A rapid extraction method for acidic drugs in hemolyzed blood.

abstract：:Cannabinoids were extracted from serum with C18 SPE cartridges and analyzed as their trimethylsilyl (TMS) derivatives. A benchtop gas chromatography-tandem mass spectrometry (GC-MS-MS) system based on an ion trap with external ionization was used. Quantitation was done in relation to trideuterated internal standards i...

journal_title：Journal of analytical toxicology

authors： Weller JP,Wolf M,Szidat S

更新日期：2000-07-01 00:00:00

abstract：:A rapid, specific and quantitative high-performance liquid chromatography assay procedure is described for the determination of ICI 125, 211, (I), a guanidino-thiazole H2-receptor antagonist, in small samples of animal plasma. A 0.2 mL aliquot of plasma is extracted at pH 9 with ethyl acetate. After reconstitution in ...

journal_title：Journal of analytical toxicology

authors： Monson K,Simon RK,Malbica JO

更新日期：1980-09-01 00:00:00

abstract：:Methods for extraction of cocaine, some of its metabolites, morphine, and codeine from hair and methods for analyzing the extracts have been investigated. Results of these studies have shown that extractions with 0.1N HCl are efficient at removing the target compounds from hair and appear to be as effective as enzymat...

journal_title：Journal of analytical toxicology

authors： Welch MJ,Sniegoski LT,Allgood CC,Habram M

更新日期：1993-11-01 00:00:00

abstract：:Exemplars of current commercial breath-alcohol simulators were studied to ascertain their suitability for control tests and as calibrators in breath-alcohol analysis. Temperature, effluent volumes and pressures, effluent-alcohol concentration, and alcohol depletion were measured for simulators coupled with various cur...

journal_title：Journal of analytical toxicology

authors： Dubowski KM,Essary NA

更新日期：1991-09-01 00:00:00

abstract：:First synthesized in 1970, propafenone is a frequently used 1C antiarrhythmic drug metabolized into two major metabolites, 5-hydroxypropafenone and norpropafenone. Paradoxically, fatal intoxication is rarely described, and only six cases have been reported in the literature. We report our experience with two patients ...

journal_title：Journal of analytical toxicology

authors： Clarot F,Goullé JP,Horst M,Vaz E,Lacroix C,Proust B

更新日期：2003-11-01 00:00:00

abstract：:Screening for emerging drugs of abuse, specifically synthetic cathinones and synthetic cannabinoids, is difficult for high-throughput laboratories as immunoassay kits are often unavailable. Consequently, most laboratories employ liquid chromatography-tandem mass spectrometry (LC-MS-MS) screening, which can be complex ...

journal_title：Journal of analytical toxicology

authors： Neifeld JR,Regester LE,Holler JM,Vorce SP,Magluilo J Jr,Ramos G,Bosy TZ

更新日期：2016-06-01 00:00:00

abstract：:The method presented describes a sensitive and specific quantitative assay for the determination of flumazenil in human plasma. Flumazenil and an internal standard, midazolam, are isolated by a basic extraction. The final extract is separated on a 25-m BP-1 capillary column and drugs are detected by selected ion monit...

journal_title：Journal of analytical toxicology

authors： Kintz P,Mangin P

更新日期：1991-07-01 00:00:00

abstract：:Caffeine is the world's most widely consumed drug with its main source found in coffee. We evaluated the caffeine content of caffeinated and decaffeinated specialty coffee samples obtained from coffee shops. Caffeine was isolated from the coffee by liquid-liquid extraction and analyzed by gas chromatography with nitro...

journal_title：Journal of analytical toxicology

authors： McCusker RR,Goldberger BA,Cone EJ

更新日期：2003-10-01 00:00:00

abstract：:An analytical procedure for the determination of the new pain medication tapentadol and its main metabolite N-desmethyltapentadol (DMT), in urine and oral fluid has been developed and validated using liquid chromatography with tandem mass spectral detection (LC-MS-MS). Oral fluid was collected using Quantisal™ devices...

journal_title：Journal of analytical toxicology

authors： Coulter C,Taruc M,Tuyay J,Moore C

更新日期：2010-10-01 00:00:00

abstract：:Analysis and interpretation of the findings for the drug of abuse gamma hydroxybutyric acid (GHB) in fatalities has become very problematic. This is primarily because of variable data in postmortem biological fluids resulting from the endogenous nature of the compound, possible postmortem production, and varying metho...

