Quantitative high-performance liquid chromatography determination of ICI 125,211 in plasma.

abstract：:Salicylate excretion was studied in the breast milk of a nursing mother (Patient A) taking chronic therapeutic doses of aspirin, and caffeine excretion was monitored in the breast milk of a nursing mother (Patient B) who was a heavy coffee drinker. Salicylate concentrations were maximal in serum at 2.25 hours (10.8 mg...

journal_title：Journal of analytical toxicology

authors： Bailey DN,Weibert RT,Naylor AJ,Shaw RF

更新日期：1982-03-01 00:00:00

abstract：:Oxymorphone (OM), a prescription opioid and metabolite of oxycodone, was included in the recently published proposed revisions to the Mandatory Guidelines for Federal Workplace Drug Testing Programs. To facilitate toxicological interpretation, this study characterized the time course of OM and its metabolite, noroxymo...

journal_title：Journal of analytical toxicology

authors： DePriest AZ,Heltsley R,Black DL,Mitchell JM,LoDico C,Flegel R,Cone EJ

更新日期：2016-10-01 00:00:00

abstract：:A rapid and efficient high-performance liquid chromatographic method using a reversed-phase eluent of methanol-water with butylamine on a silica column was developed for the separation and quantitation of clomipramine (CMI), its demethylated metabolites (desmethyl-clomipramine and didesmethyl-clomipramine [DDCMI]), an...

journal_title：Journal of analytical toxicology

authors： Coudoré F,Hourcade F,Molinier-Manoukian C,Eschalier A,Lavarenne J

更新日期：1996-03-01 00:00:00

abstract：:Ethiofencarb is one of the carbamate compounds, which are, in general, less toxic than organophosphorus insecticides. This is due to their reversible acetylcholinesterase inhibition and relative inability to cross the blood-brain barrier. Generally, ethiofencarb is regarded to be of low toxicity (LD(50) > 200 mg/kg); ...

journal_title：Journal of analytical toxicology

authors： Al-Samarraie MS,Karinen R,Rognum T,Hasvold I,Opdal Stokke M,Christophersen AS

更新日期：2009-09-01 00:00:00

abstract：:Methods for extraction of cocaine, some of its metabolites, morphine, and codeine from hair and methods for analyzing the extracts have been investigated. Results of these studies have shown that extractions with 0.1N HCl are efficient at removing the target compounds from hair and appear to be as effective as enzymat...

journal_title：Journal of analytical toxicology

authors： Welch MJ,Sniegoski LT,Allgood CC,Habram M

更新日期：1993-11-01 00:00:00

abstract：:An automated column-switching liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometric (LC-APCI-MS) method for the simultaneous determination of frequently encountered benzodiazepine hypnotics and their relevant metabolites in urine has been established. A column-switching online solid-phase ...

journal_title：Journal of analytical toxicology

authors： Miki A,Tatsuno M,Katagi M,Nishikawa M,Tsuchihashi H

更新日期：2002-03-01 00:00:00

abstract：:A high-performance liquid chromatographic method was used for the detection of etodolac in equine serum and urine. The method consisted of a one-step liquid-liquid extraction, separation on a reversed-phase (RP-18) column and detection using an ultraviolet detector. Additional confirmation methods included a HPLC coup...

journal_title：Journal of analytical toxicology

authors： Koupai-Abyazani MR,Esaw B,Laviolette B

更新日期：1999-05-01 00:00:00

abstract：:Prolintane is a sympathomimetic amine with pharmacologic properties similar to d-amphetamine. Side effects include insomnia, nervousness, and irritability. Overdoses of prolintane may cause hallucinations, psychosis, and death. The drug is commonly prescribed in Africa, Australia, and Europe but is not available in th...

journal_title：Journal of analytical toxicology

authors： Kyle PB,Daley WP

更新日期：2007-09-01 00:00:00

abstract：:The purpose of this study was to determine the performance characteristics of the Cozart Methadone Microplate ELISA assay for the detection of methadone and methadone metabolites in hair specimens. One hundred and ten hair specimens were collected from volunteers (n=46) with a history of drug use and from drug-related...

journal_title：Journal of analytical toxicology

authors： Cooper G,Wilson L,Reid C,Baldwin D,Hand C,Spiehler V

更新日期：2005-10-01 00:00:00

abstract：:A sensitive and rugged gas chromatographic-mass spectrometric (GC-MS) method was developed for determining 11 polycyclic aromatic hydrocarbons (PAHs) in 4-g specimens of human lung, breast, and liver tissue. The method quantitation limit (MQL) was 0.01-0.02 ng/g for benzo[a]pyrene (BaP) and six other five- and six-rin...

