A simple, rapid gas-liquid chromatographic procedure for the determination of valproic acid in serum.

abstract：INTRODUCTION:We encountered unexpected false positive urine results in three patients for amphetamine-type substances by immunoassay, measured as part of community drug prevention programmes. Kavain was identified in all three urine samples by gas chromatography mass spectrometry (GC-MS). No other potential cross-react...

journal_title：Journal of analytical toxicology

authors： Madhavaram H,Patel T,Kyle C

更新日期：2020-12-16 00:00:00

abstract：:Heart blood free oxycodone concentrations in oxycodone-related and mixed drug overdose deaths were compared with those found incidentally at autopsy in medical examiner cases. Between 2000 and 2005, 67 oxycodone-positive postmortem cases were identified. Thirty of 67 cases (44.8%) were determined to be drug overdoses....

journal_title：Journal of analytical toxicology

authors： Thompson JG,Vanderwerf S,Seningen J,Carr M,Kloss J,Apple FS

更新日期：2008-10-01 00:00:00

abstract：:A thin layer chromatographic (TLC) method for the high volume screening of urine for methylphenidate (Ritalin) abuse is presented. The method utilizes charcoal extraction of ritalinic acid from urine and a simple test-tube methylation step for the conversion of the ritalinic acid to methylphenidate. The methylphenidat...

journal_title：Journal of analytical toxicology

authors： Manno BR,Manno JE,Dempsey CA

更新日期：1986-05-01 00:00:00

abstract：:The purpose of this study was to develop and validate a gas chromatography-mass spectrometry method to detect drugs of abuse in a single sample of tooth. Pulverized samples of dental materials were subjected to acid hydrolysis to detect opiates, cocaine and their metabolites. The residual dental materials from these a...

journal_title：Journal of analytical toxicology

authors： Ottaviani G,Cameriere R,Cippitelli M,Froldi R,Tassoni G,Zampi M,Cingolani M

更新日期：2017-01-01 00:00:00

abstract：:A high performance liquid chromatographic method is described for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: lidocaine, mexiletine, disopyramide, and quinidine. An isocratic system using a reverse phase column was used to separate these compounds. Coefficients of variation were les...

journal_title：Journal of analytical toxicology

authors： Dusci LJ,Hackett LP

更新日期：1985-03-01 00:00:00

abstract：:Methods for extraction of cocaine, some of its metabolites, morphine, and codeine from hair and methods for analyzing the extracts have been investigated. Results of these studies have shown that extractions with 0.1N HCl are efficient at removing the target compounds from hair and appear to be as effective as enzymat...

journal_title：Journal of analytical toxicology

authors： Welch MJ,Sniegoski LT,Allgood CC,Habram M

更新日期：1993-11-01 00:00:00

abstract：:A forensic standard procedure is described that combines enzyme-linked immunoassay for screening and gas chromatography-mass spectrometry (GC-MS) for confirmation to detect drugs of abuse in a sample before used to detect opioids and cocaine. We used two equal aliquots of the same previously selected cannabinoid posit...

journal_title：Journal of analytical toxicology

authors： Tassoni G,Cippitelli M,Ottaviani G,Froldi R,Cingolani M

更新日期：2016-07-01 00:00:00

abstract：:Screening for emerging drugs of abuse, specifically synthetic cathinones and synthetic cannabinoids, is difficult for high-throughput laboratories as immunoassay kits are often unavailable. Consequently, most laboratories employ liquid chromatography-tandem mass spectrometry (LC-MS-MS) screening, which can be complex ...

journal_title：Journal of analytical toxicology

authors： Neifeld JR,Regester LE,Holler JM,Vorce SP,Magluilo J Jr,Ramos G,Bosy TZ

更新日期：2016-06-01 00:00:00

abstract：:Although many deaths occur annually from heroin intoxication, the presence of heroin has not been reported in postmortem tissues. Recognizing heroin's susceptibility to rapid chemical and metabolic hydrolysis, extraction procedures were developed for the efficient recovery of heroin, 6-acetylmorphine, and morphine fro...

journal_title：Journal of analytical toxicology

authors： Goldberger BA,Cone EJ,Grant TM,Caplan YH,Levine BS,Smialek JE

更新日期：1994-01-01 00:00:00

abstract：:A liquid chromatography-tandem mass spectrometry method was developed for the simultaneous quantification of 26 benzodiazepines and metabolites, zolpidem and zopiclone, in blood, urine, and hair. Drugs were extracted from all matrices by liquid-liquid extraction with 1-chlorobutane. Chromatography was achieved using a...

