Abstract:
:A previously reported procedure for quantification of LSD in urine was modified to permit measurement of the drug in plasma. After addition of deuterium-labelled LSD, the plasma is extracted and the extract is treated with trifluoroacetylimidazole to convert the LSD to its N-trifluoroacetyl derivative. The derivatized LSD is analyzed by capillary column gas chromatography/negative ion chemical ionization. Plasma fortified with known concentrations of LSD gave linear responses from 0.1 to 3.0 ng/mL with this assay. The method was used to determine pharmacokinetic parameters for LSD after oral administration (1 microgram/kg) to a male volunteer. The apparent plasma half-life was determined to be 5.1 h. The peak plasma concentration of 1.9 ng/mL occurred 3 h after administration.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Papac DI,Foltz RLdoi
10.1093/jat/14.3.189subject
Has Abstractpub_date
1990-05-01 00:00:00pages
189-90issue
3eissn
0146-4760issn
1945-2403journal_volume
14pub_type
杂志文章abstract::A simple and efficient method, based on the adsorption properties of octadecasilane bonded silica, is described for the rapid extraction of acidic drugs from whole post mortem blood. The blood was diluted, passed through an extraction column containing the bonded silica and the absorbed drugs were eluted with methanol...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/7.3.116
更新日期:1983-05-01 00:00:00
abstract::Radioactive methadone, phenytoin, phenobarbital, and diazepam were easily and efficiently removed from human urine samples by adsorption on C18 bonded silica phases. These techniques were simpler than conventional extractions at pH 9.3 or 5.2 with dichloromethane, XAD-2 and methanol, or Celite 560 and dichloromethane....
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/9.6.269
更新日期:1985-11-01 00:00:00
abstract::We present an analytical method for the determination of heroin, free 6-acetylmorphine (6-AM), and free morphine in blood, urine, and vitreous humor. This method is used in postmortem cases where heroin is the suspected cause of death. The analytical protocol includes the following steps: liquid-liquid extraction at p...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/21.2.127
更新日期:1997-03-01 00:00:00
abstract::Analysis of drugs in hair differs from their analysis in other tissues due to the extended detection window, as well as the opportunity that segmental hair analysis offers for the detection of changes in drug intake over time. The antipsychotic drug chlorprothixene is widely used, but few reports exist on chlorprothix...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bky038
更新日期:2018-11-01 00:00:00
abstract::Oxymorphone (OM), a prescription opioid and metabolite of oxycodone, was included in the recently published proposed revisions to the Mandatory Guidelines for Federal Workplace Drug Testing Programs. To facilitate toxicological interpretation, this study characterized the time course of OM and its metabolite, noroxymo...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkw064
更新日期:2016-10-01 00:00:00
abstract::A method for determining the chemical warfare agent soman (GD) in rat plasma has been validated and applied to low-level inhalation exposure studies currently being conducted. This method utilizes a fluoride ion-based regeneration assay with isotope dilution followed by large volume injection gas chromatography with a...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/32.1.92
更新日期:2008-01-01 00:00:00
abstract::A rapid and efficient high-performance liquid chromatographic method using a reversed-phase eluent of methanol-water with butylamine on a silica column was developed for the separation and quantitation of clomipramine (CMI), its demethylated metabolites (desmethyl-clomipramine and didesmethyl-clomipramine [DDCMI]), an...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/20.2.101
更新日期:1996-03-01 00:00:00
abstract::This study shows a simple, rapid, and specific method for the quantitative determination of cyanide ion in body fluids, especially blood, by fluorimetry. It is based upon the transformation of cyanide ion into hydrocyanic acid, which then reacts with 2,3-naphthalenedialdehyde and taurine in a self-contained system. Th...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/22.5.363
更新日期:1998-09-01 00:00:00
abstract::We devised a highly sensitive method for simultaneously determining methamphetamine (MA) and amphetamine (AP) enantiomers, desmethylselegiline (DMSG) and selegiline (SG), in human hair using a derivatization technique and high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS). M...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/30.4.232
更新日期:2006-05-01 00:00:00
abstract::Dried blood spots (DBS) on filter paper have been used in human medicine since the 1960s, predominantly for screening in-borne metabolic disorders and more recently, for toxicology. Despite its 50-year existence, this technology has not been adopted by veterinarians for routine diagnoses and research. We have validate...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkt048
更新日期:2013-09-01 00:00:00
abstract::The testing for drugs of abuse in hair is increasingly used to detect illicit substances. Laboratories have implemented various decontamination, or washing, procedures in order to eliminate concerns regarding potential contamination of the hair with drug from the environment. However, the effect of these decontaminati...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/25.7.490
更新日期:2001-10-01 00:00:00
abstract::The List of Prohibited Substances and Methods (the List), an International Standard published yearly by the World Anti-Doping Agency (WADA), determines which substances and methods are prohibited in sport in- and out-of-competition. Stimulants are included within drug class S.6 under the in-competition testing sectio...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/anatox/35.9.613
更新日期:2011-11-01 00:00:00
abstract::Improvements have been made in recent years in on-site or point-of-care (POC) immunoassay testing devices. We evaluated the DrugCheck 9 cup, a new qualitative visually read, competitive binding, immunoassay cup that measures nine analytes. The study was performed according to the recent National Laboratory Certificati...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.3.190
更新日期:2004-04-01 00:00:00
abstract::Cyclopropylfentanyl is a fentanyl analog implicated in 78 deaths in Europe and over 100 deaths in the United States, but toxicological information including metabolism data about this drug is scarce. The aim of this study was to provide the exact structure of abundant and unique metabolites of cyclopropylfentanyl alon...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz057
