Metabolism and the urinary excretion profile of the recently scheduled designer drug N-Benzylpiperazine (BZP) in the rat.

abstract：:Urinary metabolites of famprofazone following oral administration in humans were identified by gas chromatography-mass spectrometry with electron impact-ionization and comparison with the spectra and retention times of authentic standards. The metabolites were determined following selective derivatization with N-methy...

journal_title：Journal of analytical toxicology

authors： Shin HS,Park BB,Choi SN,Oh JJ,Hong CP,Ryu H

更新日期：1998-01-01 00:00:00

abstract：:A new point-of-care colloidal metal immunoassay urine drugs-of-abuse testing device, the BIOSITE TRIAGE Plus Propoxyphene (TPP), was evaluated for the rapid detection of dextropropoxyphene (PPY) and/or its primary metabolite, norpropoxyphene (NP), in urine at a total PPY/NP concentration of 300 ng/mL or greater. This ...

journal_title：Journal of analytical toxicology

authors： Poklis A,Poklis JL,Tarnai LD,Backer RC

更新日期：2004-09-01 00:00:00

abstract：:Nicotine is the major addictive compound in tobacco and is responsible for tobacco dependence. It is primarily metabolized to cotinine (COT) and trans-3'-hydroxycotinine (3HC) by the liver enzyme cytochrome P-450 2A6 (CYP2A6). The 3HC/COT ratio measured in the saliva of smokers is highly correlated with the intrinsic ...

journal_title：Journal of analytical toxicology

authors： Lea RA,Dickson S,Benowitz NL

更新日期：2006-07-01 00:00:00

abstract：:Methoxphenidine (MXP, 2-MeO-diphenidine) is a dissociative anaesthetic drug of the diarylethylamine type, recently introduced for recreational purposes through the online-based sale of new psychoactive substances (NPS). The concentration of MXP in hair has never been reported, either in cases of chemsex use or in fata...

journal_title：Journal of analytical toxicology

authors： Goncalves R,Castaing N,Titier K,Dumestre-Toulet V

更新日期：2021-02-01 00:00:00

abstract：:The concentrations of amphetamine and methamphetamine in a new lyophilized human urine reference material (RM) were determined at the National Institute of Standards and Technology, in cooperation with the College of American Pathologists. In order to minimize the possibility of undetected bias, two different methods ...

journal_title：Journal of analytical toxicology

authors： Ellerbe P,Long T,Welch MJ

更新日期：1993-05-01 00:00:00

abstract：:A 22-year-old male with more than 28 needle marks on his right arm was found dead. First, he was suspected as a drug abuser. Blood, urine, spleen, and injection-site tissue was collected during autopsy. The blood and urine specimens were screened for drugs. Immunoassay studies did not show any illegal drugs. However, ...

journal_title：Journal of analytical toxicology

authors： Chung H,Choi H,Kim E,Jin W,Lee H,Yoo Y

更新日期：2000-05-01 00:00:00

abstract：:In methanol intoxication, increased levels of the metabolite formate are associated with metabolic acidosis and an increased risk for ocular and neurological dysfunction. A simple method for plasma formate measurement by adaptation of a manual enzymatic assay to a Cobas Mira S analyzer is presented. Six microliters of...

journal_title：Journal of analytical toxicology

authors： Blomme B,Lheureux P,Gerlo E,Maes V

更新日期：2001-03-01 00:00:00

abstract：:The U.S. Drug Enforcement Administration has several different systems for collecting information on drugs of abuse. One is an early warning system, which collects information to provide scientific data and interpretation on drug abuse. Another is the collection of data from evidence submitted to DEA laboratories. Thi...

journal_title：Journal of analytical toxicology

authors： Frank RS

更新日期：1987-11-01 00:00:00

abstract：:A protocol is described for the preparation and characterization of bovine blood lead (Pb) reference material (RM). Adult bovine animals are orally dosed with Pb as Pb(NO3)2, and blood is collected directly from the jugular vein into 5-mL evacuated, low-Pb glass tubes containing EDTA as anticoagulant. The blood is coo...

journal_title：Journal of analytical toxicology

authors： Cox DH,Duncan CE,Wyatt GP,Meadow JS,Robinson JB

更新日期：1989-07-01 00:00:00

abstract：:We devised a highly sensitive method for simultaneously determining methamphetamine (MA) and amphetamine (AP) enantiomers, desmethylselegiline (DMSG) and selegiline (SG), in human hair using a derivatization technique and high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS). M...

