Direct determination of ethyl glucuronide and ethyl sulfate in postmortem urine specimens using hydrophilic interaction liquid chromatography-electrospray ionization-tandem mass spectrometry.

abstract：:Sterile whole human blood control materials were commercially prepared in batches containing anticoagulants and preservatives and approximately 90, 150, and 230 mg/dL ethanol with and without 0.3% (w/v) sodium azide. Aliquots in sealed vials were stored by the manufacturer at 2-8 degrees C until shipped monthly to thr...

journal_title：Journal of analytical toxicology

authors： Dubowski KM,Gadsden RH Sr,Poklis A

更新日期：1997-10-01 00:00:00

abstract：:There have been numerous reports of lead poisoning resulting from the ingestion of foreign bodies. A case involving the ingestion of spent air rifle pellets is described. No clinical symptoms were observed, despite the fact that the young child exhibited elevated blood lead levels as high as 2.7 micromol/L (56 microg/...

journal_title：Journal of analytical toxicology

authors： Treble RG,Thompson TS

更新日期：2002-09-01 00:00:00

abstract：:Despite the efforts to prevent the spread of new psychoactive substances (NPS) such as synthetic amphetamine derivatives, it is apparent that newer types of NPS are still emerging on the market in recent years. Due to high potential for their abuse, reliable analytical methods are required to determine these substance...

journal_title：Journal of analytical toxicology

authors： Kim JY,Suh S,Park J,In MK

更新日期：2018-11-01 00:00:00

abstract：:A high performance liquid chromatographic method is described for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: lidocaine, mexiletine, disopyramide, and quinidine. An isocratic system using a reverse phase column was used to separate these compounds. Coefficients of variation were les...

journal_title：Journal of analytical toxicology

authors： Dusci LJ,Hackett LP

更新日期：1985-03-01 00:00:00

abstract：:A sensitive and specific method for the quantitative determination of D,L-methadone (MD) and its metabolites, D,L-2-ethyl-1,5-dimethyl-3, 3-diphenylpyrrolinium (EDDP) and D,L-2-ethyl-5-methyl-3, 3-diphenyl-1-pyrroline (EMDP), in hair has been developed. Deuterated internal standards of MD, EMDP, and EDDP were added to...

journal_title：Journal of analytical toxicology

authors： Wilkins DG,Nagasawa PR,Gygi SP,Foltz RL,Rollins DE

更新日期：1996-10-01 00:00:00

abstract：:The retention index system is a reproducible means for the identification of drugs in toxicology samples analyzed by gas chromatography with flame ionization detectors. Nitrogen-phosphorus (NP) detectors do not respond well to the standard n-alkanes, which lack nitrogen and phosphorus groups and which are used to obta...

journal_title：Journal of analytical toxicology

authors： Watts VW,Simonick TF

更新日期：1987-09-01 00:00:00

abstract：:Although many deaths occur annually from heroin intoxication, the presence of heroin has not been reported in postmortem tissues. Recognizing heroin's susceptibility to rapid chemical and metabolic hydrolysis, extraction procedures were developed for the efficient recovery of heroin, 6-acetylmorphine, and morphine fro...

journal_title：Journal of analytical toxicology

authors： Goldberger BA,Cone EJ,Grant TM,Caplan YH,Levine BS,Smialek JE

更新日期：1994-01-01 00:00:00

abstract：:A previously reported procedure for quantification of LSD in urine was modified to permit measurement of the drug in plasma. After addition of deuterium-labelled LSD, the plasma is extracted and the extract is treated with trifluoroacetylimidazole to convert the LSD to its N-trifluoroacetyl derivative. The derivatized...

journal_title：Journal of analytical toxicology

authors： Papac DI,Foltz RL

更新日期：1990-05-01 00:00:00

abstract：:We report the validation of a quantitative method for paraquat in plasma and urine using high-performance liquid chromatography (HPLC) with ultraviolet detection (260 nm). Furthermore, we illustrate the use of this method in the clinic (over five years), in conjunction with a qualitative urine paraquat screen. Urine o...

journal_title：Journal of analytical toxicology

authors： Taylor PJ,Salm P,Pillans PI

更新日期：2001-09-01 00:00:00

abstract：:Bleach, nitrite, chromate, and hydrogen peroxide-peroxidase are effective urine adulterants used by the illicit drug users to conceal marijuana-positive results. Methods for detecting nitrite and chromate are available. Effects of other oxidizing agents that could possibly be used as adulterants and are difficult to d...

