Abstract:
:The dramatic rise in maternal drug abuse and the incidence of positive drug findings during neonatal testing has increased the need for prenatal toxicological testing for drugs of abuse. Human amniotic fluid samples collected after 13-39 weeks of pregnancy were screened for cocaine metabolite (benzoylecgonine) by fluorescence polarization immunoassay (FPIA). All positive samples, as well as any accompanying maternal serum, were confirmed by gas chromatography/mass spectrometry (GC/MS) for cocaine and its metabolites. Five samples out of 450 were positive for cocaine, benzoylecgonine, and ecgonine methyl ester by GC/MS. In addition, one sample was also positive for cocaethylene. Two maternal serum samples were positive for benzoylecgonine and ecgonine methyl ester. The presence of cocaine, benzoylecgonine, ecgonine methyl ester, and cocaethylene in the amniotic fluid suggests that the fetus is exposed to cocaine and its metabolites through maternal circulation. The impact of this exposure on the health of the newborn is unknown.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Ripple MG,Goldberger BA,Caplan YH,Blitzer MG,Schwartz Sdoi
10.1093/jat/16.5.328keywords:
subject
Has Abstractpub_date
1992-09-01 00:00:00pages
328-31issue
5eissn
0146-4760issn
1945-2403journal_volume
16pub_type
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