Analysis of codeine positivity in urine of pain management patients.

abstract：:A 24-year-old man known to consume illegal drugs was found dead in his apartment. A reclosable plastic zipper bag containing several hundred milligrams of a brown powder was found close to the dead body and the first assumption of the investigators was death due to heroin intoxication. Therefore, a legal autopsy was o...

journal_title：Journal of analytical toxicology

authors： Dussy FE,Hangartner S,Hamberg C,Berchtold C,Scherer U,Schlotterbeck G,Wyler D,Briellmann TA

更新日期：2016-11-01 00:00:00

abstract：:In June 1986, an epidemic of poisoning occurred in Sierra Leone, West Africa; it involved 49 persons--with 14 deaths. Our laboratory's approach and investigation of this incident is described. Using positive chemical ionization mass spectrometry and nuclear magnetic resonance spectroscopy, the toxicant was identified ...

journal_title：Journal of analytical toxicology

authors： Hill RH Jr,Alley CC,Ashley DL,Cline RE,Head SL,Needham LL,Etzel RA

更新日期：1990-07-01 00:00:00

abstract：:The aim of this study was to investigate the early-phase postmortem redistribution of the enantiomers of citalopram (CIT) and its metabolites demethylcitalopram (DCIT) and didemethylcitalopram (DDCIT) in a rat model. Furthermore, we wanted to examine the role of the lungs as a reservoir of postmortem drug release and ...

journal_title：Journal of analytical toxicology

authors： Kugelberg FC,Kingbäck M,Carlsson B,Druid H

更新日期：2005-05-01 00:00:00

abstract：:A blood concentration of tetrahydrocannabinol (THC) in the low nanograms-per-milliliter range is often claimed to result from drug use more than 24-48 h previously. The present investigation determined concentrations of cannabinoids in blood collected at least 24 h from smoking in an in-patient setting. During samplin...

journal_title：Journal of analytical toxicology

authors： Skopp G,Pötsch L

更新日期：2008-03-01 00:00:00

abstract：:A quantitative analysis was developed for the determination of cocaine, benzoylecgonine, and cocaethylene in oral fluid using liquid chromatography-tandem mass spectrometry. After internal standardization and solid-phase extraction, chromatographic separation was achieved on a reversed-phase column by gradient elution...

journal_title：Journal of analytical toxicology

authors： Clauwaert K,Decaestecker T,Mortier K,Lambert W,Deforce D,Van Peteghem C,Van Bocxlaer J

更新日期：2004-11-01 00:00:00

abstract：:Urine specimens containing 11 common beta blockers were processed using solid-phase extraction technology to extract the drugs from the urine matrix, then converted to their cyclic methaneboronates by treatment with methaneboronic acid in ethyl acetate. The compounds tested included acebutolol, atenolol, alprenolol, b...

journal_title：Journal of analytical toxicology

authors： Branum GD,Sweeney S,Palmeri A,Haines L,Huber C

更新日期：1998-03-01 00:00:00

abstract：:Results of urine drug analyses for three racing greyhounds that tested positive for caffeine in this laboratory were contested by the animal trainer, who asserted that positives were achieved from deliberate chocolate feeding by a rival kennel. The metabolism and excretion of methylxanthines was examined by high-perfo...

journal_title：Journal of analytical toxicology

authors： Wells DJ,Hanks BM,Yarbrough CS,Davis MA

更新日期：1988-01-01 00:00:00

abstract：:A new tetracyclic antidepressant drug, maprotiline hydrochloride was found to be the agent of death in a 23-year-old subject following massive injestion (4.5-6.0 g). The case may be the first reported maprotiline death (sole cause) in the United States. Analytical parameters were studies and various chromatographic an...

journal_title：Journal of analytical toxicology

authors： Rejent TA,Doyle RE

更新日期：1982-07-01 00:00:00

abstract：:This paper describes two relatively simple methods for the microdetermination of urinary cadmium (U-Cd) and urinary nickel (U-Ni) using electrothermal atomic absorption spectrometry. Reduction of nonspecific absorption interferences was achieved by temperature programming and background correction using a deuterium ar...

journal_title：Journal of analytical toxicology

authors： Ong CN,Chua LH,Lee BL,Ong HY,Chia KS

更新日期：1990-01-01 00:00:00

abstract：:Poisoning with agricultural chemicals is a major threat for wildlife all over the world. We have developed and validated an analytical scheme aimed to the identification and quantification of a wide range of pesticides in fresh liver from wildlife specimens that are routinely delivered to the forensic laboratories for...

