Development and Validation of an Analytical Method for Volatiles with Endogenous Production in Putrefaction and Submersion Situations.

abstract：:The fraction of any surface-adsorbed contaminant available for absorption is considered the bioaccessible fraction. Applied previously to contaminants such as pesticides and heavy metals on surfaces such as soil, food and cosmetics, the term may also be used to describe the fraction of drug residue bound to work surfa...

journal_title：Journal of analytical toxicology

authors： Doran GS,Howitt JA

更新日期：2019-03-01 00:00:00

abstract：:This article reports the impact of diuresis on urinary excretion of ethanol in seven healthy volunteers who drank 1000 mL of export beer (44 g ethanol) in 30 min and, 120 min later, ingested 500 or 1000 mL of water within 5 min. Urine was voided before drinking started and every 30-60 min for 360 min after the start o...

journal_title：Journal of analytical toxicology

authors： Bendtsen P,Jones AW

更新日期：1999-11-01 00:00:00

abstract：:A 22-year-old male with more than 28 needle marks on his right arm was found dead. First, he was suspected as a drug abuser. Blood, urine, spleen, and injection-site tissue was collected during autopsy. The blood and urine specimens were screened for drugs. Immunoassay studies did not show any illegal drugs. However, ...

journal_title：Journal of analytical toxicology

authors： Chung H,Choi H,Kim E,Jin W,Lee H,Yoo Y

更新日期：2000-05-01 00:00:00

abstract：:This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart ...

journal_title：Journal of analytical toxicology

authors： Charlier C,Kintz P,Dubois N,Plomteux G

更新日期：2004-03-01 00:00:00

abstract：:Vitreous humor is a fluid contained in the eye that is largely composed of water. The advantages of vitreous humor as a specimen for postmortem drug analysis include its relatively low susceptibility to contamination and the ability to analyze vitreous humor with little or no pretreatment. The postmortem analysis of e...

journal_title：Journal of analytical toxicology

authors： Cox D,Jufer Phipps RA,Levine B,Jacobs A,Fowler D

更新日期：2007-10-01 00:00:00

abstract：:An analytical database, using high-performance liquid chromatography (HPLC) with diode array ultraviolet (UV) detection, of over 250 toxicologically relevant drugs has been extensively applied to both clinical and forensic toxicology. This general drug screening system, based on a mixed-phase (octadecyl/cyanopropyl) c...

journal_title：Journal of analytical toxicology

authors： Elliott SP,Hale KA

更新日期：1998-07-01 00:00:00

abstract：:Despite the efforts to prevent the spread of new psychoactive substances (NPS) such as synthetic amphetamine derivatives, it is apparent that newer types of NPS are still emerging on the market in recent years. Due to high potential for their abuse, reliable analytical methods are required to determine these substance...

journal_title：Journal of analytical toxicology

authors： Kim JY,Suh S,Park J,In MK

更新日期：2018-11-01 00:00:00

abstract：:An extraction and concentration procedure using a unique solid-phase extraction tube was developed for the analysis of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in urine. Absolute and relative recoveries of the drug metabolite were found to be greater than 85% and 92%, respectively. The extraction procedur...

journal_title：Journal of analytical toxicology

authors： Parry RC,Nolan L,Shirey RE,Wachob GD,Gisch DJ

更新日期：1990-01-01 00:00:00

abstract：:During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. A case recently received by CAMI screened positive for the anticonvulsant medication carbamazepine (CBZ;...

journal_title：Journal of analytical toxicology

authors： Lewis RJ,Angier MK,Johnson RD

更新日期：2014-10-01 00:00:00

abstract：:A 25 mg oral dose of cocaine HCl given to a single volunteer resulted in a peak urinary cocaine concentration of 269 ng/mL at 1 h, and a peak benzoylecgonine concentration of 7,940 ng/mL at 12 h. Urine benzoylecgonine concentrations remained in excess of 300 ng/mL for 48 h. We conclude that small, oral doses of cocain...

journal_title：Journal of analytical toxicology

authors： Baselt RC,Chang R

更新日期：1987-03-01 00:00:00

abstract：:A high-performance liquid chromatographic method was used for the detection of etodolac in equine serum and urine. The method consisted of a one-step liquid-liquid extraction, separation on a reversed-phase (RP-18) column and detection using an ultraviolet detector. Additional confirmation methods included a HPLC coup...

