Determination of benzodiazepines in oral fluid using LC-MS-MS.

abstract：:This study of 20,089 urine specimens from chronic pain patients provided a unique opportunity to evaluate the prevalence of prescription opiates and metabolites, assess the usefulness of inclusion of normetabolites in the test panel, and compare opiate and oxycodone screening results to liquid chromatography with tand...

journal_title：Journal of analytical toxicology

authors： Heltsley R,Zichterman A,Black DL,Cawthon B,Robert T,Moser F,Caplan YH,Cone EJ

更新日期：2010-01-01 00:00:00

abstract：:A GC/MS method for the simultaneous determination of morphine, codeine, and O-6-monoacetylmorphine as well as other semisynthetic opiates in urine is described. The method employs 2H6-acetic anhydride to acetylate free hydroxyl groups on all of the opiates. As a result, the same hydrolysis and extraction procedure is ...

journal_title：Journal of analytical toxicology

authors： Bowie LJ,Kirkpatrick PB

更新日期：1989-11-01 00:00:00

abstract：:An extraction and concentration procedure using a unique solid-phase extraction tube was developed for the analysis of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in urine. Absolute and relative recoveries of the drug metabolite were found to be greater than 85% and 92%, respectively. The extraction procedur...

journal_title：Journal of analytical toxicology

authors： Parry RC,Nolan L,Shirey RE,Wachob GD,Gisch DJ

更新日期：1990-01-01 00:00:00

abstract：:A new method was developed to apply the advantages of automated gas chromatographic headspace analysis to delayed measurement of alcohol in whole breath (W-B). End-expiratory breath and vapor-alcohol samples were collected in sealed, heated 22-mL glass vials, stored for 0-15 days, and thereafter analyzed for alcohol b...

journal_title：Journal of analytical toxicology

authors： Dubowski KM,Essary NA

更新日期：1982-09-01 00:00:00

abstract：:A relatively simple procedure for the determination of carboxyhemoglobin percent saturation in postmortem samples is described. The procedure involves a quick and accurate method for calibration of the gas chromatograph to carbon monoxide. The mixed gases are extracted from blood prior to introduction into the gas chr...

journal_title：Journal of analytical toxicology

authors： Hobbs LD,Jachimczyk JA,Schloegel EL

更新日期：1980-07-01 00:00:00

abstract：:Oral fluid (OF) is increasingly used for clinical, forensic and workplace drug testing as an alternative to urine. Uncertainties surrounding OF collection device performance, drug stability and testing reproducibility may be partially responsible for delays in the implementation of OF testing in regulated drug testing...

journal_title：Journal of analytical toxicology

authors： Samano KL,Anne L,Johnson T,Tang K,Sample RH

更新日期：2015-10-01 00:00:00

abstract：:A method for the simultaneous measurement of buprenorphine and its N-dealkylated metabolite, norbuprenorphine, in human plasma was developed with negative chemical ionization tandem mass spectrometry. Buprenorphine and norbuprenorphine were extracted from biological fluids by solid-phase extraction. The samples were d...

journal_title：Journal of analytical toxicology

authors： Kuhlman JJ Jr,Magluilo J Jr,Cone E,Levine B

更新日期：1996-07-01 00:00:00

abstract：:This paper describes two relatively simple methods for the microdetermination of urinary cadmium (U-Cd) and urinary nickel (U-Ni) using electrothermal atomic absorption spectrometry. Reduction of nonspecific absorption interferences was achieved by temperature programming and background correction using a deuterium ar...

journal_title：Journal of analytical toxicology

authors： Ong CN,Chua LH,Lee BL,Ong HY,Chia KS

更新日期：1990-01-01 00:00:00

abstract：:Publications reporting concentrations of caffeine in postmortem blood were reviewed if the cause of death was attributed to overdosing (poisoning) with drugs. Age and gender of the deceased, the manner of death (accident, suicide or undetermined) and types of co-ingested drugs were evaluated in relation to the concent...

journal_title：Journal of analytical toxicology

authors： Jones AW

更新日期：2017-04-01 00:00:00

abstract：:Toxicological analyses of medicines and chemicals in formaldehyde-treated specimens are a component of forensic toxicology. This review involves two parts: (i) reactions of formaldehyde with substances in tissues fixed with formalin (aqueous formaldehyde solution) and (ii) the stability of substances in formalin-treat...