journal_title：Journal of analytical toxicology

authors： Laloup M,Ramirez Fernandez Mdel M,De Boeck G,Wood M,Maes V,Samyn N

更新日期：2005-10-01 00:00:00

abstract：:A group of 16 volatile substances (ethyl acetate, 2-propanol, 1-propanol, methanol, acetone, ethanol, acetaldehyde, diethyl ether, methyl ethyl ketone, 1-butanol, 2-butanol, t-butanol, isobutanol, 2-methyl-1-butanol, 3-methyl-1-butanol, 1-pentanol) were qualitatively and quantitatively analyzed through a method develo...

journal_title：Journal of analytical toxicology

authors： Pinto M,Eusébio E,Monteiro C

更新日期：2020-10-08 00:00:00

abstract：:Draft guidelines for the use of oral fluid for workplace drug testing are under development by the Substance Abuse and Mental Health Services Administration (SAMHSA) in cooperation with industry and researchers. Comparison studies of the effectiveness of oral fluid testing versus urine testing are needed to establish ...

journal_title：Journal of analytical toxicology

authors： Cone EJ,Presley L,Lehrer M,Seiter W,Smith M,Kardos KW,Fritch D,Salamone S,Niedbala RS

更新日期：2002-11-01 00:00:00

abstract：:A fast and efficient multiresidue extraction-purification procedure was developed for low levels (ppb range) of phenanthrene and hydroxyphenanthrene in biological matrices, in order to quantify phenanthrene and metabolites in blood, milk, urine, and biological tissues of lactating goats. Detection and identification o...

journal_title：Journal of analytical toxicology

authors： Grova N,Monteau F,Le Bizec B,Feidt C,Andre F,Rychen G

更新日期：2005-04-01 00:00:00

abstract：:This manuscript details a validated liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (LC-APCI-MS-MS) method for the quantification of methadone and its metabolites 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyroline (EMDP) in 0.5 mL ...

journal_title：Journal of analytical toxicology

authors： Choo RE,Jansson LM,Scheidweiler K,Huestis MA

更新日期：2007-06-01 00:00:00

abstract：:Confirmation of drugs of abuse by gas chromatography-mass spectrometry (GC-MS) is the most time-consuming process used by drug-testing laboratories. Cost effectiveness and competitive turnaround times for testing results demand fast, efficient, and reliable extraction methods. We applied the Cerex Polycrom-THC solid-p...

journal_title：Journal of analytical toxicology

authors： Crockett DK,Nelson G,Dimson P,Urry FM

更新日期：2000-05-01 00:00:00

abstract：:We report a case involving unusually high postmortem morphine concentrations in a 44-year-old male with end-stage pancreatic cancer. He was receiving morphine for pain control via a single subclavian intravenous catheter. Allegations of foul play were made by family members at the time of death, so a full autopsy was ...

journal_title：Journal of analytical toxicology

authors： Kerrigan S,Honey D,Baker G

更新日期：2004-09-01 00:00:00

abstract：:In clinical and forensic toxicology, general unknown screening is used to detect and identify exogenous compounds. In this study, we aimed to develop a fast (15 min) comprehensive screening method for 500 toxicologically relevant analytes based on ultra-performance liquid chromatography (UPLC) coupled with a quadrupol...

journal_title：Journal of analytical toxicology

authors： Humbert L,Grisel F,Richeval C,Lhermitte M

更新日期：2010-11-01 00:00:00

abstract：:We devised a highly sensitive method for simultaneously determining methamphetamine (MA) and amphetamine (AP) enantiomers, desmethylselegiline (DMSG) and selegiline (SG), in human hair using a derivatization technique and high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS). M...

journal_title：Journal of analytical toxicology

authors： Nishida K,Itoh S,Inoue N,Kudo K,Ikeda N

更新日期：2006-05-01 00:00:00

abstract：:Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique called solid-phase...

journal_title：Journal of analytical toxicology

authors： Guan F,Seno H,Ishii A,Watanabe K,Kumazawa T,Hattori H,Suzuki O

更新日期：1999-01-01 00:00:00

abstract：:The present study evaluates the suitability of headspace gas chromatography (GC) with a capillary column as a method for determining the ethanol content in different biological fluids. This procedure allows the use of headspace GC not only as a reference method but also in routine diagnostics and monitoring work. The ...

journal_title：Journal of analytical toxicology

authors： Macchia T,Mancinelli R,Gentili S,Lugaresi EC,Raponi A,Taggi F

更新日期：1995-07-01 00:00:00

abstract：:A method for analyzing urine for the presence of basic drugs and their metabolites using two fused silica capillary columns is described along with operating conditions and column characteristics. Urine extracts were injected into a gas chromatograph equipped with nitrogen phosphorous detectors (GC/NPD) and two capill...