journal_title：Journal of analytical toxicology

authors： Koupai-Abyazani MR,Esaw B,Laviolette B

更新日期：1999-05-01 00:00:00

abstract：:We describe an assay for measuring cocaine and benzoylecgonine in meconium of infants born to mothers suspected of using cocaine during their pregnancy. The assay involves the use of fluorescence polarization immunoassay (FPIA) to screen for benzoylecgonine in a methanolic extract of the meconium. The FPIA is sensitiv...

journal_title：Journal of analytical toxicology

authors： Clark GD,Rosenzweig IB,Raisys V,Callahan CM,Grant TM,Streissguth AP

更新日期：1992-07-01 00:00:00

abstract：:In clinical and forensic toxicology, general unknown screening is used to detect and identify exogenous compounds. In this study, we aimed to develop a fast (15 min) comprehensive screening method for 500 toxicologically relevant analytes based on ultra-performance liquid chromatography (UPLC) coupled with a quadrupol...

journal_title：Journal of analytical toxicology

authors： Humbert L,Grisel F,Richeval C,Lhermitte M

更新日期：2010-11-01 00:00:00

abstract：:Urine drug testing (UDT) is an emerging standard of care in the evaluation and treatment of chronic non-cancer pain patients with opioid analgesics. UDT may be used both to verify adherence with the opioid analgesic regimen and to monitor abstinence from non-prescribed or illicit controlled substances. In the former s...

journal_title：Journal of analytical toxicology

authors： Bertholf RL,Johannsen LM,Reisfield GM

更新日期：2015-01-01 00:00:00

abstract：:The aim of the present study was to develop and validate a method for the detection and quantitation of drugs of abuse in oral fluids. Fortified oral fluid samples (made in-house) and samples from donors collected with Quantasil oral fluid collection kits from Immunalysis were screened on an Olympus 5400 using reagent...

journal_title：Journal of analytical toxicology

authors： Kala SV,Harris SE,Freijo TD,Gerlich S

更新日期：2008-10-01 00:00:00

abstract：:The measurement of cefoperazone concentrations in cerebral spinal fluid (CSF) is important to understanding the biodisposition and pharmacokinetic behavior of the drug. We have demonstrated that cefoperazone is unstable in methanol and at alkaline pH and these factors may affect the accurate quantitation of the drug i...

journal_title：Journal of analytical toxicology

authors： Kinniburgh DW,Jennison TA,Matsen JM

更新日期：1982-03-01 00:00:00

abstract：:A liquid chromatographic method for the determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and male and female B6C3F1 mouse urine was developed for use in supporting toxicokinetic studies, validated, and used to analyze urine samples for a preliminary dose level range-find...

journal_title：Journal of analytical toxicology

authors： Gaudette NF,Lodge JW

更新日期：2005-01-01 00:00:00

abstract：:Bupropion is a "second generation" antidepressant agent structurally related to the phenethylamines. Postmortem toxicology data are presented from three suicidal drug overdoses in which bupropion was detected. In two cases in which bupropion was the major toxicology finding, peripheral blood levels of the parent drug ...

journal_title：Journal of analytical toxicology

authors： Friel PN,Logan BK,Fligner CL

更新日期：1993-11-01 00:00:00

abstract：:Because mycotoxins occur worldwide in grain and grain products, evaluating their effects on the health of the population has become important. The development of a high performance liquid chromatographic (HPLC) procedure was investigated for the analysis of aflatoxin B1, citrinin, and ochratoxin A, from hydrolyzed hum...

journal_title：Journal of analytical toxicology

authors： Orti DL,Hill RH Jr,Liddle JA,Needham LL,Vickers L

更新日期：1986-03-01 00:00:00

abstract：:Analysis of drugs in hair differs from their analysis in other tissues due to the extended detection window, as well as the opportunity that segmental hair analysis offers for the detection of changes in drug intake over time. The antipsychotic drug chlorprothixene is widely used, but few reports exist on chlorprothix...

journal_title：Journal of analytical toxicology

authors： Günther KN,Johansen SS,Wicktor P,Banner J,Linnet K

更新日期：2018-11-01 00:00:00

abstract：:A gas chromatographic-chemical ionization mass spectrometric (GC-CIMS) method is described for the determination of cocaine, benzoylecgonine, and norcocaine. The procedure uses stable isotopes as internal standards and a mixture of methane-ammonia as chemical ionization reagent gas. Run-to-run and within-run coefficie...

