Abstract:
:A sensitive method for identifying and quantifying brucine by means of liquid chromatography-tandem mass spectrometry is presented in this article. Based on a solid-phase extraction for human serum, the validation indicated limits of detection and quantification of 0.12 and 0.23 ng/mL, respectively. In one case of lethal suicidal brucine monointoxication, brucine concentrations of 1.51 μg/mL, 1.69 μg/mL, 9.94 μg/mL, 16.4 μg/g, 0.99 μg/g, 0.75 μg/g, and 1.95 mg/g were determined in femoral blood, urine, bile collected from the gallbladder, liver tissue, cerebellum, cerebrum, and stomach contents, respectively.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Teske J,Weller JP,Albrecht UV,Fieguth Adoi
10.1093/anatox/35.4.248subject
Has Abstractpub_date
2011-05-01 00:00:00pages
248-53issue
4eissn
0146-4760issn
1945-2403journal_volume
35pub_type
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