Acidic Drug Concentrations in Postmortem Vitreous Humor and Peripheral Blood.

abstract：:In cases of death by inert gas asphyxiation, it can be difficult to obtain toxicological evidence supporting assignment of a cause of death. Because of its low mass and high diffusivity, and its common use as a carrier gas, helium presents a particular challenge in this respect. We describe a rapid and simple gas chro...

journal_title：Journal of analytical toxicology

authors： Schaff JE,Karas RP,Marinetti L

更新日期：2012-03-01 00:00:00

abstract：:Analysis and interpretation of the findings for the drug of abuse gamma hydroxybutyric acid (GHB) in fatalities has become very problematic. This is primarily because of variable data in postmortem biological fluids resulting from the endogenous nature of the compound, possible postmortem production, and varying metho...

journal_title：Journal of analytical toxicology

authors： Elliott SP

更新日期：2004-01-01 00:00:00

abstract：:Niflumic acid is a nonsteroidal, anti-inflammatory drug widely prescribed in Greece. We recently noticed that this drug cross-reacts for cannabinoids in a kinetic interaction of microparticles in a solution (KIMS) immunoassay method but does not in an enzyme multiplied immunoassay technique (EMIT) immunoassay method. ...

journal_title：Journal of analytical toxicology

authors： Kovatsi L,Pouliopoulos A,Papadaki A,Samanidou V,Tsoukali H

更新日期：2010-05-01 00:00:00

abstract：:An isotope dilution gas chromatography-tandem mass spectrometric (GC-MS-MS) method was developed for quantitating the urinary metabolites of the organophosphorus nerve agents sarin, soman, tabun (GA), VX, and GF. Urine samples were concentrated by codistillation with acetonitrile, derivatized by methylation with diazo...

journal_title：Journal of analytical toxicology

authors： Driskell WJ,Shih M,Needham LL,Barr DB

更新日期：2002-01-01 00:00:00

abstract：:Analytical methods were developed to determine the presence of ethylenediaminetetraacetic acid (EDTA) in dried bloodstains to provide probative information when allegations of evidence tampering have been made in criminal cases. A simple screening method using ion chromatography to analyze stains was found to be quant...

journal_title：Journal of analytical toxicology

authors： Miller ML,McCord BR,Martz R,Budowle B

更新日期：1997-11-01 00:00:00

abstract：:The objective of this project was to validate a new high-throughput homogeneous enzyme immunoassay (HEIA) for the rapid detection of carisoprodol in human urine. Carisoprodol (Soma(®)) and meprobamate are widely prescribed as musculoskeletal pain relief drugs and are listed as one of the 10 most frequently identified ...

journal_title：Journal of analytical toxicology

authors： Wang G,Huynh K,Barhate R,Rodrigues W,Moore C,Coulter C,Vincent M,Soares J

更新日期：2011-03-01 00:00:00

abstract：:In an attempt to improve the sensitivity and selectivity of thin-layer chromatographic analysis for the detection of strychnine and crimidine in biological samples, a rapid high-performance thin-layer chromatographic (HPTLC) method with densitometry is described. Fortified dog serum and stomach content samples were an...

journal_title：Journal of analytical toxicology

authors： De Saqui-Sannes P,Nups P,Le Bars P,Burgat V

更新日期：1996-05-01 00:00:00

abstract：:A simple gas chromatography-mass spectrometry (GC-MS) procedure has been developed for the main metabolites of organophosphorus nerve agents, alkylmethylphosphonic acids (AMPAs; alkyl = Et, i-Pr, and pinacolyl) in biofluids via extractive pentafluorobenzylation. The derivatization was carried out under liquid-liquid-s...

journal_title：Journal of analytical toxicology

authors： Miki A,Katagi M,Tsuchihashi H,Yamashita M

更新日期：1999-03-01 00:00:00

abstract：:To evaluate liquid chromatography-high-resolution mass spectrometry (LC-HR-MS) for urine toxicology screening, 29 analytes were quantitated in 152 urine specimens from patients with chronic pain using two unique mass spectrometry platforms. De-identified specimens were quantitated in April of 2011 by liquid chromatogr...

journal_title：Journal of analytical toxicology

authors： Crews BO,Pesce AJ,West R,Nguyen H,Fitzgerald RL

更新日期：2012-11-01 00:00:00

abstract：:We devised a highly sensitive method for simultaneously determining methamphetamine (MA) and amphetamine (AP) enantiomers, desmethylselegiline (DMSG) and selegiline (SG), in human hair using a derivatization technique and high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS). M...