journal_title：Journal of analytical toxicology

authors： Chinn DM,Crouch DJ,Peat MA,Finkle BS,Jennison TA

更新日期：1980-01-01 00:00:00

abstract：:Radioactive methadone, phenytoin, phenobarbital, and diazepam were easily and efficiently removed from human urine samples by adsorption on C18 bonded silica phases. These techniques were simpler than conventional extractions at pH 9.3 or 5.2 with dichloromethane, XAD-2 and methanol, or Celite 560 and dichloromethane....

journal_title：Journal of analytical toxicology

authors： Hyde PM

更新日期：1985-11-01 00:00:00

abstract：:Cotinine biomarker measurements involving both smokers and nonsmokers must accommodate a broad range of concentrations. Thus, we have routinely preclassified unknown samples as being either "high" or "low" by using an enzyme-linked immunoassay for cotinine prior to analysis by tandem mass spectrometry (MS). Although t...

journal_title：Journal of analytical toxicology

authors： Bernert JT,Harmon TL,Sosnoff CS,McGuffey JE

更新日期：2005-11-01 00:00:00

abstract：:A sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the quantitation of oxymorphone (OM) in human whole blood and liver. Sample preparation was done by solid-phase extraction, using deuterated OM as the internal standard. Separation was achieved using a Waters Aquity UPLC ...

journal_title：Journal of analytical toxicology

authors： Crum ED,Bailey KM,Richards-Waugh LL,Clay DJ,Gebhardt MA,Kraner JC

更新日期：2013-10-01 00:00:00

abstract：:In this study, we investigated the effectiveness of the Roche Kinetic Interaction of Microparticles in Solution (KIMS) screening assay for cannabinoid metabolites. Urine specimens (N = 1689) were collected during elimination of cannabinoids from 25 subjects with a history of marijuana use. Specimens were analyzed conc...

journal_title：Journal of analytical toxicology

authors： Lyons TP,Okano CK,Kuhnle JA,Bruins MR,Darwin WD,Moolchan ET,Huestis MA

更新日期：2001-10-01 00:00:00

abstract：:A colchicine blood concentration 250 microgram/L was determined in a 39-year-old white female 2 hours following the ingestion of an oral overdose of the drug. At death, 40 hours following ingestion, no drug was detected. Colchicine was extracted from buffered blood using dichloromethane. The evaporated extract was red...

journal_title：Journal of analytical toxicology

authors： Caplan YH,Orloff KG,Thompson BC

更新日期：1980-05-01 00:00:00

abstract：:A method utilizing microwave dissolution in a closed Teflon bomb followed by hydride generation atomic absorption spectrometry has been used for the routine analysis of arsenic in fish species from the coast of the province of Granada, Spain. The technique was evaluated for decomposing biological standard reference ma...

journal_title：Journal of analytical toxicology

authors： Navarro M,López H,López MC,Sánchez M

更新日期：1992-05-01 00:00:00

abstract：:About 22,000 samples of oral fluid have been collected in five population studies in Norway using either the Intercept or Statsure oral fluid sampling devices. The prevalence of alcohol and drugs was found to be higher in oral fluid samples with small volumes than in those with large volumes for both sampling devices;...

journal_title：Journal of analytical toxicology

authors： Gjerde H,Normann PT,Christophersen AS

更新日期：2010-09-01 00:00:00

abstract：:The post mortem findings of pentazocine and tripelennamine ("T's and Blues") in abusers dying in the City of St. Louis between July 1, 1979 and July 30, 1981 are presented. Thirty-three deaths were homicides; 30 black males, ages 21-38; one white male, age 26, died from gunshot wounds; and two black females, age 18 an...

journal_title：Journal of analytical toxicology

authors： Poklis A,Mackell MA

更新日期：1982-05-01 00:00:00

abstract：:A variety of chemical agents were evaluated to determine their effects on fluorescence polarization immunoassays for drugs of abuse. Sixteen different agents, at concentrations up to 10%, were tested against urine assays for cannabinoids, cocaine (metabolite), amphetamines, opiates, phencyclidine (PCP), and barbiturat...

journal_title：Journal of analytical toxicology

authors： Schwarzhoff R,Cody JT

更新日期：1993-01-01 00:00:00