journal_title：Journal of analytical toxicology

authors： Paul BD,Jacobs A

更新日期：2002-10-01 00:00:00

abstract：:A GC/MS method for the simultaneous determination of morphine, codeine, and O-6-monoacetylmorphine as well as other semisynthetic opiates in urine is described. The method employs 2H6-acetic anhydride to acetylate free hydroxyl groups on all of the opiates. As a result, the same hydrolysis and extraction procedure is ...

journal_title：Journal of analytical toxicology

authors： Bowie LJ,Kirkpatrick PB

更新日期：1989-11-01 00:00:00

abstract：:A new tetracyclic antidepressant drug, maprotiline hydrochloride was found to be the agent of death in a 23-year-old subject following massive injestion (4.5-6.0 g). The case may be the first reported maprotiline death (sole cause) in the United States. Analytical parameters were studies and various chromatographic an...

journal_title：Journal of analytical toxicology

authors： Rejent TA,Doyle RE

更新日期：1982-07-01 00:00:00

abstract：:This paper describes two relatively simple methods for the microdetermination of urinary cadmium (U-Cd) and urinary nickel (U-Ni) using electrothermal atomic absorption spectrometry. Reduction of nonspecific absorption interferences was achieved by temperature programming and background correction using a deuterium ar...

journal_title：Journal of analytical toxicology

authors： Ong CN,Chua LH,Lee BL,Ong HY,Chia KS

更新日期：1990-01-01 00:00:00

abstract：:A method for the simultaneous extraction of the hallucinogens psilocin, bufotenine, lysergic acid diethylamide (LSD) as well as iso-LSD, nor-LSD and O-H-LSD from hair with hydrochloride acid and methanol is presented. Clean-up of the hair extracts is performed with solid phase extraction using a mixed-mode cation exch...

journal_title：Journal of analytical toxicology

authors： Martin R,Schürenkamp J,Gasse A,Pfeiffer H,Köhler H

更新日期：2015-03-01 00:00:00

abstract：:An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method was developed and validated for the simultaneous determination of Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THC-COOH) in whole blo...

journal_title：Journal of analytical toxicology

authors： Jamey C,Szwarc E,Tracqui A,Ludes B

更新日期：2008-06-01 00:00:00

abstract：:cis(Z)-Clopenthixol and trans(E)-clopenthixol were determined by gas chromatography-mass spectrometry and high-performance liquid chromatography-diode-array detection in necropic samples from a postmortem case. The peripheral blood concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol were 278 and 177 ng/mL,...

journal_title：Journal of analytical toxicology

authors： Rop PP

更新日期：2001-07-01 00:00:00

abstract：:A rapid capillary gas-liquid chromatographic method for the determination of barbiturates in plasma at concentrations of clinical importance is presented. This method employs a rapid and simple extraction procedure and direct flame ionization detection with no derivatization. ...

journal_title：Journal of analytical toxicology

authors： Wallace JE,Hall LR,Harris SC

更新日期：1983-07-01 00:00:00

abstract：:Exemplars of current commercial breath-alcohol simulators were studied to ascertain their suitability for control tests and as calibrators in breath-alcohol analysis. Temperature, effluent volumes and pressures, effluent-alcohol concentration, and alcohol depletion were measured for simulators coupled with various cur...

journal_title：Journal of analytical toxicology

authors： Dubowski KM,Essary NA

更新日期：1991-09-01 00:00:00

abstract：:Given that external contamination must be considered in hair analysis, there is still a demand for reliable tools to differentiate between incorporation of drugs into the hair as a result of drug consumption and of the hair shaft by external contamination. With the aim of establishing alternative discrimination parame...

journal_title：Journal of analytical toxicology

authors： Scholz C,Quednow BB,Herdener M,Kraemer T,Baumgartner MR

更新日期：2019-08-23 00:00:00

abstract：:An automated solid-phase extraction (SPE) protocol followed by gas chromatography coupled with tandem mass spectrometry was developed for quantification of caffeine, cyamemazine, meprobamate, morphine and 6-monoacetylmorphine (6-MAM) in 11 biological matrices [blood, urine, bile, vitreous humor, liver, kidney, lung an...

