Domestic abuse of the European rave drug prolintane.

abstract：:Two cases of lethal overdose by temazepam are presented. In both cases, temazepam was the only drug detected, and there was no involvement of alcohol. The drug concentrations in blood, urine, and liver were measured. ...

journal_title：Journal of analytical toxicology

authors： Martin CD,Chan SC

更新日期：1986-03-01 00:00:00

abstract：:We report the validation of a quantitative method for paraquat in plasma and urine using high-performance liquid chromatography (HPLC) with ultraviolet detection (260 nm). Furthermore, we illustrate the use of this method in the clinic (over five years), in conjunction with a qualitative urine paraquat screen. Urine o...

journal_title：Journal of analytical toxicology

authors： Taylor PJ,Salm P,Pillans PI

更新日期：2001-09-01 00:00:00

abstract：:A rapid and simple method is described for the separation of quinidine (Q), its metabolites 3-hydroxyquinidine (30HQ) and 2'oxoquinidinone (QD) as well as the quinidine salt contaminant, dihydroquinidine (DHQ) in plasma by high pressure liquid chromatography (HPLC). A silica column was used with methanol: 1 N ammonium...

journal_title：Journal of analytical toxicology

authors： Pershing LK,Peat MA,Finkle BS

更新日期：1982-05-01 00:00:00

abstract：:Methoxphenidine (MXP, 2-MeO-diphenidine) is a dissociative anaesthetic drug of the diarylethylamine type, recently introduced for recreational purposes through the online-based sale of new psychoactive substances (NPS). The concentration of MXP in hair has never been reported, either in cases of chemsex use or in fata...

journal_title：Journal of analytical toxicology

authors： Goncalves R,Castaing N,Titier K,Dumestre-Toulet V

更新日期：2021-02-01 00:00:00

abstract：:Hypertension is one of the most important modifiable risk factor causing cardiovascular disease. Unfortunately, non-adherence to antihypertensive medications is frequently observed in hypertensive patients and can lead to an increase in morbidity and mortality. Until recently, there was no robust clinical method to ob...

journal_title：Journal of analytical toxicology

authors： Burns AD,Alghamadi R,Iqbal A,Davies T,Lane D,Patel P,Gupta P

更新日期：2020-12-10 00:00:00

abstract：:Due to the lack of certified reference material, a reliable quantification in complex postmortem matrices can only be performed either by the addition of isotope-labelled standards or by the standard addition method. Although standard addition is a basic quantification procedure, its practical implementation is challe...

journal_title：Journal of analytical toxicology

authors： Reiter B,Stimpfl T

更新日期：2015-11-01 00:00:00

abstract：:A rapid and simple liquid chromatography tandem mass spectrometry method was developed and validated for the simultaneous determination of L-ephedrine, pseudoephedrine, and caffeine in male Fisher-344 rat plasma at nanogram-per-milliliter concentrations for use in support of toxicology studies. Only 25 μL of plasma is...

journal_title：Journal of analytical toxicology

authors： Cooper SD,Fletcher BL,Silinski MA,Brown SS,Lodge JW,Fernando RA,Collins BJ

更新日期：2011-07-01 00:00:00

abstract：:This work was aimed at developing and validating a hydrophilic interaction chromatography (HILIC)-electrospray ionization (ESI)-ion trap-tandem mass spectrometric method for identification and quantification of ethyl glucuronide (ETG) and ethyl sulfate (ETS) as ethanol biomarkers and at employing this method for analy...

journal_title：Journal of analytical toxicology

authors： Al-Asmari AI,Anderson RA,Appelblad P

更新日期：2010-06-01 00:00:00

abstract：:Oral fluid (OF) is increasingly used for clinical, forensic and workplace drug testing as an alternative to urine. Uncertainties surrounding OF collection device performance, drug stability and testing reproducibility may be partially responsible for delays in the implementation of OF testing in regulated drug testing...

journal_title：Journal of analytical toxicology

authors： Samano KL,Anne L,Johnson T,Tang K,Sample RH

更新日期：2015-10-01 00:00:00

abstract：:The objective was to develop a simple routine method for quantitative measurement of endogenous formic acid in plasma and whole blood using headspace gas chromatography-flame ionization detection. (GC-FID). Two-hundred microliters of sample was placed in a 1-mL glass vial. Fifty microliters of aqueous ethanol (10%) wa...

journal_title：Journal of analytical toxicology

authors： Sokoro A,Lehotay D,Eichhorst J,Treble R

更新日期：2007-07-01 00:00:00

abstract：:The misuse of the commonly used chemical diethylene glycol (DEG) has lead to many poisonings worldwide. Methods were developed for analysis of DEG and its potential metabolites; ethylene glycol, glycolic acid, oxalic acid, diglycolic acid and hydroxyethoxy acetic acid in human urine, serum and cerebrospinal fluid samp...

