Trazodone overdose: report of two cases.

abstract：:Cannabinoids were extracted from serum with C18 SPE cartridges and analyzed as their trimethylsilyl (TMS) derivatives. A benchtop gas chromatography-tandem mass spectrometry (GC-MS-MS) system based on an ion trap with external ionization was used. Quantitation was done in relation to trideuterated internal standards i...

journal_title：Journal of analytical toxicology

authors： Weller JP,Wolf M,Szidat S

更新日期：2000-07-01 00:00:00

abstract：:Storage of drug-based evidence inside sealed safes may allow chemical vapors to accumulate, creating concerns of drug exposure by inhalation, or the possibility of cross-contamination of drug evidence. Air samples were taken from inside eight drug safes and one small storage room at nine city and country police statio...

journal_title：Journal of analytical toxicology

authors： Doran GS,Deans R,De Filippis C,Kostakis C,Howitt JA

更新日期：2018-06-01 00:00:00

abstract：:Radioactive methadone, phenytoin, phenobarbital, and diazepam were easily and efficiently removed from human urine samples by adsorption on C18 bonded silica phases. These techniques were simpler than conventional extractions at pH 9.3 or 5.2 with dichloromethane, XAD-2 and methanol, or Celite 560 and dichloromethane....

journal_title：Journal of analytical toxicology

authors： Hyde PM

更新日期：1985-11-01 00:00:00

abstract：:Synthetic cathinones have recently emerged as a substitute for common drugs of abuse. Synthetic cathinones can elicit powerful adverse effects such as delusions, hallucinations and potentially dangerous behavior. To develop a method to analyze 10 synthetic cathinones in oral fluid, we implemented a combined approach o...

journal_title：Journal of analytical toxicology

authors： Amaratunga P,Lorenz Lemberg B,Lemberg D

更新日期：2013-11-01 00:00:00

abstract：:Urine drug testing (UDT) is an emerging standard of care in the evaluation and treatment of chronic non-cancer pain patients with opioid analgesics. UDT may be used both to verify adherence with the opioid analgesic regimen and to monitor abstinence from non-prescribed or illicit controlled substances. In the former s...

journal_title：Journal of analytical toxicology

authors： Bertholf RL,Johannsen LM,Reisfield GM

更新日期：2015-01-01 00:00:00

abstract：:Despite the efforts to prevent the spread of new psychoactive substances (NPS) such as synthetic amphetamine derivatives, it is apparent that newer types of NPS are still emerging on the market in recent years. Due to high potential for their abuse, reliable analytical methods are required to determine these substance...

journal_title：Journal of analytical toxicology

authors： Kim JY,Suh S,Park J,In MK

更新日期：2018-11-01 00:00:00

abstract：:The metabolism of N-benzylpiperazine (BZP), a recently scheduled designer drug, in the rat has been studied by analyzing its urinary metabolites. p-Hydroxy-BZP (p-OH-BZP) was unequivocally identified as the main metabolite along with a minor metabolite m-hydroxy-BZP (m-OH-BZP), using gas chromatography-mass spectromet...

journal_title：Journal of analytical toxicology

authors： Tsutsumi H,Katagi M,Miki A,Shima N,Kamata T,Nakajima K,Inoue H,Kishi T,Tsuchihashi H

更新日期：2006-01-01 00:00:00

abstract：:Vitreous humor is a fluid contained in the eye that is largely composed of water. The advantages of vitreous humor as a specimen for postmortem drug analysis include its relatively low susceptibility to contamination and the ability to analyze vitreous humor with little or no pretreatment. The postmortem analysis of e...

journal_title：Journal of analytical toxicology

authors： Cox D,Jufer Phipps RA,Levine B,Jacobs A,Fowler D

更新日期：2007-10-01 00:00:00

abstract：:In order to achieve accurate quantitation of drugs and metabolites (analytes) in complex matrices, 2H- (and less commonly 13C-) labeled analogues of the analytes are now routinely adapted as the internal standards (IS) using linear calibration models to fit data generated by selected ion monitoring gas chromatography-...

journal_title：Journal of analytical toxicology

authors： Whiting TC,Liu RH,Chang WT,Bodapati MR

更新日期：2001-04-01 00:00:00

abstract：:An isotope dilution gas chromatography-tandem mass spectrometric (GC-MS-MS) method was developed for quantitating the urinary metabolites of the organophosphorus nerve agents sarin, soman, tabun (GA), VX, and GF. Urine samples were concentrated by codistillation with acetonitrile, derivatized by methylation with diazo...

