Urine concentration Does Not Affect Biochemical Testing for Non-Adherence.

abstract：:This report describes a possible suicide by overdosage with diltiazem. The decreased, a 39-year-old male who had been under treatment for an unidentified heart condition, was discovered on the bathroom floor in his residence. Comprehensive drug screens performed on available postmortem specimens revealed the presence ...

journal_title：Journal of analytical toxicology

authors： Kalin JR,Wood KM,Lee AJ

更新日期：1994-05-01 00:00:00

abstract：:An expert system applied as a screening test for amphetamine analogues found in recreational-drug exhibits (tablets or powders) is described. The knowledge base defining the reference Fourier transform infrared spectroscopic (FTIR) spectral patterns has been built according to criteria encompassing toxicological, phar...

journal_title：Journal of analytical toxicology

authors： Praisler M,Dirinck I,Van Bocxlaer JF,De Leenheer AP,Massart DL

更新日期：2001-01-01 00:00:00

abstract：:Ethiofencarb is one of the carbamate compounds, which are, in general, less toxic than organophosphorus insecticides. This is due to their reversible acetylcholinesterase inhibition and relative inability to cross the blood-brain barrier. Generally, ethiofencarb is regarded to be of low toxicity (LD(50) > 200 mg/kg); ...

journal_title：Journal of analytical toxicology

authors： Al-Samarraie MS,Karinen R,Rognum T,Hasvold I,Opdal Stokke M,Christophersen AS

更新日期：2009-09-01 00:00:00

abstract：:An analytical method for determining exposure to 2,2'-dichlorodiethyl sulfide (sulfur mustard, HD) has been enhanced. The method is based on the cleavage of adducted HD (protein-hydroxyethylthioethyl esters) to produce thiodiglycol. Following cleavage, a deuterated internal standard is added, and the analytes are extr...

journal_title：Journal of analytical toxicology

authors： Lawrence RJ,Smith JR,Boyd BL,Capacio BR

更新日期：2008-01-01 00:00:00

abstract：:A method for the simultaneous analysis of cocaine (COC), derivatized benzoylecgonine (BE), and derivatized ecgonine methyl ester (EME) has been developed. Blood or urine containing deuterated analogs of the three analytes is extracted by pouring over a Chem-Elut column and eluting with chloroform/isopropanol (9:1). Th...

journal_title：Journal of analytical toxicology

authors： Isenschmid DS,Levine BS,Caplan YH

更新日期：1988-09-01 00:00:00

abstract：:Acetaminophen (APAP, n-acetyl-p-aminophenol) and salicylate (ASA, acetylsalicylic acid) are two of the most frequently overdosed drugs reported in the emergency room. Most APAP and ASA tests are performed with analytical instruments in laboratories, which are not always ideal for emergency situations. A rapid membrane...

journal_title：Journal of analytical toxicology

authors： Song W,Dou C

更新日期：2003-09-01 00:00:00

abstract：:Results of urine drug analyses for three racing greyhounds that tested positive for caffeine in this laboratory were contested by the animal trainer, who asserted that positives were achieved from deliberate chocolate feeding by a rival kennel. The metabolism and excretion of methylxanthines was examined by high-perfo...

journal_title：Journal of analytical toxicology

authors： Wells DJ,Hanks BM,Yarbrough CS,Davis MA

更新日期：1988-01-01 00:00:00

abstract：:Ethanol is the most frequently identified compound in forensic toxicology. Although confirmation involving mass spectrometry is desirable, relatively few methods have been published to date. A novel technique utilizing a Dean's Switch to simultaneously quantitate and confirm ethyl alcohol by flame-ionization (FID) and...

journal_title：Journal of analytical toxicology

authors： Tiscione NB,Alford I,Yeatman DT,Shan X

更新日期：2011-09-01 00:00:00

abstract：:A selected ion monitoring gas chromatographic/mass spectrometric method for the quantitative determination of benzene in air, breath, and blood was developed utilizing a headspace assay with benzene-d3 as an internal standard. Limits of detection for 2 ng/mL in blood and 0.1 ppb in a 5-L sample of air or breath were a...

journal_title：Journal of analytical toxicology

authors： Gruenke LD,Craig JC,Wester RC,Maibach HI

更新日期：1986-11-01 00:00:00

abstract：:Amoxapine, a tricyclic antidepressant, is metabolized to 8-hydroxyamoxapine and 7-hydroxyamoxapine. There are few reports on the metabolism of this drug and correlation of clinical symptoms in overdose patients. Five such patients admitted to the Emergency Unit of the University of Cincinnati Hospital were studied. Cl...

