Abstract：
:Sixteen apparently intact procainamide tablets, in varied stages of drug depletion, were found distributed throughout the gastrointestinal tract of a man who died of arteriosclerotic heart disease with pulmonary complications. The tablets were found to contain procainamide by a thin layer chromatography system with cataloged compound identification characteristics. The drug was confirmed by ultraviolet spectrophotometry and gas chromatography/mass spectrometry. The concentration of the drug in the liver was in a therapeutic range and the drug was not attributed as contributing to the cause of death.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Griesemer ECdoi
10.1093/jat/8.5.244subject
Has Abstractpub_date
1984-09-01 00:00:00pages
244-5issue
5eissn
0146-4760issn
1945-2403journal_volume
8pub_type
杂志文章abstract：:A rapid, simple, highly sensitive procedure for the simultaneous analysis of bromazepam, alprazolam, clonazepam, lorazepam, oxazepam, diazepam, midazolam, flurazepam, flunitrazepam, nordiazepam, triazolam, temazepam, nitrazepam, and chlordiazepoxide in oral fluid is described, using liquid chromatography coupled to a ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/31.9.596
更新日期：2007-11-01 00:00:00
abstract：:This manuscript details a validated liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (LC-APCI-MS-MS) method for the quantification of methadone and its metabolites 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyroline (EMDP) in 0.5 mL ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/31.5.265
更新日期：2007-06-01 00:00:00
abstract：:This study describes a matrix-assisted laser-desorption-ionization (MALDI) mass spectrometry for rapid screening of 12 diuretics in spiked urine. C60 is used as the matrix for MALDI. Diuretics are directly analyzed by C60-MALDI without previous derivatization. The fact that most diuretic molecules contain sulfate grou...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/23.5.337
更新日期：1999-09-01 00:00:00
abstract：:Urine drug testing (UDT) is an emerging standard of care in the evaluation and treatment of chronic non-cancer pain patients with opioid analgesics. UDT may be used both to verify adherence with the opioid analgesic regimen and to monitor abstinence from non-prescribed or illicit controlled substances. In the former s...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bku109
更新日期：2015-01-01 00:00:00
abstract：:An analytical procedure for simultaneous determination of codeine and morphine in urine is described. The detection of codeine and morphine is based on liquid-liquid extraction and derivatization to the acetylated compounds. The acetylated codeine and morphine are separated by capillary gas chromatography and identifi...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/9.5.222
更新日期：1985-09-01 00:00:00
abstract：:Bone was analyzed for ketamine and norketamine to examine whether different patterns of drug exposure could be discriminated. Rats received (intraperitoneally) one 75 mg/kg dose (Acute-1 and Acute-2 groups), three 25-mg/kg doses 1 hour apart (Repeated group), or nine single daily ketamine doses of 75 mg/kg followed by...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bks045
更新日期：2012-07-01 00:00:00
abstract：:This paper describes two relatively simple methods for the microdetermination of urinary cadmium (U-Cd) and urinary nickel (U-Ni) using electrothermal atomic absorption spectrometry. Reduction of nonspecific absorption interferences was achieved by temperature programming and background correction using a deuterium ar...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/14.1.29
更新日期：1990-01-01 00:00:00
abstract：:Percutaneous vapor dosing studies have generally used saturated vapor concentration (SVC) measurements to estimate the exposure dose (Ct) of vapor produced from a volatile liquid within a closed system. The purpose of this study was to clarify whether the assumption was valid when translated to a biological system (pi...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/30.3.165
更新日期：2006-04-01 00:00:00
abstract：:The objective was to develop a simple routine method for quantitative measurement of endogenous formic acid in plasma and whole blood using headspace gas chromatography-flame ionization detection. (GC-FID). Two-hundred microliters of sample was placed in a 1-mL glass vial. Fifty microliters of aqueous ethanol (10%) wa...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/31.6.342
更新日期：2007-07-01 00:00:00
abstract：:An analytical database, using high-performance liquid chromatography (HPLC) with diode array ultraviolet (UV) detection, of over 250 toxicologically relevant drugs has been extensively applied to both clinical and forensic toxicology. This general drug screening system, based on a mixed-phase (octadecyl/cyanopropyl) c...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/22.4.279
更新日期：1998-07-01 00:00:00
abstract：:Fentanyl is a potent, short-acting narcotic analgesic widely used as a surgical anesthetic and for the control of pain when administered in the form of a transdermal patch. The success of the patch can be attributed to fentanyl's low molecular weight and its highly lipophilic nature, which enables it to be readily abs...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/24.7.627
更新日期：2000-10-01 00:00:00
abstract：:The aim of this study was to investigate the early-phase postmortem redistribution of the enantiomers of citalopram (CIT) and its metabolites demethylcitalopram (DCIT) and didemethylcitalopram (DDCIT) in a rat model. Furthermore, we wanted to examine the role of the lungs as a reservoir of postmortem drug release and ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/29.4.223
更新日期：2005-05-01 00:00:00
abstract：:A hair screening method has been developed for the detection of methamphetamine using an immunoassay analyzer (AxSYM) with a fluorescence polarization immunoassay (FPIA) technique. The method consisted of washing, cutting and digesting a hair sample (5 mg) with an enzymatic digestion solution. The digested hair sample...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkt011
更新日期：2013-05-01 00:00:00
abstract：:A relatively simple procedure for the determination of carboxyhemoglobin percent saturation in postmortem samples is described. The procedure involves a quick and accurate method for calibration of the gas chromatograph to carbon monoxide. The mixed gases are extracted from blood prior to introduction into the gas chr...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/4.4.181
更新日期：1980-07-01 00:00:00