journal_title：Journal of analytical toxicology

authors： Nishida K,Itoh S,Inoue N,Kudo K,Ikeda N

更新日期：2006-05-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI), a still-emerging, non-invasive neuroimaging tool, has been applied to a wide range of questions in sensory, motor control, and cognitive psychology. Only more recently has it been applied to understand the sites and mechanisms of action of pharmacological agents within the...

journal_title：Journal of analytical toxicology

authors： Stein EA

更新日期：2001-07-01 00:00:00

abstract：:Urinary metabolites of famprofazone following oral administration in humans were identified by gas chromatography-mass spectrometry with electron impact-ionization and comparison with the spectra and retention times of authentic standards. The metabolites were determined following selective derivatization with N-methy...

journal_title：Journal of analytical toxicology

authors： Shin HS,Park BB,Choi SN,Oh JJ,Hong CP,Ryu H

更新日期：1998-01-01 00:00:00

abstract：:A clinical study was designed to determine if there was a predictable relationship between saliva and plasma codeine concentrations. Drug-free volunteers (n = 17) were administered a 30-mg dose of liquid codeine phosphate. Plasma and saliva specimens were collected at various times for 24 h after administration. Plasm...

journal_title：Journal of analytical toxicology

authors： O'Neal CL,Crouch DJ,Rollins DE,Fatah A,Cheever ML

更新日期：1999-10-01 00:00:00

abstract：:A woman was alleged to have committed suicide by consuming a gasoline additive shortly before jumping from a second floor balcony within her home. She was found dead by police with a multitude of injuries, lying nude in a partially evaporated unknown residue that was later determined to be methanol. Samples collected ...

journal_title：Journal of analytical toxicology

authors： Avella J,Briglia E,Harleman G,Lehrer M

更新日期：2005-10-01 00:00:00

abstract：:The dramatic rise in maternal drug abuse and the incidence of positive drug findings during neonatal testing has increased the need for prenatal toxicological testing for drugs of abuse. Human amniotic fluid samples collected after 13-39 weeks of pregnancy were screened for cocaine metabolite (benzoylecgonine) by fluo...

journal_title：Journal of analytical toxicology

authors： Ripple MG,Goldberger BA,Caplan YH,Blitzer MG,Schwartz S

更新日期：1992-09-01 00:00:00

abstract：:A rapid, sensitive, and specific method for the determination of opiates and cocaine and metabolites in urine, plasma, and blood was established. A one-step extraction followed by liquid chromatography-electrospray ionization tandem mass spectrometry operating in multiple reaction monitoring mode was used. Two chromat...

journal_title：Journal of analytical toxicology

authors： Cailleux A,Le Bouil A,Auger B,Bonsergent G,Turcant A,Allain P

更新日期：1999-11-01 00:00:00

abstract：:Baclofen (Lioresal), a lipophilic analogue of c-aminobutyric acid (GABA), and carisoprodol (Soma), a central nervous system depressant with an unknown mechanism of pharmacologic action, are categorized as muscle relaxants. Baclofen is used clinically in the management of spasticity and its sequelae secondary to severe...

journal_title：Journal of analytical toxicology

authors： Miksa IR,Poppenga RH

更新日期：2003-07-01 00:00:00

abstract：:Proton nuclear magnetic resonance spectroscopy (1H MRS) has been used to identify ethanol in vivo and to detect other exogenous low molecular weight volatiles in human serum. 1H MRS was used to detect and quantitate 15 human sera containing various concentrations and combinations of ethanol, isopropanol, acetone, and ...

journal_title：Journal of analytical toxicology

authors： Pappas AA,Thompson JR,Fuller GL,Porter WH,Gadsden RH

更新日期：1993-09-01 00:00:00

abstract：:A fatal case attributed to flecainide intoxication is presented. Quantitation was by capillary gas chromatography with nitrogen-phosphorus detection. The flecainide concentration in the blood was 13 mg/L as compared to a therapeutic range in serum of 0.2-1.0 mg/L. Flecainide concentrations in other specimens were as f...

journal_title：Journal of analytical toxicology

authors： Levine B,Chute D,Caplan YH

更新日期：1990-09-01 00:00:00

abstract：:Two cases of overdose due to ingestion of trazodone are described. In one case, blood collected several hours following ingestion of an estimated 4 or more grams contained a trazodone concentration of 25.7 mg/L. Recovery was uneventful. The second case did not survive and death was attributed to the ingestion of multi...