journal_title：Journal of analytical toxicology

authors： Elliott SP

更新日期：2004-01-01 00:00:00

abstract：:We report the validation of a quantitative method for paraquat in plasma and urine using high-performance liquid chromatography (HPLC) with ultraviolet detection (260 nm). Furthermore, we illustrate the use of this method in the clinic (over five years), in conjunction with a qualitative urine paraquat screen. Urine o...

journal_title：Journal of analytical toxicology

authors： Taylor PJ,Salm P,Pillans PI

更新日期：2001-09-01 00:00:00

abstract：:A rapid and sensitive solid-phase extraction method for the lysergic acid diethylamide (LSD) metabolite 2-oxo-3-hydroxy-LSD (O-H-LSD) was developed for use in a forensic laboratory. The method uses a positive-pressure manifold anion-exchange polymer-based solid-phase extraction with subsequent analysis by liquid chrom...

journal_title：Journal of analytical toxicology

authors： Horn CK,Klette KL,Stout PR

更新日期：2003-10-01 00:00:00

abstract：:Deuterium-labeled analogues are available for a variety of drugs, but the amphetamines (amphetamine and methamphetamine) have more options available than any other drug. The analytical method and circumstances of its use can have a significant impact on the decision of what is the best internal standard to use. More t...

journal_title：Journal of analytical toxicology

authors： Valtier S,Cody JT

更新日期：1995-10-01 00:00:00

abstract：:Postmortem findings are presented for fourteen cases of Verapamil induced or related deaths. Liver, blood, and stomach concentrations of Verapamil alone or in combination with alcohol or other drugs are given with the age and sex of each victim and with the coroner's findings. The significance of these levels is discu...

journal_title：Journal of analytical toxicology

authors： Chan LF,Chhuy LH,Crowley RJ

更新日期：1987-07-01 00:00:00

abstract：:Cyclopropylfentanyl is a fentanyl analog implicated in 78 deaths in Europe and over 100 deaths in the United States, but toxicological information including metabolism data about this drug is scarce. The aim of this study was to provide the exact structure of abundant and unique metabolites of cyclopropylfentanyl alon...

journal_title：Journal of analytical toxicology

authors： Vikingsson S,Rautio T,Wallgren J,Åstrand A,Watanabe S,Dahlén J,Wohlfarth A,Konradsson P,Wu X,Kronstrand R,Gréen H

更新日期：2019-09-10 00:00:00

abstract：:Vitreous humor is a potential alternative matrix for postmortem toxicology drug screens when peripheral blood is unavailable. It is easily and reliably collected and may not suffer from the same postmortem redistribution as seen in blood. Here, we compared the concentrations of 7 acidic drugs (acetaminophen, ibuprofen...

journal_title：Journal of analytical toxicology

authors： Hubbard JA,Navarrete AL,Fitzgerald RL,McIntyre IM

更新日期：2019-11-06 00:00:00

abstract：:A high-performance liquid chromatographic method was used for the detection of etodolac in equine serum and urine. The method consisted of a one-step liquid-liquid extraction, separation on a reversed-phase (RP-18) column and detection using an ultraviolet detector. Additional confirmation methods included a HPLC coup...

journal_title：Journal of analytical toxicology

authors： Koupai-Abyazani MR,Esaw B,Laviolette B

更新日期：1999-05-01 00:00:00

abstract：:During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. A case recently received by CAMI screened positive for the anticonvulsant medication carbamazepine (CBZ;...

journal_title：Journal of analytical toxicology

authors： Lewis RJ,Angier MK,Johnson RD

更新日期：2014-10-01 00:00:00

abstract：:Gas chromatography-mass spectrometry (GC-MS), which combines the separation power of GC with the power of MS for the identification of unknown compounds, possesses high potential in systematic toxicological analysis (STA). Different factors, however, do not allow this potential to be fully exploited. Between them, the...

journal_title：Journal of analytical toxicology

authors： Polettini A

更新日期：1996-11-01 00:00:00

abstract：:Acetaminophen (APAP, n-acetyl-p-aminophenol) and salicylate (ASA, acetylsalicylic acid) are two of the most frequently overdosed drugs reported in the emergency room. Most APAP and ASA tests are performed with analytical instruments in laboratories, which are not always ideal for emergency situations. A rapid membrane...