journal_title：Journal of analytical toxicology

authors： Driskell WJ,Shih M,Needham LL,Barr DB

更新日期：2002-01-01 00:00:00

abstract：:Uncertainty is an inherent property of all measurements. The magnitude of this uncertainty will determine the number of meaningful digits that should be reported in a measurement result. Several statistical arguments are considered providing evidence that three digit truncated results are more appropriate than two sin...

journal_title：Journal of analytical toxicology

authors： Gullberg RG

更新日期：2015-06-01 00:00:00

abstract：:An ultra-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of 25 common pharmaceuticals in whole blood. The selected pharmaceuticals represent the most frequently detected drugs in our forensic laboratory with basic properties such as analgesics, antid...

journal_title：Journal of analytical toxicology

authors： Nielsen MK,Johansen SS

更新日期：2012-09-01 00:00:00

abstract：:An automated column-switching liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometric (LC-APCI-MS) method for the simultaneous determination of frequently encountered benzodiazepine hypnotics and their relevant metabolites in urine has been established. A column-switching online solid-phase ...

journal_title：Journal of analytical toxicology

authors： Miki A,Tatsuno M,Katagi M,Nishikawa M,Tsuchihashi H

更新日期：2002-03-01 00:00:00

abstract：:A rapid and sensitive assay for pyridinium oximes in plasma and tissue was developed. The method was suitable for the analysis of mono- and di-pyridinium oximes and utilizes ultrafiltration followed by cation-exchange high-performance liquid chromatography with UV detection. The assay was originally developed for the ...

journal_title：Journal of analytical toxicology

authors： Singh H,Moorad-Doctor D,Ratcliffe RH,Wachtel K,Castillo A,Garcia GE

更新日期：2007-03-01 00:00:00

abstract：:The quantity of thiocyanate ion in vegetables has been determined due to its relationship with endemic goiter. The technique is based on the use of gas chromatography with electron capture detection (ECD), which provides good sensitivities. ...

journal_title：Journal of analytical toxicology

authors： Olea Serrano MR,Ruiz Lopez MD,Justica Palomares H

更新日期：1988-11-01 00:00:00

abstract：:Doxepin is a tricyclic antidepressant that is widely prescribed for the treatment of mild depression. In this study, hair samples collected from a patient receiving 25 mg of doxepin daily were analyzed. Doxepin was administered to the patient for 4 months (June 15 to October 15, 1996). Five hair samples were collected...

journal_title：Journal of analytical toxicology

authors： Negrusz A,Moore CM,Perry JL

更新日期：1998-10-01 00:00:00

abstract：:We devised a highly sensitive method for simultaneously determining methamphetamine (MA) and amphetamine (AP) enantiomers, desmethylselegiline (DMSG) and selegiline (SG), in human hair using a derivatization technique and high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS). M...

journal_title：Journal of analytical toxicology

authors： Nishida K,Itoh S,Inoue N,Kudo K,Ikeda N

更新日期：2006-05-01 00:00:00

abstract：:An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method was developed and validated for the simultaneous determination of Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THC-COOH) in whole blo...

journal_title：Journal of analytical toxicology

authors： Jamey C,Szwarc E,Tracqui A,Ludes B

更新日期：2008-06-01 00:00:00

abstract：:Analytical methods were developed to determine the presence of ethylenediaminetetraacetic acid (EDTA) in dried bloodstains to provide probative information when allegations of evidence tampering have been made in criminal cases. A simple screening method using ion chromatography to analyze stains was found to be quant...

journal_title：Journal of analytical toxicology

authors： Miller ML,McCord BR,Martz R,Budowle B

更新日期：1997-11-01 00:00:00

abstract：:Postmortem redistribution (PMR) constitutes a multifaceted process, which complicates the interpretation of drug concentrations by forensic toxicologists. The present study aimed to apply quantitative structure-activity relationship (QSAR) analysis for modeling PMR data of structurally related drugs, 10 benzodiazepine...

journal_title：Journal of analytical toxicology

authors： Giaginis C,Tsantili-Kakoulidou A,Theocharis S

更新日期：2014-06-01 00:00:00

abstract：:Different analytical procedures for quantitation of total morphine and codeine in urine were evaluated. Hydrolysis of urine with hydrochloric acid and four different enzymes was compared. In order to effect complete hydrolysis of glucuronide conjugates, hydrolysis with 6.5M HCl containing bisulphite and heating at 100...