journal_title：Journal of analytical toxicology

authors： Hime GW,Bednarczyk LR

更新日期：1982-09-01 00:00:00

abstract：:Understanding cocaine and metabolites urinary excretion following smoking is important for interpretation of urine test results in judicial, workplace and treatment settings. In National Institute on Drug Abuse approved studies on a secure research unit, six subjects smoked placebo, 10, 20, and 40 mg cocaine with a pr...

journal_title：Journal of analytical toxicology

authors： Huestis MA,Darwin WD,Shimomura E,Lalani SA,Trinidad DV,Jenkins AJ,Cone EJ,Jacobs AJ,Smith ML,Paul BD

更新日期：2007-10-01 00:00:00

abstract：:Publications reporting concentrations of caffeine in postmortem blood were reviewed if the cause of death was attributed to overdosing (poisoning) with drugs. Age and gender of the deceased, the manner of death (accident, suicide or undetermined) and types of co-ingested drugs were evaluated in relation to the concent...

journal_title：Journal of analytical toxicology

authors： Jones AW

更新日期：2017-04-01 00:00:00

abstract：:Human urine was tested for tricyclic antidepressants with fluorescence polarization immunoassay (FPIA) reagents on Abbott's ADx system and with EIA reagents on Syva's ETS system. A 75-ng/mL imipramine calibrator cutoff was used with the ADx system and a 300-ng/mL nortriptyline calibrator cutoff with the ETS system. Th...

journal_title：Journal of analytical toxicology

authors： Meenan GM,Barlotta S,Lehrer M

更新日期：1990-09-01 00:00:00

abstract：:A gas chromatographic-chemical ionization mass spectrometric (GC-CIMS) method is described for the determination of cocaine, benzoylecgonine, and norcocaine. The procedure uses stable isotopes as internal standards and a mixture of methane-ammonia as chemical ionization reagent gas. Run-to-run and within-run coefficie...

journal_title：Journal of analytical toxicology

authors： Chinn DM,Crouch DJ,Peat MA,Finkle BS,Jennison TA

更新日期：1980-01-01 00:00:00

abstract：:The testing for drugs of abuse in hair is increasingly used to detect illicit substances. Laboratories have implemented various decontamination, or washing, procedures in order to eliminate concerns regarding potential contamination of the hair with drug from the environment. However, the effect of these decontaminati...

journal_title：Journal of analytical toxicology

authors： Paulsen RB,Wilkins DG,Slawson MH,Shaw K,Rollins DE

更新日期：2001-10-01 00:00:00

abstract：:Clonazepam, nitrazepam and flunitrazepam are frequently used benzodiazepines, both as prescribed medication and as drugs of abuse. Little is, however, known about how these drugs are excreted in oral fluid. It has been claimed that the parent drugs are more likely to be detected in oral fluid than the 7-amino metaboli...

journal_title：Journal of analytical toxicology

authors： Vindenes V,Strand DH,Koksæter P,Gjerde H

更新日期：2016-05-01 00:00:00

abstract：:A multi-residue analytical method was developed for the determination in amniotic fluid (AF) of 13 illicit phenethylamines, including 12 compounds never investigated in this matrix before. Samples were subject to solid-phase extraction using; hydrophilic-lipophilic balance cartridges which gave good recoveries and low...

journal_title：Journal of analytical toxicology

authors： Burrai L,Nieddu M,Carta A,Trignano C,Sanna R,Boatto G

更新日期：2016-04-01 00:00:00

abstract：:A method for the determination of seven polychlorinated biphenyl residues in plasma by gas chromatography-mass spectrometry was developed. The analytes were isolated from human plasma by liquid-liquid extraction, followed by solid-phase extraction, and separation on an HP5 Trace column. Ionization mode was electronic ...

journal_title：Journal of analytical toxicology

authors： Charlier C,Dubois N,Cucchiaro S,Plomteux G

更新日期：2003-03-01 00:00:00

abstract：:A case report involving a 34-year-old white male who was found dead at home by his roommate is presented. At the time of his death, he was being treated with tramadol/acetaminophen, metaxalone, oxycodone, and amitriptyline. The decedent's mother stated that he had been taking increasing amounts of pain medication in o...

journal_title：Journal of analytical toxicology

authors： Bynum ND,Poklis JL,Gaffney-Kraft M,Garside D,Ropero-Miller JD

更新日期：2005-07-01 00:00:00