journal_title：Journal of analytical toxicology

authors： Song W,Dou C

更新日期：2003-09-01 00:00:00

abstract：:High doses of nutmeg (seeds from Myristica fragrans Houtt.) can be abused as a psychoactive drug due to phenylpropene ingredients. During controlled abstinence, e.g., in forensic psychiatric clinics, nutmeg abuse has to be distinguished from an ingestion of other spices having phenylpropene ingredients (e.g., black pe...

journal_title：Journal of analytical toxicology

authors： Neukamm MA,Schwelm HM,Vieser S,Schiesel N,Auwärter V

更新日期：2020-01-07 00:00:00

abstract：:The effects of decomposition microclimate on the distribution of dextromethorphan (DXM) and dextrorphan (DXT) in skeletonized remains of rats acutely exposed to DXM were examined. Animals (n = 10) received DXM (75 mg/kg, i.p.), were euthanized 30 min post-dose and immediately allowed to decompose at either Site A (sha...

journal_title：Journal of analytical toxicology

authors： Unger KA,Watterson JH

更新日期：2016-10-01 00:00:00

abstract：:The objective of this project was to validate a new high-throughput homogeneous enzyme immunoassay (HEIA) for the rapid detection of carisoprodol in human urine. Carisoprodol (Soma(®)) and meprobamate are widely prescribed as musculoskeletal pain relief drugs and are listed as one of the 10 most frequently identified ...

journal_title：Journal of analytical toxicology

authors： Wang G,Huynh K,Barhate R,Rodrigues W,Moore C,Coulter C,Vincent M,Soares J

更新日期：2011-03-01 00:00:00

abstract：:About 22,000 samples of oral fluid have been collected in five population studies in Norway using either the Intercept or Statsure oral fluid sampling devices. The prevalence of alcohol and drugs was found to be higher in oral fluid samples with small volumes than in those with large volumes for both sampling devices;...

journal_title：Journal of analytical toxicology

authors： Gjerde H,Normann PT,Christophersen AS

更新日期：2010-09-01 00:00:00

abstract：:This manuscript reviews data available in the scientific literature relative to drug testing for the five mandated drug classes and circumstances other than abuse of the drug itself that could result in a positive test. For marijuana, passive inhalation, unknowing oral ingestion, and the use of Marinol are discussed. ...

journal_title：Journal of analytical toxicology

authors： elSohly MA,Jones AB

更新日期：1995-10-01 00:00:00

abstract：:Feces are a possible medium to be used for horse doping control. Efficient methods for detecting drugs in feces collected from various animals are routinely applied in institutes of food safety in Belgium. We have already tested whether they are applicable to horse feces. In this report, accelerated solvent extraction...

journal_title：Journal of analytical toxicology

authors： Popot MA,Donval A,Bonnaire Y,Huau J

更新日期：2006-06-01 00:00:00

abstract：:An assay for neurotoxic esterase (neuropathy target esterase, NTE) was developed by Johnson (1,2) to assess the delayed neurotoxic potential of organophosphorus compounds. NTE activity is calculated from the rate of phenyl valerate hydrolysis resistant to paraoxon and sensitive to mipafox inhibition under specified co...

journal_title：Journal of analytical toxicology

authors： Kayyali US,Moore TB,Randall JC,Richardson RJ

更新日期：1991-03-01 00:00:00

abstract：:An improved method for the simultaneous determination of cocaine and its metabolites, benzoylecgonine (BE), norcocaine, and ecgoninemethylester (EME), in rat plasma and urine is described. Following derivatization of EME to p-fluorococaine, chromatography was performed on two high-performance liquid chromatography (HP...

journal_title：Journal of analytical toxicology

authors： Jamdar SC,Pantuck CB,Diaz J,Mets B

更新日期：2000-09-01 00:00:00

abstract：:A rapid capillary gas-liquid chromatographic method for the determination of barbiturates in plasma at concentrations of clinical importance is presented. This method employs a rapid and simple extraction procedure and direct flame ionization detection with no derivatization. ...

journal_title：Journal of analytical toxicology

authors： Wallace JE,Hall LR,Harris SC

更新日期：1983-07-01 00:00:00

abstract：:In an effort to determine a practical, efficient, and economical alternative for the use of a radioimmunoassay (RIA) for the detection of lysergic acid diethylamide (LSD) in human urine, the performance of two photometric immunoassays (Dade Behring EMIT II and Microgenics CEDIA) and the Diagnostics Products Corp. (DPC...

journal_title：Journal of analytical toxicology

authors： Wiegand RF,Klette KL,Stout PR,Gehlhausen JM

更新日期：2002-10-01 00:00:00