journal_title：Journal of analytical toxicology

authors： Bévalot F,Bottinelli C,Cartiser N,Fanton L,Guitton J

更新日期：2014-06-01 00:00:00

abstract：:Human exposure to organophosphate pesticides can be estimated from the presence of urinary metabolites. An isotope-dilution gas chromatography-tandem mass spectrometry (GC-MS-MS) method was developed for quantitating the six dialkyl phosphate urinary metabolites of at least 29 organophosphate pesticides. Urine samples...

journal_title：Journal of analytical toxicology

authors： Bravo R,Driskell WJ,Whitehead RD Jr,Needham LL,Barr DB

更新日期：2002-07-01 00:00:00

abstract：:A liquid chromatographic method for the determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and male and female B6C3F1 mouse urine was developed for use in supporting toxicokinetic studies, validated, and used to analyze urine samples for a preliminary dose level range-find...

journal_title：Journal of analytical toxicology

authors： Gaudette NF,Lodge JW

更新日期：2005-01-01 00:00:00

abstract：:A high-performance liquid chromatographic system based on gradient elution of an alumina packing material coated with polybutadiene is presented. The chromatographic eluent is a mixture of methanol and water, both containing 0.0125M NaOH. The effluent is monitored by photodiode array detection. The system allows detec...

journal_title：Journal of analytical toxicology

authors： Lambert WE,Meyer E,De Leenheer AP

更新日期：1995-03-01 00:00:00

abstract：:The collection and analysis of drugs in oral fluid (OF) at the roadside has become more feasible with the introduction of portable testing devices such as the Alere™ DDS®2 Mobile Test System (DDS®2). The objective of this study was to compare the on-site results for the DDS®2 to laboratory-based confirmatory assays wi...

journal_title：Journal of analytical toxicology

authors： Krotulski AJ,Mohr ALA,Friscia M,Logan BK

更新日期：2018-04-01 00:00:00

abstract：:We present an analytical method for the determination of heroin, free 6-acetylmorphine (6-AM), and free morphine in blood, urine, and vitreous humor. This method is used in postmortem cases where heroin is the suspected cause of death. The analytical protocol includes the following steps: liquid-liquid extraction at p...

journal_title：Journal of analytical toxicology

authors： Guillot JG,Lefebvre M,Weber JP

更新日期：1997-03-01 00:00:00

abstract：:Poisoning with agricultural chemicals is a major threat for wildlife all over the world. We have developed and validated an analytical scheme aimed to the identification and quantification of a wide range of pesticides in fresh liver from wildlife specimens that are routinely delivered to the forensic laboratories for...

journal_title：Journal of analytical toxicology

authors： Luzardo OP,Ruiz-Suárez N,Valerón PF,Camacho M,Zumbado M,Henríquez-Hernández LA,Boada LD

更新日期：2014-04-01 00:00:00

abstract：:A selective, sensitive, and reliable method was devised to determine concentrations of amitriptyline and its major metabolite, nortriptyline, in human plasma using high-performance liquid chromatography (HPLC) combined with UV and particle beam mass spectrometry (PBMS). Amitriptyline and nortriptyline were effectively...

journal_title：Journal of analytical toxicology

authors： Kudo K,Jitsufuchi N,Imamura T

更新日期：1997-05-01 00:00:00

abstract：:A method utilizing microwave dissolution in a closed Teflon bomb followed by hydride generation atomic absorption spectrometry has been used for the routine analysis of arsenic in fish species from the coast of the province of Granada, Spain. The technique was evaluated for decomposing biological standard reference ma...

journal_title：Journal of analytical toxicology

authors： Navarro M,López H,López MC,Sánchez M

更新日期：1992-05-01 00:00:00

abstract：:Decomposed bone and plasma samples of rats exposed to amitriptyline (AMI) and citalopram (CIT) under different dosing patterns were analyzed. Wistar rats received one acute dose (120 mg AMI/kg and 40 mg CIT/kg; n = 5) or two doses (40 mg AMI/kg and 13 mg CIT/kg, n = 5) 40 min apart. After collection of perimortem bloo...

journal_title：Journal of analytical toxicology

authors： Watterson JH,Cornthwaite HM

更新日期：2013-10-01 00:00:00

abstract：:Previous studies have shown that drug concentrations in blood can change during storage, especially at room temperature, but even labile drugs such as cocaine may be stable in dried blood spots (DBS). A new method has been developed for the analysis of hydrolytically labile drugs in blood spots on filter paper in orde...

journal_title：Journal of analytical toxicology

authors： Alfazil AA,Anderson RA

更新日期：2008-09-01 00:00:00