Abstract:
:A multi-residue analytical method was developed for the determination in amniotic fluid (AF) of 13 illicit phenethylamines, including 12 compounds never investigated in this matrix before. Samples were subject to solid-phase extraction using; hydrophilic-lipophilic balance cartridges which gave good recoveries and low matrix effects on analysis of the extracts. The quantification was performed by liquid chromatography electrospray tandem mass spectrometry. The water-acetonitrile mobile phase containing 0.1% formic acid, used with a C18 reversed phase column, provided adequate separation, resolution and signal-to-noise ratio for the analytes and the internal standard. The final optimized method was validated according to international guidelines. A monitoring campaign to assess fetal exposure to these 13 substances of abuse has been performed on AF test samples obtained from pregnant women. All mothers (n = 194) reported no use of drugs of abuse during pregnancy, and this was confirmed by the analytical data.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Burrai L,Nieddu M,Carta A,Trignano C,Sanna R,Boatto Gdoi
10.1093/jat/bkv143subject
Has Abstractpub_date
2016-04-01 00:00:00pages
194-200issue
3eissn
0146-4760issn
1945-2403pii
bkv143journal_volume
40pub_type
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