journal_title：Journal of analytical toxicology

authors： Lin Z,Lafolie P,Beck O

更新日期：1994-05-01 00:00:00

abstract：:Buprenorphine, which is used in France as a substitution drug for opioid addiction, is widely abused, and several fatal cases have been reported. In order to confirm a recent intoxication or to establish retrospectively chronic abuse, a simple and reliable gas chromatographic-mass spectrometric method was developed an...

journal_title：Journal of analytical toxicology

authors： Vincent F,Bessard J,Vacheron J,Mallaret M,Bessard G

更新日期：1999-07-01 00:00:00

abstract：:Sulfur mustard (SM) is a chemical warfare agent that causes painful blisters and chemically modifies endogenous biomacromolecules by alkylation to hydroxyethylthioethyl (HETE) adducts representing valuable long-term markers for post-exposure analysis. The albumin adduct formed in human plasma in vitro (HETE bound to t...

journal_title：Journal of analytical toxicology

authors： Gandor F,Gawlik M,Thiermann H,John H

更新日期：2015-05-01 00:00:00

abstract：:A simple and sensitive method for determination of N,N-dimethyltryptamine (DMT) by gas chromatography (GC) with surface ionization detection (SID) is presented. Whole blood or urine, containing DMT and gramine (internal standard), was subjected to solid-phase extraction with a Sep-Pak C18 cartridge before analysis by ...

journal_title：Journal of analytical toxicology

authors： Ishii A,Seno H,Suzuki O,Hattori H,Kumazawa T

更新日期：1997-01-01 00:00:00

abstract：:Gas chromatographic-mass spectrometric (GC-MS) quantitation of 25 cannabis sed oils determined delta 9-tetrahydrocannabinol (THC) concentrations from 3 to 1500 micrograms/g oil. In a pilot study, the morning urine of six volunteers who had ingested 11 or 22 g of the oil, which contained the highest THC content (1500 m...

journal_title：Journal of analytical toxicology

authors： Lehmann T,Sager F,Brenneisen R

更新日期：1997-09-01 00:00:00

abstract：:The gelsemium plants are highly poisonous but toxicological evaluation of suspected poisoning cases has been hampered by the chemical complexity of the gelsemium toxins involved. A novel liquid chromatography-tandem mass spectrometry protocol was optimized for the collective detection of gelsemine and related alkaloid...

journal_title：Journal of analytical toxicology

authors： Lai CK,Chan YW

更新日期：2009-01-01 00:00:00

abstract：:An analytical procedure for the determination of the new pain medication tapentadol and its main metabolite N-desmethyltapentadol (DMT), in urine and oral fluid has been developed and validated using liquid chromatography with tandem mass spectral detection (LC-MS-MS). Oral fluid was collected using Quantisal™ devices...

journal_title：Journal of analytical toxicology

authors： Coulter C,Taruc M,Tuyay J,Moore C

更新日期：2010-10-01 00:00:00

abstract：:Endogenous γ-hydroxybutyric acid (GHB) concentrations in blood and urine are well documented, but there are very little data on natural levels in saliva, a biological matrix increasingly used for drug testing. We measured endogenous GHB concentrations in 120 unpaid volunteers who also provided anonymous epidemiologica...

journal_title：Journal of analytical toxicology

authors： De Paoli G,Walker KM,Pounder DJ

更新日期：2011-04-01 00:00:00

abstract：:From a public health point of view, cocaine (COC) presents serious clinical problems and deaths from overdose and lifelong addiction patterns, not to mention its involvement in crime, in the United States. This study subjected rhesus monkeys to one intravenous administration of COC (1 mg/kg), which closely imitates th...

journal_title：Journal of analytical toxicology

authors： Saady JJ,Bowman ER,Aceto MD

更新日期：1995-11-01 00:00:00

abstract：:A feasibility study was performed to examine the effectiveness of hair testing in determining the prevalence of drug use in a young adult population. The study included 200 randomly selected young adults in Norway. It was designed to make the collection, preparation and analysis of the samples as little resource deman...

journal_title：Journal of analytical toxicology

authors： Lund HM,Gjerde H,de Courtade SM,Oiestad EL,Christophersen AS

更新日期：2013-07-01 00:00:00