journal_title：Journal of analytical toxicology

authors： Perala AW,Filary MJ,Bartels MJ,McMartin KE

更新日期：2014-05-01 00:00:00

abstract：:cis(Z)-Clopenthixol and trans(E)-clopenthixol were determined by gas chromatography-mass spectrometry and high-performance liquid chromatography-diode-array detection in necropic samples from a postmortem case. The peripheral blood concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol were 278 and 177 ng/mL,...

journal_title：Journal of analytical toxicology

authors： Rop PP

更新日期：2001-07-01 00:00:00

abstract：:The aim of this study is to investigate the distribution of methamphetamine (MA) and its metabolite amphetamine (AP) in rat models of acute and subacute MA-ethanol combination abuse. Rats were fed with 20% ethanol for 4 weeks (chronic active-drinking group), and MA was injected intraperitoneally into chronically drink...

journal_title：Journal of analytical toxicology

authors： Liang M,Liu Y,Zheng N,Ananda S,Liu L

更新日期：2012-01-01 00:00:00

abstract：:A GC/MS method for the simultaneous determination of morphine, codeine, and O-6-monoacetylmorphine as well as other semisynthetic opiates in urine is described. The method employs 2H6-acetic anhydride to acetylate free hydroxyl groups on all of the opiates. As a result, the same hydrolysis and extraction procedure is ...

journal_title：Journal of analytical toxicology

authors： Bowie LJ,Kirkpatrick PB

更新日期：1989-11-01 00:00:00

abstract：:Synthetic cathinones inhibit monoamine transporters, such as serotonin, norepinephrine, and dopamine transporters, and act on the central nervous system via increasing synaptic concentrations of monoamines. These compounds, which are highly addictive and potentially poisonous, are new psychoactive substances. In this ...

journal_title：Journal of analytical toxicology

authors： Fujita Y,Mita T,Usui K,Kamijo Y,Kikuchi S,Onodera M,Fujino Y,Inoue Y

更新日期：2018-01-01 00:00:00

abstract：:This study compares fluoride concentrations ([F]) in surface and whole bone for up to 27 days following an acute oral dose of F. Four groups of rats received single oral F dose (50 mg/kg body weight), and the control group received deionized water (n = 10/group). Groups were euthanized at 1, 3, 9, or 27 days after F a...

journal_title：Journal of analytical toxicology

authors： Buzalaf MA,Caroselli EE,de Carvalho JG,de Oliveira RC,da Silva Cardoso VE,Whitford GM

更新日期：2005-11-01 00:00:00

abstract：:For many reasons, forensic toxicologists are being asked to determine and report their measurement uncertainty in blood alcohol analysis. While understood conceptually, the elements and computations involved in determining measurement uncertainty are generally foreign to most forensic toxicologists. Several establishe...

journal_title：Journal of analytical toxicology

authors： Gullberg RG

更新日期：2012-04-01 00:00:00

abstract：:Use of methiopropamine (MPA), a synthetic metamfetamine analog, has been detected since 2011 in Europe, but there is limited information on its acute toxicity. A 30-year-old man was admitted to the emergency department in a confused state, with paranoid delusion, auditory and visual hallucinatory experiences, and inco...

journal_title：Journal of analytical toxicology

authors： Daveluy A,Castaing N,Cherifi H,Richeval C,Humbert L,Faure I,Labadie M,Allorge D,Haramburu F,Molimard M,Titier K

更新日期：2016-11-01 00:00:00

abstract：:Data from previous experimental studies on the detection time of oxazepam and zopiclone in biological matrices are limited. The aim of this study was to examine the detection time in urine and oral fluid after single oral doses of oxazepam and zopiclone. Ten healthy volunteers received 25 mg of oxazepam in the evening...

journal_title：Journal of analytical toxicology

authors： Bruun LD,Kjeldstadli K,Temte V,Birdal M,Bachs L,Langødegård M,Strand DH,Gaare KI,Øiestad E,Høiseth G

更新日期：2019-06-01 00:00:00

abstract：:Poisoning with agricultural chemicals is a major threat for wildlife all over the world. We have developed and validated an analytical scheme aimed to the identification and quantification of a wide range of pesticides in fresh liver from wildlife specimens that are routinely delivered to the forensic laboratories for...

journal_title：Journal of analytical toxicology

authors： Luzardo OP,Ruiz-Suárez N,Valerón PF,Camacho M,Zumbado M,Henríquez-Hernández LA,Boada LD

