Abstract:
:A rapid, sensitive, and specific method for the determination of opiates and cocaine and metabolites in urine, plasma, and blood was established. A one-step extraction followed by liquid chromatography-electrospray ionization tandem mass spectrometry operating in multiple reaction monitoring mode was used. Two chromatographic runs were performed, each in less than 6 min. The lower limit for accurate quantitative determination was 5 microg/L for cocaine and metabolites and 10 microg/L for opiates. Linearity was obtained from 10 to 1000 microg/L. Intraday (n = 6) and interday (n = 6) precisions and recoveries (n = 6) were determined at 10 or 25, 100, and 1000 microg/L concentrations. Precisions with a coefficient of variation less than 15% were obtained. Recoveries between 85 and 115% were determined.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Cailleux A,Le Bouil A,Auger B,Bonsergent G,Turcant A,Allain Pdoi
10.1093/jat/23.7.620keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
620-4issue
7eissn
0146-4760issn
1945-2403journal_volume
23pub_type
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