journal_title：Journal of analytical toxicology

authors： Tasset JJ,Pesce AJ

更新日期：1984-05-01 00:00:00

abstract：:Nicotine is the major addictive compound in tobacco and is responsible for tobacco dependence. It is primarily metabolized to cotinine (COT) and trans-3'-hydroxycotinine (3HC) by the liver enzyme cytochrome P-450 2A6 (CYP2A6). The 3HC/COT ratio measured in the saliva of smokers is highly correlated with the intrinsic ...

journal_title：Journal of analytical toxicology

authors： Lea RA,Dickson S,Benowitz NL

更新日期：2006-07-01 00:00:00

abstract：:Different analytical procedures for quantitation of total morphine and codeine in urine were evaluated. Hydrolysis of urine with hydrochloric acid and four different enzymes was compared. In order to effect complete hydrolysis of glucuronide conjugates, hydrolysis with 6.5M HCl containing bisulphite and heating at 100...

journal_title：Journal of analytical toxicology

authors： Lin Z,Lafolie P,Beck O

更新日期：1994-05-01 00:00:00

abstract：:Because mycotoxins occur worldwide in grain and grain products, evaluating their effects on the health of the population has become important. The development of a high performance liquid chromatographic (HPLC) procedure was investigated for the analysis of aflatoxin B1, citrinin, and ochratoxin A, from hydrolyzed hum...

journal_title：Journal of analytical toxicology

authors： Orti DL,Hill RH Jr,Liddle JA,Needham LL,Vickers L

更新日期：1986-03-01 00:00:00

abstract：:A gas chromatographic/mass spectrometric (GC/MS) method for the rapid quantitation of atropine (AT) in blood is presented. A 2.0-mL blood specimen containing deuterated N-methyl-atropine as the internal standard was alkaline-hydrolyzed to convert atropine to tropine. The tropine was extracted by organic solvent which ...

journal_title：Journal of analytical toxicology

authors： Saady JJ,Poklis A

更新日期：1989-09-01 00:00:00

abstract：:The List of Prohibited Substances and Methods (the List), an International Standard published yearly by the World Anti-Doping Agency (WADA), determines which substances and methods are prohibited in sport in- and out-of-competition. Stimulants are included within drug class S.6 under the in-competition testing sectio...

journal_title：Journal of analytical toxicology

authors： Boghosian T,Mazzoni I,Barroso O,Rabin O

更新日期：2011-11-01 00:00:00

abstract：:In methanol intoxication, increased levels of the metabolite formate are associated with metabolic acidosis and an increased risk for ocular and neurological dysfunction. A simple method for plasma formate measurement by adaptation of a manual enzymatic assay to a Cobas Mira S analyzer is presented. Six microliters of...

journal_title：Journal of analytical toxicology

authors： Blomme B,Lheureux P,Gerlo E,Maes V

更新日期：2001-03-01 00:00:00

abstract：:Synthetic cannabinoids emerged on the designer drug market in recent years due to their ability to produce cannabis-like effects without the risk of detection by traditional drug testing techniques such as immunoassay and gas chromatography-mass spectrometry. As government agencies work to schedule existing synthetic ...

journal_title：Journal of analytical toxicology

authors： Knittel JL,Holler JM,Chmiel JD,Vorce SP,Magluilo J Jr,Levine B,Ramos G,Bosy TZ

更新日期：2016-04-01 00:00:00

abstract：:Bupropion is a "second generation" antidepressant agent structurally related to the phenethylamines. Postmortem toxicology data are presented from three suicidal drug overdoses in which bupropion was detected. In two cases in which bupropion was the major toxicology finding, peripheral blood levels of the parent drug ...

journal_title：Journal of analytical toxicology

authors： Friel PN,Logan BK,Fligner CL

更新日期：1993-11-01 00:00:00

abstract：:Storage of drug-based evidence inside sealed safes may allow chemical vapors to accumulate, creating concerns of drug exposure by inhalation, or the possibility of cross-contamination of drug evidence. Air samples were taken from inside eight drug safes and one small storage room at nine city and country police statio...

journal_title：Journal of analytical toxicology

authors： Doran GS,Deans R,De Filippis C,Kostakis C,Howitt JA

更新日期：2018-06-01 00:00:00

abstract：:Part I. Expert 4: The object of this study was to investigate the applicability of commercially available expert system shells to interpretation in forensic toxicology. Amitriptyline toxicology was selected as a pilot trial. Blood and tissue concentrations of amitriptyline and nortriptyline in fatal and nonfatal amitr...