journal_title：Journal of analytical toxicology

authors： Root I,Ohlson GB

更新日期：1984-03-01 00:00:00

abstract：:This manuscript reviews data available in the scientific literature relative to drug testing for the five mandated drug classes and circumstances other than abuse of the drug itself that could result in a positive test. For marijuana, passive inhalation, unknowing oral ingestion, and the use of Marinol are discussed. ...

journal_title：Journal of analytical toxicology

authors： elSohly MA,Jones AB

更新日期：1995-10-01 00:00:00

abstract：:Ethanol is the most frequently identified compound in forensic toxicology. Although confirmation involving mass spectrometry is desirable, relatively few methods have been published to date. A novel technique utilizing a Dean's Switch to simultaneously quantitate and confirm ethyl alcohol by flame-ionization (FID) and...

journal_title：Journal of analytical toxicology

authors： Tiscione NB,Alford I,Yeatman DT,Shan X

更新日期：2011-09-01 00:00:00

abstract：:A simple, rapid, and reliable gas-liquid chromatographic (GLC) confirmation procedure was developed for urine samples found positive by the EMIT-dau benzodiazepine metabolite assay. The procedure involves acid hydrolysis, organic extraction, and identification using GLC-nitrogen-phosphorus detection (NPD). The method ...

journal_title：Journal of analytical toxicology

authors： Verebey K,Jukofsky D,Mulé SJ

更新日期：1982-11-01 00:00:00

abstract：:An improved method has been developed for the quantitative determination of cyanide in human blood by headspace gas chromatography with electron-capture detection. In this novel method, cyanide was detected after conversion of hydrogen cyanide into cyanogen chloride by a reaction with chloramine T. The advantage of th...

journal_title：Journal of analytical toxicology

authors： Odoul M,Fouillet B,Nouri B,Chambon R,Chambon P

更新日期：1994-07-01 00:00:00

abstract：:The effects of storage time and temperature on blood alcohol concentration were evaluated in this two-part study involving 34 ethanol-negative and 21 ethanol-positive volunteers. Multiple 10-mL Vacutainer(®) blood tubes containing 100 mg of sodium fluoride and 20 mg of potassium oxalate were collected from living pers...

journal_title：Journal of analytical toxicology

authors： Vance CS,Carter CR,Carter RJ,Del Valle MM,Peña JR

更新日期：2015-09-01 00:00:00

abstract：:Solid-phase extraction (SPE) and a one-step derivatization are combined with gas chromatography-negative ion chemical ionization-mass spectrometry to simplify a previously reported method for the determination of naltrexone and its metabolite, 6-beta-naltrexol, in human plasma. Deuterated isotopomers of naltrexone and...

journal_title：Journal of analytical toxicology

authors： Huang W,Moody DE,Foltz RL,Walsh SL

更新日期：1997-07-01 00:00:00

abstract：:Publications reporting concentrations of caffeine in postmortem blood were reviewed if the cause of death was attributed to overdosing (poisoning) with drugs. Age and gender of the deceased, the manner of death (accident, suicide or undetermined) and types of co-ingested drugs were evaluated in relation to the concent...

journal_title：Journal of analytical toxicology

authors： Jones AW

更新日期：2017-04-01 00:00:00

abstract：:Results of urine drug analyses for three racing greyhounds that tested positive for caffeine in this laboratory were contested by the animal trainer, who asserted that positives were achieved from deliberate chocolate feeding by a rival kennel. The metabolism and excretion of methylxanthines was examined by high-perfo...

journal_title：Journal of analytical toxicology

authors： Wells DJ,Hanks BM,Yarbrough CS,Davis MA

更新日期：1988-01-01 00:00:00

abstract：:A simple isocratic HPLC procedure for the analysis of cocaine in plasma, with or without an internal standard, is described for the first time. Basified plasma was extracted in ether, re-extracted in acetic acid, which was subsequently basified prior to the final extraction in n-hexane. The hexane extract was evaporat...

journal_title：Journal of analytical toxicology

authors： Masoud AN,Krupski DM

更新日期：1980-11-01 00:00:00

abstract：:A method is presented for the analysis of trace amounts of dinitroaniline herbicides in tissue and excreta. The method employs extraction of the tissue or excreta with organic solvent, clean up by liquid/liquid partitioning or silica gel chromatography, and ultimate analysis by gas chromatography using electron captur...

journal_title：Journal of analytical toxicology

authors： Edgerton TR,Scott W,Linder RE

更新日期：1985-01-01 00:00:00