journal_title：Journal of analytical toxicology

authors： Nishida K,Itoh S,Inoue N,Kudo K,Ikeda N

更新日期：2006-05-01 00:00:00

abstract：:Percutaneous vapor dosing studies have generally used saturated vapor concentration (SVC) measurements to estimate the exposure dose (Ct) of vapor produced from a volatile liquid within a closed system. The purpose of this study was to clarify whether the assumption was valid when translated to a biological system (pi...

journal_title：Journal of analytical toxicology

authors： Dalton CH,Maidment MP,Jenner J,Chilcott RP

更新日期：2006-04-01 00:00:00

abstract：:Human urine was tested for tricyclic antidepressants with fluorescence polarization immunoassay (FPIA) reagents on Abbott's ADx system and with EIA reagents on Syva's ETS system. A 75-ng/mL imipramine calibrator cutoff was used with the ADx system and a 300-ng/mL nortriptyline calibrator cutoff with the ETS system. Th...

journal_title：Journal of analytical toxicology

authors： Meenan GM,Barlotta S,Lehrer M

更新日期：1990-09-01 00:00:00

abstract：:The maximum stability conditions for cocaine and its metabolite benzoylecgonine (BE) in urine were analyzed. Suggestions were presented after careful review of many studies and personal communications concerning cocaine and BE stability in urine. The optimal storage conditions for urine specimens with cocaine and BE w...

journal_title：Journal of analytical toxicology

authors： Hippenstiel MJ,Gerson B

更新日期：1994-03-01 00:00:00

abstract：:Caffeine is the most widely consumed drug in the world with coffee representing a major source of intake. Despite widespread availability, various medical conditions necessitate caffeine-restricted diets. Patients on certain prescription medications are advised to discontinue caffeine intake. Such admonition has impli...

journal_title：Journal of analytical toxicology

authors： McCusker RR,Fuehrlein B,Goldberger BA,Gold MS,Cone EJ

更新日期：2006-10-01 00:00:00

abstract：:Separating drugs which are both polar and basic has long been difficult because of the limited operating pH range of conventional HPLC columns. This paper describes a liquid chromatographic method capable of being used with either diode-array or mass spectrometric detection for the identification and quantitation of 1...

journal_title：Journal of analytical toxicology

authors： Goeringer KE,McIntyre lM,Drummer OH

更新日期：2003-01-01 00:00:00

abstract：:In preparation for a treatment program concerning the medical coprescription of heroin and methadone to treatment-resistant addicts in the Netherlands, we studied a novel strategy for monitoring co-use of illicit (nonprescribed) heroin. A deuterated analogue of heroin was added (1:20) to pharmaceutical, smokable heroi...

journal_title：Journal of analytical toxicology

authors： Klous MG,Rook EJ,Hillebrand MJ,van den Brink W,van Ree JM,Beijnen JH

更新日期：2005-09-01 00:00:00

abstract：:A method for the determination of the antidepressant drug trazodone is presented. 8-Hydroxyloxapine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection usin...

journal_title：Journal of analytical toxicology

authors： Rifai N,Levtzow CB,Howlett CM,Phillips JC,Parker NC,Cross RE

更新日期：1988-05-01 00:00:00

abstract：:3,4-Methylenedioxypyrovalerone (MDPV) is a psychoactive, synthetic analog of the central nervous system stimulant cathinone. Its recent popularity as a recreational drug in the United States has led to numerous reports to poison control centers across the country. As with other synthetic cathinones, the recreational u...

journal_title：Journal of analytical toxicology

authors： Wyman JF,Lavins ES,Engelhart D,Armstrong EJ,Snell KD,Boggs PD,Taylor SM,Norris RN,Miller FP

更新日期：2013-04-01 00:00:00

abstract：:Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique called solid-phase...

journal_title：Journal of analytical toxicology

authors： Guan F,Seno H,Ishii A,Watanabe K,Kumazawa T,Hattori H,Suzuki O

更新日期：1999-01-01 00:00:00

abstract：:The dramatic rise in maternal drug abuse and the incidence of positive drug findings during neonatal testing has increased the need for prenatal toxicological testing for drugs of abuse. Human amniotic fluid samples collected after 13-39 weeks of pregnancy were screened for cocaine metabolite (benzoylecgonine) by fluo...

