Abstract:
:A woman was alleged to have committed suicide by consuming a gasoline additive shortly before jumping from a second floor balcony within her home. She was found dead by police with a multitude of injuries, lying nude in a partially evaporated unknown residue that was later determined to be methanol. Samples collected at autopsy were found to contain methanol in the following concentrations: femoral blood 31.2 mg/dL, pulmonary artery blood 111.0 mg/dL, aortic blood 77.8 mg/dL, vitreous fluid 196.4 mg/dL, brain 22.0 mg/100 g, liver 21.2 mg/100 g, and kidney 25.9 mg/100 g using a headspace gas chromatographic method. Significantly, no methanol was detected in samples recovered from the esophagus, stomach, duodenum, small intestine, bile, or urine. These findings are inconsistent with either recent or delayed oral ingestion of methanol. We concluded that absorption of methanol occurred dermally and through the oral mucosa as she lay dying and saturated in the fuel additive. Based upon the toxicological data and a comprehensive forensic investigation (including documentation and analysis of evidence recovered at the scene and the autopsy), the cause of death was determined to be blunt impact trauma and methanol poisoning.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Avella J,Briglia E,Harleman G,Lehrer Mdoi
10.1093/jat/29.7.734keywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
734-7issue
7eissn
0146-4760issn
1945-2403journal_volume
29pub_type
杂志文章abstract::An online automatic sample cleanup system was developed for use with electrospray ionization tandem mass spectrometry (ESI-MS-MS) for the quantitative detection of the benzene exposure biomarker S-phenylmercapturic acid (S-PMA) in human urine. The sample clean-up system was constructed with an autosampling device, a r...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.4.205
更新日期:2002-05-01 00:00:00
abstract::The concentrations of amphetamine and methamphetamine in a new lyophilized human urine reference material (RM) were determined at the National Institute of Standards and Technology, in cooperation with the College of American Pathologists. In order to minimize the possibility of undetected bias, two different methods ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/17.3.165
更新日期:1993-05-01 00:00:00
abstract::Hydrocodone in combination with acetaminophen is commonly used to control moderate pain and is metabolized by cytochrome P4502D6 to form the active metabolite, hydromorphone. The purpose of this study was to determine the metabolic relationship and variability between hydrocodone and its conversion to hydromorphone us...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bks019
更新日期:2012-05-01 00:00:00
abstract::A liquid chromatographic-mass spectrometric assay with atmospheric pressure chemical ionization is presented for quantification (selected-ion mode) of tramadol (T) and O-desmethyltramadol (ODT) in blood plasma after liquid-liquid extraction. The enantiomeric separation was achieved on a Chiralpak AD column containing ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/30.7.463
更新日期:2006-09-01 00:00:00
abstract::Sampling and drug stability in oral fluid (OF) are crucial factors when interpreting forensic toxicological analysis, mainly because samples may not be analyzed immediately after collection, potentially altering drug concentrations. Therefore, the stability of some common drugs of abuse (morphine, codeine, 6-monoacety...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz114
更新日期:2020-07-31 00:00:00
abstract::A simple, time-saving procedure to measure aluminum (AI) in whole blood, plasma, and water samples of low ionic strength by flameless atomic absorption spectrometry is presented. With this procedure, an analagous pretreatment is given to all samples. Moreover, the pretreated samples are analyzed using an identical pro...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/9.3.97
更新日期:1985-05-01 00:00:00
abstract::The opioids codeine and morphine have legitimate uses in managing chronic pain conditions, but they are frequently abused. Patients prescribed opioids submit urine samples for medication compliance monitoring, and the interpretation of the results is complex. The purpose of this study was to evaluate the percentage of...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkv031
更新日期:2015-06-01 00:00:00
abstract::Radioactive methadone, phenytoin, phenobarbital, and diazepam were easily and efficiently removed from human urine samples by adsorption on C18 bonded silica phases. These techniques were simpler than conventional extractions at pH 9.3 or 5.2 with dichloromethane, XAD-2 and methanol, or Celite 560 and dichloromethane....
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/9.6.269
更新日期:1985-11-01 00:00:00
abstract::Synthetic cannabinoids are a group of compounds that are structurally diverse and are commonly found in various herbal incense and potpourri blends, which are sold in convenience stores, smoke shops and over the Internet. During the past few years, multiple state and federal legislations have been enacted controlling ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkt062
更新日期:2013-10-01 00:00:00
abstract::First synthesized in 1970, propafenone is a frequently used 1C antiarrhythmic drug metabolized into two major metabolites, 5-hydroxypropafenone and norpropafenone. Paradoxically, fatal intoxication is rarely described, and only six cases have been reported in the literature. We report our experience with two patients ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.8.595
更新日期:2003-11-01 00:00:00
abstract::An assay for neurotoxic esterase (neuropathy target esterase, NTE) was developed by Johnson (1,2) to assess the delayed neurotoxic potential of organophosphorus compounds. NTE activity is calculated from the rate of phenyl valerate hydrolysis resistant to paraoxon and sensitive to mipafox inhibition under specified co...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/15.2.86
更新日期:1991-03-01 00:00:00
abstract::A sensitive and specific gas chromatography/mass spectrometry (GC/MS) method has been developed for the simultaneous analysis of methampthetamine and its metabolites (amphetamine, p-hydroxymethamphetamine, and p-hydroxyamphetamine) in monkey urine. The method has been applied to the analysis of urine samples from monk...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/13.2.117
更新日期:1989-03-01 00:00:00
abstract::Storage of drug-based evidence inside sealed safes may allow chemical vapors to accumulate, creating concerns of drug exposure by inhalation, or the possibility of cross-contamination of drug evidence. Air samples were taken from inside eight drug safes and one small storage room at nine city and country police statio...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章,多中心研究
