Abstract:
:The purpose of this study was to develop and validate a gas chromatography-mass spectrometry method to detect drugs of abuse in a single sample of tooth. Pulverized samples of dental materials were subjected to acid hydrolysis to detect opiates, cocaine and their metabolites. The residual dental materials from these analyses were subjected to basic extraction to detect cannabis products (Δ9-tetrahydrocannabinol, cannabidiol and cannabinol). The method showed a good linearity between 0.05 and 2 ng/mg for all substances. The limit of detection ranged from 0.02 to 0.03 ng/mg, and the limit of quantification was 0.05 ng/mg. The application of the method to samples of teeth obtained from drug addicts was successful. It can be applied in post-mortem cases, especially when limited amounts of sample are available.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Ottaviani G,Cameriere R,Cippitelli M,Froldi R,Tassoni G,Zampi M,Cingolani Mdoi
10.1093/jat/bkw105subject
Has Abstractpub_date
2017-01-01 00:00:00pages
32-36issue
1eissn
0146-4760issn
1945-2403pii
bkw105journal_volume
41pub_type
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