更新日期：2014-04-01 00:00:00

abstract：:In an attempt to improve the sensitivity and selectivity of thin-layer chromatographic analysis for the detection of strychnine and crimidine in biological samples, a rapid high-performance thin-layer chromatographic (HPTLC) method with densitometry is described. Fortified dog serum and stomach content samples were an...

journal_title：Journal of analytical toxicology

authors： De Saqui-Sannes P,Nups P,Le Bars P,Burgat V

更新日期：1996-05-01 00:00:00

abstract：:3,4-Methylenedioxypyrovalerone (MDPV) is a psychoactive, synthetic analog of the central nervous system stimulant cathinone. Its recent popularity as a recreational drug in the United States has led to numerous reports to poison control centers across the country. As with other synthetic cathinones, the recreational u...

journal_title：Journal of analytical toxicology

authors： Wyman JF,Lavins ES,Engelhart D,Armstrong EJ,Snell KD,Boggs PD,Taylor SM,Norris RN,Miller FP

更新日期：2013-04-01 00:00:00

abstract：:In Europe, the compound 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy, Adam), in addition to cannabis, is the most abused illicit drug at all-night "techno" parties. Methods for the determination of MDMA and its metabolites, 4-hydroxy-3-methoxymethamphetamine (HMMA), 3,4-dihydroxy-methamphetamine (HHMA), 3,4-methyl...

journal_title：Journal of analytical toxicology

authors： Helmlin HJ,Bracher K,Bourquin D,Vonlanthen D,Brenneisen R

更新日期：1996-10-01 00:00:00

abstract：:A rapid, reproducible and sensitive reversed phase liquid chromatography-mass spectrometry method was developed and validated for the identification and semi-quantitative confirmation of stimulants in urine. The method is capable of separating compounds such as cocaine and metabolites, amphetamines, substituted cathin...

journal_title：Journal of analytical toxicology

authors： O'Byrne PM,Kavanagh PV,McNamara SM,Stokes SM

更新日期：2013-03-01 00:00:00

abstract：:A rapid, sensitive, and specific method for the determination of opiates and cocaine and metabolites in urine, plasma, and blood was established. A one-step extraction followed by liquid chromatography-electrospray ionization tandem mass spectrometry operating in multiple reaction monitoring mode was used. Two chromat...

journal_title：Journal of analytical toxicology

authors： Cailleux A,Le Bouil A,Auger B,Bonsergent G,Turcant A,Allain P

更新日期：1999-11-01 00:00:00

abstract：:Cyanohydrins, also be called cyanoalcohols, are important industrial precursors to carboxylic acids and some amino acids. Acetone cyanohydrin (ACH) and formaldehyde cyanohydrin (glycolonitrile, FCH), which are the typical examples of cyanohydrins, are classified as extremely hazardous substances. As the cyanohydrins c...

journal_title：Journal of analytical toxicology

authors： Zheng S,Yuan X,Wang W,Liang C,Cao F,Zhang R

更新日期：2016-06-01 00:00:00

abstract：:Toxicological analyses of medicines and chemicals in formaldehyde-treated specimens are a component of forensic toxicology. This review involves two parts: (i) reactions of formaldehyde with substances in tissues fixed with formalin (aqueous formaldehyde solution) and (ii) the stability of substances in formalin-treat...

journal_title：Journal of analytical toxicology

authors： Takayasu T

更新日期：2013-11-01 00:00:00

abstract：:Oxymorphone (OM), a prescription opioid and metabolite of oxycodone, was included in the recently published proposed revisions to the Mandatory Guidelines for Federal Workplace Drug Testing Programs. To facilitate toxicological interpretation, this study characterized the time course of OM and its metabolite, noroxymo...

journal_title：Journal of analytical toxicology

authors： DePriest AZ,Heltsley R,Black DL,Mitchell JM,LoDico C,Flegel R,Cone EJ

更新日期：2016-10-01 00:00:00

abstract：:The effect of long-term room temperature storage on the stability of ethanol in whole blood specimens was investigated. One hundred and seventeen preserved whole blood case samples (110 of 117 with two tubes of blood in each case) were used for this study. One tube from each case was initially tested for blood alcohol...

journal_title：Journal of analytical toxicology

authors： Tiscione NB,Vacha RE,Alford I,Yeatman DT,Shan X

更新日期：2015-07-01 00:00:00

abstract：:A hair screening method has been developed for the detection of methamphetamine using an immunoassay analyzer (AxSYM) with a fluorescence polarization immunoassay (FPIA) technique. The method consisted of washing, cutting and digesting a hair sample (5 mg) with an enzymatic digestion solution. The digested hair sample...

journal_title：Journal of analytical toxicology

authors： Cheong JC,Suh S,Ko BJ,Lee JI,Kim JY,Suh YJ,In MK

更新日期：2013-05-01 00:00:00