更新日期:2019-09-10 00:00:00
abstract::A colchicine blood concentration 250 microgram/L was determined in a 39-year-old white female 2 hours following the ingestion of an oral overdose of the drug. At death, 40 hours following ingestion, no drug was detected. Colchicine was extracted from buffered blood using dichloromethane. The evaporated extract was red...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/4.3.153
更新日期:1980-05-01 00:00:00
abstract::A 22-year-old male with more than 28 needle marks on his right arm was found dead. First, he was suspected as a drug abuser. Blood, urine, spleen, and injection-site tissue was collected during autopsy. The blood and urine specimens were screened for drugs. Immunoassay studies did not show any illegal drugs. However, ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/24.4.305
更新日期:2000-05-01 00:00:00
abstract::cis(Z)-Clopenthixol and trans(E)-clopenthixol were determined by gas chromatography-mass spectrometry and high-performance liquid chromatography-diode-array detection in necropic samples from a postmortem case. The peripheral blood concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol were 278 and 177 ng/mL,...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/25.5.348
更新日期:2001-07-01 00:00:00
abstract::Although many deaths occur annually from heroin intoxication, the presence of heroin has not been reported in postmortem tissues. Recognizing heroin's susceptibility to rapid chemical and metabolic hydrolysis, extraction procedures were developed for the efficient recovery of heroin, 6-acetylmorphine, and morphine fro...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/18.1.22
更新日期:1994-01-01 00:00:00
abstract::Propane can be responsible for several types of lethal intoxication and explosions. Quantifying it would be very helpful to determine in some cases the cause of death. Some gas chromatography-mass spectrometry (GC-MS) methods of propane measurements do already exist. The main drawback of these GC-MS methods described ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkt098
更新日期:2014-03-01 00:00:00
abstract::Exposure to drugs and toxins is a major cause for the rising number of emergency department visits each year. Immunoassays are commonly used in the emergency department to provide rapid turnaround time for acute care. The purpose of this study was to compare two automated immunoassay chemistry analyzers to determine w...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bks028
更新日期:2012-06-01 00:00:00
abstract::In Europe, the compound 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy, Adam), in addition to cannabis, is the most abused illicit drug at all-night "techno" parties. Methods for the determination of MDMA and its metabolites, 4-hydroxy-3-methoxymethamphetamine (HMMA), 3,4-dihydroxy-methamphetamine (HHMA), 3,4-methyl...
journal_title:Journal of analytical toxicology
pub_type: 临床试验,杂志文章
doi:10.1093/jat/20.6.432
更新日期:1996-10-01 00:00:00
abstract::A rapid and sensitive solid-phase extraction method for the lysergic acid diethylamide (LSD) metabolite 2-oxo-3-hydroxy-LSD (O-H-LSD) was developed for use in a forensic laboratory. The method uses a positive-pressure manifold anion-exchange polymer-based solid-phase extraction with subsequent analysis by liquid chrom...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.7.459
更新日期:2003-10-01 00:00:00
abstract::A clinical study was designed to determine if there was a predictable relationship between saliva and plasma codeine concentrations. Drug-free volunteers (n = 17) were administered a 30-mg dose of liquid codeine phosphate. Plasma and saliva specimens were collected at various times for 24 h after administration. Plasm...
journal_title:Journal of analytical toxicology
pub_type: 临床试验,杂志文章
doi:10.1093/jat/23.6.452
更新日期:1999-10-01 00:00:00
abstract::Previous measurements of elemental concentrations in liver mitochondria have generally required homogenization and fractionation of liver tissue, a procedure in which it is difficult to rule out ion movement between subcellular units. New techniques involving cryoultramicrotomy of rapidly frozen tissue, high resolutio...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/9.4.145
更新日期:1985-07-01 00:00:00
abstract::In this study, the relationships between the concentrations of R/S-methamphetamine (MA) and its metabolite R/S-amphetamine (AP), the AP/MA ratio in hair samples, and MA dependence were investigated by performing segmental hair analysis in MA users. Authentic hair samples collected from 10 chronic MA abusers were cut i...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz089
更新日期:2020-07-31 00:00:00
abstract::Since the introduction in 1990, the solid-phase microextraction (SPME) technology has brought significant progress in many fields of forensic sciences due to the versatility of this fast and solventless alternative to conventional extraction techniques. A systematic review about SPME applications in forensic context f...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz077
更新日期:2020-04-30 00:00:00
abstract::An automated column-switching liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometric (LC-APCI-MS) method for the simultaneous determination of frequently encountered benzodiazepine hypnotics and their relevant metabolites in urine has been established. A column-switching online solid-phase ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.2.87
更新日期:2002-03-01 00:00:00
abstract::Results of urine drug analyses for three racing greyhounds that tested positive for caffeine in this laboratory were contested by the animal trainer, who asserted that positives were achieved from deliberate chocolate feeding by a rival kennel. The metabolism and excretion of methylxanthines was examined by high-perfo...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/12.1.30
更新日期:1988-01-01 00:00:00
abstract::Methoxphenidine (MXP, 2-MeO-diphenidine) is a dissociative anaesthetic drug of the diarylethylamine type, recently introduced for recreational purposes through the online-based sale of new psychoactive substances (NPS). The concentration of MXP in hair has never been reported, either in cases of chemsex use or in fata...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkab016
更新日期:2021-02-01 00:00:00
abstract::In cases of death by inert gas asphyxiation, it can be difficult to obtain toxicological evidence supporting assignment of a cause of death. Because of its low mass and high diffusivity, and its common use as a carrier gas, helium presents a particular challenge in this respect. We describe a rapid and simple gas chro...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bks002
更新日期:2012-03-01 00:00:00