicologists. Several establishe...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bks012
更新日期：2012-04-01 00:00:00
abstract：:Quantitative analysis of Δ9-tetrahydrocannabinol (Δ9-THC) in oral fluid has gained increasing interest in clinical and forensic toxicology laboratories. New medicinal and/or recreational cannabinoid products require laboratories to distinguish different patterns of cannabinoid use. This study validated a high-performa...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkaa184
更新日期：2020-12-03 00:00:00
abstract：:We developed a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) method to measure metabolites of atrazine, phenylurea, and sulfonylurea herbicides in human urine. The metabolites measured in the method include atrazine mercapturate, desethyl atrazine, and desisopropyl atrazine as markers of...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/31.4.181
更新日期：2007-05-01 00:00:00
abstract：:In this study, the relationships between the concentrations of R/S-methamphetamine (MA) and its metabolite R/S-amphetamine (AP), the AP/MA ratio in hair samples, and MA dependence were investigated by performing segmental hair analysis in MA users. Authentic hair samples collected from 10 chronic MA abusers were cut i...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkz089
更新日期：2020-07-31 00:00:00
abstract：:An assay for neurotoxic esterase (neuropathy target esterase, NTE) was developed by Johnson (1,2) to assess the delayed neurotoxic potential of organophosphorus compounds. NTE activity is calculated from the rate of phenyl valerate hydrolysis resistant to paraoxon and sensitive to mipafox inhibition under specified co...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/15.2.86
更新日期：1991-03-01 00:00:00
abstract：:Two cases of lethal overdose by temazepam are presented. In both cases, temazepam was the only drug detected, and there was no involvement of alcohol. The drug concentrations in blood, urine, and liver were measured. ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/10.2.77
更新日期：1986-03-01 00:00:00
abstract：:The Connecticut Department of Public Safety laboratory recently addressed a legal challenge to a hospital alcohol dehydrogenase (ADH)-based serum ethanol determination based on the suggestion of interference by lactate dehydrogenase (LDH)-catalyzed oxidation of lactate. Both ADH- and LDH-oxidations require NAD(+) (pre...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/33.8.561
更新日期：2009-10-01 00:00:00
abstract：:The opioids codeine and morphine have legitimate uses in managing chronic pain conditions, but they are frequently abused. Patients prescribed opioids submit urine samples for medication compliance monitoring, and the interpretation of the results is complex. The purpose of this study was to evaluate the percentage of...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkv031
更新日期：2015-06-01 00:00:00
abstract：:This manuscript details a validated liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (LC-APCI-MS-MS) method for the quantification of methadone and its metabolites 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyroline (EMDP) in 0.5 mL ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/31.5.265
更新日期：2007-06-01 00:00:00