journal_title：Journal of analytical toxicology

authors： Ripple MG,Goldberger BA,Caplan YH,Blitzer MG,Schwartz S

更新日期：1992-09-01 00:00:00

abstract：:Given that external contamination must be considered in hair analysis, there is still a demand for reliable tools to differentiate between incorporation of drugs into the hair as a result of drug consumption and of the hair shaft by external contamination. With the aim of establishing alternative discrimination parame...

journal_title：Journal of analytical toxicology

authors： Scholz C,Quednow BB,Herdener M,Kraemer T,Baumgartner MR

更新日期：2019-08-23 00:00:00

abstract：:An extraction and concentration procedure using a unique solid-phase extraction tube was developed for the analysis of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in urine. Absolute and relative recoveries of the drug metabolite were found to be greater than 85% and 92%, respectively. The extraction procedur...

journal_title：Journal of analytical toxicology

authors： Parry RC,Nolan L,Shirey RE,Wachob GD,Gisch DJ

更新日期：1990-01-01 00:00:00

abstract：:Quetiapine fumarate (Seroquel) is a dibenzothiazepine psychotropic agent that was introduced in 1997 for treating psychoses. Quetiapine is being found with increasing frequency in postmortem cases in Virginia. We report the postmortem results and histories of 20 quetiapine cases from the Office of the Chief Medical Ex...

journal_title：Journal of analytical toxicology

authors： Flammia DD,Valouch T,Venuti S

更新日期：2006-05-01 00:00:00

abstract：:An online automatic sample cleanup system was developed for use with electrospray ionization tandem mass spectrometry (ESI-MS-MS) for the quantitative detection of the benzene exposure biomarker S-phenylmercapturic acid (S-PMA) in human urine. The sample clean-up system was constructed with an autosampling device, a r...

journal_title：Journal of analytical toxicology

authors： Liao PC,Li CM,Lin LC,Hung CW,Shih TS

更新日期：2002-05-01 00:00:00

abstract：:During periodate degradation of interfering ephedrine, pseudoephedrine, and phenylpropanolamine in the extraction of methamphetamine from urine, it was observed that a small amount of methamphetamine was demethylated to amphetamine. although all three interfering phenylpropanolamines could be degraded by periodate at ...

journal_title：Journal of analytical toxicology

authors： Paul BD,Past MR,McKinley RM,Foreman JD,McWhorter LK,Snyder JJ

更新日期：1994-10-01 00:00:00

abstract：:A 5-mg dose of cocaine free base applied to the volar forearm skin surface of a volunteer resulted in a maximal urinary benzoylecgonine concentration of 55 ng/mL at 48 h, using discrete urine specimens. A total of 58 micrograms of benzoylecgonine, representing 1.2% of the dose, was excreted in the 96-h urine. An ident...

journal_title：Journal of analytical toxicology

authors： Baselt RC,Chang JY,Yoshikawa DM

更新日期：1990-11-01 00:00:00

abstract：:A method is presented for the positive identification of quinine and quinidine. The method requires extraction of the compounds from an alkaline solution into an organic solvent and concentration of the sample by evaporation of the solvent. The sample is chromatographed without derivatization and may be detected by th...

journal_title：Journal of analytical toxicology

authors： Furner RL,Brown GB,Scott JW

更新日期：1981-11-01 00:00:00

abstract：:Sterile whole human blood control materials were commercially prepared in batches containing anticoagulants and preservatives and approximately 90, 150, and 230 mg/dL ethanol with and without 0.3% (w/v) sodium azide. Aliquots in sealed vials were stored by the manufacturer at 2-8 degrees C until shipped monthly to thr...

journal_title：Journal of analytical toxicology

authors： Dubowski KM,Gadsden RH Sr,Poklis A

更新日期：1997-10-01 00:00:00

abstract：:Toxicological analyses of medicines and chemicals in formaldehyde-treated specimens are a component of forensic toxicology. This review involves two parts: (i) reactions of formaldehyde with substances in tissues fixed with formalin (aqueous formaldehyde solution) and (ii) the stability of substances in formalin-treat...

journal_title：Journal of analytical toxicology

authors： Takayasu T

更新日期：2013-11-01 00:00:00

abstract：:An enzyme multiplied immunoassay technique (EMIT) was used to test for opiates (morphine, hydromorphone, and codeine) in extracts of blood, bile, and tissue homogenates. All immunoassay opiate positive specimens were then tested by a reversed-phase liquid chromatographic procedure using electrochemical detection (LCEC...

journal_title：Journal of analytical toxicology

authors： Hepler BR,Sutheimer C,Sunshine I,Sebrosky GF

更新日期：1984-03-01 00:00:00