journal_title：Journal of analytical toxicology

authors： Luzardo OP,Ruiz-Suárez N,Valerón PF,Camacho M,Zumbado M,Henríquez-Hernández LA,Boada LD

更新日期：2014-04-01 00:00:00

abstract：:A case of lethal overdose by prilocaine, a local anaesthetic, is presented. The patient died in the dental office during treatment, and the time course of events was documented. The drug concentration in blood, urine, and liver was measured. ...

journal_title：Journal of analytical toxicology

authors： Kaliciak HA,Chan SC

更新日期：1986-03-01 00:00:00

abstract：:This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart ...

journal_title：Journal of analytical toxicology

authors： Charlier C,Kintz P,Dubois N,Plomteux G

更新日期：2004-03-01 00:00:00

abstract：:A 25 mg oral dose of cocaine HCl given to a single volunteer resulted in a peak urinary cocaine concentration of 269 ng/mL at 1 h, and a peak benzoylecgonine concentration of 7,940 ng/mL at 12 h. Urine benzoylecgonine concentrations remained in excess of 300 ng/mL for 48 h. We conclude that small, oral doses of cocain...

journal_title：Journal of analytical toxicology

authors： Baselt RC,Chang R

更新日期：1987-03-01 00:00:00

abstract：:In an attempt to improve the sensitivity and selectivity of thin-layer chromatographic analysis for the detection of strychnine and crimidine in biological samples, a rapid high-performance thin-layer chromatographic (HPTLC) method with densitometry is described. Fortified dog serum and stomach content samples were an...

journal_title：Journal of analytical toxicology

authors： De Saqui-Sannes P,Nups P,Le Bars P,Burgat V

更新日期：1996-05-01 00:00:00

abstract：:A relatively simple procedure for the determination of carboxyhemoglobin percent saturation in postmortem samples is described. The procedure involves a quick and accurate method for calibration of the gas chromatograph to carbon monoxide. The mixed gases are extracted from blood prior to introduction into the gas chr...

journal_title：Journal of analytical toxicology

authors： Hobbs LD,Jachimczyk JA,Schloegel EL

更新日期：1980-07-01 00:00:00

abstract：:A rapid and sensitive assay for pyridinium oximes in plasma and tissue was developed. The method was suitable for the analysis of mono- and di-pyridinium oximes and utilizes ultrafiltration followed by cation-exchange high-performance liquid chromatography with UV detection. The assay was originally developed for the ...

journal_title：Journal of analytical toxicology

authors： Singh H,Moorad-Doctor D,Ratcliffe RH,Wachtel K,Castillo A,Garcia GE

更新日期：2007-03-01 00:00:00

abstract：:Selegiline (SE) is a selective, irreversible monoamine oxidase-B inhibitor, used for reducing symptoms in early-stage Parkinson's disease. The metabolites of SE include l-methamphetamine, l-amphetamine and desmethylselegiline (DSE). The stereoisomers of SE metabolites, d-methamphetamine and d-amphetamine are highly ad...

journal_title：Journal of analytical toxicology

authors： Shin I,Choi H,Kang S,Kim J,Park Y,Yang W

更新日期：2020-05-30 00:00:00

abstract：:The aim of this study was to develop, optimize, and validate an analytical procedure to determine a group of eight amphetamines, amphetamine (AMP), ephedrine (EP), methcathinone (MTC), paramethoxyamphetamine (PMA), methamphetamine (MA), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methyle...

journal_title：Journal of analytical toxicology

authors： Stanaszek R,Piekoszewski W

更新日期：2004-03-01 00:00:00

abstract：:A previously reported procedure for quantification of LSD in urine was modified to permit measurement of the drug in plasma. After addition of deuterium-labelled LSD, the plasma is extracted and the extract is treated with trifluoroacetylimidazole to convert the LSD to its N-trifluoroacetyl derivative. The derivatized...

journal_title：Journal of analytical toxicology

authors： Papac DI,Foltz RL

更新日期：1990-05-01 00:00:00

abstract：:An enzyme multiplied immunoassay technique (EMIT) was used to test for opiates (morphine, hydromorphone, and codeine) in extracts of blood, bile, and tissue homogenates. All immunoassay opiate positive specimens were then tested by a reversed-phase liquid chromatographic procedure using electrochemical detection (LCEC...

