Abstract:
:A GC/MS method for the simultaneous determination of morphine, codeine, and O-6-monoacetylmorphine as well as other semisynthetic opiates in urine is described. The method employs 2H6-acetic anhydride to acetylate free hydroxyl groups on all of the opiates. As a result, the same hydrolysis and extraction procedure is used for all analytes. Quantitation is achieved using gas chromatography/mass spectrometry in the electron impact mode and with selected ion monitoring of the three most characteristic ions for each analyte. Ratios of these three ions are used for verifying identity while the molecular ions are used for quantitation. The detection limit for all analytes is less than 10 ng/mL.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Bowie LJ,Kirkpatrick PBdoi
10.1093/jat/13.6.326subject
Has Abstractpub_date
1989-11-01 00:00:00pages
326-9issue
6eissn
0146-4760issn
1945-2403journal_volume
13pub_type
杂志文章abstract::As part of a search for phencyclidine (PCP) antagonists, a series of eleven aryl-substituted PCP analogs were prepared and characterized. TLC and GC elution profiles of these derivatives are described in a number of systems allowing for the tentative identification of the PCP analogs. Further, MS, NMR, UV/vis and IR s...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/7.5.252
更新日期:1983-09-01 00:00:00
abstract::A sensitive and reproducible gas chromatographic procedure for the quantitative determination of urinary o-cresol is described. The first step involves acid hydrolysis (2N HCl, 100 degrees C, 10 min), which yields unconjugated o-cresol. After extraction (methylene chloride, pH 2), the organic layer is concentrated by ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/20.5.309
更新日期:1996-09-01 00:00:00
abstract::We describe herewith the case of a patient presenting to the emergency department for worsening ear-nose-throat symptoms. As chemsex was evocated by the family, patient's serum was submitted to a new psychoactive substances screening. After a simple liquid liquid extraction, serum was injected on a high-resolution mas...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkaa172
更新日期:2020-11-04 00:00:00
abstract::In this study, we investigated the effectiveness of the Roche Kinetic Interaction of Microparticles in Solution (KIMS) screening assay for cannabinoid metabolites. Urine specimens (N = 1689) were collected during elimination of cannabinoids from 25 subjects with a history of marijuana use. Specimens were analyzed conc...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/25.7.559
更新日期:2001-10-01 00:00:00
abstract::A method that measures 12 analytes in urine and reflects possible exposure to pesticides was developed. The sample preparation involves enzyme hydrolysis and solvent extraction through the use of laboratory robotics, followed by phase-transfer catalysis derivatization and silica cleanup. Samples are analyzed by capill...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/19.5.323
更新日期:1995-09-01 00:00:00
abstract::Percutaneous vapor dosing studies have generally used saturated vapor concentration (SVC) measurements to estimate the exposure dose (Ct) of vapor produced from a volatile liquid within a closed system. The purpose of this study was to clarify whether the assumption was valid when translated to a biological system (pi...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/30.3.165
更新日期:2006-04-01 00:00:00
abstract::A total of 183 random, whole-blood specimens was collected from healthy individuals within the State of Queensland (Australia), and the bromide concentration was determined by wavelength-dispersive X-ray fluorescence spectrometry (WDXRF). The intensity of the tube Compton scatter line was used to account for differenc...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/22.3.225
更新日期:1998-05-01 00:00:00
abstract::An arsenic death was investigated six and one half years after the demise. Analysis of tissue embedded in paraffin blocks demonstrated toxic concentrations. Spectrophotometry was employed with the use of a hydride generator to provide specificity and sensitivity to less than 0.05 microgram. ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/6.5.260
更新日期:1982-09-01 00:00:00
abstract::The List of Prohibited Substances and Methods (the List), an International Standard published yearly by the World Anti-Doping Agency (WADA), determines which substances and methods are prohibited in sport in- and out-of-competition. Stimulants are included within drug class S.6 under the in-competition testing sectio...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/anatox/35.9.613
更新日期:2011-11-01 00:00:00
abstract::In preparation for a treatment program concerning the medical coprescription of heroin and methadone to treatment-resistant addicts in the Netherlands, we studied a novel strategy for monitoring co-use of illicit (nonprescribed) heroin. A deuterated analogue of heroin was added (1:20) to pharmaceutical, smokable heroi...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.6.564
更新日期:2005-09-01 00:00:00
abstract::Methods for extraction of cocaine, some of its metabolites, morphine, and codeine from hair and methods for analyzing the extracts have been investigated. Results of these studies have shown that extractions with 0.1N HCl are efficient at removing the target compounds from hair and appear to be as effective as enzymat...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/17.7.389
更新日期:1993-11-01 00:00:00
abstract::A method for the detection and quantitation of methamphetamine and its major metabolite in hair, nails, sweat, and saliva from habitual users of methamphetamine by mass fragmentography has been developed. Hair and nail samples were washed with water and methanol to remove the external contamination, processed with 0.6...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/13.3.176
更新日期:1989-05-01 00:00:00
abstract::To determine the degree of ethanol absorption and the resultant formation and urinary excretion of its conjugated metabolites following intensive use of high ethanol content mouthwash, 10 subjects gargled with Listerine(®) antiseptic 4 times daily for 3¼ days. First morning void urine specimens were collected on each ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/anatox/35.5.264
更新日期:2011-06-01 00:00:00
abstract::A method for the determination of seven polychlorinated biphenyl residues in plasma by gas chromatography-mass spectrometry was developed. The analytes were isolated from human plasma by liquid-liquid extraction, followed by solid-phase extraction, and separation on an HP5 Trace column. Ionization mode was electronic ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.2.74