doi:10.1093/jat/bky011
更新日期:2018-06-01 00:00:00
abstract::Quetiapine fumarate (Seroquel) is a dibenzothiazepine psychotropic agent that was introduced in 1997 for treating psychoses. Quetiapine is being found with increasing frequency in postmortem cases in Virginia. We report the postmortem results and histories of 20 quetiapine cases from the Office of the Chief Medical Ex...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/30.4.287
更新日期:2006-05-01 00:00:00
abstract::We describe an assay for measuring cocaine and benzoylecgonine in meconium of infants born to mothers suspected of using cocaine during their pregnancy. The assay involves the use of fluorescence polarization immunoassay (FPIA) to screen for benzoylecgonine in a methanolic extract of the meconium. The FPIA is sensitiv...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/16.4.261
更新日期:1992-07-01 00:00:00
abstract::The metabolism of N-benzylpiperazine (BZP), a recently scheduled designer drug, in the rat has been studied by analyzing its urinary metabolites. p-Hydroxy-BZP (p-OH-BZP) was unequivocally identified as the main metabolite along with a minor metabolite m-hydroxy-BZP (m-OH-BZP), using gas chromatography-mass spectromet...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/30.1.38
更新日期:2006-01-01 00:00:00
abstract::A rapid and simple method is described for the separation of quinidine (Q), its metabolites 3-hydroxyquinidine (30HQ) and 2'oxoquinidinone (QD) as well as the quinidine salt contaminant, dihydroquinidine (DHQ) in plasma by high pressure liquid chromatography (HPLC). A silica column was used with methanol: 1 N ammonium...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/6.3.153
更新日期:1982-05-01 00:00:00
abstract::The aim of the present study was to develop and validate a method for the detection and quantitation of drugs of abuse in oral fluids. Fortified oral fluid samples (made in-house) and samples from donors collected with Quantasil oral fluid collection kits from Immunalysis were screened on an Olympus 5400 using reagent...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/32.8.605
更新日期:2008-10-01 00:00:00
abstract::Phenazepam and etizolam were the first uncontrolled benzodiazepines available for sale in the UK. Pyrazolam, flubromazepam and diclazepam are not used medicinally anywhere in the world; they are produced exclusively for the uncontrolled, recreational market. It is important to know whether potentially abused drugs lik...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkv122
更新日期:2016-03-01 00:00:00
abstract::The purpose of this study was to develop and validate a gas chromatography-mass spectrometry method to detect drugs of abuse in a single sample of tooth. Pulverized samples of dental materials were subjected to acid hydrolysis to detect opiates, cocaine and their metabolites. The residual dental materials from these a...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkw105
更新日期:2017-01-01 00:00:00
abstract::A group of 16 volatile substances (ethyl acetate, 2-propanol, 1-propanol, methanol, acetone, ethanol, acetaldehyde, diethyl ether, methyl ethyl ketone, 1-butanol, 2-butanol, t-butanol, isobutanol, 2-methyl-1-butanol, 3-methyl-1-butanol, 1-pentanol) were qualitatively and quantitatively analyzed through a method develo...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkaa154
更新日期:2020-10-08 00:00:00
abstract::The purpose of this study was to determine the performance characteristics of the Cozart Methadone Microplate ELISA assay for the detection of methadone and methadone metabolites in hair specimens. One hundred and ten hair specimens were collected from volunteers (n=46) with a history of drug use and from drug-related...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.7.678
更新日期:2005-10-01 00:00:00
abstract::Publications reporting concentrations of caffeine in postmortem blood were reviewed if the cause of death was attributed to overdosing (poisoning) with drugs. Age and gender of the deceased, the manner of death (accident, suicide or undetermined) and types of co-ingested drugs were evaluated in relation to the concent...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章,评审
doi:10.1093/jat/bkx011
更新日期:2017-04-01 00:00:00
abstract::Since the introduction in 1990, the solid-phase microextraction (SPME) technology has brought significant progress in many fields of forensic sciences due to the versatility of this fast and solventless alternative to conventional extraction techniques. A systematic review about SPME applications in forensic context f...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz077
更新日期:2020-04-30 00:00:00
abstract::Pharmacogenomics is the study of the linkage between an individual's genotype and the disposition of drugs in the body. The first association between adverse drug reactions and inherited variations was recognized in the 1950s, and since then, pharmacogenomics has come a long way. The importance of pharmacogenomics is ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章,评审
doi:10.1093/jat/30.2.65
更新日期:2006-03-01 00:00:00
abstract::Fentanyl is a potent, short-acting narcotic analgesic widely used as a surgical anesthetic and for the control of pain when administered in the form of a transdermal patch. The success of the patch can be attributed to fentanyl's low molecular weight and its highly lipophilic nature, which enables it to be readily abs...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/24.7.627
更新日期:2000-10-01 00:00:00
abstract::Draft guidelines for the use of oral fluid for workplace drug testing are under development by the Substance Abuse and Mental Health Services Administration (SAMHSA) in cooperation with industry and researchers. Comparison studies of the effectiveness of oral fluid testing versus urine testing are needed to establish ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.8.541
更新日期:2002-11-01 00:00:00
abstract::A simple and efficient method, based on the adsorption properties of octadecasilane bonded silica, is described for the rapid extraction of acidic drugs from whole post mortem blood. The blood was diluted, passed through an extraction column containing the bonded silica and the absorbed drugs were eluted with methanol...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/7.3.116
更新日期:1983-05-01 00:00:00
abstract::This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.2.138
更新日期:2004-03-01 00:00:00
abstract::This manuscript details a validated liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (LC-APCI-MS-MS) method for the quantification of methadone and its metabolites 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyroline (EMDP) in 0.5 mL ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/31.5.265
更新日期:2007-06-01 00:00:00