Abstract:
:cis(Z)-Clopenthixol and trans(E)-clopenthixol were determined by gas chromatography-mass spectrometry and high-performance liquid chromatography-diode-array detection in necropic samples from a postmortem case. The peripheral blood concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol were 278 and 177 ng/mL, respectively. The level of the active cis(Z)-isomer is within the toxic range. Other associated drugs' concentrations were within their therapeutic ranges. Postmortem redistribution of the drug and instability of the drug due to trans-isomerization were discussed.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Rop PPdoi
10.1093/jat/25.5.348keywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
348-52issue
5eissn
0146-4760issn
1945-2403journal_volume
25pub_type
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