Abstract：
:An enzyme multiplied immunoassay technique (EMIT) was used to test for opiates (morphine, hydromorphone, and codeine) in extracts of blood, bile, and tissue homogenates. All immunoassay opiate positive specimens were then tested by a reversed-phase liquid chromatographic procedure using electrochemical detection (LCEC). Blood specimens were then quantitated by LCEC. The sensitivity of the immunoassay (as morphine) was 0.020 mg/L, 0.200 mg/L, and 0.100 mg/kg for blood, bile, and tissue homogenates, respectively, with 2% intrarun and 7% interrun precision. The LCEC method was linear from 0.005 to 0.300 mg/L for morphine, hydromorphone, and codeine (nalorphine internal standard) with detection limits of 0.005 mg/L for each analyte. Intrarun and interrun precision varied from 1 to 2% and 6 to 11%, respectively. Recoveries, using a double extraction technique, ranged from 70 to 95%. These two methods, applied to 495 post mortem cases, demonstrated a 6% incidence of opiates, with no false positives.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Hepler BR,Sutheimer C,Sunshine I,Sebrosky GFdoi
10.1093/jat/8.2.78subject
Has Abstractpub_date
1984-03-01 00:00:00pages
78-90issue
2eissn
0146-4760issn
1945-2403journal_volume
8pub_type
杂志文章abstract：:Use of methiopropamine (MPA), a synthetic metamfetamine analog, has been detected since 2011 in Europe, but there is limited information on its acute toxicity. A 30-year-old man was admitted to the emergency department in a confused state, with paranoid delusion, auditory and visual hallucinatory experiences, and inco...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkw073
更新日期：2016-11-01 00:00:00
abstract：:The present study evaluates the suitability of headspace gas chromatography (GC) with a capillary column as a method for determining the ethanol content in different biological fluids. This procedure allows the use of headspace GC not only as a reference method but also in routine diagnostics and monitoring work. The ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/19.4.241
更新日期：1995-07-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/32.1.31
更新日期：2008-01-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/29.8.814
更新日期：2005-11-01 00:00:00
abstract：:While earlier studies have attempted to resolve the challenges encountered when interpreting gamma-hydroxybutyric acid (GHB) concentrations in hair (primarily due to its endogenous presence), few have had large sample sizes. The first objective of this study was to evaluate the inter-individual variation of endogenous...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkaa080
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/32.1.92
更新日期：2008-01-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/11.6.237
更新日期：1987-11-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/34.5.261
更新日期：2010-06-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkw019
更新日期：2016-05-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bky073
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/24.7.562
更新日期：2000-10-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkw025
更新日期：2016-06-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/33.8.439
更新日期：2009-10-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/28.5.384
更新日期：2004-07-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/33.7.389
更新日期：2009-09-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/20.6.509
更新日期：1996-10-01 00:00:00
abstract：:Baclofen (Lioresal), a lipophilic analogue of c-aminobutyric acid (GABA), and carisoprodol (Soma), a central nervous system depressant with an unknown mechanism of pharmacologic action, are categorized as muscle relaxants. Baclofen is used clinically in the management of spasticity and its sequelae secondary to severe...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/27.5.275
更新日期：2003-07-01 00:00:00
abstract：:A sensitive method for identifying and quantifying brucine by means of liquid chromatography-tandem mass spectrometry is presented in this article. Based on a solid-phase extraction for human serum, the validation indicated limits of detection and quantification of 0.12 and 0.23 ng/mL, respectively. In one case of let...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/anatox/35.4.248
更新日期：2011-05-01 00:00:00
abstract：:A 69-year-old male radio technician drank an unknown amount of a liquid and died within 5 h at a hospital. Mainly silver, potassium, and calcium, among other substances, were found in the residue of the liquid from the empty bottle by means of the spectrographic method (30.7% silver and 25.5% potassium using atomic ab...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/21.7.580
更新日期：1997-11-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/21.6.420
更新日期：1997-10-01 00:00:00
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journal_title：Journal of analytical toxicology
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doi：10.1093/jat/13.3.176
更新日期：1989-05-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章,多中心研究
doi：10.1093/jat/bky011
更新日期：2018-06-01 00:00:00
abstract：:A rapid and sensitive assay for pyridinium oximes in plasma and tissue was developed. The method was suitable for the analysis of mono- and di-pyridinium oximes and utilizes ultrafiltration followed by cation-exchange high-performance liquid chromatography with UV detection. The assay was originally developed for the ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/31.2.69
更新日期：2007-03-01 00:00:00
abstract：:An arsenic death was investigated six and one half years after the demise. Analysis of tissue embedded in paraffin blocks demonstrated toxic concentrations. Spectrophotometry was employed with the use of a hydride generator to provide specificity and sensitivity to less than 0.05 microgram. ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/6.5.260
更新日期：1982-09-01 00:00:00
abstract：:The gelsemium plants are highly poisonous but toxicological evaluation of suspected poisoning cases has been hampered by the chemical complexity of the gelsemium toxins involved. A novel liquid chromatography-tandem mass spectrometry protocol was optimized for the collective detection of gelsemine and related alkaloid...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/33.1.56
更新日期：2009-01-01 00:00:00
abstract：:Ethylene glycol (EG), a relatively infrequent cause of fatal intoxication, presents an analytical challenge for forensic confirmation in postmortem toxicology. We report EG and glycolic acid (GA) quantification in postmortem blood by gas chromatography coupled with ion trap mass spectrometry (GC-MS) analysis using a m...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/33.8.508
更新日期：2009-10-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/6.1.10
更新日期：1982-01-01 00:00:00
abstract：:Exposure to drugs and toxins is a major cause for the rising number of emergency department visits each year. Immunoassays are commonly used in the emergency department to provide rapid turnaround time for acute care. The purpose of this study was to compare two automated immunoassay chemistry analyzers to determine w...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bks028
更新日期：2012-06-01 00:00:00
abstract：:A simple, rapid, and reliable gas-liquid chromatographic (GLC) confirmation procedure was developed for urine samples found positive by the EMIT-dau benzodiazepine metabolite assay. The procedure involves acid hydrolysis, organic extraction, and identification using GLC-nitrogen-phosphorus detection (NPD). The method ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/6.6.305
更新日期：1982-11-01 00:00:00
abstract：:A high performance liquid chromatographic method is reported, which incorporates three internal standards (I-cinchonidine, N-propylprocainamide, and para-chlorodisopyramide) for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: quinidine, procainamide, N-acetylprocainamide, and disopyrami...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/7.2.65
更新日期：1983-03-01 00:00:00