journal_title：Journal of analytical toxicology

authors： Takayasu T

更新日期：2013-11-01 00:00:00

abstract：:A simple, rapid method for the gas-liquid chromatographic (GLC) determination of valproic acid in serum without prior derivatization on a Nukol wide-bore capillary column is presented. The method was determined to have a lower limit of detection (LOD) of 5 mg/L and a lower limit of quantitation (LOQ) of 10 mg/L; the m...

journal_title：Journal of analytical toxicology

authors： Wohler AS,Poklis A

更新日期：1997-07-01 00:00:00

abstract：:Deuterium-labeled analogues are available for a variety of drugs, but the amphetamines (amphetamine and methamphetamine) have more options available than any other drug. The analytical method and circumstances of its use can have a significant impact on the decision of what is the best internal standard to use. More t...

journal_title：Journal of analytical toxicology

authors： Valtier S,Cody JT

更新日期：1995-10-01 00:00:00

abstract：:The Rapid Stat assay, a point-of-collection drug-testing device for detection of amphetamines, cannabinoids, cocaine, opiates, methadone, and benzodiazepines in oral fluid, was evaluated for cannabis and amphetamine-type stimulants. The Rapid Stat tests (n = 134) were applied by police officers in routine traffic chec...

journal_title：Journal of analytical toxicology

authors： Röhrich J,Zörntlein S,Becker J,Urban R

更新日期：2010-04-01 00:00:00

abstract：:N,N-Diethyl-m-toluamide (DEET) is an effective component of several insect repellent products. A 19-year-old woman was admitted to the emergency department following ingestion of 15-25 mL 95% diethyltoluamide (Muscol). Serum and urine toxicology screening tests were negative except for detection of DEET. DEET was qual...

journal_title：Journal of analytical toxicology

authors： Fraser AD,MacNeil A,Theriault M,Morzycki W

更新日期：1995-05-01 00:00:00

abstract：:cis(Z)-Clopenthixol and trans(E)-clopenthixol were determined by gas chromatography-mass spectrometry and high-performance liquid chromatography-diode-array detection in necropic samples from a postmortem case. The peripheral blood concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol were 278 and 177 ng/mL,...

journal_title：Journal of analytical toxicology

authors： Rop PP

更新日期：2001-07-01 00:00:00

abstract：:Cyanohydrins, also be called cyanoalcohols, are important industrial precursors to carboxylic acids and some amino acids. Acetone cyanohydrin (ACH) and formaldehyde cyanohydrin (glycolonitrile, FCH), which are the typical examples of cyanohydrins, are classified as extremely hazardous substances. As the cyanohydrins c...

journal_title：Journal of analytical toxicology

authors： Zheng S,Yuan X,Wang W,Liang C,Cao F,Zhang R

更新日期：2016-06-01 00:00:00

abstract：:This article reports the investigation by 1H nuclear magnetic resonance (1H NMR) spectroscopy of biological fluids in a case of intentional poisoning with tetrahydrofuran (THF). Occupational exposures to this solvent are well documented, but acute poisoning cases are extremely rare, and the one presented here is the s...

journal_title：Journal of analytical toxicology

authors： Cartigny B,Azaroual N,Imbenotte M,Sadeg N,Testart F,Richecoeur J,Vermeersch G,Lhermitte M

更新日期：2001-05-01 00:00:00

abstract：:The purpose of this study was to determine the performance characteristics of the Cozart Methadone Microplate ELISA assay for the detection of methadone and methadone metabolites in hair specimens. One hundred and ten hair specimens were collected from volunteers (n=46) with a history of drug use and from drug-related...

journal_title：Journal of analytical toxicology

authors： Cooper G,Wilson L,Reid C,Baldwin D,Hand C,Spiehler V

更新日期：2005-10-01 00:00:00

abstract：:High doses of nutmeg (seeds from Myristica fragrans Houtt.) can be abused as a psychoactive drug due to phenylpropene ingredients. During controlled abstinence, e.g., in forensic psychiatric clinics, nutmeg abuse has to be distinguished from an ingestion of other spices having phenylpropene ingredients (e.g., black pe...

journal_title：Journal of analytical toxicology

authors： Neukamm MA,Schwelm HM,Vieser S,Schiesel N,Auwärter V

更新日期：2020-01-07 00:00:00

abstract：:Conditions for the enzymatic hydrolysis of benzodiazepine conjugates were systematically examined. Optimal recovery of the free drugs occurs when 1 mL of urine buffered to pH 4.5 is incubated with 5000 U of Helix pomatia beta-glucuronidase at 56 degrees C for 2 h. Urine specimens containing conjugates of temazepam, ox...