journal_title：Journal of analytical toxicology

authors： Beach JB,Pellizzari E,Keever JT,Ellis L

更新日期：2000-11-01 00:00:00

abstract：:A method for the simultaneous measurement of buprenorphine and its N-dealkylated metabolite, norbuprenorphine, in human plasma was developed with negative chemical ionization tandem mass spectrometry. Buprenorphine and norbuprenorphine were extracted from biological fluids by solid-phase extraction. The samples were d...

journal_title：Journal of analytical toxicology

authors： Kuhlman JJ Jr,Magluilo J Jr,Cone E,Levine B

更新日期：1996-07-01 00:00:00

abstract：:Pharmacogenomics is the study of the linkage between an individual's genotype and the disposition of drugs in the body. The first association between adverse drug reactions and inherited variations was recognized in the 1950s, and since then, pharmacogenomics has come a long way. The importance of pharmacogenomics is ...

journal_title：Journal of analytical toxicology

authors： Kupiec TC,Raj V,Vu N

更新日期：2006-03-01 00:00:00

abstract：:A selective, sensitive, and reliable method was devised to determine concentrations of amitriptyline and its major metabolite, nortriptyline, in human plasma using high-performance liquid chromatography (HPLC) combined with UV and particle beam mass spectrometry (PBMS). Amitriptyline and nortriptyline were effectively...

journal_title：Journal of analytical toxicology

authors： Kudo K,Jitsufuchi N,Imamura T

更新日期：1997-05-01 00:00:00

abstract：:An online automatic sample cleanup system was developed for use with electrospray ionization tandem mass spectrometry (ESI-MS-MS) for the quantitative detection of the benzene exposure biomarker S-phenylmercapturic acid (S-PMA) in human urine. The sample clean-up system was constructed with an autosampling device, a r...

journal_title：Journal of analytical toxicology

authors： Liao PC,Li CM,Lin LC,Hung CW,Shih TS

更新日期：2002-05-01 00:00:00

abstract：:A method for the determination of the antidepressant drug trazodone is presented. 8-Hydroxyloxapine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection usin...

journal_title：Journal of analytical toxicology

authors： Rifai N,Levtzow CB,Howlett CM,Phillips JC,Parker NC,Cross RE

更新日期：1988-05-01 00:00:00

abstract：:Six separate methods to detect oxidants in urine were developed. The presence of the oxidants was established by initial oxidation of ferrous to ferric ion and detecting the ferric by chromogenic oxidation or complex formation. The reagents for chromogenic oxidation were N,N-dimethylamoino-1,4-phenylenediamine (DMPDA)...

journal_title：Journal of analytical toxicology

authors： Paul BD

更新日期：2004-10-01 00:00:00

abstract：:Metabolic transformation of zearalenone (ZEA), a mycotoxin which can contaminate both food and feed, results in the formation of five metabolites, one of them being zeranol (α-ZAL), which can be abused in farm animals as a growth promoter. To the best of our knowledge, there is no analytical method that can distinguis...

journal_title：Journal of analytical toxicology

authors： Vulić A,Lešić T,Kudumija N,Mikuš T,Pleadin J

更新日期：2019-03-01 00:00:00

abstract：:Analytical methods were developed to determine the presence of ethylenediaminetetraacetic acid (EDTA) in dried bloodstains to provide probative information when allegations of evidence tampering have been made in criminal cases. A simple screening method using ion chromatography to analyze stains was found to be quant...

journal_title：Journal of analytical toxicology

authors： Miller ML,McCord BR,Martz R,Budowle B

更新日期：1997-11-01 00:00:00

abstract：:A case report involving a 34-year-old white male who was found dead at home by his roommate is presented. At the time of his death, he was being treated with tramadol/acetaminophen, metaxalone, oxycodone, and amitriptyline. The decedent's mother stated that he had been taking increasing amounts of pain medication in o...

journal_title：Journal of analytical toxicology

authors： Bynum ND,Poklis JL,Gaffney-Kraft M,Garside D,Ropero-Miller JD

更新日期：2005-07-01 00:00:00

abstract：:In cases of death by inert gas asphyxiation, it can be difficult to obtain toxicological evidence supporting assignment of a cause of death. Because of its low mass and high diffusivity, and its common use as a carrier gas, helium presents a particular challenge in this respect. We describe a rapid and simple gas chro...

