Abstract:
:The measurement of cefoperazone concentrations in cerebral spinal fluid (CSF) is important to understanding the biodisposition and pharmacokinetic behavior of the drug. We have demonstrated that cefoperazone is unstable in methanol and at alkaline pH and these factors may affect the accurate quantitation of the drug in CSF. Buffering CSF samples with acetate is recommended to improve cefoperazone stability in CSF.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Kinniburgh DW,Jennison TA,Matsen JMdoi
10.1093/jat/6.2.85subject
Has Abstractpub_date
1982-03-01 00:00:00pages
85-7issue
2eissn
0146-4760issn
1945-2403journal_volume
6pub_type
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journal_title:Journal of analytical toxicology
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journal_title:Journal of analytical toxicology
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journal_title:Journal of analytical toxicology
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