journal_title：Journal of analytical toxicology

authors： Meatherall R

更新日期：1994-11-01 00:00:00

abstract：:We described a simple procedure for the flash heater methylation of valproic acid and cyclohexylacetic acid (internal standard) by gas-liquid chromatography (GLC). A small volume (100 microL) of sample is acidified with 10% perchloric acid and extracted into hexane. An aliquot is back extracted into 5% tetramethylammo...

journal_title：Journal of analytical toxicology

authors： Calendrillo BA,Reynoso G

更新日期：1980-11-01 00:00:00

abstract：:Percutaneous vapor dosing studies have generally used saturated vapor concentration (SVC) measurements to estimate the exposure dose (Ct) of vapor produced from a volatile liquid within a closed system. The purpose of this study was to clarify whether the assumption was valid when translated to a biological system (pi...

journal_title：Journal of analytical toxicology

authors： Dalton CH,Maidment MP,Jenner J,Chilcott RP

更新日期：2006-04-01 00:00:00

abstract：:A liquid chromatographic method was developed for the analysis of indandione and 4-hydroxycoumarin anticoagulant rodenticides in blood serum and liver. The method enabled the measurement of serum and liver concentrations of eight anticoagulant rodenticides: brodifacoum, bromadiolone, chlorophacinone, coumafuryl, couma...

journal_title：Journal of analytical toxicology

authors： Chalermchaikit T,Felice LJ,Murphy MJ

更新日期：1993-01-01 00:00:00

abstract：:The gelsemium plants are highly poisonous but toxicological evaluation of suspected poisoning cases has been hampered by the chemical complexity of the gelsemium toxins involved. A novel liquid chromatography-tandem mass spectrometry protocol was optimized for the collective detection of gelsemine and related alkaloid...

journal_title：Journal of analytical toxicology

authors： Lai CK,Chan YW

更新日期：2009-01-01 00:00:00

abstract：:A rapid and simple liquid chromatography tandem mass spectrometry method was developed and validated for the simultaneous determination of L-ephedrine, pseudoephedrine, and caffeine in male Fisher-344 rat plasma at nanogram-per-milliliter concentrations for use in support of toxicology studies. Only 25 μL of plasma is...

journal_title：Journal of analytical toxicology

authors： Cooper SD,Fletcher BL,Silinski MA,Brown SS,Lodge JW,Fernando RA,Collins BJ

更新日期：2011-07-01 00:00:00

abstract：:In order to achieve accurate quantitation of drugs and metabolites (analytes) in complex matrices, 2H- (and less commonly 13C-) labeled analogues of the analytes are now routinely adapted as the internal standards (IS) using linear calibration models to fit data generated by selected ion monitoring gas chromatography-...

journal_title：Journal of analytical toxicology

authors： Whiting TC,Liu RH,Chang WT,Bodapati MR

更新日期：2001-04-01 00:00:00

abstract：:The guidelines for screening of urinary cannabinoids require that all specimens testing positive should be confirmed by gas chromatography-mass spectrometry at a confirmatory test cutoff value of 15 ng/mL of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH). To assess the impact of lowering the confirmatory test cuto...

journal_title：Journal of analytical toxicology

authors： Lecompte Y,Perrin M,Salle S,Roussel O

更新日期：2012-10-01 00:00:00

abstract：:Hop-derived iso-α-acid (IAA) ingredient congeners are specific to beer. Concentrations of IAAs were determined in blood of five volunteers over 6 h following the consumption of small volumes of beer containing relatively high (Pale Ale beer) or low (wheat beer) concentrations of IAAs. IAAs were quickly absorbed with p...

journal_title：Journal of analytical toxicology

authors： Rodda LN,Gerostamoulos D,Drummer OH

更新日期：2014-07-01 00:00:00

abstract：:A liquid chromatographic method for the determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and male and female B6C3F1 mouse urine was developed for use in supporting toxicokinetic studies, validated, and used to analyze urine samples for a preliminary dose level range-find...

journal_title：Journal of analytical toxicology

authors： Gaudette NF,Lodge JW

更新日期：2005-01-01 00:00:00

abstract：:A 59-year-old white male accidentally ingested a mouthful of a plant growth chemical, Cycocel, containing 11.8% of the active ingredient (2-chloroethyl)trimethylammonium chloride (chlormequat). He was seen by a family physician and then transferred to a hospital where he died as a result of ventricular fibrillation, w...

journal_title：Journal of analytical toxicology

authors： Winek CL,Wahba WW,Edelstein JM

更新日期：1990-07-01 00:00:00