journal_title：Journal of analytical toxicology

authors： Schaff JE,Karas RP,Marinetti L

更新日期：2012-03-01 00:00:00

abstract：:Two cases of lethal overdose by temazepam are presented. In both cases, temazepam was the only drug detected, and there was no involvement of alcohol. The drug concentrations in blood, urine, and liver were measured. ...

journal_title：Journal of analytical toxicology

authors： Martin CD,Chan SC

更新日期：1986-03-01 00:00:00

abstract：INTRODUCTION:We encountered unexpected false positive urine results in three patients for amphetamine-type substances by immunoassay, measured as part of community drug prevention programmes. Kavain was identified in all three urine samples by gas chromatography mass spectrometry (GC-MS). No other potential cross-react...

journal_title：Journal of analytical toxicology

authors： Madhavaram H,Patel T,Kyle C

更新日期：2020-12-16 00:00:00

abstract：:The quantification of drugs of abuse in keratinized matrices is becoming of special relevance for monitoring consumption and for post-mortem investigations. We aimed to implement an analytical method for the simultaneous detection of morphine (MORF), 6-monoacetylmorphine (6-MAM), methadone (MET), 2-ethylidene-1,5-dime...

journal_title：Journal of analytical toxicology

authors： Magalhães TP,Cravo S,Silva DDD,Dinis-Oliveira RJ,Afonso C,Lourdes Bastos M,Carmo H

更新日期：2018-04-01 00:00:00

abstract：:This study compares fluoride concentrations ([F]) in surface and whole bone for up to 27 days following an acute oral dose of F. Four groups of rats received single oral F dose (50 mg/kg body weight), and the control group received deionized water (n = 10/group). Groups were euthanized at 1, 3, 9, or 27 days after F a...

journal_title：Journal of analytical toxicology

authors： Buzalaf MA,Caroselli EE,de Carvalho JG,de Oliveira RC,da Silva Cardoso VE,Whitford GM

更新日期：2005-11-01 00:00:00

abstract：:A preliminary investigation was undertaken to determine the feasibility of monitoring saliva levels of drugs for forensic purposes. Single oral doses of the title compounds were administered to healthy volunteers. Plasma and saliva levels were measured and ratios calculated for all drugs except diazepam. Saliva/plasma...

journal_title：Journal of analytical toxicology

authors： Sharp ME,Wallace SM,Hindmarsh KW,Peel HW

更新日期：1983-01-01 00:00:00

abstract：:Use of methiopropamine (MPA), a synthetic metamfetamine analog, has been detected since 2011 in Europe, but there is limited information on its acute toxicity. A 30-year-old man was admitted to the emergency department in a confused state, with paranoid delusion, auditory and visual hallucinatory experiences, and inco...

journal_title：Journal of analytical toxicology

authors： Daveluy A,Castaing N,Cherifi H,Richeval C,Humbert L,Faure I,Labadie M,Allorge D,Haramburu F,Molimard M,Titier K

更新日期：2016-11-01 00:00:00

abstract：:A colchicine blood concentration 250 microgram/L was determined in a 39-year-old white female 2 hours following the ingestion of an oral overdose of the drug. At death, 40 hours following ingestion, no drug was detected. Colchicine was extracted from buffered blood using dichloromethane. The evaporated extract was red...

journal_title：Journal of analytical toxicology

authors： Caplan YH,Orloff KG,Thompson BC

更新日期：1980-05-01 00:00:00

abstract：:Carfentanil is a mu (μ) opioid receptor agonist and is estimated to be ~10,000 times more potent than morphine in animal (non-human) models. It is not approved for human use and is only used to immobilize large exotic animals in veterinary medicine. In mid-2016, carfentanil emerged as a contaminant in street heroin in...

journal_title：Journal of analytical toxicology

authors： Shanks KG,Behonick GS

更新日期：2017-07-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI), a still-emerging, non-invasive neuroimaging tool, has been applied to a wide range of questions in sensory, motor control, and cognitive psychology. Only more recently has it been applied to understand the sites and mechanisms of action of pharmacological agents within the...

journal_title：Journal of analytical toxicology

authors： Stein EA

更新日期：2001-07-01 00:00:00

abstract：:Dried blood spots (DBS) on filter paper have been used in human medicine since the 1960s, predominantly for screening in-borne metabolic disorders and more recently, for toxicology. Despite its 50-year existence, this technology has not been adopted by veterinarians for routine diagnoses and research. We have validate...

journal_title：Journal of analytical toxicology

authors： Lehner AF,Rumbeiha W,Shlosberg A,Stuart K,Johnson M,Domenech R,Langner H

更新日期：2013-09-01 00:00:00