更新日期:2003-03-01 00:00:00
abstract::The post mortem findings of pentazocine and tripelennamine ("T's and Blues") in abusers dying in the City of St. Louis between July 1, 1979 and July 30, 1981 are presented. Thirty-three deaths were homicides; 30 black males, ages 21-38; one white male, age 26, died from gunshot wounds; and two black females, age 18 an...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/6.3.109
更新日期:1982-05-01 00:00:00
abstract::Acetaminophen (APAP, n-acetyl-p-aminophenol) and salicylate (ASA, acetylsalicylic acid) are two of the most frequently overdosed drugs reported in the emergency room. Most APAP and ASA tests are performed with analytical instruments in laboratories, which are not always ideal for emergency situations. A rapid membrane...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.6.366
更新日期:2003-09-01 00:00:00
abstract::A modification of the Syva EMIT-tox Serum Barbiturate Assay was developed to provide a rapid and practical method for quantitating serum barbiturates. Standard curves for eight selected barbiturates were run using specific sets of standards for each. Correlation coefficients, slopes, and y-intercepts for the curves of...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/7.6.257
更新日期:1983-11-01 00:00:00
abstract::A simple gas chromatography-mass spectrometry (GC-MS) procedure has been developed for the main metabolites of organophosphorus nerve agents, alkylmethylphosphonic acids (AMPAs; alkyl = Et, i-Pr, and pinacolyl) in biofluids via extractive pentafluorobenzylation. The derivatization was carried out under liquid-liquid-s...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/23.2.86
更新日期:1999-03-01 00:00:00
abstract::Despite the efforts to prevent the spread of new psychoactive substances (NPS) such as synthetic amphetamine derivatives, it is apparent that newer types of NPS are still emerging on the market in recent years. Due to high potential for their abuse, reliable analytical methods are required to determine these substance...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bky037
更新日期:2018-11-01 00:00:00
abstract::About 22,000 samples of oral fluid have been collected in five population studies in Norway using either the Intercept or Statsure oral fluid sampling devices. The prevalence of alcohol and drugs was found to be higher in oral fluid samples with small volumes than in those with large volumes for both sampling devices;...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/34.7.416
更新日期:2010-09-01 00:00:00
abstract::A simple and efficient method, based on the adsorption properties of octadecasilane bonded silica, is described for the rapid extraction of acidic drugs from whole post mortem blood. The blood was diluted, passed through an extraction column containing the bonded silica and the absorbed drugs were eluted with methanol...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/7.3.116
更新日期:1983-05-01 00:00:00
abstract::Urine drug testing is common for workplace drug testing, prescription management, emergency medicine and the criminal justice system. Unsurprisingly, with the significant consequences based upon the results of urine drug testing, a donor in need of concealing the contents of their sample is highly motivated to cheat t...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkw119
更新日期:2017-03-01 00:00:00
abstract::A selected ion monitoring gas chromatographic/mass spectrometric method for the quantitative determination of benzene in air, breath, and blood was developed utilizing a headspace assay with benzene-d3 as an internal standard. Limits of detection for 2 ng/mL in blood and 0.1 ppb in a 5-L sample of air or breath were a...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/10.6.225
更新日期:1986-11-01 00:00:00
abstract::A group of 16 volatile substances (ethyl acetate, 2-propanol, 1-propanol, methanol, acetone, ethanol, acetaldehyde, diethyl ether, methyl ethyl ketone, 1-butanol, 2-butanol, t-butanol, isobutanol, 2-methyl-1-butanol, 3-methyl-1-butanol, 1-pentanol) were qualitatively and quantitatively analyzed through a method develo...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkaa154
更新日期:2020-10-08 00:00:00
abstract::To study the disposition kinetics of methamphetamine (MAP), we have developed a sensitive high-performance liquid chromatographic (HPLC) assay to quantitate the enantiomers of MAP and its major metabolites, amphetamine (AP), p-hydroxymethamphetamine (p-OH-MAP), and p-hydroxyamphetamine (p-OH-AP), the latter two of whi...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/19.3.139
更新日期:1995-05-01 00:00:00
abstract::Human urine was tested for tricyclic antidepressants with fluorescence polarization immunoassay (FPIA) reagents on Abbott's ADx system and with EIA reagents on Syva's ETS system. A 75-ng/mL imipramine calibrator cutoff was used with the ADx system and a 300-ng/mL nortriptyline calibrator cutoff with the ETS system. Th...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/14.5.273
更新日期:1990-09-01 00:00:00
abstract::Separating drugs which are both polar and basic has long been difficult because of the limited operating pH range of conventional HPLC columns. This paper describes a liquid chromatographic method capable of being used with either diode-array or mass spectrometric detection for the identification and quantitation of 1...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.1.30
更新日期:2003-01-01 00:00:00
abstract::A method for the simultaneous extraction of the hallucinogens psilocin, bufotenine, lysergic acid diethylamide (LSD) as well as iso-LSD, nor-LSD and O-H-LSD from hair with hydrochloride acid and methanol is presented. Clean-up of the hair extracts is performed with solid phase extraction using a mixed-mode cation exch...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bku141
更新日期:2015-03-01 00:00:00
abstract::Synthetic cannabinoids emerged on the designer drug market in recent years due to their ability to produce cannabis-like effects without the risk of detection by traditional drug testing techniques such as immunoassay and gas chromatography-mass spectrometry. As government agencies work to schedule existing synthetic ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkv137
更新日期:2016-04-01 00:00:00
abstract::Cyclizine is an antihistamine with sedative effect used to treat motion sickness. A few studies have reported on cyclizine abuse among teenagers, and cyclizine abuse has been reported among opioid dependants receiving methadone, with the combination having been reported to produce strong psychoactive effects. Few repo...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkt100
更新日期:2014-03-01 00:00:00