journal_title：Journal of analytical toxicology

authors： Hepler BR,Sutheimer C,Sunshine I,Sebrosky GF

更新日期：1984-03-01 00:00:00

abstract：:Improvements have been made in recent years in on-site or point-of-care (POC) immunoassay testing devices. We evaluated the DrugCheck 9 cup, a new qualitative visually read, competitive binding, immunoassay cup that measures nine analytes. The study was performed according to the recent National Laboratory Certificati...

journal_title：Journal of analytical toxicology

authors： Taylor EH,Pizzo P

更新日期：2004-04-01 00:00:00

abstract：:The effects of decomposition microclimate on the distribution of dextromethorphan (DXM) and dextrorphan (DXT) in skeletonized remains of rats acutely exposed to DXM were examined. Animals (n = 10) received DXM (75 mg/kg, i.p.), were euthanized 30 min post-dose and immediately allowed to decompose at either Site A (sha...

journal_title：Journal of analytical toxicology

authors： Unger KA,Watterson JH

更新日期：2016-10-01 00:00:00

abstract：:Part I. Expert 4: The object of this study was to investigate the applicability of commercially available expert system shells to interpretation in forensic toxicology. Amitriptyline toxicology was selected as a pilot trial. Blood and tissue concentrations of amitriptyline and nortriptyline in fatal and nonfatal amitr...

journal_title：Journal of analytical toxicology

authors： Spiehler V,Spiehler E,Osselton MD

更新日期：1988-07-01 00:00:00

abstract：:A 22-year-old male with more than 28 needle marks on his right arm was found dead. First, he was suspected as a drug abuser. Blood, urine, spleen, and injection-site tissue was collected during autopsy. The blood and urine specimens were screened for drugs. Immunoassay studies did not show any illegal drugs. However, ...

journal_title：Journal of analytical toxicology

authors： Chung H,Choi H,Kim E,Jin W,Lee H,Yoo Y

更新日期：2000-05-01 00:00:00

abstract：:A GC/MS method for the simultaneous determination of morphine, codeine, and O-6-monoacetylmorphine as well as other semisynthetic opiates in urine is described. The method employs 2H6-acetic anhydride to acetylate free hydroxyl groups on all of the opiates. As a result, the same hydrolysis and extraction procedure is ...

journal_title：Journal of analytical toxicology

authors： Bowie LJ,Kirkpatrick PB

更新日期：1989-11-01 00:00:00

abstract：:The abuse of the designer amphetamines such as 3,4-methylenedioxymethamphetamine (MDMA) is increasing throughout the world. They have become popular drugs at all night techno dance parties, and their detection is an important issue. The objective of the presented study was to identify an unknown compound detected by t...

journal_title：Journal of analytical toxicology

authors： Maresova V,Hampl J,Chundela Z,Zrcek F,Polasek M,Chadt J

更新日期：2005-07-01 00:00:00

abstract：:A sensitive and robust ultra-high-performance liquid chromatography-tandem mass spectrometry method has been developed and validated for the quantification of acetaminophen, dexchlorpheniramine, caffeine, cotinine and salicylic acid in postmortem blood samples from children younger than 4 years. The sample was prepare...

journal_title：Journal of analytical toxicology

authors： Krpo M,Arnestad M,Karinen R

更新日期：2018-03-01 00:00:00

abstract：:A liquid chromatographic method was developed for the analysis of indandione and 4-hydroxycoumarin anticoagulant rodenticides in blood serum and liver. The method enabled the measurement of serum and liver concentrations of eight anticoagulant rodenticides: brodifacoum, bromadiolone, chlorophacinone, coumafuryl, couma...

journal_title：Journal of analytical toxicology

authors： Chalermchaikit T,Felice LJ,Murphy MJ

更新日期：1993-01-01 00:00:00

abstract：:The purpose of this study was to determine the performance characteristics of the Cozart Methadone Microplate ELISA assay for the detection of methadone and methadone metabolites in hair specimens. One hundred and ten hair specimens were collected from volunteers (n=46) with a history of drug use and from drug-related...

journal_title：Journal of analytical toxicology

authors： Cooper G,Wilson L,Reid C,Baldwin D,Hand C,Spiehler V

更新日期：2005-10-01 00:00:00

abstract：:A preliminary investigation was undertaken to determine the feasibility of monitoring saliva levels of drugs for forensic purposes. Single oral doses of the title compounds were administered to healthy volunteers. Plasma and saliva levels were measured and ratios calculated for all drugs except diazepam. Saliva/plasma...

journal_title：Journal of analytical toxicology

authors： Sharp ME,Wallace SM,Hindmarsh KW,Peel HW

更新日期：1983-01-01 00:00:00