journal_title：Journal of analytical toxicology

authors： Spiehler V,Spiehler E,Osselton MD

更新日期：1988-07-01 00:00:00

abstract：:About 22,000 samples of oral fluid have been collected in five population studies in Norway using either the Intercept or Statsure oral fluid sampling devices. The prevalence of alcohol and drugs was found to be higher in oral fluid samples with small volumes than in those with large volumes for both sampling devices;...

journal_title：Journal of analytical toxicology

authors： Gjerde H,Normann PT,Christophersen AS

更新日期：2010-09-01 00:00:00

abstract：:In mothers who had no prenatal care and in their newborns, the presence of cocaine and benzoylecgonine (BE) was determined in urine, hair, and meconium. Samples of urine and hair were obtained from pregnant women who entered the hospital for delivery. Cocaine usage was assessed by a urinary enzyme-multiplied immunoass...

journal_title：Journal of analytical toxicology

authors： DiGregorio GJ,Ferko AP,Barbieri EJ,Ruch EK,Chawla H,Keohane D,Rosenstock R,Aldano A

更新日期：1994-09-01 00:00:00

abstract：:The abuse of the designer amphetamines such as 3,4-methylenedioxymethamphetamine (MDMA) is increasing throughout the world. They have become popular drugs at all night techno dance parties, and their detection is an important issue. The objective of the presented study was to identify an unknown compound detected by t...

journal_title：Journal of analytical toxicology

authors： Maresova V,Hampl J,Chundela Z,Zrcek F,Polasek M,Chadt J

更新日期：2005-07-01 00:00:00

abstract：:This article reports the impact of diuresis on urinary excretion of ethanol in seven healthy volunteers who drank 1000 mL of export beer (44 g ethanol) in 30 min and, 120 min later, ingested 500 or 1000 mL of water within 5 min. Urine was voided before drinking started and every 30-60 min for 360 min after the start o...

journal_title：Journal of analytical toxicology

authors： Bendtsen P,Jones AW

更新日期：1999-11-01 00:00:00

abstract：:The collection and analysis of drugs in oral fluid (OF) at the roadside has become more feasible with the introduction of portable testing devices such as the Alere™ DDS®2 Mobile Test System (DDS®2). The objective of this study was to compare the on-site results for the DDS®2 to laboratory-based confirmatory assays wi...

journal_title：Journal of analytical toxicology

authors： Krotulski AJ,Mohr ALA,Friscia M,Logan BK

更新日期：2018-04-01 00:00:00

abstract：:Due to the lack of certified reference material, a reliable quantification in complex postmortem matrices can only be performed either by the addition of isotope-labelled standards or by the standard addition method. Although standard addition is a basic quantification procedure, its practical implementation is challe...

journal_title：Journal of analytical toxicology

authors： Reiter B,Stimpfl T

更新日期：2015-11-01 00:00:00

abstract：:Separating drugs which are both polar and basic has long been difficult because of the limited operating pH range of conventional HPLC columns. This paper describes a liquid chromatographic method capable of being used with either diode-array or mass spectrometric detection for the identification and quantitation of 1...

journal_title：Journal of analytical toxicology

authors： Goeringer KE,McIntyre lM,Drummer OH

更新日期：2003-01-01 00:00:00

abstract：:This article reports the investigation by 1H nuclear magnetic resonance (1H NMR) spectroscopy of biological fluids in a case of intentional poisoning with tetrahydrofuran (THF). Occupational exposures to this solvent are well documented, but acute poisoning cases are extremely rare, and the one presented here is the s...

journal_title：Journal of analytical toxicology

authors： Cartigny B,Azaroual N,Imbenotte M,Sadeg N,Testart F,Richecoeur J,Vermeersch G,Lhermitte M

更新日期：2001-05-01 00:00:00

abstract：:The synthetic chemical 4-aminobiphenyl (4-ABP) has been shown to be a bladder carcinogen in both man and animals. A valid radioimmunoassay for a metabolite of 4-ABP has been developed as a means to monitor potential human exposure to 4-ABP. The antibody was produced by the immunization of two female New Zealand White ...

journal_title：Journal of analytical toxicology

authors： Johnson HJ Jr,Cernosek SF Jr,Gutierrez-Cernosek RM,Brown LL

更新日期：1980-03-01 00:00:00

abstract：:A sensitive and specific method was developed for the quantitative analysis of l-alpha-acetylmethadol (LAAM), l-alpha-acetyl-N-normethadol (norLAAM), and l-alpha-acetyl-N,N-dinormethadol (dinorLAAM) in hair. In the development of this method, it was determined that sample pretreatment methods performed by the laborato...

journal_title：Journal of analytical toxicology

authors： Wilkins DG,Valdez AS,Krueger GG,Rollins DE

更新日期：1997-10-01 00:00:00