abstract：:Gamma-hydroxybutyrate (GHB) is an endogenous compound, but its presence in postmortem blood presents a challenge when interpreting elevated levels as GHB is misused as a recreational drug and is also produced postmortem. A total of 387 postmortem cases (273 male and 114 female) submitted to the toxicology laboratory b...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bku088
更新日期：2014-10-01 00:00:00
abstract：:Vitreous humor is a potential alternative matrix for postmortem toxicology drug screens when peripheral blood is unavailable. It is easily and reliably collected and may not suffer from the same postmortem redistribution as seen in blood. Here, we compared the concentrations of 7 acidic drugs (acetaminophen, ibuprofen...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkz076
更新日期：2019-11-06 00:00:00
abstract：:Doxepin is a tricyclic antidepressant that is widely prescribed for the treatment of mild depression. In this study, hair samples collected from a patient receiving 25 mg of doxepin daily were analyzed. Doxepin was administered to the patient for 4 months (June 15 to October 15, 1996). Five hair samples were collected...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/22.6.531
更新日期：1998-10-01 00:00:00
abstract：:The content, chemical form, and distribution of mercury and selenium in edible tissue were determined for several samples of fish and other marine animal organisms (mollusks, crustaceans and pods). For most fish samples, except Pacific blue marlin, 53 to 94% of the total mercury content was present as methylmercury, b...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/6.1.10
更新日期：1982-01-01 00:00:00
abstract：:Methods for extraction of cocaine, some of its metabolites, morphine, and codeine from hair and methods for analyzing the extracts have been investigated. Results of these studies have shown that extractions with 0.1N HCl are efficient at removing the target compounds from hair and appear to be as effective as enzymat...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/17.7.389
更新日期：1993-11-01 00:00:00
abstract：:Preliminary data regarding the use of vernix caseosa (VC) as an alternative to other biological specimens for the determination of fetal cocaine exposure are presented. Advantages of VC analysis include its presence on all newborn babies, historical record of drug exposure, and ease of collection and storage. Fifteen ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/20.6.509
更新日期：1996-10-01 00:00:00
abstract：:An expert system applied as a screening test for amphetamine analogues found in recreational-drug exhibits (tablets or powders) is described. The knowledge base defining the reference Fourier transform infrared spectroscopic (FTIR) spectral patterns has been built according to criteria encompassing toxicological, phar...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/25.1.45
更新日期：2001-01-01 00:00:00
abstract：:A quantitative gas chromatographic assay for the determination of phenelzine in plasma or other fluids is presented. A stable derivative is formed by cyclization with acetylacetone, and the derivative is separated, purified, and concentrated by liquid-liquid solvent extraction. Analysis of the extracts is by capillary...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/12.2.98
更新日期：1988-03-01 00:00:00
abstract：:An automated solid-phase extraction (SPE) protocol followed by gas chromatography coupled with tandem mass spectrometry was developed for quantification of caffeine, cyamemazine, meprobamate, morphine and 6-monoacetylmorphine (6-MAM) in 11 biological matrices [blood, urine, bile, vitreous humor, liver, kidney, lung an...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bku029
更新日期：2014-06-01 00:00:00
abstract：:Vitreous humor is a fluid contained in the eye that is largely composed of water. The advantages of vitreous humor as a specimen for postmortem drug analysis include its relatively low susceptibility to contamination and the ability to analyze vitreous humor with little or no pretreatment. The postmortem analysis of e...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/31.8.537
更新日期：2007-10-01 00:00:00
abstract：:Publications reporting concentrations of caffeine in postmortem blood were reviewed if the cause of death was attributed to overdosing (poisoning) with drugs. Age and gender of the deceased, the manner of death (accident, suicide or undetermined) and types of co-ingested drugs were evaluated in relation to the concent...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章,评审
doi：10.1093/jat/bkx011
更新日期：2017-04-01 00:00:00
abstract：:A method for determining the chemical warfare agent soman (GD) in rat plasma has been validated and applied to low-level inhalation exposure studies currently being conducted. This method utilizes a fluoride ion-based regeneration assay with isotope dilution followed by large volume injection gas chromatography with a...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/32.1.92
更新日期：2008-01-01 00:00:00
abstract：:A fatal case attributed to flecainide intoxication is presented. Quantitation was by capillary gas chromatography with nitrogen-phosphorus detection. The flecainide concentration in the blood was 13 mg/L as compared to a therapeutic range in serum of 0.2-1.0 mg/L. Flecainide concentrations in other specimens were as f...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/14.5.335
更新日期：1990-09-01 00:00:00
abstract：:A study of the urinary concentration of fentanyl (F) and its major metabolite norfentanyl (NF) in chronic pain patients treated with the Duragesic continuous release transdermal patches is presented. These patches are available in 10, 20, 30, and 40 cm(2) sizes releasing 25, 50, 75, and 100 microg/h F, respectively. F...
journal_title：Journal of analytical toxicology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/jat/28.6.422
更新日期：2004-09-01 00:00:00
abstract：:External contamination of hair or nails by inorganic arsenic compounds cannot effectively be removed with H2O or dilute HCl. The use of a modified Gutzeit apparatus allowed to establish or rule out external contamination. It was found that contaminated samples will generate large amounts of arsine gas when treated wit...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/7.5.216
更新日期：1983-09-01 00:00:00
abstract：:To evaluate liquid chromatography-high-resolution mass spectrometry (LC-HR-MS) for urine toxicology screening, 29 analytes were quantitated in 152 urine specimens from patients with chronic pain using two unique mass spectrometry platforms. De-identified specimens were quantitated in April of 2011 by liquid chromatogr...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bks071
更新日期：2012-11-01 00:00:00
