Abstract:
:The percent recovery of mercury from human hair digest samples, using the peak height cold-vapor atomic adsorption method is 73.0% +/- 10.3%. This value and its reproducibility are raised to 102.2% +/- 6.3% by use of peak area measurements in place of peak height. The so-called matrix effect is thus eliminated, and its origin shown to be in the slower (but still quantitative) release of mercury from biological samples. Although greater reliability is obtained using peak area, this is gained at the cost of analysis time.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Wigfield DC,Croteau SM,Perkins SLdoi
10.1093/jat/5.1.52subject
Has Abstractpub_date
1981-01-01 00:00:00pages
52-5issue
1eissn
0146-4760issn
1945-2403journal_volume
5pub_type
杂志文章abstract::The metabolism of N-benzylpiperazine (BZP), a recently scheduled designer drug, in the rat has been studied by analyzing its urinary metabolites. p-Hydroxy-BZP (p-OH-BZP) was unequivocally identified as the main metabolite along with a minor metabolite m-hydroxy-BZP (m-OH-BZP), using gas chromatography-mass spectromet...
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更新日期:2006-01-01 00:00:00
abstract::Analytical chemical procedures are described to determine residues of the drugs clofibrate and tibric acid in animal feed, wastewater, and human urine. Clofibrate was extracted from animal feed and human urine with hexane, whereas residues from wastewater were collected on a Sep-PakTM then eluted with methanol for ana...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/6.4.175
更新日期:1982-07-01 00:00:00
abstract::Vitreous humor is a potential alternative matrix for postmortem toxicology drug screens when peripheral blood is unavailable. It is easily and reliably collected and may not suffer from the same postmortem redistribution as seen in blood. Here, we compared the concentrations of 7 acidic drugs (acetaminophen, ibuprofen...
journal_title:Journal of analytical toxicology
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更新日期:2019-11-06 00:00:00
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journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/14.1.39
更新日期:1990-01-01 00:00:00
abstract::Amoxapine, a tricyclic antidepressant, is metabolized to 8-hydroxyamoxapine and 7-hydroxyamoxapine. There are few reports on the metabolism of this drug and correlation of clinical symptoms in overdose patients. Five such patients admitted to the Emergency Unit of the University of Cincinnati Hospital were studied. Cl...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/8.3.124
更新日期:1984-05-01 00:00:00
abstract::A simple gas chromatography-mass spectrometry (GC-MS) procedure has been developed for the main metabolites of organophosphorus nerve agents, alkylmethylphosphonic acids (AMPAs; alkyl = Et, i-Pr, and pinacolyl) in biofluids via extractive pentafluorobenzylation. The derivatization was carried out under liquid-liquid-s...
journal_title:Journal of analytical toxicology
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doi:10.1093/jat/23.2.86
更新日期:1999-03-01 00:00:00
abstract::Buprenorphine, which is used in France as a substitution drug for opioid addiction, is widely abused, and several fatal cases have been reported. In order to confirm a recent intoxication or to establish retrospectively chronic abuse, a simple and reliable gas chromatographic-mass spectrometric method was developed an...
journal_title:Journal of analytical toxicology
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更新日期:1999-07-01 00:00:00
abstract::Vitreous humor is a fluid contained in the eye that is largely composed of water. The advantages of vitreous humor as a specimen for postmortem drug analysis include its relatively low susceptibility to contamination and the ability to analyze vitreous humor with little or no pretreatment. The postmortem analysis of e...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/31.8.537
更新日期:2007-10-01 00:00:00
abstract::Four kinds of volatile anesthetics (halothane, enflurane, isoflurane, and sevoflurane) that were dissolved in 3 microL of experimental plasma samples were examined by the pulse-heating gas chromatographic-mass spectrometric method, and this approach was found to be reliable for qualitative and quantitative analysis. T...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
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更新日期:1995-03-01 00:00:00
abstract::A 25 mg oral dose of cocaine HCl given to a single volunteer resulted in a peak urinary cocaine concentration of 269 ng/mL at 1 h, and a peak benzoylecgonine concentration of 7,940 ng/mL at 12 h. Urine benzoylecgonine concentrations remained in excess of 300 ng/mL for 48 h. We conclude that small, oral doses of cocain...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/11.2.81
更新日期:1987-03-01 00:00:00
abstract::In order to achieve accurate quantitation of drugs and metabolites (analytes) in complex matrices, 2H- (and less commonly 13C-) labeled analogues of the analytes are now routinely adapted as the internal standards (IS) using linear calibration models to fit data generated by selected ion monitoring gas chromatography-...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
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更新日期:2001-04-01 00:00:00
abstract::Heart blood free oxycodone concentrations in oxycodone-related and mixed drug overdose deaths were compared with those found incidentally at autopsy in medical examiner cases. Between 2000 and 2005, 67 oxycodone-positive postmortem cases were identified. Thirty of 67 cases (44.8%) were determined to be drug overdoses....
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/32.8.673
更新日期:2008-10-01 00:00:00
abstract::Solid-phase extraction (SPE) and a one-step derivatization are combined with gas chromatography-negative ion chemical ionization-mass spectrometry to simplify a previously reported method for the determination of naltrexone and its metabolite, 6-beta-naltrexol, in human plasma. Deuterated isotopomers of naltrexone and...
journal_title:Journal of analytical toxicology
pub_type: 临床试验,杂志文章
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更新日期:1997-07-01 00:00:00
abstract::An analytical method for determining exposure to 2,2'-dichlorodiethyl sulfide (sulfur mustard, HD) has been enhanced. The method is based on the cleavage of adducted HD (protein-hydroxyethylthioethyl esters) to produce thiodiglycol. Following cleavage, a deuterated internal standard is added, and the analytes are extr...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/32.1.31
更新日期:2008-01-01 00:00:00
abstract::Anticoagulant rodenticides are the largest group of poisons used to kill harmful rodents. Their fundamental mode of action consists in the inhibition of the vitamin K epoxide reductase, which causes blood-clotting alteration, ultimately leading to hemorrhagic events as the cause of death. In this study, we developed a...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkw019
更新日期:2016-05-01 00:00:00
abstract::Cyanohydrins, also be called cyanoalcohols, are important industrial precursors to carboxylic acids and some amino acids. Acetone cyanohydrin (ACH) and formaldehyde cyanohydrin (glycolonitrile, FCH), which are the typical examples of cyanohydrins, are classified as extremely hazardous substances. As the cyanohydrins c...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkw023
更新日期:2016-06-01 00:00:00
abstract::Oral fluid (OF) is increasingly used for clinical, forensic and workplace drug testing as an alternative to urine. Uncertainties surrounding OF collection device performance, drug stability and testing reproducibility may be partially responsible for delays in the implementation of OF testing in regulated drug testing...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkv093
更新日期:2015-10-01 00:00:00
abstract::In cases of death by inert gas asphyxiation, it can be difficult to obtain toxicological evidence supporting assignment of a cause of death. Because of its low mass and high diffusivity, and its common use as a carrier gas, helium presents a particular challenge in this respect. We describe a rapid and simple gas chro...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bks002
更新日期:2012-03-01 00:00:00
abstract::Selegiline (SE) is a selective, irreversible monoamine oxidase-B inhibitor, used for reducing symptoms in early-stage Parkinson's disease. The metabolites of SE include l-methamphetamine, l-amphetamine and desmethylselegiline (DSE). The stereoisomers of SE metabolites, d-methamphetamine and d-amphetamine are highly ad...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
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abstract::A fatality due to the ingestion of isoniazid, a tuberculostatic agent, is presented. Isoniazid was extracted by a single step extraction procedure, derivatized with trifluoroacetic anhydride, and identified and quantified by gas chromatography/mass spectrometry (GC/MS). The distribution of isoniazid was as follows: he...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
abstract::A group of 16 volatile substances (ethyl acetate, 2-propanol, 1-propanol, methanol, acetone, ethanol, acetaldehyde, diethyl ether, methyl ethyl ketone, 1-butanol, 2-butanol, t-butanol, isobutanol, 2-methyl-1-butanol, 3-methyl-1-butanol, 1-pentanol) were qualitatively and quantitatively analyzed through a method develo...
journal_title:Journal of analytical toxicology
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更新日期:2020-10-08 00:00:00
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journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkt062
更新日期:2013-10-01 00:00:00
abstract::Dehydroepiandrosterone (DHEA) is an endogenous androgenic steroid produced by the ovaries and adrenal glands. Research suggests that DHEA can be converted to testosterone in peripheral tissues. Classified as a nutritional supplement, this compound may be purchased without a prescription. The military and international...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/22.6.455
更新日期:1998-10-01 00:00:00
abstract::Previous measurements of elemental concentrations in liver mitochondria have generally required homogenization and fractionation of liver tissue, a procedure in which it is difficult to rule out ion movement between subcellular units. New techniques involving cryoultramicrotomy of rapidly frozen tissue, high resolutio...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/9.4.145
更新日期:1985-07-01 00:00:00
abstract::Benzoylecgonine (BZE) extraction from urine was explored using Cerex Polycrom Clin II solid-phase extraction (SPE) columns and the Speedisk 48 Pressure Processor as an alternative to the Prep1 automated sample processor and XTRX Type RP/W columns. Linearity for urine standards extracted using the Cerex-Speedisk method...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
abstract::Analysis and interpretation of the findings for the drug of abuse gamma hydroxybutyric acid (GHB) in fatalities has become very problematic. This is primarily because of variable data in postmortem biological fluids resulting from the endogenous nature of the compound, possible postmortem production, and varying metho...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.1.20
更新日期:2004-01-01 00:00:00
abstract::Exposure to drugs and toxins is a major cause for the rising number of emergency department visits each year. Immunoassays are commonly used in the emergency department to provide rapid turnaround time for acute care. The purpose of this study was to compare two automated immunoassay chemistry analyzers to determine w...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
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abstract::Sampling and drug stability in oral fluid (OF) are crucial factors when interpreting forensic toxicological analysis, mainly because samples may not be analyzed immediately after collection, potentially altering drug concentrations. Therefore, the stability of some common drugs of abuse (morphine, codeine, 6-monoacety...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz114
更新日期:2020-07-31 00:00:00
abstract::Suvorexant (Belsomra®) is a novel dual orexin receptor antagonist used for the treatment of insomnia. The prevalence of suvorexant in forensic samples is relatively unknown, which demonstrates the need for robust analytical assays for the detection of this sedative hypnotic in forensic toxicology laboratories. In this...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz083
更新日期:2020-04-30 00:00:00
abstract::An automated solid-phase extraction (SPE) protocol followed by gas chromatography coupled with tandem mass spectrometry was developed for quantification of caffeine, cyamemazine, meprobamate, morphine and 6-monoacetylmorphine (6-MAM) in 11 biological matrices [blood, urine, bile, vitreous humor, liver, kidney, lung an...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bku029
更新日期:2014-06-01 00:00:00